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  1. Article ; Online: Screw sense and screw sensibility: communicating information by conformational switching in helical oligomers.

    Morris, David T J / Clayden, Jonathan

    Chemical Society reviews

    2023  Volume 52, Issue 7, Page(s) 2480–2496

    Abstract: ... the means by which G-protein coupled receptors (GPCRs) use extracellular signals to modulate intracellular ...

    Abstract Biological systems have evolved a number of different strategies to communicate information on the molecular scale. Among these, the propagation of conformational change is among the most important, being the means by which G-protein coupled receptors (GPCRs) use extracellular signals to modulate intracellular processes, and the way that opsin proteins translate light signals into nerve impulses. The developing field of foldamer chemistry has allowed chemists to employ conformationally well-defined synthetic structures likewise to mediate information transfer, making use of mechanisms that are not found in biological contexts. In this review, we discuss the use of switchable screw-sense preference as a communication mechanism. We discuss the requirements for functional communication devices, and show how dynamic helical foldamers derived from the achiral monomers such as α-aminoisobutyric acid (Aib) and
    MeSH term(s) Molecular Conformation
    Language English
    Publishing date 2023-04-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/d2cs00982j
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  2. Article ; Online: Call for the development and use of nurse practitioner sensitive outcome measures.

    Driscoll, Andrea / Clayden, Suzie / Lowe, Grainne

    European journal of cardiovascular nursing

    2024  

    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2151245-0
    ISSN 1873-1953 ; 1474-5151
    ISSN (online) 1873-1953
    ISSN 1474-5151
    DOI 10.1093/eurjcn/zvae008
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5938: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Functional brain connectivity in children with focal epilepsy: A systematic review of functional MRI studies.

    Feng, Xiyu / Piper, Rory J / Prentice, Freya / Clayden, Jonathan D / Baldeweg, Torsten

    Seizure

    2024  Volume 117, Page(s) 164–173

    Abstract: ... for the default mode network. Focal epilepsy disrupted FC in children both locally (e.g., seizure-onset zones, or ... within-brain subnetworks) and globally (e.g., whole-brain network architecture). The wide variety of FC ...

    Abstract Epilepsy is increasingly recognised as a brain network disorder and many studies have investigated functional connectivity (FC) in children with epilepsy using functional MRI (fMRI). This systematic review of fMRI studies, published up to November 2023, investigated profiles of FC changes and their clinical relevance in children with focal epilepsy compared to healthy controls. A literature search in PubMed and Web of Science yielded 62 articles. We categorised the results into three groups: 1) differences in correlation-based FC between patients and controls; 2) differences in other FC measures between patients and controls; and 3) associations between FC and disease variables (for example, age of onset), cognitive and seizure outcomes. Studies revealed either increased or decreased FC across multiple brain regions in children with focal epilepsy. However, findings lacked consistency: conflicting FC alterations (decreased and increased FC) co-existed within or between brain regions across all focal epilepsy groups. The studies demonstrated overall that 1) interhemispheric connections often displayed abnormal connectivity and 2) connectivity within and between canonical functional networks was decreased, particularly for the default mode network. Focal epilepsy disrupted FC in children both locally (e.g., seizure-onset zones, or within-brain subnetworks) and globally (e.g., whole-brain network architecture). The wide variety of FC study methodologies limits clinical application of the results. Future research should employ longitudinal designs to understand the evolution of brain networks during the disease course and explore the potential of FC biomarkers for predicting cognitive and postsurgical seizure outcomes.
    MeSH term(s) Humans ; Epilepsies, Partial/physiopathology ; Epilepsies, Partial/diagnostic imaging ; Child ; Magnetic Resonance Imaging ; Brain/diagnostic imaging ; Brain/physiopathology ; Nerve Net/diagnostic imaging ; Nerve Net/physiopathology ; Connectome
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1137610-7
    ISSN 1532-2688 ; 1059-1311
    ISSN (online) 1532-2688
    ISSN 1059-1311
    DOI 10.1016/j.seizure.2024.02.021
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3573: Show issues Location:
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  4. Article ; Online: Evaluation of an Ambulatory Emergency Care Centre at a tertiary hospital in Perth, Western Australia.

    Keane, Carolyn / Clayden, Vanessa / Scott, Gillian

    Australasian emergency care

    2022  Volume 25, Issue 4, Page(s) 289–295

    Abstract: Background: Emergency Departments around the world are under increasing pressure due to rising demand. In the United Kingdom ambulatory emergency care has been demonstrated to deliver safe and effective care for emergency patients and has now become an ... ...

    Abstract Background: Emergency Departments around the world are under increasing pressure due to rising demand. In the United Kingdom ambulatory emergency care has been demonstrated to deliver safe and effective care for emergency patients and has now become an accepted treatment modality.
    Methods: This paper outlines a quality improvement project undertaken to evaluate an ambulatory emergency care centre implemented at a tertiary hospital in Perth, Western Australia, from February to August 2021.
    Results: The findings demonstrated a 4% improvement in the Western Australian Emergency Access Target for a four week period, a 6.3% reduction in the number of patients admitted with a length of stay less than 24 h and that patient's attending the Ambulatory Emergency Care Centre were managed as safely as if they were seen in the Emergency Department.
    MeSH term(s) Australia ; Emergency Medical Services ; Emergency Service, Hospital ; Humans ; Tertiary Care Centers ; Western Australia
    Language English
    Publishing date 2022-02-10
    Publishing country Australia
    Document type Journal Article
    ISSN 2588-994X
    ISSN (online) 2588-994X
    DOI 10.1016/j.auec.2022.02.001
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  5. Article ; Online: De novo design of discrete, stable 3

    Kumar, Prasun / Paterson, Neil G / Clayden, Jonathan / Woolfson, Derek N

    Nature

    2022  Volume 607, Issue 7918, Page(s) 387–392

    Abstract: The α-helix is pre-eminent in structural ... ...

    Abstract The α-helix is pre-eminent in structural biology
    MeSH term(s) Crystallography, X-Ray ; Drug Design ; Hydrophobic and Hydrophilic Interactions ; Peptides/chemical synthesis ; Peptides/chemistry ; Protein Folding ; Protein Stability ; Protein Structure, Secondary
    Chemical Substances Peptides
    Language English
    Publishing date 2022-06-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-022-04868-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  6. Article ; Online: Light-mediated control of activity in a photosensitive foldamer that mimics an esterase.

    Pollastrini, Matteo / Marafon, Giulia / Clayden, Jonathan / Moretto, Alessandro

    Chemical communications (Cambridge, England)

    2021  Volume 57, Issue 18, Page(s) 2269–2272

    Abstract: We report a catalytic foldamer in which a fumaramide chromophore links a Ser residue to a helical domain that contains within its sequence the residues His and Asp. Photoisomerization of the fumaramide chromophore (with E geometry) to the corresponding ... ...

    Abstract We report a catalytic foldamer in which a fumaramide chromophore links a Ser residue to a helical domain that contains within its sequence the residues His and Asp. Photoisomerization of the fumaramide chromophore (with E geometry) to the corresponding maleamide (with Z geometry) brings together a 'catalytic triad' of Ser, His, and Asp, triggering esterase activity that is absent in the fumaramide isomer. The fumaramide/maleamide linker thus acts as a light-sensitive switchable cofactor for activation of catalytic activity in short foldamers.
    MeSH term(s) Amides/chemistry ; Biomimetic Materials/chemistry ; Catalysis ; Catalytic Domain ; Esterases/chemistry ; Maleimides/chemistry ; Models, Molecular ; Peptidomimetics/chemistry ; Photochemical Processes ; Protein Folding ; Stereoisomerism ; Structure-Activity Relationship
    Chemical Substances Amides ; Maleimides ; Peptidomimetics ; maleimide (2519R1UGP8) ; fumaramide (627-64-5) ; Esterases (EC 3.1.-)
    Language English
    Publishing date 2021-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc08309g
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  7. Article ; Online: Constipation in children.

    Clayden, Graham

    Indian pediatrics

    2010  Volume 47, Issue 12, Page(s) 1013–1014

    MeSH term(s) Child ; Constipation/epidemiology ; Humans ; India/epidemiology
    Language English
    Publishing date 2010-11-08
    Publishing country India
    Document type Comment ; Editorial
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
    DOI 10.1007/s13312-010-0167-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 859: Show issues Location:
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  8. Article ; Online: Dynamic and Persistent Cyclochirality in Hydrogen-Bonded Derivatives of Medium-Ring Triamines.

    Morris, David T J / Wales, Steven M / Echavarren, Javier / Žabka, Matej / Marsico, Giulia / Ward, John W / Pridmore, Natalie E / Clayden, Jonathan

    Journal of the American Chemical Society

    2023  Volume 145, Issue 34, Page(s) 19030–19041

    Abstract: Cyclic triureas derived from 1,4,7-triazacyclononane (TACN) were synthesized; X-ray crystallography showed a chiral bowl-like conformation with each urea hydrogen-bonded to its neighbor with uniform directionality, forming a "cyclochiral" closed loop of ... ...

    Abstract Cyclic triureas derived from 1,4,7-triazacyclononane (TACN) were synthesized; X-ray crystallography showed a chiral bowl-like conformation with each urea hydrogen-bonded to its neighbor with uniform directionality, forming a "cyclochiral" closed loop of hydrogen bonds. Variable-temperature
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c06570
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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
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  9. Article: The impact of multiple language exposure on cognition during childhood: evidence from the UK Millennium Cohort Study.

    Clayden, Jonathan D / Hope, Steven / Argyri, Froso / Goksan, Sezgi / Stefani, Artemis / Wei, Li / Liegeois, Frederique Jeanne

    Frontiers in psychology

    2023  Volume 14, Page(s) 1158333

    Abstract: ... cohort study, which provides information on perinatal and environmental factors (e.g., languages spoken ...

    Abstract Introduction: Many studies argue that exposure to, and use of, multiple languages in childhood has beneficial effects beyond the linguistic domain, including on executive functions (EFs), although recent evidence remains controversial. EFs encompass abilities necessary for regulating goal-directed behaviours in everyday life and, in children, EFs strongly predict later academic achievement and wellbeing. One theoretical framework distinguishes "hot" EFs, which have a reward or affective component, from "cool" EFs that do not. How exposure to more than one language in early childhood modulates hot and cool EFs in later childhood, alongside other environmental and cognitive factors, remains poorly understood.
    Methods: We analysed data from the UK Millennium Cohort Study, a large-scale, nationally representative longitudinal cohort study, which provides information on perinatal and environmental factors (e.g., languages spoken in the home, maternal education) alongside cognitive measures assessed in English. At 3 years, we examined the effect of multiple language exposure on the Bracken school readiness assessment (knowledge of shapes, letters, etc.), and on naming vocabulary. At age 11, we examined the predictors of cool EF, measured with a spatial working memory task; hot EF, measured using a gambling task; and vocabulary, measured using a verbal reasoning task.
    Results: Data from 16,134 children were analysed. At age 3, a negative effect of multiple language exposure on school readiness and vocabulary was observed, but the difference was smaller with higher maternal education. At age 11, there was also a negative effect on vocabulary, but smaller than that observed at age 3. There were no direct effects of language exposure on either spatial working memory or gambling scores. For hot EF, the multiple language exposure effects were indirect, mediated by early cognition, and the most significant predictor of gambling strategy was sex. For cool EF, school readiness and vocabulary at age 3 were the strongest predictors.
    Discussion: Our findings, based on a UK population sample, highlight the importance of considering socioeconomic status and early-life abilities when interpreting the effects of language environments on hot and cool EFs.
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1158333
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  10. Book: Constipation in childhood

    Clayden, Graham / Agnarsson, Ulfur

    (Oxford medical publications)

    1991  

    Author's details Graham Clayden and Ulfur Agnarsson
    Series title Oxford medical publications
    Keywords Constipation / in infancy & childhood ; Kind ; Verstopfung
    Subject Kindheit ; Kindesalter ; Kindschaft ; Kinder ; Darmträgheit ; Darmverstopfung ; Koprostase ; Obstipation ; Stuhlverstopfung ; Constipation
    Size VIII, 123, 21 S. : Ill.
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT003817440
    ISBN 0-19-262044-4 ; 0-19-262027-4 ; 978-0-19-262044-6 ; 978-0-19-262027-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 2566 order for loan Magazin

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