Article ; Online: Comparison of spectral domain optical coherence tomography parameters between disc suspects and "pre-perimetric" glaucomatous discs classified on disc photo.
Indian journal of ophthalmology
2021 Volume 69, Issue 3, Page(s) 603–610
Abstract: Purpose: The aim of this study was to compare SD-OCT parameters between disc suspects and "pre-perimetric" glaucomatous discs classified on disc photos.: Methods: Disc photos of suspicious discs with normal Humphrey visual fields (HVF) were graded as ...
| Abstract | Purpose: The aim of this study was to compare SD-OCT parameters between disc suspects and "pre-perimetric" glaucomatous discs classified on disc photos. Methods: Disc photos of suspicious discs with normal Humphrey visual fields (HVF) were graded as normal or pre-perimetric glaucomatous based on the consensus of three masked glaucoma specialists. RNFL and GCL-IPL maps of SD-OCT (Cirrus OCT) of these eyes were studied. Quantitative RNFL parameters were compared. Both groups were also compared with respect to parameters being classified as abnormal (at the 1% level), and the pattern of GCL-IPL and NFL maps were assessed qualitatively and classified as normal or pre-perimetric glaucomatous by a masked glaucoma specialist. Results: The average and inferior RNFL thicknesses were decreased in pre-perimetric glaucomatous eyes compared to normal eyes (p 0.01) The average, minimal, inferotemporal and inferior sector GCL-IPL thicknesses were decreased in pre-perimetric glaucomatous eyes (all P < 0.002) The highest AUC was for the inferior RNFL thickness (0.771) followed by average RNFL thickness (0.757) The sensitivity and specificity for any one abnormal RNFL parameter was 71.9% and 59.7%, for GCL-IPL parameters was 70% and 69.1% The positive (PLR) and negative likelihood ratios (NLR) were 1.78 and 0.47 for RNFL and 2.26 and 0.43 for GCL-IPL parameters. For the qualitative assessment of RNFL and GCL-IPL maps, the sensitivity, specificity, PLR and NLR were 75%, 77.2%, 3.29, and 0.32, respectively. Conclusion: Pre-perimetric disc suspects had greater OCT changes compared to normal disc suspects. Qualitative assessment of RNFL and GCL-IPL maps had the highest discriminatory ability. |
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| MeSH term(s) | Cross-Sectional Studies ; Glaucoma/diagnosis ; Humans ; Intraocular Pressure ; Nerve Fibers ; Retinal Ganglion Cells ; Tomography, Optical Coherence |
| Language | English |
| Publishing date | 2021-02-16 |
| Publishing country | India |
| Document type | Journal Article |
| ZDB-ID | 187392-1 |
| ISSN | 1998-3689 ; 0301-4738 |
| ISSN (online) | 1998-3689 |
| ISSN | 0301-4738 |
| DOI | 10.4103/ijo.IJO_1309_20 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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