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Article ; Online: Peas in the Pod: Systemic Therapy for Systemic Disease, Radiation for Local Disease.

Mendenhall, William M

International journal of radiation oncology, biology, physics

2021 Volume 111, Issue 2, Page(s) 311

Language	English
Publishing date	2021-09-02
Publishing country	United States
Document type	Letter
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2021.05.127
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Book: Radiation therapy for skin cancer

Cognetta, Armand B. / Mendenhall, William M.

2013

Author's details	Armand B. Cognetta ; William M. Mendenhall ed
Language	English
Size	XII, 251 S. : Ill., graph. Darst.
Publisher	Springer
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT017734944
ISBN	978-1-4614-6985-8 ; 9781461469865 ; 1-4614-6985-6 ; 1461469864
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2013 A 2168	available for loan (reading room)	Lesesaal EG

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Article ; Online: Proton Radiotherapy for Skull-Base Malignancies: Imaging Considerations of Radiotherapy and Complications.

Holtzman, Adam L / Dagan, Roi / Mendenhall, William M

Oral and maxillofacial surgery clinics of North America

2023 Volume 35, Issue 3, Page(s) 469–484

Abstract: Proton therapy (PT) is a form of highly conformal external-beam radiotherapy used to mitigate acute and late effects following radiotherapy. Indications for treatment include both benign and malignant skull-base and central nervous system pathologies. ... ...

Abstract	Proton therapy (PT) is a form of highly conformal external-beam radiotherapy used to mitigate acute and late effects following radiotherapy. Indications for treatment include both benign and malignant skull-base and central nervous system pathologies. Studies have demonstrated that PT shows promising results in minimizing neurocognitive decline and reducing second malignancies with low rates of central nervous system necrosis. Future directions and advances in biologic optimization may provide additional benefits beyond the physical properties of particle dosimetry.
MeSH term(s)	Humans ; Protons ; Skull Base Neoplasms/diagnostic imaging ; Skull Base Neoplasms/radiotherapy ; Proton Therapy/adverse effects ; Proton Therapy/methods ; Diagnostic Imaging ; Skull ; Radiotherapy Dosage
Chemical Substances	Protons
Language	English
Publishing date	2023-03-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1316546-x
ISSN	1558-1365 ; 1042-3699
ISSN (online)	1558-1365
ISSN	1042-3699
DOI	10.1016/j.coms.2023.02.003
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Article ; Online: Local salvage of radiorecurrent prostate cancer.

Henderson, Randal H / Bryant, Curtis / Nichols, R Charles / Mendenhall, William M / Mendenhall, Nancy P

The Prostate

2023 Volume 83, Issue 11, Page(s) 1001–1010

Abstract: Background: Locally recurrent prostate cancer following primary external beam radiotherapy without distant metastasis is a challenging problem, with no current consensus on the optimal management of these patients. Traditional whole-gland salvage ... ...

Abstract	Background: Locally recurrent prostate cancer following primary external beam radiotherapy without distant metastasis is a challenging problem, with no current consensus on the optimal management of these patients. Traditional whole-gland salvage treatments offered up to a 50% 5-year disease-free survival rate but with troubling levels of risk for significant complications. Recent progress in advanced imaging techniques has allowed a more accurate selection of patients with local-only recurrence and a selection of patients that may be suitable for newer partial-gland salvage treatments that may reduce late complications. Methods: This article reviews advances in patient selection and provides an overview of whole- and partial-gland salvage results from selected recent meta-analyses, multi-institutional series, and studies from centers of excellence for these treatment approaches. Results: Salvage radical prostatectomy produces 5-year relapse-free survival (RFS) rates in the 50%-60% range with severe gastrointestinal (GI) toxicity in < 2% but severe genitourinary (GU) toxicity in 15%-23% of patients. The whole-gland options of high and low dose rate brachytherapy and stereotactic body radiation therapy appear to offer similar 5-year control rates, with low severe GU and GI toxicity rates of 4%-8% and <2%, respectively. Cryotherapy and high-intensity focused ultrasound (HIFU) offer similar 5-year RFS rates but carry significant risks for severe GU and GI toxicity in the range of 10%-27% and <2%, respectively. Early results of partial-gland salvage techniques in selected patients appear promising, with 3-year RFS rates of 48%-72% and rare grade 3 toxicity. Conclusion: It is important to understand the relative effectiveness and risks of the various treatment options to effectively counsel patients who face this distressing clinical situation. Whole-gland salvage options offer the possibility of long-term control but with significant risks of severe toxicity. Emerging data for the partial-gland salvage options in appropriately selected patients may offer hope of reasonable control rates with reduced severe toxicity.
MeSH term(s)	Male ; Humans ; Neoplasm Recurrence, Local/therapy ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/surgery ; Prostatic Neoplasms/drug therapy ; Brachytherapy/adverse effects ; Brachytherapy/methods ; Prostate/pathology ; Prostatectomy ; Salvage Therapy/methods
Language	English
Publishing date	2023-05-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604707-5
ISSN	1097-0045 ; 0270-4137
ISSN (online)	1097-0045
ISSN	0270-4137
DOI	10.1002/pros.24551
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Article ; Online: A descriptive examination of international family/shared meals: Prevalence, meal types, media at meals, and emotional well-being.

Berge, Jerica M / Doherty, William J / Klemenhagen, Kristen C / Hersch, Derek / Mendenhall, Tai J / Danner, Christine

Families, systems & health : the journal of collaborative family healthcare

2024

Abstract: Introduction: Studies in the United States have shown associations between family/shared meal frequency and child health and well-being. Less is known about family/shared meal characteristics (e.g., frequency, meal type, meal activities) in adults and ... ...

Abstract	Introduction: Studies in the United States have shown associations between family/shared meal frequency and child health and well-being. Less is known about family/shared meal characteristics (e.g., frequency, meal type, meal activities) in adults and international samples and whether there are protective associations between family/shared meal frequency and emotional well-being. Also unknown, is whether family meals provide protective associations for other family members in the household. Method: In a 2022 cross-sectional study, an online survey was administered in the United States, Italy, and Germany. One adult respondent (49.5% female; Mage = 45.6) from each household ( Results: The majority of adults across countries engaged in six or more family/shared meals per week, with more meals on weekends. Breakfast, lunch, and dinner family/shared meals were more common on weekends, and European countries reported engaging in a higher prevalence of all meal types. Higher frequency of family/shared meals was significantly correlated with fewer depressive symptoms, more connectedness, and higher levels of happiness in adults across countries and in a second household member. Discussion: Family/shared meals were beneficial across an international sample and may provide protective spillover effects for multiple household members. Clinicians and researchers who work with families may want to consider assessing for and intervening on family meal frequency. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1326859-4
ISSN	1939-0602 ; 1091-7527 ; 0736-1718
ISSN (online)	1939-0602
ISSN	1091-7527 ; 0736-1718
DOI	10.1037/fsh0000874
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Book: Organ preservation

Mendenhall, William M.

(Hematology/oncology clinics of North America ; 15,2)

2001

Author's details	William M. Mendenhall, guest ed
Series title	Hematology/oncology clinics of North America ; 15,2 Hematology, oncology clinics of North America
Collection	Hematology, oncology clinics of North America
Language	English
Size	VII S., S. 219 - 406 : Ill., graph. Darst.
Publisher	Saunders
Publishing place	Philadelphia u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT013048904
Database	Catalogue ZB MED Medicine, Health

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Se 1077 -15,2-	verfügbar in Königswinter	Königswinter

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Article ; Online: Adaptive radiotherapy for head and neck cancer: Pitfalls and possibilities from the radiation oncologist's point of view.

Nuyts, Sandra / Bollen, Heleen / Eisbruch, Avrahram / Strojan, Primoz / Mendenhall, William M / Ng, Sweet Ping / Ferlito, Alfio

Cancer medicine

2024 Volume 13, Issue 8, Page(s) e7192

Abstract: Background: Patients with head and neck cancer (HNC) may experience substantial anatomical changes during the course of radiotherapy treatment. The implementation of adaptive radiotherapy (ART) proves effective in managing the consequent impact on the ... ...

Abstract	Background: Patients with head and neck cancer (HNC) may experience substantial anatomical changes during the course of radiotherapy treatment. The implementation of adaptive radiotherapy (ART) proves effective in managing the consequent impact on the planned dose distribution. Methods: This narrative literature review comprehensively discusses the diverse strategies of ART in HNC and the documented dosimetric and clinical advantages associated with these approaches, while also addressing the current challenges for integration of ART into clinical practice. Results and conclusion: Although based on mainly non-randomized and retrospective trials, there is accumulating evidence that ART has the potential to reduce toxicity and improve quality of life and tumor control in HNC patients treated with RT. However, several questions remain regarding accurate patient selection, the ideal frequency and timing of replanning, and the appropriate way for image registration and dose calculation. Well-designed randomized prospective trials, with a predetermined protocol for both image registration and dose summation, are urgently needed to further investigate the dosimetric and clinical benefits of ART.
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.7192
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Article ; Online: Small Cell Carcinoma of the Head and Neck: Update on the University of Florida Experience.

Saldivar, Brittany / Kharod, Shivam M / Mendenhall, William M

Cancer investigation

2021 Volume 39, Issue 10, Page(s) 808–811

Abstract: We updated the University of Florida experience treating head and neck small cell carcinoma. Eight patients received a median of 67.7 Gy between 1989 and 2017. The 2-year rates of local, regional, distant, and disease control were 73, 60, 33, and 13%, ... ...

Abstract	We updated the University of Florida experience treating head and neck small cell carcinoma. Eight patients received a median of 67.7 Gy between 1989 and 2017. The 2-year rates of local, regional, distant, and disease control were 73, 60, 33, and 13%, respectively. The 2-year overall survival rate was 38%; median survival was 1.4 years. The longest disease-free period was 9.5 years after treatment with no evidence of disease. Radiotherapy is an acceptable treatment for these patients, who tend to have poor outcomes and distant metastatic disease. Superior systemic chemotherapy may improve outcomes and decrease the likelihood of distant recurrence.
MeSH term(s)	Adult ; Aged ; Carcinoma, Small Cell/mortality ; Carcinoma, Small Cell/therapy ; Female ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/therapy ; Humans ; Male ; Middle Aged
Language	English
Publishing date	2021-09-23
Publishing country	England
Document type	Journal Article
ZDB-ID	604942-4
ISSN	1532-4192 ; 0735-7907
ISSN (online)	1532-4192
ISSN	0735-7907
DOI	10.1080/07357907.2020.1849255
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Article ; Online: Flap Reconstruction Results in Longer Overall Treatment Time in Patients Treated with Surgery and Adjuvant Radiotherapy for Carcinoma of the Oral Cavity and Larynx.

Drescher, Nicolette R / Latortue, Tayna / Brisson, Ryan J / Cassidy, Vincent D / Amdur, Robert J / Mendenhall, William M / Hitchcock, Kathryn E

American journal of clinical oncology

2024

Abstract: Objective: There is an inverse relationship between cancer cure and overall treatment time (OTT) in patients treated with surgical resection and radiotherapy (RT).: Methods: OTT was evaluated based on the reconstruction procedure in 420 patients with ...

Abstract	Objective: There is an inverse relationship between cancer cure and overall treatment time (OTT) in patients treated with surgical resection and radiotherapy (RT). Methods: OTT was evaluated based on the reconstruction procedure in 420 patients with oral cavity and larynx cancers treated with surgery and RT between 1991 and 2020. Results: With OTT >85 days, the difference between no versus yes flap reconstruction was ~20 percentage points and significant for all comparisons: primary closure (+/- skin graft), 49%, vs. rotation or free flap, 71% (P<0.0001); primary closure (+/- skin graft), 49%, versus free flap without bone, 66% (P=0.0358); and primary closure (+/- skin graft), 49%, versus free flap with bone, 82% (P<0.0001). Conclusions: The use of flap reconstructions results in substantial increases in OTT. Findings suggest a need to reevaluate current policies regarding the choice of reconstruction and starting RT sooner after surgery.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	604536-4
ISSN	1537-453X ; 0277-3732
ISSN (online)	1537-453X
ISSN	0277-3732
DOI	10.1097/COC.0000000000001090
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Article ; Online: Impact of mandated drug monitoring on opioid use during highly conformal radiotherapy for oropharynx cancer.

Gracie, Jayden / Holtzman, Adam L / Dagan, Roi / Bryant, Curtis M / Morris, Christopher G / Mendenhall, William M

Annals of palliative medicine

2023 Volume 12, Issue 6, Page(s) 1146–1154

Abstract: Background: Prescription drug monitoring programs (PDMPs) have proliferated due to increasing opioid-related deaths. We evaluated acute opioid use changes for 64 patients treated with highly conformal radiotherapy (RT) following a state-mandated PDMP.!## ...

Abstract	Background: Prescription drug monitoring programs (PDMPs) have proliferated due to increasing opioid-related deaths. We evaluated acute opioid use changes for 64 patients treated with highly conformal radiotherapy (RT) following a state-mandated PDMP. Methods: Patients receiving proton therapy (PT) (n=40), intensity-modulated RT (IMRT) (n=14), or both (n=10) were divided into preintervention (n=26) and postintervention cohorts (n=38); records were reviewed retrospectively under an institutional review board (IRB)-approved tracking protocol. Dosages prescribed during acute therapy (during RT-3 months post-RT) and patient-reported pain (Defense and Veterans Pain Rating Scale) were endpoints. Dosages were treated as responses in Chi-square tests (three-level ordinal response). Results: Overall, 72% (n=46) received opioids; of which 22% (n=10) of all patients and 10% (n=2) of opioid-naive patients continued analgesic management 3 months post-RT. Median total doses were 975 and 1,025 morphine milligram equivalents (MME) in pre- and postintervention groups, with no significant differences in MME prescribed (P=0.8) or uncontrolled pain (P=0.3). Statistically significant factors were tonsil primaries (P<0.01) and alcohol use (P=0.02). Uncontrolled pain episodes during and post-RT did not vary per cohort (P=0.19). Conclusions: PDMP use was not associated with management changes in patient-reported acute pain during RT (IMRT or PT). Following highly conformal RT, few patients remained on narcotics 3 months post-RT.
MeSH term(s)	Humans ; Analgesics, Opioid/adverse effects ; Retrospective Studies ; Drug Monitoring ; Opioid-Related Disorders/drug therapy ; Radiotherapy, Conformal ; Acute Pain/drug therapy ; Oropharyngeal Neoplasms/drug therapy ; Oropharyngeal Neoplasms/radiotherapy ; Oropharyngeal Neoplasms/chemically induced
Chemical Substances	Analgesics, Opioid ; MME (78185-58-7)
Language	English
Publishing date	2023-10-27
Publishing country	China
Document type	Journal Article
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-23-404
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