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  1. Article ; Online: Management of diabetes in patients with COVID-19.

    Khalangot, Mykola

    The lancet. Diabetes & endocrinology

    2020  Volume 8, Issue 8, Page(s) 669

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Diabetes Mellitus ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-22
    Publishing country England
    Document type Letter ; Comment
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(20)30235-7
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  2. Article ; Online: COVID-19 and SIADH relations: impact of the positive pressure ventilation.

    Khalangot, Mykola

    American journal of physiology. Endocrinology and metabolism

    2020  Volume 319, Issue 1, Page(s) E196

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Inappropriate ADH Syndrome ; Pandemics ; Pneumonia, Viral ; Positive-Pressure Respiration ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00288.2020
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  5. Article ; Online: Management of diabetes in patients with COVID-19

    Khalangot, Mykola

    The Lancet Diabetes & Endocrinology

    2020  Volume 8, Issue 8, Page(s) 669

    Keywords Internal Medicine ; Endocrinology, Diabetes and Metabolism ; Endocrinology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2213-8587
    DOI 10.1016/s2213-8587(20)30235-7
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: RAAS inhibitors are associated with a better chance of surviving of inpatients with Covid-19 without a diagnosis of diabetes mellitus, compared with similar patients who did not require antihypertensive therapy or were treated with other antihypertensives.

    Khalangot, Mykola / Sheichenko, Nadiia / Gurianov, Vitaly / Zakharchenko, Tamara / Kravchenko, Victor / Tronko, Mykola

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1077959

    Abstract: Purpose: The effect of renin-angiotensin-aldosterone system (RAAS) inhibitors in combination with COVID-19 and diabetes mellitus (DM) remains unknown. We assessed the risk of death in COVID-19 inpatients based on the presence or absence of DM, arterial ... ...

    Abstract Purpose: The effect of renin-angiotensin-aldosterone system (RAAS) inhibitors in combination with COVID-19 and diabetes mellitus (DM) remains unknown. We assessed the risk of death in COVID-19 inpatients based on the presence or absence of DM, arterial hypertension (AH) and the use of RAAS inhibitors or other antihypertensives.
    Methods: The results of treatment of all adult PCR-confirmed COVID-19 inpatients (n = 1097, women 63.9%) from 02/12/2020 to 07/01/2022 are presented. The presence of DM at the time of admission and the category of antihypertensive drugs during hospital stay were noted. Leaving the hospital due to recovery or death was considered as a treatment outcome. Multivariable logistic regression analysis was used to assess the risk of death. Patients with COVID-19 without AH were considered the reference group.
    Results: DM was known in 150 of 1,097 patients with COVID-19 (13.7%). Mortality among DM inpatients was higher: 20.0%
    Conclusion: This result raises a question about the study of RAAS inhibitors effect in patients with Covid-19 without AH.
    MeSH term(s) Adult ; Humans ; Male ; Female ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/pharmacology ; Renin-Angiotensin System ; COVID-19/complications ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Inpatients ; Angiotensin Receptor Antagonists/therapeutic use ; Angiotensin Receptor Antagonists/pharmacology ; Hypertension/complications ; Hypertension/drug therapy ; Hypertension/diagnosis ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/chemically induced ; COVID-19 Testing
    Chemical Substances Antihypertensive Agents ; Angiotensin-Converting Enzyme Inhibitors ; Angiotensin Receptor Antagonists
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1077959
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  7. Article: Long-term impact of pre-natal exposure to the Ukraine famine of 1932-1933 on adult type 2 diabetes mellitus.

    Lumey, L H / Li, Chihua / Khalangot, Mykola / Levchuk, Nataliia / Wolowyna, Oleh

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Importance: The long-term impacts of early-life famine exposure on Type 2 Diabetes Mellitus (T2DM) have been widely documented across countries, but it remains less clear what is the critical time window and if there is a dose-response between famine ... ...

    Abstract Importance: The long-term impacts of early-life famine exposure on Type 2 Diabetes Mellitus (T2DM) have been widely documented across countries, but it remains less clear what is the critical time window and if there is a dose-response between famine intensity and risk of T2DM.
    Objective: To establish the relation between prenatal famine exposure and adult Type 2 diabetes mellitus (T2DM).
    Design: A national cross-sectional study.
    Setting: The man-made Ukrainian Holodomor famine of 1932-1933.
    Participants: A total number of 128,225 T2DM cases diagnosed at age 40 or over from the national diabetes register 2000-2008 in Ukraine. The population at risk includes 10,186,016 Soviet Ukraine births (excepting one oblast/province) between 1930-1938 classified by month and year and oblast of birth.
    Exposure: Births born in January-June 1934 from oblasts that experienced extreme, severe, or significant famine in 1932-1933. Famine intensity was measured based on the excess mortality during the famine.
    Main outcomes and measures: T2DM diagnosis was based on WHO (1999) criteria.
    Results: We observed in univariate analysis a 1.8-fold increase in T2DM (OR 1.80; 95% CI 1.74-1.85) among individuals born in the first half-year of 1934 in regions with extreme, severe, or significant famine. We observed no increase among individuals born in regions with no famine. In multivariate analysis across regions and adjusting for season of birth we observed a larger than 2-fold increase (OR 2.21; 95% CI 2.00-2.45). There was a dose-response by famine intensity, with ORs increasing from 1.94 to 2.39 across regions. The pattern was similar in men and women.
    Conclusions and relevance: Births in the first half-year of 1934 were conceived at the height of the Ukraine famine in 1933. This relation for T2DM outcomes points to early gestation as a critical time window relating maternal nutrition in pregnancy to offspring health in later life. Further studies of biological mechanisms should focus on this time window for which changes in DNA methylation and later body size have also been observed.
    Language English
    Publishing date 2023-12-04
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.02.23299317
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  8. Article ; Online: Relationship between hyperglycemia, waist circumference, and the course of COVID-19: Mortality risk assessment.

    Khalangot, Mykola / Sheichenko, Nadiia / Gurianov, Vitaly / Vlasenko, Viola / Kurinna, Yulia / Samson, Oksana / Tronko, Mykola

    Experimental biology and medicine (Maywood, N.J.)

    2021  Volume 247, Issue 3, Page(s) 200–206

    Abstract: An observational study was conducted in Ukraine to determine the independent mortality risks among adult inpatients with COVID-19. The results of treatment of COVID-19 inpatients ( ...

    Abstract An observational study was conducted in Ukraine to determine the independent mortality risks among adult inpatients with COVID-19. The results of treatment of COVID-19 inpatients (
    MeSH term(s) Aged ; Body Mass Index ; COVID-19/epidemiology ; COVID-19/etiology ; COVID-19/mortality ; COVID-19/therapy ; Comorbidity ; Diabetes Mellitus/epidemiology ; Female ; Humans ; Hyperglycemia/complications ; Hyperglycemia/epidemiology ; Length of Stay ; Leukocyte Count ; Male ; Middle Aged ; Obesity, Abdominal/epidemiology ; Risk Assessment ; Treatment Outcome ; Ukraine/epidemiology ; Waist Circumference
    Language English
    Publishing date 2021-10-20
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.1177/15353702211054452
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  9. Article ; Online: Telomere length in different metabolic categories: Clinical associations and modification potential.

    Khalangot, Mykola / Krasnienkov, Dmytro / Vaiserman, Alexander

    Experimental biology and medicine (Maywood, N.J.)

    2020  Volume 245, Issue 13, Page(s) 1115–1121

    Abstract: Impact statement: Metabolic disorders are known to be associated with accelerated telomere attrition. Their pathophysiological heterogeneity suggests the importance of multiple tests in examining these associations. However, oral glucose tolerance test ( ...

    Abstract Impact statement: Metabolic disorders are known to be associated with accelerated telomere attrition. Their pathophysiological heterogeneity suggests the importance of multiple tests in examining these associations. However, oral glucose tolerance test (OGTT) has rarely been performed in such studies to date. There are few studies aimed at determining leukocyte telomere length (LTL) in different categories of impaired glucose tolerance (IGT), and those that do exist do not take into account the impaired fasting glucose (IFG)/IGT categorization. Therefore, we believe our study, when the OGTT was used, is important to the field. This testing made it possible to determine whether LTLs are associated with glucose levels in different hyperglycemic categories. Our data indicate that relationships between LTLs and IFG/IGT levels are not the same. This distinction can potentially be used in categorization of metabolic disorders and in determining the effectiveness of interventions aimed at treating diabetes and other metabolic abnormalities.
    MeSH term(s) Animals ; Blood Glucose/metabolism ; Fasting/physiology ; Humans ; Leukocytes/metabolism ; Metabolic Syndrome/metabolism ; Telomere/metabolism
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2020-06-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.1177/1535370220931509
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  10. Article: Metabolic and Anthropometric Parameters of Persons at Risk of Developing Type 2 Diabetes Mellitus Before and After 3 Months of Consuming Insoluble Dietary Fiber.

    Khalangot, Mykola D / Gurianov, Vitaly G / Zakharchenko, Tamara F / Pysarenko, Yurii M / Kravchenko, Victor I

    Nutrition and metabolic insights

    2022  Volume 15, Page(s) 11786388221125181

    Abstract: Background: Observational studies have shown that insoluble fiber (IF) can be effective in preventing type 2 diabetes (T2D), but there is a lack of experimental data on the effect of short-term consumption of IF on metabolic parameters. We tried to ... ...

    Abstract Background: Observational studies have shown that insoluble fiber (IF) can be effective in preventing type 2 diabetes (T2D), but there is a lack of experimental data on the effect of short-term consumption of IF on metabolic parameters. We tried to investigate whether there was an improvement in glycemia and body composition in individuals at risk for T2D after 3 months of IF consumption.
    Methods: This "Type 2 Diabetes Mellitus Prevention Ukraine (T2DPUA)" study describes participants with impaired fasting glucose (IFG) as determined by ADA criteria. The study involved 30 people, including 21 women (70%). Daily, 15 g of IF derived from wheat was used. T2DPUA did not have a placebo group and the intervention lasted 3 months. Evaluation of fasting plasma glucose (FPG) and 2h plasma glucose (2hPG), glycated hemoglobin (HbA1c), total cholesterol, HDL-cholesterol, triacylglycerols, uric acid, and γ-glutamyl transferase was performed. The baseline and 3-monthly anthropometric examinations included measurements of weight, waist and hip circumference. Fat mass was assessed by bioelectrical impedance analysis. Paired samples
    Result: A decrease of FPG (
    Conclusion and recommendation: Data about improvement of glycemia and body composition over a short period of using IF by individuals with IFG are new and deserve larger studies.
    Language English
    Publishing date 2022-09-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2594646-8
    ISSN 1178-6388
    ISSN 1178-6388
    DOI 10.1177/11786388221125181
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