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Article ; Online: c-MYB and DMTF1 in Cancer.

Fry, Elizabeth A / Inoue, Kazushi

2019 Volume 37, Issue 1, Page(s) 46–65

Abstract: The c-Myb gene encodes a transcription factor that regulates cell proliferation, differentiation ... that it is a bona fide oncogene. c-MYB is often overexpressed by translocation in human tumors with t(6;7 ... q23;q34) resulting in c-MYB-TCRβ in T cell ALL, t(X;6)(p11;q23) with c-MYB-GATA1 ...

Abstract	The c-Myb gene encodes a transcription factor that regulates cell proliferation, differentiation, and apoptosis through protein-protein interaction and transcriptional regulation of signaling pathways. The protein is frequently overexpressed in human leukemias, breast cancers, and other solid tumors suggesting that it is a bona fide oncogene. c-MYB is often overexpressed by translocation in human tumors with t(6;7)(q23;q34) resulting in c-MYB-TCRβ in T cell ALL, t(X;6)(p11;q23) with c-MYB-GATA1 in acute basophilic leukemia, and t(6;9)(q22-23;p23-24) with c-MYB-NF1B in adenoid cystic carcinoma. Antisense oligonucleotides to c-MYB were developed to purge bone marrow cells to eliminate tumor cells in leukemias. Recently, small molecules that inhibit c-MYB activity have been developed to disrupt its interaction with p300. The Dmp1 (cyclin D binding myb-like protein 1; Dmtf1) gene was isolated through its virtue for binding to cyclin D2. It is a transcription factor that has a Myb-like repeat for DNA binding. The Dmtf1 protein directly binds to the Arf promoter for transactivation and physically interacts with p53 to activate the p53 pathway. The gene is hemizygously deleted in 35-42% of human cancers and is associated with longer survival. The significances of aberrant expression of c-MYB and DMTF1 proteins in human cancers and their clinical significances are discussed.
MeSH term(s)	ADP-Ribosylation Factors/genetics ; Gene Expression Regulation, Neoplastic ; Hemizygote ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Oligonucleotides, Antisense/pharmacology ; Oligonucleotides, Antisense/therapeutic use ; Promoter Regions, Genetic ; Proto-Oncogene Proteins c-myb/genetics ; Proto-Oncogene Proteins c-myb/metabolism ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/therapeutic use ; Survival Analysis ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Translocation, Genetic ; Up-Regulation
Chemical Substances	DMTF1 protein, human ; MYB protein, human ; Oligonucleotides, Antisense ; Proto-Oncogene Proteins c-myb ; Small Molecule Libraries ; Transcription Factors ; ADP-Ribosylation Factors (EC 3.6.5.2)
Language	English
Publishing date	2019-01-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	604942-4
ISSN	1532-4192 ; 0735-7907
ISSN (online)	1532-4192
ISSN	0735-7907
DOI	10.1080/07357907.2018.1550090
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Article ; Online: Safety, tolerability, and pharmacokinetics of AL-335 in healthy volunteers and hepatitis C virus-infected subjects.

McClure, Matthew W / Berliba, Elina / Tsertsvadze, Tengiz / Streinu-Cercel, Adrian / Vijgen, Leen / Astruc, Béatrice / Patat, Alain / Westland, Christopher / Chanda, Sushmita / Zhang, Qingling / Kakuda, Thomas N / Vuong, Jennifer / Khorlin, Nick / Beigelman, Leonid / Blatt, Lawrence M / Fry, John

PloS one

2018 Volume 13, Issue 10, Page(s) e0204974

Abstract: Background: The nucleotide analog AL-335 is a pangenotypic hepatitis C virus (HCV ...

Abstract	Background: The nucleotide analog AL-335 is a pangenotypic hepatitis C virus (HCV) nonstructural protein (NS)5B inhibitor being evaluated as treatment for chronic HCV infection. Methods: This three-part randomized, double-blind study evaluated the safety and pharmacokinetics of single and multiple ascending oral doses of AL-335. Healthy volunteers (HVs) received single doses of AL-335 (100-1,200 mg) or placebo in a fasted or fed (400 mg) state. Non-cirrhotic subjects (HCV genotype [GT]1-4) and GT1-infected subjects with Child Pugh A cirrhosis received multiple doses of AL-335 (400, 800, 1,200 mg) or placebo once daily (QD) for 7 days. Results: Forty-eight HVs and 64 subjects with HCV GT1-4 were randomized and received treatment. AL-335 was well tolerated in HVs and HCV-infected subjects with/without cirrhosis. AL-335 was rapidly absorbed and converted to the metabolites ALS-022399 and ALS-022227. ALS-022227 exposure increased less than dose-proportionally and was unaffected by food, while AL-335 and ALS-022399 exposure increased with food by 85% and 50%, respectively, in HVs. Rapid and dose-dependent reductions in HCV-RNA were observed in GT1-infected subjects. In non-cirrhotic, GT1-4-infected subjects receiving AL-335 800 mg QD, potent antiviral activity was observed, regardless of genotype (mean maximum reductions in HCV-RNA of 4.0-4.8 log10 IU/mL). The same dose in GT1-infected cirrhotic subjects resulted in a 3.5 log10 IU/mL mean maximum reduction in HCV-RNA. Conclusions: AL-335 was well tolerated when administered as single and multiple doses, with an acceptable pharmacokinetic profile. The drug also demonstrated potent antiviral activity in HCV GT1-4-infected subjects, including GT1-infected subjects with cirrhosis.
MeSH term(s)	Adult ; Alanine/adverse effects ; Alanine/analogs & derivatives ; Alanine/pharmacokinetics ; Alanine/therapeutic use ; Antiviral Agents/adverse effects ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/therapeutic use ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Genotype ; Half-Life ; Hepacivirus/genetics ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Humans ; Liver Cirrhosis/complications ; Male ; Middle Aged ; Phosphoramides ; Placebo Effect ; RNA, Viral/blood ; Uridine/adverse effects ; Uridine/analogs & derivatives ; Uridine/pharmacokinetics ; Uridine/therapeutic use
Chemical Substances	Antiviral Agents ; Phosphoramides ; RNA, Viral ; Alanine (OF5P57N2ZX) ; adafosbuvir (S83770Y75R) ; Uridine (WHI7HQ7H85)
Language	English
Publishing date	2018-10-16
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0204974
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Article ; Online: "What does that mean?": The content validity of the ISPCAN Child Abuse Screening Tool - Child version (ICAST-C) in Romania, South Africa, and the Philippines.

Neelakantan, Lakshmi / Fry, Deborah / Florian, Lani / Silion, Doriana / Filip, Madalina / Thabeng, Mildred / Te, Kathlyn / Sunglao, Jun Angelo / Lu, Mengyao / Ward, Catherine L / Baban, Adriana / Jocson, Rosanne M / Alampay, Liane / Meinck, Franziska

Child abuse & neglect

2022 Volume 134, Page(s) 105869

Abstract: ... Child Abuse Screening Tool (Children's Version), known as the ICAST-C Version 3, is used widely to assess ... Objective: This study aimed to assess the content validity of the ICAST-C with adolescents in Romania ... on the relevance, comprehensibility, and comprehensiveness of the ICAST-C. Data were analysed using template ...

Abstract	Background: The International Society for Prevention of Child Abuse and Neglect (ISPCAN) Child Abuse Screening Tool (Children's Version), known as the ICAST-C Version 3, is used widely to assess violence against children, but there is limited psychometric evidence, especially on content validity. Objective: This study aimed to assess the content validity of the ICAST-C with adolescents in Romania, South Africa, and the Philippines. Methods: A purposive sample of adolescents (N = 53, 51 % female) were recruited from urban areas in Romania, the Eastern Cape Province of South Africa, and Metro Manila, Philippines. Semi-structured one-on-one in-depth cognitive interviews sought adolescent perspectives on the relevance, comprehensibility, and comprehensiveness of the ICAST-C. Data were analysed using template analysis. Results: The ICAST-C was broadly perceived to be relevant and comprehensive in measuring violence against children in all study locations. However, there were issues with the comprehensibility of the measure, described at three levels: interpreting items, undertaking coherent elaborations of relevant behaviors and places, and generating a coherent response to the questions. Conclusions: Suggestions to revise the ICAST-C include, among others, adding a practice or how-to section on answering the survey, clarifying the intent of questions, especially on neglect and sexual abuse, emphasizing that questions cover all locations, and asking more positive questions. Pilot studies testing the content validity and cultural appropriateness are needed as a matter of practice in large self-report surveys.
MeSH term(s)	Child ; Adolescent ; Female ; Humans ; Male ; Philippines ; Romania ; South Africa/epidemiology ; Child Abuse/diagnosis ; Child Abuse/prevention & control ; Child Abuse/psychology ; Psychometrics
Language	English
Publishing date	2022-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	799143-5
ISSN	1873-7757 ; 0145-2134
ISSN (online)	1873-7757
ISSN	0145-2134
DOI	10.1016/j.chiabu.2022.105869
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Article ; Online: Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies.

The Journal of biological chemistry

2016 Volume 291, Issue 31, Page(s) 16292–16306

Abstract: ... reveal several distinct open and closed conformations of the peptide linking N- and C-terminal domains ... with a camelid antibody fragment show that the doublecortin C-terminal domain adopts the same well defined ... specific for the C-terminal doublecortin domain affected microtubule binding, whereas a monoclonal mouse ...

Abstract	Doublecortin is a microtubule-associated protein produced during neurogenesis. The protein stabilizes microtubules and stimulates their polymerization, which allows migration of immature neurons to their designated location in the brain. Mutations in the gene that impair doublecortin function and cause severe brain formation disorders are located on a tandem repeat of two doublecortin domains. The molecular mechanism of action of doublecortin is only incompletely understood. Anti-doublecortin antibodies, such as the rabbit polyclonal Abcam 18732, are widely used as neurogenesis markers. Here, we report the generation and characterization of antibodies that bind to single doublecortin domains. The antibodies were used as tools to obtain structures of both domains. Four independent crystal structures of the N-terminal domain reveal several distinct open and closed conformations of the peptide linking N- and C-terminal domains, which can be related to doublecortin function. An NMR assignment and a crystal structure in complex with a camelid antibody fragment show that the doublecortin C-terminal domain adopts the same well defined ubiquitin-like fold as the N-terminal domain, despite its reported aggregation and molten globule-like properties. The antibodies' unique domain specificity also renders them ideal research tools to better understand the role of individual domains in doublecortin function. A single chain camelid antibody fragment specific for the C-terminal doublecortin domain affected microtubule binding, whereas a monoclonal mouse antibody specific for the N-terminal domain did not. Together with steric considerations, this suggests that the microtubule-interacting doublecortin domain observed in cryo-electron micrographs is the C-terminal domain rather than the N-terminal one.
MeSH term(s)	Animals ; Antibodies, Monoclonal, Murine-Derived/chemistry ; Camelus ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Humans ; Mice ; Microtubule-Associated Proteins/chemistry ; Neuropeptides/chemistry ; Protein Domains ; Protein Structure, Quaternary ; Rabbits ; Single-Chain Antibodies/chemistry
Chemical Substances	Antibodies, Monoclonal, Murine-Derived ; Microtubule-Associated Proteins ; Neuropeptides ; Single-Chain Antibodies ; doublecortin protein
Language	English
Publishing date	2016-05-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M116.726547
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Article: Patterns and potential drivers of intraspecific variability in the body C, N, and P composition of a terrestrial consumer, the snowshoe hare (

Rizzuto, Matteo / Leroux, Shawn J / Vander Wal, Eric / Wiersma, Yolanda F / Heckford, Travis R / Balluffi-Fry, Juliana

Ecology and evolution

2019 Volume 9, Issue 24, Page(s) 14453–14464

Abstract: ... concentrations of carbon (C), nitrogen (N), and phosphorus (P). However, we still have a rudimentary ...

Abstract	Intraspecific variability in ecological traits is widespread in nature. Recent evidence, mostly from aquatic ecosystems, shows individuals differing at the most fundamental level, that of their chemical composition. Age, sex, or body size and condition may be key drivers of intraspecific variability in the body concentrations of carbon (C), nitrogen (N), and phosphorus (P). However, we still have a rudimentary understanding of the patterns and drivers of intraspecific variability in chemical composition of terrestrial consumers, particularly vertebrates.Here, we investigate the elemental composition of the snowshoe hare
Language	English
Publishing date	2019-12-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.5880
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Article ; Online: Point-of-care Hepatitis C virus testing and linkage to treatment in an Australian inner-city emergency department.

Hutton, J / Doyle, J / Zordan, R / Weiland, T / Cocco, A / Howell, J / Iser, S / Snell, J / Fry, S / New, K / Sloane, R / Jarman, M / Phan, D / Tran, S / Pedrana, A / Williams, B / Johnson, J / Glasgow, S / Thompson, A

The International journal on drug policy

2019 Volume 72, Page(s) 84–90

Abstract: Background: In Australia, Hepatitis C Virus (HCV) treatment is declining, despite broad access ...

Abstract	Background: In Australia, Hepatitis C Virus (HCV) treatment is declining, despite broad access to direct-acting antiviral medication. People who inject drugs are proportionally over-represented in emergency department presentations. Emergency department assessment of people who have injected drugs for HCV presents an opportunity to engage this marginalised population with treatment. We describe the outcomes of risk-based screening and point-of-care anti-HCV testing for emergency department patients, and linkage to outpatient antiviral treatment. Methods: During the three-month study period, consecutive adult patients who presented to the emergency department during the study times were screened for risk factors and offered the OraQuick oral HCV antibody test. Those with reactive results were offered venepuncture in the emergency department for confirmatory testing and direct-acting antiviral treatment in clinic. The main outcome measures were the number and proportion of viremic participants that were linked to the hepatitis clinic, commenced treatment and achieved a sustained viral response. Secondary outcome measures were the proportion (%) of presentations screened that were oral antibody reactive, and the prevalence and type of HCV risk factors. Results: During the study period, 2408 of the 3931 (61%) presentations to the emergency department were eligible for screening. Of these 2408 patients, 1122 (47%) participated, 307 (13%) declined participation and 977 (41%) could not be approached during their time in the emergency department. Among the 1122 participants, 378 (34%) reported at least one risk factor. Subsequently, 368 (97%) of the 378 participants underwent OraQuick anti-HCV test, and 50 (14%) had a reactive result. A risk factor of ever having injected drugs was present in 44 (88%) of participants who were sero-positive. Of the 45 that had blood tested, 30 (67%) were HCV ribonucleic acid (RNA) positive. Three participants died. Of the 27 remaining participants, 10 (37%) commenced treatment and 7 of these 10 (70%) obtained a cure. There was a high rate of homelessness (24%) among anti-HCV positive participants. Conclusion: Among emergency department participants with a risk factor for HCV, positive serology was common using a rapid point-of-care test. A history of injecting drug use was identified as the risk factor with highest yield for positive HCV serology, and is suitable as a single screening question. However, linkage to care post ED presentation was low in this marginalised population. There is a need for new pathways to improve the care cascade for marginalised individuals living with HCV infection.
MeSH term(s)	Adult ; Antiviral Agents/administration & dosage ; Australia ; Emergency Service, Hospital ; Female ; Follow-Up Studies ; Hepacivirus/isolation & purification ; Hepatitis C/diagnosis ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Homeless Persons/statistics & numerical data ; Humans ; Male ; Mass Screening/methods ; Mass Screening/statistics & numerical data ; Middle Aged ; Point-of-Care Systems ; Prospective Studies ; RNA, Viral/analysis ; Risk Factors ; Substance Abuse, Intravenous/complications ; Substance Abuse, Intravenous/epidemiology
Chemical Substances	Antiviral Agents ; RNA, Viral
Language	English
Publishing date	2019-07-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2010000-0
ISSN	1873-4758 ; 0955-3959
ISSN (online)	1873-4758
ISSN	0955-3959
DOI	10.1016/j.drugpo.2019.06.021
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Article ; Online: The tasks of self-managing hepatitis C: the significance of disclosure.

Fry, Margaret / Bates, Glen

Psychology & health

2012 Volume 27, Issue 4, Page(s) 460–474

Abstract: The narratives of those with hepatitis C were viewed through the lens of Corbin and Strauss' ... hepatitis C positive interviewees described the challenges and turning points in adjusting ... with hepatitis C. Unique challenges emerged beyond those described by Corbin and Strauss (1988), namely ...

Abstract	The narratives of those with hepatitis C were viewed through the lens of Corbin and Strauss' [Corbin, J., & Strauss, A. (1988). Unending work and care: Managing chronic illness at home. The Jossey-Bass health series and The Jossey-Bass social and behavioral science series. San Francisco, CA: Jossey-Bass.] self-management model for chronic illness, using qualitative methodology. Fifteen Australian hepatitis C positive interviewees described the challenges and turning points in adjusting to their diagnosis. The data were analysed using open- and closed-coding methods. Support was found for a self-management model encompassing medical, emotional and life role facets for those adjusting to life with hepatitis C. Unique challenges emerged beyond those described by Corbin and Strauss (1988), namely that disclosure impacted both positively and negatively on the tasks of self-management. It was concluded that self-management may be compromised by disclosure, particularly distress derived from hepatitis C-related stigma. The self-management tasks described contribute to broadening clinicians' understanding of the challenges faced by those living with hepatitis C.
MeSH term(s)	Adaptation, Psychological ; Adult ; Anxiety/psychology ; Cognitive Dissonance ; Denial (Psychology) ; Emotions ; Female ; Health Behavior ; Helplessness, Learned ; Hepatitis C, Chronic/psychology ; Hepatitis C, Chronic/transmission ; Humans ; Life Style ; Male ; Middle Aged ; Physician-Patient Relations ; Prejudice ; Quality of Life/psychology ; Self Care/psychology ; Social Stigma ; Victoria
Language	English
Publishing date	2012
Publishing country	England
Document type	Journal Article
ZDB-ID	625255-2
ISSN	1476-8321 ; 0887-0446
ISSN (online)	1476-8321
ISSN	0887-0446
DOI	10.1080/08870446.2011.592982
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Article ; Online: Serum C-reactive protein and S100A12 concentrations in dogs with hepatic disease.

Craig, S M / Fry, J K / Rodrigues Hoffmann, A / Manino, P / Heilmann, R M / Suchodolski, J S / Steiner, J M / Hottinger, H A / Hunter, S L / Lidbury, J A

The Journal of small animal practice

2016 Volume 57, Issue 9, Page(s) 459–464

Abstract: Objectives: To describe serum C-reactive protein and S100A12 concentrations in dogs with hepatic ... the severity of hepatic necroinflammation.: Methods: Serum C-reactive protein and S100A12 concentrations ... was scored.: Results: C-reactive protein and S100A12 concentrations were greater than the upper ...

Abstract	Objectives: To describe serum C-reactive protein and S100A12 concentrations in dogs with hepatic disease and to determine whether there is a relationship between the concentration of either and the severity of hepatic necroinflammation. Methods: Serum C-reactive protein and S100A12 concentrations were measured in 46 dogs undergoing hepatic biopsy. Dogs were divided into three groups: congenital portosystemic shunts, chronic hepatitis and hepatic neoplasia. The histological severity of hepatic necroinflammation was scored. Results: C-reactive protein and S100A12 concentrations were greater than the upper limit of the reference intervals in 39 and 26% of dogs, respectively. There was no association of disease group with C-reactive protein (P=0·1733) or S100A12 (P=0·1513) concentrations. There was a positive correlation between serum C-reactive protein concentration and hepatic necroinflammatory activity (rs =0·428, P=0·006). Clinical significance: Increased serum C-reactive protein and S100A12 concentrations were observed in a subpopulation of dogs with various types of hepatic diseases, suggesting acute-phase inflammation and activation of phagocytic cells, respectively. Dogs with higher hepatic necroinflammatory activity scores tended to have higher serum C-reactive protein concentrations. Further studies are needed to confirm this finding in a larger group of dogs.
MeSH term(s)	Animals ; Biomarkers/blood ; Blood Proteins/metabolism ; Dog Diseases/blood ; Dog Diseases/pathology ; Dogs ; Female ; Liver Diseases/blood ; Male ; Predictive Value of Tests ; S100A12 Protein/blood ; Severity of Illness Index
Chemical Substances	Biomarkers ; Blood Proteins ; S100A12 Protein
Language	English
Publishing date	2016-09
Publishing country	England
Document type	Journal Article
ZDB-ID	410743-3
ISSN	1748-5827 ; 0022-4510 ; 1748-5827
ISSN (online)	1748-5827
ISSN	0022-4510 ; 1748-5827
DOI	10.1111/jsap.12504
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Article: Production and decay of xi(c)(0) at BABAR.

Aubert, B / Barate, R / Boutigny, D / Couderc, F / Karyotakis, Y / Lees, J P / Poireau, V / Tisserand, V / Zghiche, A / Grauges, E / Palano, A / Pappagallo, M / Pompili, A / Chen, J C / Qi, N D / Rong, G / Wang, P / Zhu, Y S / Eigen, G /

Ofte, I / Stugu, B / Abrams, G S / Borgland, A W / Breon, A B / Brown, D N / Button-Shafer, J / Cahn, R N / Charles, E / Day, C T / Gill, M S / Gritsan, A V / Groysman, Y / Jacobsen, R G / Kadel, R W / Kadyk, J / Kerth, L T / Kolomensky, Yu G / Kukartsev, G / Lynch, G / Mir, L M / Oddone, P J / Orimoto, T J / Pripstein, M / Roe, N A / Ronan, M T / Wenzel, W A / Barrett, M / Ford, K E / Harrison, T J / Hart, A J / Hawkes, C M / Morgan, S E / Watson, A T / Fritsch, M / Goetzen, K / Held, T / Koch, H / Lewandowski, B / Pelizaeus, M / Peters, K / Schroeder, T / Steinke, M / Boyd, J T / Burke, J P / Chevalier, N / Cottingham, W N / Kelly, M P / Cuhadar-Donszelmann, T / Hearty, C / Knecht, N S / Mattison, T S / McKenna, J A / Thiessen, D / Khan, A / Kyberd, P / Teodorescu, L / Blinov, A E / Blinov, V E / Bukin, A D / Druzhinin, V P / Golubev, V B / Ivanchenko, V N / Kravchenko, E A / Onuchin, A P / Serednyakov, S I / Skovpen, Yu I / Solodov, E P / Yushkov, A N / Best, D / Bondioli, M / Bruinsma, M / Chao, M / Eschrich, I / Kirkby, D / Lankford, A J / Mandelkern, M / Mommsen, R K / Roethel, W / Stoker, D P / Buchanan, C / Hartfiel, B L / Weinstein, A J R / Foulkes, S D / Gary, J W / Long, O / Shen, B C / Wang, K / Zhang, L / Del Re, D / Hadavand, H K / Hill, E J / MacFarlane, D B / Paar, H P / Rahatlou, S / Sharma, V / Berryhill, J W / Campagnari, C / Cunha, A / Dahmes, B / Hong, T M / Lu, A / Mazur, M A / Richman, J D / Verkerke, W / Beck, T W / Eisner, A M / Flacco, C J / Heusch, C A / Kroseberg, J / Lockman, W S / Nesom, G / Schalk, T / Schumm, B A / Seiden, A / Spradlin, P / Williams, D C / Wilson, M G / Albert, J / Chen, E / Dubois-Felsmann, G P / Dvoretskii, A / Hitlin, D G / Narsky, I / Piatenko, T / Porter, F C / Ryd, A / Samuel, A / Yang, S / Andreassen, R / Jayatilleke, S / Mancinelli, G / Meadows, B T / Sokoloff, M D / Blanc, F / Bloom, P / Chen, S / Ford, W T / Nauenberg, U / Olivas, A / Rankin, P / Ruddick, W O / Smith, J G / Ulmer, K A / Zhang, J / Chen, A / Eckhart, E A / Harton, J L / Soffer, A / Toki, W H / Wilson, R J / Zeng, Q / Spaan, B / Altenburg, D / Brandt, T / Brose, J / Dickopp, M / Feltresi, E / Hauke, A / Klose, V / Lacker, H M / Maly, E / Nogowski, R / Otto, S / Petzold, A / Schott, G / Schubert, J / Schubert, K R / Schwierz, R / Sundermann, J E / Bernard, D / Bonneaud, G R / Grenier, P / Schrenk, S / Thiebaux, Ch / Vasileiadis, G / Verderi, M / Bard, D J / Clark, P J / Gradl, W / Muheim, F / Playfer, S / Xie, Y / Andreotti, M / Azzolini, V / Bettoni, D / Bozzi, C / Calabrese, R / Cibinetto, G / Luppi, E / Negrini, M / Piemontese, L / Sarti, A / Anulli, F / Baldini-Ferroli, R / Calcaterra, A / de Sangro, R / Finocchiaro, G / Patteri, P / Peruzzi, I M / Piccolo, M / Zallo, A / Buzzo, A / Capra, R / Contri, R / Lo Vetere, M / Macri, M / Monge, M R / Passaggio, S / Patrignani, C / Robutti, E / Santroni, A / Tosi, S / Bailey, S / Brandenburg, G / Chaisanguanthum, K S / Morii, M / Won, E / Dubitzky, R S / Langenegger, U / 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Physical review letters

2005 Volume 95, Issue 14, Page(s) 142003

Abstract: Using 116.1 fb(-1) of data collected by the BABAR detector, we present an analysis of xi(c)(0 ... production in B decays and from the cc continuum, with the xi(c)(0) decaying into omega- K+ and xi- pi+ final ... states. We measure the ratio of branching fractions B(xi(c)(0) --> omega- K+)/B(xi(c)(0) --> xi- pi+ ...

Abstract	Using 116.1 fb(-1) of data collected by the BABAR detector, we present an analysis of xi(c)(0) production in B decays and from the cc continuum, with the xi(c)(0) decaying into omega- K+ and xi- pi+ final states. We measure the ratio of branching fractions B(xi(c)(0) --> omega- K+)/B(xi(c)(0) --> xi- pi+) spectrum is measured on and 40 MeV below the upsilon(4S) resonance. From these spectra the branching fraction product B(B --> xi(c)(0)X) x B(xi(c)(0) --> xi- pi+) is measured to be (2.11 +/- 0.19 +/- 0.25) x 10(-4), and the cross-section product sigma(e+ e- --> xi(c)(0)X) x B(xi(c)(0) --> xi- pi+) from the continuum is measured to be (388 +/- 39 +/- 41) fb at a center-of-mass energy of 10.58 GeV.
Language	English
Publishing date	2005-09-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.95.142003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Protein C Activity in Dogs

Michael M. Fry / Karl R. Snyder / Karen M. Tobias / Baye G. Williamson / G. Ann Reed

Veterinary Medicine International, Vol

Adaptation of a Commercial Human Colorimetric Assay and Evaluation of Effects of Storage Time and Temperature

2011 Volume 2011

Abstract: Objectives of this study were to adapt a commercial human protein C (PC) colorimetric assay for use ...

Abstract	Objectives of this study were to adapt a commercial human protein C (PC) colorimetric assay for use in dogs and to investigate effects of various storage conditions. The human assay was modified by using pooled canine plasma for calibration and by increasing the activation time. PC activity was measured in fresh canine plasma and in plasma stored under various conditions. PC activity of some stored samples was significantly different from that of fresh plasma; however, differences were small. No difference was detected in samples stored under similar conditions but analyzed in different laboratories using similar methodology. Results of this study indicate that the human colorimetric assay is suitable for canine samples if pooled canine plasma is used for calibration, that Clinical and Laboratory Standards Institute sample storage guidelines developed for testing in humans are appropriate for dogs, and that comparisons of results from laboratories using similar methodology are legitimate.
Keywords	Veterinary medicine ; SF600-1100
Subject code	630
Language	English
Publishing date	2011-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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