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  1. Article: Sterility.

    Routh, Amand

    Buffalo medical journal

    2023  Volume 37, Issue 1, Page(s) 44–50

    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 426473-3
    ISSN 1040-3817
    ISSN 1040-3817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    AMP -385/400-: Show issues

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  2. Article: Use of Apomorphia in Cases of Poisoning.

    Routh, Amand

    The Southern medical record

    2022  Volume 13, Issue 12, Page(s) 455–456

    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: DPAC: A Tool for Differential Poly(A)-Cluster Usage from Poly(A)-Targeted RNAseq Data.

    Routh, Andrew

    G3 (Bethesda, Md.)

    2019  Volume 9, Issue 6, Page(s) 1825–1830

    Abstract: Poly(A)-tail targeted RNAseq approaches, such as 3'READS, PAS-Seq and Poly(A)-ClickSeq, are becoming popular alternatives to random-primed RNAseq to focus sequencing reads just to the 3' ends of polyadenylated RNAs to identify poly(A)-sites and ... ...

    Abstract Poly(A)-tail targeted RNAseq approaches, such as 3'READS, PAS-Seq and Poly(A)-ClickSeq, are becoming popular alternatives to random-primed RNAseq to focus sequencing reads just to the 3' ends of polyadenylated RNAs to identify poly(A)-sites and characterize changes in their usage. Additionally, we and others have demonstrated that these approaches perform similarly to other RNAseq strategies for differential gene expression analysis, while saving on the volume of sequencing data required and providing a simpler library synthesis strategy. Here, we present DPAC (
    MeSH term(s) Biomarkers ; Cluster Analysis ; Computational Biology/methods ; Exons ; Gene Expression Regulation ; Gene Knockdown Techniques ; HeLa Cells ; Humans ; Molecular Sequence Annotation ; Poly A ; Polyadenylation ; RNA, Messenger/genetics ; Sequence Analysis, RNA ; Software
    Chemical Substances Biomarkers ; RNA, Messenger ; Poly A (24937-83-5)
    Language English
    Publishing date 2019-06-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1534/g3.119.400273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recurrent Papillary Bladder Tumors in a Boy With Lynch Syndrome.

    Tua-Caraccia, Rafael / Livingston, Austin / Routh, Jonathan C

    Urology

    2023  Volume 181, Page(s) 133–135

    Abstract: Lynch syndrome (LS) is an autosomal dominant genetic disorder defined by germline mutations in one of four mismatch repair genes including PMS2, MLH2, MSH1, MSH2, or deletion in the EPCAM gene. ...

    Abstract Lynch syndrome (LS) is an autosomal dominant genetic disorder defined by germline mutations in one of four mismatch repair genes including PMS2, MLH2, MSH1, MSH2, or deletion in the EPCAM gene.
    MeSH term(s) Male ; Humans ; Child ; Urinary Bladder Neoplasms/complications ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/genetics ; Carcinoma, Transitional Cell/complications ; Carcinoma, Transitional Cell/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/complications ; Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Urinary Bladder ; DNA Mismatch Repair
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2023.06.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1142: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 275: Show issues

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  5. Article ; Online: Investigating impact of CORDEX-based predicted climatic and LCM-based LULC scenarios on hydrologic response of a semi-gauged Indian catchment.

    Mitra, Shreyashi Santra / Kumar, Akhilesh / Santra, Abhisek / Routh, Shidharth

    Environmental monitoring and assessment

    2023  Volume 195, Issue 4, Page(s) 450

    Abstract: The present study aims at documenting the impact of different climate and land use change scenarios on runoff in the Kangsabati River basin. While the study relies on India Meteorological Department (IMD), National Oceanic and Atmospheric Administration' ... ...

    Abstract The present study aims at documenting the impact of different climate and land use change scenarios on runoff in the Kangsabati River basin. While the study relies on India Meteorological Department (IMD), National Oceanic and Atmospheric Administration's Physical Sciences Laboratory (NOAA-PSL), and a multi-model ensemble of six driving models from Coordinated Regional Downscaling Experiment-Regional Climate Models (CORDEX RCM) for climate data input, it depends on IDRISI Selva's Land Change Modeller (LCM) and Soil and Water Assessment Tool (SWAT) model to generate projected land use land change maps and simulate its streamflow response, respectively. A total of four land use and land cover (LULC) scenarios, representing four projected land use change, were modelled across three climatic scenarios, called Representative Concentration Pathways (RCPs). With runoff being predominantly impacted more by climate change than LULC, volumetric runoff is expected to be 12-46% higher than the baseline period of 1982-2017. Conversely, while surface runoff is expected to decrease by 4-28% in lower parts of the basin, it will increase by 2-39% in the rest of it, depending on the subtle alterations in land use and climatic variability.
    MeSH term(s) Environmental Monitoring ; Soil ; Hydrology ; Forecasting ; Climate Change
    Chemical Substances Soil
    Language English
    Publishing date 2023-03-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-022-10840-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Bonn / Germany

    Z 5186: Show issues

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  6. Article: Understanding Flavivirus Capsid Protein Functions: The Tip of the Iceberg.

    Sotcheff, Stephanea / Routh, Andrew

    Pathogens (Basel, Switzerland)

    2020  Volume 9, Issue 1

    Abstract: Flaviviruses are enveloped positive-sense single-stranded RNA arboviruses, infectious to humans and many other animals and are transmitted primarily via tick or mosquito vectors. Capsid is the primary structural protein to interact with viral genome ... ...

    Abstract Flaviviruses are enveloped positive-sense single-stranded RNA arboviruses, infectious to humans and many other animals and are transmitted primarily via tick or mosquito vectors. Capsid is the primary structural protein to interact with viral genome within virus particles and is therefore necessary for efficient packaging. However, in cells, capsid interacts with many proteins and nucleic acids and we are only beginning to understand the broad range of functions of flaviviral capsids. It is known that capsid dimers interact with the membrane of lipid droplets, aiding in both viral packaging and storage of capsid prior to packaging. However, capsid dimers can bind a range of nucleic acid templates
    Language English
    Publishing date 2020-01-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens9010042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: RENAL PATHOLOGY IN CAPTIVE ADULT ALAOTRAN GENTLE LEMURS (

    Barbon, Alberto Rodriguez / Kapetanou, Athanasia / Glendewar, Gale / Denk, Daniela / Stidworthy, Mark F / Routh, Andrew

    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians

    2023  Volume 54, Issue 3, Page(s) 600–606

    Abstract: Full medical histories from captive Alaotran gentle lemurs or Bandro ( ...

    Abstract Full medical histories from captive Alaotran gentle lemurs or Bandro (
    MeSH term(s) Male ; Female ; Animals ; Azotemia/pathology ; Azotemia/veterinary ; Lemuridae ; Kidney/pathology ; Kidney Diseases/veterinary ; Kidney Diseases/pathology
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2174930-9
    ISSN 1937-2825 ; 1042-7260
    ISSN (online) 1937-2825
    ISSN 1042-7260
    DOI 10.1638/2023-0005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A multidisciplinary approach to the identification of the protein-RNA connectome in double-stranded RNA virus capsids.

    Sung, Po-Yu / Zhou, Yiyang / Kao, C Cheng / Aburigh, Ali A / Routh, Andrew / Roy, Polly

    Nucleic acids research

    2023  Volume 51, Issue 10, Page(s) 5210–5227

    Abstract: How multi-segmented double-stranded RNA (dsRNA) viruses correctly incorporate their genomes into their capsids remains unclear for many viruses, including Bluetongue virus (BTV), a Reoviridae member, with a genome of 10 segments. To address this, we used ...

    Abstract How multi-segmented double-stranded RNA (dsRNA) viruses correctly incorporate their genomes into their capsids remains unclear for many viruses, including Bluetongue virus (BTV), a Reoviridae member, with a genome of 10 segments. To address this, we used an RNA-cross-linking and peptide-fingerprinting assay (RCAP) to identify RNA binding sites of the inner capsid protein VP3, the viral polymerase VP1 and the capping enzyme VP4. Using a combination of mutagenesis, reverse genetics, recombinant proteins and in vitro assembly, we validated the importance of these regions in virus infectivity. Further, to identify which RNA segments and sequences interact with these proteins, we used viral photo-activatable ribonucleoside crosslinking (vPAR-CL) which revealed that the larger RNA segments (S1-S4) and the smallest segment (S10) have more interactions with viral proteins than the other smaller segments. Additionally, using a sequence enrichment analysis we identified an RNA motif of nine bases that is shared by the larger segments. The importance of this motif for virus replication was confirmed by mutagenesis followed by virus recovery. We further demonstrated that these approaches could be applied to a related Reoviridae member, rotavirus (RV), which has human epidemic impact, offering the possibility of novel intervention strategies for a human pathogen.
    MeSH term(s) Animals ; Humans ; Bluetongue virus/chemistry ; Bluetongue virus/metabolism ; Capsid/chemistry ; Capsid/metabolism ; RNA, Double-Stranded/genetics ; RNA, Double-Stranded/metabolism ; RNA, Viral/metabolism ; Virus Replication ; Viral Proteins/chemistry ; Viral Proteins/metabolism
    Chemical Substances RNA, Double-Stranded ; RNA, Viral ; Viral Proteins
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkad274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Building an implementation framework to address unmet contraceptive care needs in a carceral setting: a systematic review.

    Routh, Douglas / Simmons, Rebecca / Sanders, Jessica / Gero, Alexandra / Tanner, Hannah Aanderud / Turok, David K

    Health & justice

    2023  Volume 11, Issue 1, Page(s) 43

    Abstract: Background: The provision of contraceptive care for incarcerated individuals has been largely inconsistent and has contributed to, at best, inadequate care, and at worst reproductive abuses, violence, and coercion. While previous research has identified ...

    Abstract Background: The provision of contraceptive care for incarcerated individuals has been largely inconsistent and has contributed to, at best, inadequate care, and at worst reproductive abuses, violence, and coercion. While previous research has identified strategies to remedy known issues, to date, very few recommendations have been implemented across the carceral system. To address this, we conducted a systematic review of policy and practice recommendations to improve contraceptive care to reproductive-aged, incarcerated individuals in the United States.
    Methods: We conducted this systematic review utilizing the Joanna Briggs Institute methodology and framed it within the National Implementation Research Network's (NIRN) Exploration stage. We searched PubMed, PSYCInfo, SCOPUS, ProQuest, Web of Science, MedLine, Social Science Citation Index and reference sections of included materials. Basic study information, explicitly stated policy and practice recommendations, and discussions and conclusions that subtly provide recommendations were extracted in full text. We utilized a thematic analysis approach to analyze the extracted text.
    Results: A total of 45 materials met the inclusion criteria. Seven overarching themes were identified: 1) policy changes needed to implement care; 2) need for contraceptive care in carceral systems; 3) justice agency barriers regarding contraceptive care provision; 4) policy barriers to contraceptive access; 5) funding strategies to improve care; 6) patient preferences for contraceptive care delivery; and 7) healthcare provider knowledge regarding contraceptive care. The seven themes identified shed light on the need for, gaps, barriers, and facilitators of current contraceptive care provision to incarcerated individuals.
    Conclusion: This systematic review accomplished two goals of NIRN's Exploration stage. First, the compiled evidence identified a clear need for change regarding policies and practices pertaining to contraceptive care provision to incarcerated individuals in the United States. Second, our findings identified several evidence-based solutions supported both by research and professional healthcare organizations to address the identified need for change. This study provides an initial blueprint for correctional agencies to implement the necessary changes for improving contraceptive care provision to incarcerated populations. The correctional system is in a unique position to deliver much-needed care, which would result in many potential benefits to the individuals, correctional system, and community at large.
    Language English
    Publishing date 2023-10-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2740401-8
    ISSN 2194-7899
    ISSN 2194-7899
    DOI 10.1186/s40352-023-00243-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Immunoporosis: Role of Innate Immune Cells in Osteoporosis.

    Saxena, Yogesh / Routh, Sanjeev / Mukhopadhaya, Arunika

    Frontiers in immunology

    2021  Volume 12, Page(s) 687037

    Abstract: Osteoporosis or porous bone disorder is the result of an imbalance in an otherwise highly balanced physiological process known as 'bone remodeling'. The immune system is intricately involved in bone physiology as well as pathologies. Inflammatory ... ...

    Abstract Osteoporosis or porous bone disorder is the result of an imbalance in an otherwise highly balanced physiological process known as 'bone remodeling'. The immune system is intricately involved in bone physiology as well as pathologies. Inflammatory diseases are often correlated with osteoporosis. Inflammatory mediators such as reactive oxygen species (ROS), and pro-inflammatory cytokines and chemokines directly or indirectly act on the bone cells and play a role in the pathogenesis of osteoporosis. Recently, Srivastava et al. (Srivastava RK, Dar HY, Mishra PK. Immunoporosis: Immunology of Osteoporosis-Role of T Cells. Frontiers in immunology. 2018;9:657) have coined the term "immunoporosis" to emphasize the role of immune cells in the pathology of osteoporosis. Accumulated pieces of evidence suggest both innate and adaptive immune cells contribute to osteoporosis. However, innate cells are the major effectors of inflammation. They sense various triggers to inflammation such as pathogen-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), cellular stress,
    MeSH term(s) Bone Remodeling ; Bone and Bones/cytology ; Bone and Bones/immunology ; Immunity, Innate ; Lymphocytes/immunology ; Osteoporosis/immunology
    Language English
    Publishing date 2021-08-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.687037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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