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  1. Article: Fokusthema Dyspnoe – eine Einführung.

    Huber, Lars Christian / Arrigo, Mattia

    Therapeutische Umschau. Revue therapeutique

    2023  Volume 80, Issue 6, Page(s) 249–250

    Title translation Fokusthema Dyspnoe - eine Einführung.
    Language German
    Publishing date 2023-10-06
    Publishing country Switzerland
    Document type Editorial ; English Abstract
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
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  2. Article ; Online: Pulmonary Hypertension in Pulmonary Embolism.

    Arrigo, Mattia / Huber, Lars C

    The American journal of cardiology

    2023  Volume 200, Page(s) 249–250

    MeSH term(s) Humans ; Hypertension, Pulmonary/etiology ; Pulmonary Embolism/complications ; Hypertension
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Letter
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2023.05.035
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  3. Article: Vaskuläre Dyspnoe: Lungenembolie.

    Arrigo, Mattia Christian / Huber, Lars Christian

    Therapeutische Umschau. Revue therapeutique

    2023  Volume 80, Issue 6, Page(s) 265–270

    Abstract: Introduction: In clinical practice, the differentiation of pulmonary embolism from other entities often remains difficult. Of utmost importance is the estimation of the pretest probability of the disease: predictive scoring systems and the use of ... ...

    Title translation Vaskuläre Dyspnoe: Lungenembolie.
    Abstract Introduction: In clinical practice, the differentiation of pulmonary embolism from other entities often remains difficult. Of utmost importance is the estimation of the pretest probability of the disease: predictive scoring systems and the use of clinical gestalt are equally useful tools. Exclusion or confirmation of the disease requires the rationale use of additional investigations (laboratory, imaging). In this article, we provide clinical engrams and outline our diagnostic algorithm. Based on the latest recommendations, we summarize the therapeutic approach for patients with pulmonary embolism. The importance of follow-up visits after the initial event is discussed in the last part. The assessment of risk factors promoting the development of venous thromboembolism is crucial for estimating the risk of recurrence. Excessive screening (thrombophilia testing or tumor investigations) are of minor relevance.
    MeSH term(s) Humans ; Venous Thromboembolism/diagnosis ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/therapy ; Risk Factors
    Language German
    Publishing date 2023-10-09
    Publishing country Switzerland
    Document type English Abstract ; Journal Article
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
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  4. Article ; Online: Acute and Critical Care Echocardiography.

    Arrigo, Mattia

    European heart journal

    2018  Volume 39, Issue 10, Page(s) 831

    Language English
    Publishing date 2018-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehy055
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  5. Article ; Online: Prosthetic valve endocarditis: a combination of clinical findings and advanced imaging.

    Storz, Matthias / Wissmeyer, Michael / Arrigo, Mattia / Huber, Lars C

    European heart journal. Case reports

    2023  Volume 7, Issue 7, Page(s) ytad297

    Language English
    Publishing date 2023-07-06
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad297
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  6. Article ; Online: Right ventricle assessment in patients with pulmonary embolism: low risk = low yield for systematic echocardiography.

    Arrigo, Mattia / Huber, Lars C

    European heart journal

    2021  Volume 43, Issue 1, Page(s) 84–85

    MeSH term(s) Echocardiography ; Heart Ventricles/diagnostic imaging ; Humans ; Pulmonary Embolism/diagnostic imaging
    Language English
    Publishing date 2021-11-17
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab762
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  7. Article: Atemnot und Rechtsherzversagen.

    Lunk, Denny / Brüllmann, Gregor / Huber, Lars C / Arrigo, Mattia

    Praxis

    2023  Volume 112, Issue 4, Page(s) 226–230

    Abstract: Dyspnea and Right Heart ... ...

    Title translation Dyspnea and Right Heart Failure.
    Abstract Dyspnea and Right Heart Failure
    MeSH term(s) Humans ; Ventricular Dysfunction, Right/diagnosis ; Ventricular Dysfunction, Right/etiology ; Ventricular Dysfunction, Right/therapy ; Heart Failure/diagnosis ; Heart Failure/etiology ; Heart Failure/therapy ; Heart Ventricles/diagnostic imaging ; Echocardiography/adverse effects ; Dyspnea/etiology
    Language German
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type English Abstract ; Journal Article
    ZDB-ID 209026-0
    ISSN 1661-8165 ; 1661-8157 ; 0369-8394
    ISSN (online) 1661-8165
    ISSN 1661-8157 ; 0369-8394
    DOI 10.1024/1661-8157/a004012
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  8. Article: Pulmonary Embolism and Heart Failure: A Reappraisal.

    Arrigo, Mattia / Huber, Lars Christian

    Cardiac failure review

    2021  Volume 7, Page(s) e03

    Abstract: Acute heart failure and acute pulmonary embolism share many features, including epidemiological aspects, clinical presentation, risk factors and pathobiological mechanisms. As such, it is not surprising that diagnosis and management of these common ... ...

    Abstract Acute heart failure and acute pulmonary embolism share many features, including epidemiological aspects, clinical presentation, risk factors and pathobiological mechanisms. As such, it is not surprising that diagnosis and management of these common conditions might be challenging for the treating physician, in particular when both are concomitantly present. While helpful guidelines have been elaborated for both acute heart failure and pulmonary embolism, not many studies have been published on the coexistence of these diseases. With a special focus on diagnostic tools and therapeutic options, the authors review the available literature and, when evidence is lacking, present their own approach to the management of dyspnoeic patients with acute heart failure and pulmonary embolism.
    Language English
    Publishing date 2021-02-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2960293-2
    ISSN 2057-7559 ; 2057-7540
    ISSN (online) 2057-7559
    ISSN 2057-7540
    DOI 10.15420/cfr.2020.26
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  9. Article: Multiple Abscess Collections: Antibiotics or Steroids?

    Dias, Philippe Raphael / Bolt, Levin / Iking-Konert, Christof / Arrigo, Mattia / Huber, Lars C

    Case reports in immunology

    2024  Volume 2024, Page(s) 3671685

    Abstract: Aseptic abscess syndrome (AAS) is a medical rarity. The combination of multiple abscess collections in different organs, negative microbiological studies, and the association with an inflammatory bowel disease is highly suggestive for an AAS. The AAS is ... ...

    Abstract Aseptic abscess syndrome (AAS) is a medical rarity. The combination of multiple abscess collections in different organs, negative microbiological studies, and the association with an inflammatory bowel disease is highly suggestive for an AAS. The AAS is an acute neutrophilic dermatosis, so "generalized pyoderma gangraenosum" or "generalized bullous sweet syndrome" might be used synonymously. It is important to note that the diagnosis of an AAS can be made only after careful exclusion of an infectious disease. Of interest, despite the severity of the inflammation, patients with AAS are commonly hemodynamically stable. To date, no studies have investigated the optimal regimen, dose, and duration of therapy. Corticosteroids are the cornerstone of immunosuppression during the acute phase. After the induction phase, therapy might be switched to anakinra or infliximab.
    Language English
    Publishing date 2024-01-25
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2695564-7
    ISSN 2090-6617 ; 2090-6609
    ISSN (online) 2090-6617
    ISSN 2090-6609
    DOI 10.1155/2024/3671685
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  10. Article ; Online: Cost-effectiveness of NT-proBNP-supported screening of chronic heart failure in patients with or without type 2 diabetes in Austria and Switzerland.

    Walter, Evelyn / Arrigo, Mattia / Allerstorfer, Sigrid / Marty, Petra / Hülsmann, Martin

    Journal of medical economics

    2023  Volume 26, Issue 1, Page(s) 1287–1300

    Abstract: Background: Heart failure (HF) is a clinical syndrome with a global burden. Signs and symptoms of HF are nonspecific and often shared with other conditions. The N-terminal prohormone of brain natriuretic peptide (NT-proBNP) serves as a useful biomarker ... ...

    Abstract Background: Heart failure (HF) is a clinical syndrome with a global burden. Signs and symptoms of HF are nonspecific and often shared with other conditions. The N-terminal prohormone of brain natriuretic peptide (NT-proBNP) serves as a useful biomarker for the diagnosis of HF not only in patients with acute symptoms but also in outpatients with an ambiguous clinical presentation. The aim of the analysis is to evaluate the cost-effectiveness of implementing NT-proBNP in the diagnostic algorithm in patients with/without type 2 diabetes mellitus (T2DM), compared with a diagnosis based primarily on clinical signs or symptoms from the perspective of the Austrian and Swiss healthcare system.
    Methods: A time-discrete Markov model was developed to simulate the effect/improvement (lifetime-costs, quality-adjusted life-years [QALYs], and life-years [LYs]) due to an NT-proBNP screening in undetected HF patients. Undetected HF patients are included in the model according to a distribution of New York Heart Association (NYHA) classes. The model considers disease progression by transition of NYHA classes. Undetected patients may remain undetected or be detected with the help of NT-proBNP or symptoms. Patients with known HF exhibit a slower disease progression. The probability of dying is influenced by the respective NYHA class. Direct costs (2021 € or CHF) were derived from published sources. QALYs, LYs, and costs were discounted (3% p.a.).
    Results: In the per-patient analysis (at age 60 over lifetime), the incremental cost-utility ratio (ICUR)/QALY of NT-proBNP vs. no screening was €3,042 for HF patients in Austria. Considering the total cohort of undetected HF patients (
    Conclusion: Overall, the analysis concludes that screening with NT-proBNP is a highly cost-effective or cost-saving diagnostic option for patients with HF, and a sensitivity analysis confirmed these findings.
    MeSH term(s) Humans ; Middle Aged ; Natriuretic Peptide, Brain ; Cost-Benefit Analysis ; Austria ; Switzerland ; Diabetes Mellitus, Type 2/complications ; Heart Failure/diagnosis ; Biomarkers ; Chronic Disease ; Disease Progression
    Chemical Substances pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0) ; Biomarkers
    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2270945-9
    ISSN 1941-837X ; 1369-6998
    ISSN (online) 1941-837X
    ISSN 1369-6998
    DOI 10.1080/13696998.2023.2264722
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