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  1. Article ; Online: COVID-19 et diabète de type 2

    Lalau, Jean-Daniel

    Médecine des Maladies Métaboliques

    des enquêtes nationales en France et leur analyse

    2020  Volume 14, Issue 7, Page(s) 651–656

    Keywords Internal Medicine ; Nutrition and Dietetics ; Endocrinology, Diabetes and Metabolism ; Cardiology and Cardiovascular Medicine ; covid19
    Language French
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 1957-2557
    DOI 10.1016/j.mmm.2020.07.006
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: COVID and type 2 diabetes: National surveys in France and their analysis/ COVID-19 et diabète de type 2: des enquêtes nationales en France et leur analyse

    Lalau, Jean-Daniel

    Med. Mal. Metab.

    Abstract: There is the fact, and the way it is perceived. Therefore, concerning the current COVID-19 pandemic, it is important to take patient testimony into consideration; to link the objective and the subjective. It is in that spirit that results of some surveys ...

    Abstract There is the fact, and the way it is perceived. Therefore, concerning the current COVID-19 pandemic, it is important to take patient testimony into consideration; to link the objective and the subjective. It is in that spirit that results of some surveys are presented here, to which a personal analysis is added. Some facts were expected, e.g. weight gain, diabetes disequilibrium, however, some facts are less expected after crossing data with age, socio-professional categories or geographic area. It is concluded with two issues: that of temporality, which has not yet deployed by force of circumstance, and that of distrust of different sources of information.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #688906
    Database COVID19

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  3. Article ; Online: The authors reply.

    Bennis, Youssef / De Broe, Marc E / Lalau, Jean-Daniel

    Critical care medicine

    2021  Volume 49, Issue 4, Page(s) e464–e465

    Language English
    Publishing date 2021-02-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004902
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  4. Article ; Online: The authors reply.

    Bennis, Youssef / De Broe, Marc E / Lalau, Jean-Daniel

    Critical care medicine

    2021  Volume 49, Issue 4, Page(s) e461–e462

    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004901
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  5. Article ; Online: A comment on metformin and COVID-19 with regard to "Metformin use is associated with a decrease in the risk of hospitalization and mortality in COVID-19 patients with diabetes: A population-based study in Lombardy".

    Al-Salameh, Abdallah / Wiernsperger, Nicolas / Cariou, Bertrand / Lalau, Jean-Daniel

    Diabetes, obesity & metabolism

    2022  Volume 24, Issue 9, Page(s) 1888–1893

    MeSH term(s) COVID-19/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Hospitalization ; Humans ; Hypoglycemic Agents/adverse effects ; Metformin/therapeutic use ; Retrospective Studies ; SARS-CoV-2
    Chemical Substances Hypoglycemic Agents ; Metformin (9100L32L2N)
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Letter
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.14746
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  6. Article ; Online: Protection by metformin against severe Covid-19: An in-depth mechanistic analysis.

    Wiernsperger, Nicolas / Al-Salameh, Abdallah / Cariou, Bertrand / Lalau, Jean-Daniel

    Diabetes & metabolism

    2022  Volume 48, Issue 4, Page(s) 101359

    Abstract: Since the outbreak of Covid-19, several observational studies on diabetes and Covid-19 have reported a favourable association between metformin and Covid-19-related outcomes in patients with type 2 diabetes mellitus (T2DM). This is not surprising since ... ...

    Abstract Since the outbreak of Covid-19, several observational studies on diabetes and Covid-19 have reported a favourable association between metformin and Covid-19-related outcomes in patients with type 2 diabetes mellitus (T2DM). This is not surprising since metformin affects many of the pathophysiological mechanisms implicated in SARS-CoV-2 immune response, systemic spread and sequelae. A comparison of the multifactorial pathophysiological mechanisms of Covid-19 progression with metformin's well-known pleiotropic properties suggests that the treatment of patients with this drug might be particularly beneficial. Indeed, metformin could alleviate the cytokine storm, diminish virus entry into cells, protect against microvascular damage as well as prevent secondary fibrosis. Although our in-depth analysis covers many potential metformin mechanisms of action, we want to highlight more particularly its unique microcirculatory protective effects since worsening of Covid-19 disease clearly appears as largely due to severe defects in the structure and functioning of microvessels. Overall, these observations confirm that metformin is a unique, pleiotropic drug that targets many of Covid-19's pathophysiology processes in a diabetes-independent manner.
    MeSH term(s) COVID-19 ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Humans ; Metformin/therapeutic use ; Microcirculation ; SARS-CoV-2
    Chemical Substances Metformin (9100L32L2N)
    Language English
    Publishing date 2022-05-31
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 1315751-6
    ISSN 1878-1780 ; 1262-3636 ; 0338-1684
    ISSN (online) 1878-1780
    ISSN 1262-3636 ; 0338-1684
    DOI 10.1016/j.diabet.2022.101359
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  7. Article ; Online: Management of diabetes in patients with COVID-19.

    Lalau, Jean-Daniel / Al-Salameh, Abdallah

    The lancet. Diabetes & endocrinology

    2020  Volume 8, Issue 8, Page(s) 666–667

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Diabetes Mellitus ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-22
    Publishing country England
    Document type Letter ; Comment
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(20)30231-X
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  8. Article ; Online: The association between metformin treatment and COVID-19 outcomes according to metformin continuation during hospitalisation.

    Al-Salameh, Abdallah / Bennis, Youssef / Cariou, Bertrand / Lalau, Jean-Daniel

    Diabetes & metabolism

    2021  Volume 47, Issue 6, Page(s) 101297

    MeSH term(s) COVID-19/drug therapy ; Hospitalization ; Humans ; Hypoglycemic Agents/therapeutic use ; Metformin/therapeutic use ; Treatment Outcome
    Chemical Substances Hypoglycemic Agents ; Metformin (9100L32L2N)
    Language English
    Publishing date 2021-10-23
    Publishing country France
    Document type Journal Article
    ZDB-ID 1315751-6
    ISSN 1878-1780 ; 1262-3636 ; 0338-1684
    ISSN (online) 1878-1780
    ISSN 1262-3636 ; 0338-1684
    DOI 10.1016/j.diabet.2021.101297
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  9. Article ; Online: Comment on 'metformin-related lactic acidosis with acute kidney injury: results of a French observational multicenter study'.

    Lalau, Jean-Daniel / Bennis, Youssef / De Broe, Marc

    Clinical toxicology (Philadelphia, Pa.)

    2019  Volume 58, Issue 7, Page(s) 786–787

    MeSH term(s) Acidosis, Lactic/chemically induced ; Acute Kidney Injury/chemically induced ; Humans ; Hypoglycemic Agents/adverse effects ; Metformin/adverse effects
    Chemical Substances Hypoglycemic Agents ; Metformin (9100L32L2N)
    Language English
    Publishing date 2019-12-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0009-9309 ; 0731-3810 ; 1556-3650
    DOI 10.1080/15563650.2019.1678757
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  10. Article ; Online: Pharmacodynamics and pharmacokinetics of extended-release metformin in patients with type 2 diabetes and chronic kidney disease stage 3B.

    Lalau, Jean-Daniel / Bennis, Youssef / Al-Salameh, Abdallah / Hurtel-Lemaire, Anne-Sophie / Fendri, Salha

    Diabetes, obesity & metabolism

    2021  Volume 24, Issue 1, Page(s) 166–170

    MeSH term(s) Delayed-Action Preparations/therapeutic use ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Humans ; Hypoglycemic Agents/pharmacokinetics ; Hypoglycemic Agents/therapeutic use ; Metformin/pharmacokinetics ; Metformin/therapeutic use ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy
    Chemical Substances Delayed-Action Preparations ; Hypoglycemic Agents ; Metformin (9100L32L2N)
    Language English
    Publishing date 2021-10-04
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.14554
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