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  1. Article ; Online: Adults with first-time nephrotic syndrome had increased risk for thromboembolic events, higher near time of diagnosis.

    Mithoowani, Siraj / Lim, Wendy

    Annals of internal medicine

    2022  Volume 175, Issue 6, Page(s) JC70

    Abstract: Source citation: Vestergaard SV, Birn H, Darvalics B, et al. ...

    Abstract Source citation: Vestergaard SV, Birn H, Darvalics B, et al.
    MeSH term(s) Adult ; Cohort Studies ; Hemorrhage/etiology ; Humans ; Nephrotic Syndrome/complications ; Venous Thromboembolism
    Language English
    Publishing date 2022-06-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J22-0039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.178/2: Show issues Location:
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  2. Article: Functional Characterization of Core and Unique Calcite-Dissolving Bacteria Communities from Peanut Fields.

    Peper, Alan / Newton, Carter J / Lim, Sheena / Zheng, Wendy / Brenneman, Timothy / Yang, Li

    Phytopathology

    2024  , Page(s) PHYTO10230380KC

    Abstract: Calcium deficiency is a leading cause of reduced peanut ( ...

    Abstract Calcium deficiency is a leading cause of reduced peanut (
    Language English
    Publishing date 2024-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208889-7
    ISSN 1943-7684 ; 0031-949X
    ISSN (online) 1943-7684
    ISSN 0031-949X
    DOI 10.1094/PHYTO-10-23-0380-KC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 698: Show issues Location:
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  3. Article: Educational Case: Endometrial carcinoma types I and II.

    Hemann, Zachary A / Lim, Wendy Z / Kemp, Walter L

    Academic pathology

    2022  Volume 9, Issue 1, Page(s) 100023

    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2819382-9
    ISSN 2374-2895
    ISSN 2374-2895
    DOI 10.1016/j.acpath.2022.100023
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  4. Article ; Online: Management of corneal neovascularization: Current and emerging therapeutic approaches.

    Wu, Duoduo / Chan, Kai En / Lim, Blanche Xiao Hong / Lim, Dawn Ka-Ann / Wong, Wendy Meihua / Chai, Charmaine / Manotosh, Ray / Lim, Chris Hong Long

    Indian journal of ophthalmology

    2024  Volume 72, Issue Suppl 3, Page(s) S354–S371

    Abstract: Corneal neovascularization (CoNV) is a sight-threatening condition affecting an estimated 1.4 million people per year, and the incidence is expected to rise. It is a complication of corneal pathological diseases such as infective keratitis, chemical burn, ...

    Abstract Corneal neovascularization (CoNV) is a sight-threatening condition affecting an estimated 1.4 million people per year, and the incidence is expected to rise. It is a complication of corneal pathological diseases such as infective keratitis, chemical burn, corneal limbal stem cell deficiency, mechanical trauma, and immunological rejection after keratoplasties. CoNV occurs due to a disequilibrium in proangiogenic and antiangiogenic mediators, involving a complex system of molecular interactions. Treatment of CoNV is challenging, and no therapy thus far has been curative. Anti-inflammatory agents such as corticosteroids are the mainstay of treatment due to their accessibility and well-studied safety profile. However, they have limited effectiveness and are unable to regress more mature neovascularization. With the advent of advanced imaging modalities and an expanding understanding of its pathogenesis, contemporary treatments targeting a wide array of molecular mechanisms and surgical options are gaining traction. This review aims to summarize evidence regarding conventional and emerging therapeutic options for CoNV.
    MeSH term(s) Humans ; Corneal Neovascularization/diagnosis ; Corneal Neovascularization/therapy ; Corneal Neovascularization/etiology ; Angiogenesis Inhibitors/therapeutic use ; Disease Management
    Chemical Substances Angiogenesis Inhibitors
    Language English
    Publishing date 2024-04-20
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_3043_23
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    Zs.B 329: Show issues Location:
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    Zs.MO 598: Show issues

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  5. Article ; Online: Prevention of thrombosis in antiphospholipid syndrome.

    Lim, Wendy

    Hematology. American Society of Hematology. Education Program

    2016  Volume 2016, Issue 1, Page(s) 707–713

    Abstract: Antiphospholipid syndrome (APS) is an acquired autoimmune condition characterized by thrombotic events, pregnancy morbidity, and laboratory evidence of antiphospholipid antibodies (aPL). Management of these patients includes the prevention of a first ... ...

    Abstract Antiphospholipid syndrome (APS) is an acquired autoimmune condition characterized by thrombotic events, pregnancy morbidity, and laboratory evidence of antiphospholipid antibodies (aPL). Management of these patients includes the prevention of a first thrombotic episode in at-risk patients (primary prevention) and preventing recurrent thrombotic complications in patients with a history of thrombosis (secondary prevention). Assessment of thrombotic risk in these patients, balanced against estimated bleeding risks associated with antithrombotic therapy could assist clinicians in determining whether antithrombotic therapy is warranted. Thrombotic risk can be assessed by evaluating a patient's aPL profile and additional thrombotic risk factors. Although antithrombotic options for secondary prevention of venous thromboembolism (VTE) have been evaluated in clinical trials, studies in primary prevention of asymptomatic aPL-positive patients are needed. Primary prevention with aspirin may be considered in asymptomatic patients who have a high-risk aPL profile, particularly if additional risk factors are present. Secondary prevention with long-term anticoagulation is recommended based on estimated risks of VTE recurrence, although routine evaluation of thrombotic risk can assist in determining whether ongoing anticoagulation is warranted. Studies that stratify thrombotic risk in aPL-positive patients, and patients with APS evaluating antithrombotic and non-antithrombotic therapies will be useful in optimizing the management of these patients.
    MeSH term(s) Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/drug therapy ; Aspirin/therapeutic use ; Female ; Fibrinolytic Agents/therapeutic use ; Humans ; Male ; Pregnancy ; Pregnancy Complications, Cardiovascular/etiology ; Pregnancy Complications, Cardiovascular/prevention & control ; Thrombosis/etiology ; Thrombosis/prevention & control ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control
    Chemical Substances Fibrinolytic Agents ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2016-11-30
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1520-4383
    ISSN (online) 1520-4383
    DOI 10.1182/asheducation-2016.1.707
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  6. Article ; Online: Identifying novel drugs with new modes of action for neglected tropical fungal skin diseases (fungal skinNTDs) using an Open Source Drug discovery approach.

    Lim, Wilson / Verbon, Annelies / van de Sande, Wendy

    Expert opinion on drug discovery

    2022  Volume 17, Issue 6, Page(s) 641–659

    Abstract: Introduction: The three fungal skin neglected tropical diseases (NTD) - mycetoma, chromoblastomycosis and sporotrichosis - currently lack prioritization and support to establish drug discovery programs in search for novel treatment options. This has ... ...

    Abstract Introduction: The three fungal skin neglected tropical diseases (NTD) - mycetoma, chromoblastomycosis and sporotrichosis - currently lack prioritization and support to establish drug discovery programs in search for novel treatment options. This has made the efforts to identify novel drugs for these fragmented skinNTDs.
    Areas covered: To help escalate the discovery of novel drugs to treat these fungal skinNTDs, the authors have prepared an overview of the compounds with activity against fungal skinNTDs by analyzing data from individual drug discovery studies, including those performed on the Medicines for Malaria Venture (MMV) open access boxes.
    Expert opinion: The authors were unable to identify studies in which causative agents of all three skinNTDs were included, indicating that an integrated approach is currently lacking. From current available data, the azoles and iodoquinol were the only compounds with activity against causative agents from the three different fungal skinNTDs. Fungal melanin inhibition enhanced the activity of antifungal agents. For mycetoma, the fenarimols, aminothiazoles and benzimidazole carbamates are currently being investigated in the MycetOS initiative. To come to a more integrated approach to identify drugs active against all three fungal skinNTDs, compounds made in the MycetOS initiative could also be explored for chromoblastomycosis and sporotrichosis.
    MeSH term(s) Chromoblastomycosis/drug therapy ; Chromoblastomycosis/microbiology ; Dermatomycoses/drug therapy ; Drug Discovery ; Humans ; Mycetoma/drug therapy ; Mycetoma/microbiology ; Neglected Diseases/drug therapy ; Sporotrichosis/drug therapy
    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2259618-5
    ISSN 1746-045X ; 1746-0441
    ISSN (online) 1746-045X
    ISSN 1746-0441
    DOI 10.1080/17460441.2022.2080195
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    Zs.A 6388: Show issues Location:
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  7. Article ; Online: Association of Fusobacterium nucleatum infection with the clinicopathological characteristics in colorectal cancer patients.

    Pang, Siew-Wai / Armon, Subasri / Chook, Jack Bee / Chew, Jactty / Peh, Kaik-Boo / Lim, Wendy Wan-Dee / Peh, Suat Cheng / Teow, Sin-Yeang

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 124

    Abstract: Background: Colorectal cancer (CRC) is a global health problem. The gut microbiome is now recognized as an important underlying factor to the initiation and progression of CRC. Fusobacterium nucleatum (FN) is one of the most studied bacteria in the ... ...

    Abstract Background: Colorectal cancer (CRC) is a global health problem. The gut microbiome is now recognized as an important underlying factor to the initiation and progression of CRC. Fusobacterium nucleatum (FN) is one of the most studied bacteria in the aetiology of CRC. This study provided cohort evidence on the association of FN infection with clinicopathologic features in CRC patients.
    Methods: We analysed the cancerous and adjacent non-cancerous formalin-fixed paraffin embedded (FFPE) tissue of 83 CRC patients from a single medical centre in Malaysia. TaqMan probe-based qPCR targeting the 16S rRNA gene was used to detect the presence of FN in the extracted FFPE DNA. The differences in FN expression between cancer and non-cancer tissues were evaluated. Association studies between FN infection in the tumour and relative FN abundance with available clinical data were conducted.
    Results: FN was more abundant in the cancerous tissue compared to non-cancerous tissue (p = 0.0025). FN infection in the tumour was significantly associated with lymph node metastasis (p = 0.047) and cancer staging (p = 0.032), but not with other clinicopathologic variables. In double-positive patients where FN was detected in both cancerous and non-cancerous tissue, the expression fold-change of FN, calculated using 2-ΔΔCT formula, was significantly higher in patients with tumour size equal to or greater than 5 cm (p = 0.033) and in KRAS-mutated patients (p = 0.046).
    Conclusions: FN is enriched in CRC tumour tissue and is associated with tumour size, lymph node metastasis, cancer staging, and KRAS mutation in this single-centre small cohort study.
    MeSH term(s) Humans ; Cohort Studies ; Fusobacterium nucleatum/genetics ; Lymphatic Metastasis ; Proto-Oncogene Proteins p21(ras)/genetics ; RNA, Ribosomal, 16S/genetics ; Colorectal Neoplasms/genetics
    Chemical Substances Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2024-01-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-023-09150-5
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    Zs.A 1140: Show issues Location:
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  8. Article ; Online: Dengue-related Longitudinally Extensive Transverse Myelitis.

    Tan, Wendy / Lim, Christopher Thiam Seong

    Neurology India

    2019  Volume 67, Issue 4, Page(s) 1116–1117

    MeSH term(s) Dengue/pathology ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Myelitis, Transverse/diagnosis ; Myelitis, Transverse/pathology ; Spine/pathology ; Young Adult
    Language English
    Publishing date 2019-09-12
    Publishing country India
    Document type Case Reports ; Letter
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.266296
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  9. Article ; Online: Clinical efficacy of crushed prednisolone and hydrocolloid powder in the primary treatment of peristomal pyoderma gangrenosum and correlation to in vitro drug release data.

    Pearson, Wendy Ann / Prentice, David Andrew / Lim, Lee Yong / Gianoncelli, Olivia / Hashiguchi, Alice / Parisella, Tahlia Kate / Ta, Jade Thien

    International wound journal

    2024  Volume 21, Issue 3, Page(s) e14808

    Abstract: We evaluated the primary application of crushed prednisolone combined with hydrocolloid powder for clinically diagnosed peristomal pyoderma gangrenosum (PPG). We present our data on this cohort and follow-up of our previous patients. Of the 23 patients ... ...

    Abstract We evaluated the primary application of crushed prednisolone combined with hydrocolloid powder for clinically diagnosed peristomal pyoderma gangrenosum (PPG). We present our data on this cohort and follow-up of our previous patients. Of the 23 patients who were commenced on this regime, 18 healed (78%). Twenty-two patients commenced on this regime as the primary treatment for their PPG, and for one, it was a rescue remedy after failed conventional therapy. Four patients with significant medical comorbidities failed to heal and one had their stomal reversal surgery before being fully healed. The proposed treatment regime for PPG is demonstrated to be effective, inexpensive and able to be managed in the patient's usual home environment. In vitro drug release analysis was undertaken, and data are presented to provide further insights into the efficacy of this regime.
    MeSH term(s) Humans ; Prednisolone/therapeutic use ; Pyoderma Gangrenosum/drug therapy ; Pyoderma Gangrenosum/etiology ; Pyoderma Gangrenosum/diagnosis ; Powders/therapeutic use ; Drug Liberation ; Treatment Outcome
    Chemical Substances Prednisolone (9PHQ9Y1OLM) ; Powders
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2170920-8
    ISSN 1742-481X ; 1742-4801
    ISSN (online) 1742-481X
    ISSN 1742-4801
    DOI 10.1111/iwj.14808
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    Zs.A 6006: Show issues Location:
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  10. Article: Educational Case: Hereditary Colorectal Cancer and Association With Endometrial Carcinoma.

    Lim, Wendy Z / Hemann, Zachary A / Kemp, Walter L

    Academic pathology

    2021  Volume 8, Page(s) 23742895211028996

    Abstract: The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and ... ...

    Abstract The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see
    Language English
    Publishing date 2021-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2819382-9
    ISSN 2374-2895
    ISSN 2374-2895
    DOI 10.1177/23742895211028996
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