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  1. Book ; Online: Updates in management of SARS-CoV-2 infection

    Flisiak, Robert

    2022  

    Author's details Robert Flisiak (ed.)
    Language English
    Size 1 Online-Ressource (ix, 179 Seiten), Illustrationen, Diagramme
    Publisher MDPI
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Online
    Note printed edition of the special issue published in JCM ; Open Access
    HBZ-ID HT021622164
    ISBN 978-3-0365-5390-0 ; 9783036553894 ; 3-0365-5390-8 ; 3036553894
    DOI 10.3390/books978-3-0365-5390-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Updates in Management of SARS-CoV-2 Infection

    Flisiak, Robert

    2022  

    Keywords Medicine ; COVID-19 ; SARS-CoV-2 ; interleukin-6 ; tocilizumab ; therapy ; coronavirus disease 2019 ; cytokines ; severity ; prognosis ; mortality ; kidney failure ; rapid diagnostic test ; antigen detection ; Cytomegalovirus ; co-infections ; critical care ; liver markers ; inflammation ; morbidity ; personalized medicine ; liver functional tests ; COVID-19 pneumonia ; meta-analysis ; trial sequential analysis ; children ; clinical presentation ; coronavirus disease 2019 (COVID-19) ; epidemiology ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ; clinical outcome ; symptomatology ; pandemic ; angiotensin 1 receptor (AT1R) ; AT1R concentration ; angiotensin II ; symptoms' severity ; diagnosis ; artificial intelligence ; medical imaging ; systematic umbrella review ; methodological credibility ; PCR test ; COVID-19 diagnosis ; Charlson Comorbidities Index ; cluster analysis ; longitudinal cluster ; individualized management ; n/a
    Language 0|e
    Size 1 electronic resource (198 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021620758
    ISBN 9783036553900 ; 3036553908
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Ways to Eliminate Viral Hepatitis as a Global Health Threat.

    Flisiak, Robert / Zarębska-Michaluk, Dorota / Flisiak-Jackiewicz, Marta

    Viruses

    2022  Volume 14, Issue 7

    Abstract: Hepatitis B (HBV) and C (HCV) have been recognized by the World Health Organization [ ... ]. ...

    Abstract Hepatitis B (HBV) and C (HCV) have been recognized by the World Health Organization [...].
    MeSH term(s) Global Health ; Hepatitis B/epidemiology ; Hepatitis B/prevention & control ; Hepatitis, Viral, Human/epidemiology ; Hepatitis, Viral, Human/prevention & control ; Humans ; World Health Organization
    Language English
    Publishing date 2022-07-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14071554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tocilizumab for the treatment of COVID-19.

    Flisiak, Robert / Flisiak-Jackiewicz, Marta / Rzymski, Piotr / Zarębska-Michaluk, Dorota

    Expert review of anti-infective therapy

    2023  Volume 21, Issue 8, Page(s) 791–797

    Abstract: Introduction: Since the beginning of the COVID-19 pandemic, the repurposing of medicines has been pursued to find interventions effective in preventing fatal outcome of the disease. One of these drugs was tocilizumab, an interleukin-6 inhibiting ... ...

    Abstract Introduction: Since the beginning of the COVID-19 pandemic, the repurposing of medicines has been pursued to find interventions effective in preventing fatal outcome of the disease. One of these drugs was tocilizumab, an interleukin-6 inhibiting monoclonal antibody, previously used to treat several immune-related disorders.
    Areas covered: In this article, we present the results of the initial observational studies and subsequent randomized clinical trials on the efficacy and safety of tocilizumab in the treatment of COVID-19. Despite conflicting results, possibly due to the heterogeneity of the studied populations, large studies have ultimately proven that preventing IL-6 from attaching to its receptors can effectively reverse the fatal course of the disease. We also discuss the meta-analyses, which mostly supported the validity of tocilizumab therapy. We show how tocilizumab found its place in the most important recommendations on COVID-19 treatment and obtained authorization from the major regulatory authorities.
    Expert opinion: The criteria for optimizing tocilizumab therapy in COVID-19 still need to be established. They are also important considering the existing risks of future zoonotic spillovers and epidemics that may trigger hyperinflammation that could be efficiently blocked. The experience gained with tocilizumab shall be perceived as preparedness for future challenges.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; COVID-19 Drug Treatment ; Pandemics ; Treatment Outcome
    Chemical Substances tocilizumab (I031V2H011)
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2023.2226867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6106: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Early oral antiviral use in patients hospitalised with COVID-19.

    Zarębska-Michaluk, Dorota / Flisiak, Robert

    The Lancet. Infectious diseases

    2022  Volume 22, Issue 12, Page(s) 1650–1651

    MeSH term(s) Humans ; Antiviral Agents/therapeutic use ; SARS-CoV-2 ; Hospitalization ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-08-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(22)00522-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5743: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Beethoven's deafness more likely linked to viral infection than lead poisoning.

    Rzymski, Piotr / Zarębska-Michaluk, Dorota / Flisiak, Robert

    The Journal of infection

    2023  Volume 88, Issue 2, Page(s) 210

    MeSH term(s) Humans ; Deafness ; Lead Poisoning/complications ; Virus Diseases ; Germany
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Letter
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 48: Show issues

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  7. Article: Updates in Management of SARS-CoV-2 Infection.

    Flisiak, Robert / Zarębska-Michaluk, Dorota / Flisiak-Jackiewicz, Marta / Rzymski, Piotr

    Journal of clinical medicine

    2022  Volume 11, Issue 15

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide since the beginning of 2020 [ ... ]. ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide since the beginning of 2020 [...].
    Language English
    Publishing date 2022-07-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11154472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Could chronic HBV infection explain Beethoven's hearing loss? Implications for patients currently living with hepatitis B.

    Rzymski, Piotr / Zarębska-Michaluk, Dorota / Flisiak, Robert

    The Journal of infection

    2023  Volume 87, Issue 3, Page(s) 171–176

    Abstract: The cause of Ludwig van Beethoven's health deterioration, i.e., hearing loss and cirrhosis, have been subject to various studies. The genomic analysis of his hair indicates infection with the hepatitis B virus (HBV) at least 6 months prior to death. ... ...

    Abstract The cause of Ludwig van Beethoven's health deterioration, i.e., hearing loss and cirrhosis, have been subject to various studies. The genomic analysis of his hair indicates infection with the hepatitis B virus (HBV) at least 6 months prior to death. However, considering his first documented case of jaundice in the summer of 1821, second jaundice months prior to his death, and increased risk of hearing loss in HBV-infected patients, we offer an alternative hypothesis of chronic HBV infection as a cause of deafness and cirrhosis. According to it, HBV was acquired early, progressed from immune-tolerant to an immune-reactive phase, and triggered Beethoven's hearing issues when aged 28. Later, HBV infection entered the non-replication phase with at least two episodes of reactivation in the fifth decade of life accompanied by jaundice. More studies examining hearing loss in patients with chronic HBV infection are encouraged to better understand their potential otologic needs.
    MeSH term(s) Humans ; Hepatitis B virus ; Famous Persons ; Hearing Loss/etiology ; Hepatitis B ; Hepatitis B, Chronic/complications ; Liver Cirrhosis
    Language English
    Publishing date 2023-06-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 48: Show issues

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  9. Article: Meeting of Initiative Group for Central European Hepatologic Collaboration (CEHC): Warsaw, 19-21 November 2015.

    Flisiak, Robert

    Clinical and experimental hepatology

    2016  Volume 2, Issue 1, Page(s) 1

    Language English
    Publishing date 2016-03-24
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2937940-4
    ISSN 2449-8238 ; 2392-1099
    ISSN (online) 2449-8238
    ISSN 2392-1099
    DOI 10.5114/ceh.2016.58848
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Trends of Hepatitis A Virus Infection in Poland: Assessing the Potential Impact of the COVID-19 Pandemic and War in Ukraine.

    Rzymski, Piotr / Zarębska-Michaluk, Dorota / Genowska, Agnieszka / Tyszko, Piotr / Strukcinskiene, Birute / Flisiak, Robert

    Viruses

    2024  Volume 16, Issue 3

    Abstract: Hepatitis A virus (HAV) is the most common cause of acute viral hepatitis, which is preventable by vaccination. This study analyzed trends of HAV infections in Poland according to socio-demographic features in the years 2009-2022 and assessed the ... ...

    Abstract Hepatitis A virus (HAV) is the most common cause of acute viral hepatitis, which is preventable by vaccination. This study analyzed trends of HAV infections in Poland according to socio-demographic features in the years 2009-2022 and assessed the potential impact of the COVID-19 pandemic (2020-2023) and the migration of war refugees from Ukraine (since February 2022). In 2009-2022, 7115 new cases of HAV infection were diagnosed in Poland, especially among men (66.4%) and in urban areas (77.4%). Infections among men were most common at the age of 25-34 (median rate 0.43 per 10
    MeSH term(s) Male ; Humans ; Female ; Hepatitis A virus ; Poland/epidemiology ; Ukraine/epidemiology ; Pandemics ; COVID-19/epidemiology ; SARS-CoV-2 ; Hepatitis A/epidemiology
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16030469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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