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  1. Article ; Online: New perspectives in keratoconus treatment: an update on iontophoresis-assisted corneal collagen crosslinking.

    Vinciguerra, Paolo / Montericcio, Alessio / Catania, Fiammetta / Fossati, Giovanni / Raimondi, Raffaele / Legrottaglie, Emanuela Filomena / Vinciguerra, Riccardo

    International ophthalmology

    2021  Volume 41, Issue 5, Page(s) 1909–1916

    Abstract: Keratoconus is a bilateral, asymmetric and progressive corneal disease. It usually results in apical thinning and steepening with corneal deformation and impaired vision. Since the early 1990 s, corneal collagen crosslinking (CXL) has remained the ... ...

    Abstract Keratoconus is a bilateral, asymmetric and progressive corneal disease. It usually results in apical thinning and steepening with corneal deformation and impaired vision. Since the early 1990 s, corneal collagen crosslinking (CXL) has remained the primary treatment to stabilize the progression of the disease. Iontophoresis-assisted CXL (I-CXL) has been proposed as a non-invasive alternative to standard epithelium-off technique, showing promising results. In this article, we review up to date literature to provide state of art knowledge and future perspectives of I-CXL.
    MeSH term(s) Collagen/therapeutic use ; Corneal Stroma ; Corneal Topography ; Cross-Linking Reagents/therapeutic use ; Humans ; Iontophoresis ; Keratoconus/drug therapy ; Photochemotherapy ; Photosensitizing Agents/therapeutic use ; Riboflavin/therapeutic use ; Ultraviolet Rays
    Chemical Substances Cross-Linking Reagents ; Photosensitizing Agents ; Collagen (9007-34-5) ; Riboflavin (TLM2976OFR)
    Language English
    Publishing date 2021-02-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-021-01713-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Management of an ophthalmology department during COVID-19 pandemic in Milan, Italy.

    Legrottaglie, Emanuela Filomena / Balia, Laura / Camesasca, Fabrizio Ivo / Vallejo-Garcia, Jose Luis / Fossati, Giovanni / Vinciguerra, Riccardo / Rosetta, Pietro / Vinciguerra, Paolo

    European journal of ophthalmology

    2020  Volume 31, Issue 5, Page(s) 2259–2267

    Abstract: Purpose: Spreading from China, COVID-19 pandemic reached Italy, the first massively involved western nation. At the beginning of March, 2020 in Northern Italy a complete lockdown of activities was imposed. Access to all healthcare providers, was halted ... ...

    Abstract Purpose: Spreading from China, COVID-19 pandemic reached Italy, the first massively involved western nation. At the beginning of March, 2020 in Northern Italy a complete lockdown of activities was imposed. Access to all healthcare providers, was halted for patients with elective problems. We present the management experience of the Humanitas Clinical and Research Center Ophthalmology Department in Rozzano, Milan, Italy, during the lockdown.
    Methods: Containment measures were taken to reduce viral transmission and identify infected patients. All planned visits were canceled but for those not deferrable. Social distancing was introduced reducing number of visits per hour. Minor surgery for progressive pathologies was continued. As the lockdown prolonged, we reorganized patient care. All canceled cases were evaluated by electronic medical records analysis and telephonic triage, to identify, recall, and visit patients at risk of vision loss.
    Results: From March 9, to April 30, 2020 we performed a total of 930 visits and 612 exams. Some visits (
    Conclusion: In-office activities deemed not deferrable were performed safely. The recall service was highly appreciated by all patients. No patient or staff member reported symptoms of COVID-19.
    MeSH term(s) COVID-19 ; Communicable Disease Control ; Humans ; Italy/epidemiology ; Ophthalmology ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/1120672120960334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Management of an ophthalmology department during COVID-19 pandemic in Milan, Italy

    Legrottaglie, Emanuela Filomena / Balia, Laura / Camesasca, Fabrizio Ivo / Vallejo-Garcia, Jose Luis / Fossati, Giovanni / Vinciguerra, Riccardo / Rosetta, Pietro / Vinciguerra, Paolo

    Eur J Ophthalmol

    Abstract: PURPOSE: Spreading from China, COVID-19 pandemic reached Italy, the first massively involved western nation. At the beginning of March, 2020 in Northern Italy a complete lockdown of activities was imposed. Access to all healthcare providers, was halted ... ...

    Abstract PURPOSE: Spreading from China, COVID-19 pandemic reached Italy, the first massively involved western nation. At the beginning of March, 2020 in Northern Italy a complete lockdown of activities was imposed. Access to all healthcare providers, was halted for patients with elective problems. We present the management experience of the Humanitas Clinical and Research Center Ophthalmology Department in Rozzano, Milan, Italy, during the lockdown. METHODS: Containment measures were taken to reduce viral transmission and identify infected patients. All planned visits were canceled but for those not deferrable. Social distancing was introduced reducing number of visits per hour. Minor surgery for progressive pathologies was continued. As the lockdown prolonged, we reorganized patient care. All canceled cases were evaluated by electronic medical records analysis and telephonic triage, to identify, recall, and visit patients at risk of vision loss. RESULTS: From March 9, to April 30, 2020 we performed a total of 930 visits and 612 exams. Some visits (n = 698) and exams (n = 160) were deemed as necessary for continuity of care and performed as planned. Among the remaining 1283 canceled appointments, after evaluation 144 visits and 32 instrumental exams were classified as urgent and rapidly rescheduled. Performed surgical activities were limited to corneal collagen cross linking (n = 39) and intravitreal injections (n = 91), compared to 34 and 94, respectively, in the same period of 2019. CONCLUSION: In-office activities deemed not deferrable were performed safely. The recall service was highly appreciated by all patients. No patient or staff member reported symptoms of COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #788542
    Database COVID19

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  4. Article ; Online: Management of an ophthalmology department during COVID-19 pandemic in Milan, Italy

    Legrottaglie, Emanuela Filomena / Balia, Laura / Camesasca, Fabrizio Ivo / Vallejo-Garcia, Jose Luis / Fossati, Giovanni / Vinciguerra, Riccardo / Rosetta, Pietro / Vinciguerra, Paolo

    European Journal of Ophthalmology

    2020  , Page(s) 112067212096033

    Abstract: Purpose: Spreading from China, COVID-19 pandemic reached Italy, the first massively involved western nation. At the beginning of March, 2020 in Northern Italy a complete lockdown of activities was imposed. Access to all healthcare providers, was halted ... ...

    Abstract Purpose: Spreading from China, COVID-19 pandemic reached Italy, the first massively involved western nation. At the beginning of March, 2020 in Northern Italy a complete lockdown of activities was imposed. Access to all healthcare providers, was halted for patients with elective problems. We present the management experience of the Humanitas Clinical and Research Center Ophthalmology Department in Rozzano, Milan, Italy, during the lockdown. Methods: Containment measures were taken to reduce viral transmission and identify infected patients. All planned visits were canceled but for those not deferrable. Social distancing was introduced reducing number of visits per hour. Minor surgery for progressive pathologies was continued. As the lockdown prolonged, we reorganized patient care. All canceled cases were evaluated by electronic medical records analysis and telephonic triage, to identify, recall, and visit patients at risk of vision loss. Results: From March 9, to April 30, 2020 we performed a total of 930 visits and 612 exams. Some visits ( n = 698) and exams ( n = 160) were deemed as necessary for continuity of care and performed as planned. Among the remaining 1283 canceled appointments, after evaluation 144 visits and 32 instrumental exams were classified as urgent and rapidly rescheduled. Performed surgical activities were limited to corneal collagen cross linking ( n = 39) and intravitreal injections ( n = 91), compared to 34 and 94, respectively, in the same period of 2019. Conclusion: In-office activities deemed not deferrable were performed safely. The recall service was highly appreciated by all patients. No patient or staff member reported symptoms of COVID-19.
    Keywords Ophthalmology ; General Medicine ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/1120672120960334
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Graft rejection after femtosecond laser--assisted deep anterior lamellar keratoplasty: report of 3 cases.

    Mosca, Luigi / Fasciani, Romina / Mosca, Luca / Guccione, Laura / Legrottaglie, Emanuela Filomena / Siniscalco, Andrea / Riso, Monica / Balestrazzi, Emilio

    Cornea

    2011  Volume 30, Issue 8, Page(s) 912–916

    Abstract: Purpose: To report 3 cases of stromal rejection after deep anterior lamellar keratoplasty (DALK) assisted by a femtosecond laser.: Methods: Three keratoconus eyes of 2 men (22 and 30 years old) and 1 woman (24 years old) who had DALK with a 60-kHz ... ...

    Abstract Purpose: To report 3 cases of stromal rejection after deep anterior lamellar keratoplasty (DALK) assisted by a femtosecond laser.
    Methods: Three keratoconus eyes of 2 men (22 and 30 years old) and 1 woman (24 years old) who had DALK with a 60-kHz femtosecond laser developed intrastromal graft rejection with superficial and deep neovascularization after 6, 15, and 12 months, respectively. All patients underwent confocal microscopy and were treated with topical steroid therapy.
    Results: In vivo confocal microscopy revealed cellular inflammatory infiltrates in the subepithelial and middle stroma of the donor lamella without involvement of the endothelium. Graft rejection was rapidly reversed with topical steroid therapy, and a clear cornea was restored in all cases.
    Conclusions: Graft rejection remains a significant complication of lamellar surgery but is associated with good tissue restoration and complete visual recovery.
    MeSH term(s) Adult ; Corneal Stroma/pathology ; Corneal Transplantation/adverse effects ; Dexamethasone/therapeutic use ; Female ; Glucocorticoids/therapeutic use ; Graft Rejection/drug therapy ; Graft Rejection/etiology ; Humans ; Keratoconus/surgery ; Lasers, Excimer/therapeutic use ; Male ; Microscopy, Confocal ; Ophthalmic Solutions/therapeutic use ; Suture Techniques ; Visual Acuity/physiology ; Young Adult
    Chemical Substances Glucocorticoids ; Ophthalmic Solutions ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2011-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604826-2
    ISSN 1536-4798 ; 0277-3740
    ISSN (online) 1536-4798
    ISSN 0277-3740
    DOI 10.1097/ICO.0b013e3182012a1a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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