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Article: Biomechanical Modeling of Cesarean Section Scars and Scar Defects.

Scott, Adrienne K / Louwagie, Erin M / Myers, Kristin M / Oyen, Michelle L

bioRxiv : the preprint server for biology

2024

Abstract: Uterine rupture is an intrinsically biomechanical process associated with high maternal and fetal mortality. A previous Cesarean section (C-section) is the main risk factor for uterine rupture in a subsequent pregnancy due to tissue failure at the scar ... ...

Abstract	Uterine rupture is an intrinsically biomechanical process associated with high maternal and fetal mortality. A previous Cesarean section (C-section) is the main risk factor for uterine rupture in a subsequent pregnancy due to tissue failure at the scar region. Finite element modeling of the uterus and scar tissue presents a promising method to further understand and predict uterine ruptures. Using patient dimensions of an at-term uterus, a C-section scar was modeled with an applied intrauterine pressure to study how scars affect uterine stress. The scar positioning and uterine thickness were varied, and a defect was incorporated into the scar region. The modeled stress distributions confirmed clinical observations as the increased regions of stress due to scar positioning, thinning of the uterine walls, and the presence of a defect are consistent with clinical observations of features that increase the risk of uterine rupture.
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.11.03.565565
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Article ; Online: Etiologic Evaluation of Children with Autism Spectrum Disorder.

Lazar, Steven M / Challman, Thomas D / Myers, Scott M

Pediatric clinics of North America

2024 Volume 71, Issue 2, Page(s) 179–197

Abstract: Autism spectrum disorder (ASD) is clinically and etiologically heterogeneous. A causal genetic variant can be identified in approximately 20% to 25% of affected individuals with current clinical genetic testing, and all patients with an ASD diagnosis ... ...

Abstract	Autism spectrum disorder (ASD) is clinically and etiologically heterogeneous. A causal genetic variant can be identified in approximately 20% to 25% of affected individuals with current clinical genetic testing, and all patients with an ASD diagnosis should be offered genetic etiologic evaluation. We suggest that exome sequencing with copy number variant coverage should be the first-line etiologic evaluation for ASD. Neuroimaging, neurophysiologic, metabolic, and other biochemical evaluations can provide insight into the pathophysiology of ASD but should be recommended in the appropriate clinical circumstances.
MeSH term(s)	Child ; Humans ; Autism Spectrum Disorder/etiology ; Autism Spectrum Disorder/genetics ; DNA Copy Number Variations ; Genetic Testing ; Neuroimaging
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	215711-1
ISSN	1557-8240 ; 0031-3955
ISSN (online)	1557-8240
ISSN	0031-3955
DOI	10.1016/j.pcl.2023.12.002
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Book ; Online ; E-Book: Developmental and behavioral pediatrics

Voigt, Robert G. / Macias, Michelle M. / Myers, Scott M. / Tapia, Carl D.

2018

Abstract: Fully revised and expanded, the second edition of this best-selling resource provides expert guidance for primary pediatric health care professionals on caring for children with developmental and behavioral concerns - from medical evaluation and care ... ...

Title variant	American Academy of Pediatrics ; AAP developmental and behavioral pediatrics
Institution	American Academy of Pediatrics / Section on Developmental and Behavioral Pediatrics
Author's details	Section on Developmental and Behavioral Pediatrics, American Academy of Pediatrics ; editor Robert G. Voigt, MD, FAAP ; associate editors Michelle M. Macias, MD, FAAP; Scott M. Myers, MD, FAAP; Carl D. Tapia, MD, MPH, FAAP
Abstract	Fully revised and expanded, the second edition of this best-selling resource provides expert guidance for primary pediatric health care professionals on caring for children with developmental and behavioral concerns - from medical evaluation and care initiation to transition to adulthood
Keywords	Developmental Disabilities / diagnosis ; Developmental Disabilities / therapy ; Child Behavior Disorders / diagnosis ; Child Behavior Disorders / therapy
Subject code	618.92
Language	English
Size	1 Online-Ressource (xx, 671 Seiten), Illustrationen, Diagramme
Edition	2nd edition
Publisher	American Academy of Pediatrics
Publishing place	Itasca, IL
Publishing country	United States
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019796637
ISBN	978-1-61002-135-7 ; 9781610022392 ; 9781610022408 ; 9781610021340 ; 1-61002-135-5 ; 1610022394 ; 1610022408 ; 1610021347
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Article ; Online: Implications of Genetic Variants in Cerebral Palsy-Reply.

Myers, Scott M / Martin, Christa L / Moreno-De-Luca, Andres

JAMA pediatrics

2023 Volume 177, Issue 8, Page(s) 872–873

MeSH term(s)	Humans ; Cerebral Palsy/genetics
Language	English
Publishing date	2023-06-29
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2701223-2
ISSN	2168-6211 ; 2168-6203
ISSN (online)	2168-6211
ISSN	2168-6203
DOI	10.1001/jamapediatrics.2023.1858
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Article ; Online: Maternal care behavior and physiology moderate offspring outcomes following gestational exposure to opioids.

Myers, Abigail M / Bowen, Scott E / Brummelte, Susanne

Developmental psychobiology

2023 Volume 65, Issue 8, Page(s) e22433

Abstract: The opioid epidemic has resulted in a drastic increase in gestational exposure to opioids. Opioid-dependent pregnant women are typically prescribed medications for opioid use disorders ("MOUD"; e.g., buprenorphine [BUP]) to mitigate the harmful effects ... ...

Abstract	The opioid epidemic has resulted in a drastic increase in gestational exposure to opioids. Opioid-dependent pregnant women are typically prescribed medications for opioid use disorders ("MOUD"; e.g., buprenorphine [BUP]) to mitigate the harmful effects of abused opioids. However, the consequences of exposure to synthetic opioids, particularly BUP, during gestation on fetal neurodevelopment and long-term outcomes are poorly understood. Further, despite the known adverse effects of opioids on maternal care, many preclinical and clinical studies investigating the effects of gestational opioid exposure on offspring outcomes fail to report on maternal care behaviors. Considering that offspring outcomes are heavily dependent upon the quality of maternal care, it is important to evaluate the effects of gestational opioid exposure in the context of the mother-infant dyad. This review compares offspring outcomes after prenatal opioid exposure and after reduced maternal care and integrates this information to potentially identify common underlying mechanisms. We explore whether adverse outcomes after gestational BUP exposure are due to direct effects of opioids in utero, deficits in maternal care, or a combination of both factors. Finally, suggestions for improving preclinical models of prenatal opioid exposure are provided to promote more translational studies that can help to improve clinical outcomes for opioid-dependent mothers.
MeSH term(s)	Female ; Pregnancy ; Humans ; Analgesics, Opioid/adverse effects ; Buprenorphine/adverse effects ; Opioid-Related Disorders/drug therapy ; Maternal Behavior ; Mothers
Chemical Substances	Analgesics, Opioid ; Buprenorphine (40D3SCR4GZ)
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	4107-5
ISSN	1098-2302 ; 0012-1630
ISSN (online)	1098-2302
ISSN	0012-1630
DOI	10.1002/dev.22433
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Article: Genetic Testing in Neurodevelopmental Disorders.

Savatt, Juliann M / Myers, Scott M

Frontiers in pediatrics

2021 Volume 9, Page(s) 526779

Abstract: Neurodevelopmental disorders are the most prevalent chronic medical conditions encountered in pediatric primary care. In addition to identifying appropriate descriptive diagnoses and guiding families to evidence-based treatments and supports, ... ...

Abstract	Neurodevelopmental disorders are the most prevalent chronic medical conditions encountered in pediatric primary care. In addition to identifying appropriate descriptive diagnoses and guiding families to evidence-based treatments and supports, comprehensive care for individuals with neurodevelopmental disorders includes a search for an underlying etiologic diagnosis, primarily through a genetic evaluation. Identification of an underlying genetic etiology can inform prognosis, clarify recurrence risk, shape clinical management, and direct patients and families to condition-specific resources and supports. Here we review the utility of genetic testing in patients with neurodevelopmental disorders and describe the three major testing modalities and their yields - chromosomal microarray, exome sequencing (with/without copy number variant calling), and
Language	English
Publishing date	2021-02-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2021.526779
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Article ; Online: Letter to the editor.

Finucane, Brenda / Myers, Scott M / Challman, Thomas D / Martin, Christa Lese / Ledbetter, David H

Autism research : official journal of the International Society for Autism Research

2023 Volume 16, Issue 4, Page(s) 678

Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2481338-2
ISSN	1939-3806 ; 1939-3792
ISSN (online)	1939-3806
ISSN	1939-3792
DOI	10.1002/aur.2921
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Article ; Online: Acute occupational inhalation injuries-United States, 2011-2022.

Myers, Nirmala T / Dodd, Katelynn E / Hale, Janet M / Blackley, David J / Scott Laney, A / Hall, Noemi B

American journal of industrial medicine

2024 Volume 67, Issue 4, Page(s) 376–383

Abstract: Background: Inhalation injuries due to acute occupational exposures to chemicals are preventable. National surveillance of acute inhalation exposures is limited. This study identified the most common acute inhalation exposure-related incidents by ... ...

Abstract	Background: Inhalation injuries due to acute occupational exposures to chemicals are preventable. National surveillance of acute inhalation exposures is limited. This study identified the most common acute inhalation exposure-related incidents by industry sector among US workers. Methods: To characterize inhalation-related injuries and their exposures during April 2011-March 2022, state and federal records from the Occupational Safety and Health Administration (OSHA) Occupational Safety and Health Information System (OIS) accident database were analyzed. Industry-specific injury, hospitalization, and fatality rates were calculated. Results: The most frequent acute inhalation incidents investigated by OSHA were caused by inorganic gases (52.9%) such as carbon monoxide (CO) or acids, bases, and oxidizing chemical agents (12.9%) such as anhydrous ammonia. The largest number of fatal and nonfatal injuries were reported in the manufacturing (28.6%) and construction (17.2%) sectors. Conclusions: Workers were affected by acute inhalation exposures in most industries. Using this surveillance, employers can recognize frequently-occurring preventable acute inhalation exposures by industry, such as inorganic gases in the manufacturing sector, and implement prevention measures. Training of workers on exposure characteristics and limits, adverse health effects, and use of protective equipment by exposure agent can prevent inhalation injuries.
MeSH term(s)	Humans ; United States/epidemiology ; Occupational Injuries/epidemiology ; Accidents, Occupational ; Industry ; Occupational Exposure/adverse effects ; Gases
Chemical Substances	Gases
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	604538-8
ISSN	1097-0274 ; 0271-3586
ISSN (online)	1097-0274
ISSN	0271-3586
DOI	10.1002/ajim.23573
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Article ; Online: MAGIC (maternal glucose in pregnancy) understanding the glycemic profile of pregnancy, intensive CGM glucose profiling and its relationship to fetal growth: an observational study protocol.

Scott, Eleanor M / Murphy, Helen R / Myers, Jenny / Saravanan, Ponnusamy / Poston, Lucilla / Law, Graham R

BMC pregnancy and childbirth

2023 Volume 23, Issue 1, Page(s) 563

Abstract: Background: Continuous glucose monitoring (CGM) provides the most objective method of assessing glucose in daily life. Although there have been small, short-term physiologic studies of glucose metabolism in 'healthy' pregnant women a comprehensive, ... ...

Abstract	Background: Continuous glucose monitoring (CGM) provides the most objective method of assessing glucose in daily life. Although there have been small, short-term physiologic studies of glucose metabolism in 'healthy' pregnant women a comprehensive, longitudinal description of changes in glucose over the course of pregnancy and how glucose dysregulation earlier in pregnancy relates to traditional third trimester screening for gestational diabetes, fetal growth and pregnancy outcomes is lacking. This study aims to characterise longitudinal changes in glycemia across gestation using CGM, in order to understand the evolution of dysglycemia and its relationship to fetal growth. Method/design: A multi-centre, prospective, observational, cohort study of 500 healthy pregnant women, recruited in the first trimester of pregnancy. Masked CGM will be performed for a 14-day period on five occasions across pregnancy at ~ 10-12, 18-20, 26-28, 34-36 weeks gestation and postnatally. Routinely collected anthropometric and sociodemographic information will be recorded at each visit including: weight, height, blood pressure, current medication. Age, parity, ethnicity, smoking will be recorded. Blood samples will be taken at each visit for HbA1c and a sample stored. Details on fetal growth from ultrasound scans and the OGTT results will be recorded. Maternal and neonatal outcomes will be collected. CGM glucose profiling is the exposure of interest, and will be performed using standard summary statistics, functional data analysis and glucotyping. The primary maternal outcome is clinical diagnosis of GDM. The primary neonatal outcome is large for gestational age (LGA) (> 90th centile defined by customised birthweight centile). The relationship of glucose to key secondary maternal and neonatal outcomes will be explored. Discussion: This study will ascertain the relationship of maternal dysglycemia to fetal growth and outcomes. It will explore whether CGM glucose profiling can detect GDM before the OGTT; or indeed whether CGM glucose profiling may be more useful than the OGTT at detecting LGA and other perinatal outcomes. Trial registration: ISRCTN 15,706,303 https://www.isrctn.com/ISRCTN15706303 Registration date: 13th March 2023.
MeSH term(s)	Female ; Humans ; Pregnancy ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring ; Cohort Studies ; Diabetes, Gestational ; Fetal Development ; Glucose ; Observational Studies as Topic ; Pregnancy Outcome ; Prospective Studies ; Multicenter Studies as Topic
Chemical Substances	Blood Glucose ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-023-05824-x
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Article ; Online: Oligodendrocyte-selective deletion of the eIF2α kinase Perk/Eif2ak3 limits functional recovery after spinal cord injury.

Saraswat Ohri, Sujata / Forston, Michael D / Myers, Scott A / Brown, Brandon L / Andres, Kariena R / Howard, Russell M / Gao, Yonglin / Liu, Yu / Cavener, Douglas R / Hetman, Michal / Whittemore, Scott R

Glia

2024

Abstract: After spinal cord injury (SCI), re-establishing cellular homeostasis is critical to optimize functional recovery. Central to that response is PERK signaling, which ultimately initiates a pro-apoptotic response if cellular homeostasis cannot be restored. ... ...

Abstract	After spinal cord injury (SCI), re-establishing cellular homeostasis is critical to optimize functional recovery. Central to that response is PERK signaling, which ultimately initiates a pro-apoptotic response if cellular homeostasis cannot be restored. Oligodendrocyte (OL) loss and white matter damage drive functional consequences and determine recovery potential after thoracic contusive SCI. We examined acute (<48 h post-SCI) and chronic (6 weeks post-SCI) effects of conditionally deleting Perk from OLs prior to SCI. While Perk transcript is expressed in many types of cells in the adult spinal cord, its levels are disproportionately high in OL lineage cells. Deletion of OL-Perk prior to SCI resulted in: (1) enhanced acute phosphorylation of eIF2α, a major PERK substrate and the critical mediator of the integrated stress response (ISR), (2) enhanced acute expression of the downstream ISR genes Atf4, Ddit3/Chop, and Tnfrsf10b/Dr5, (3) reduced acute OL lineage-specific Olig2 mRNA, but not neuronal or astrocytic mRNAs, (4) chronically decreased OL content in the spared white matter at the injury epicenter, (5) impaired hindlimb locomotor recovery, and (6) reduced chronic epicenter white matter sparing. Cultured primary OL precursor cells with reduced PERK expression and activated ER stress response showed: (1) unaffected phosphorylation of eIF2α, (2) enhanced ISR gene induction, and (3) increased cytotoxicity. Therefore, OL-Perk deficiency exacerbates ISR signaling and potentiates white matter damage after SCI. The latter effect is likely mediated by increased loss of Perk
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	639414-0
ISSN	1098-1136 ; 0894-1491
ISSN (online)	1098-1136
ISSN	0894-1491
DOI	10.1002/glia.24525
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