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  1. Article: Cartilage Destruction by Hemophilic Arthropathy Can Be Prevented by Inhibition of the Ferroptosis Pathway in Human Chondrocytes.

    Wagener, Nele / Hardt, Sebastian / Pumberger, Matthias / Schömig, Friederike

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: 1) Background: Around 50% of hemophilia patients develop severe arthropathy, with even subclinical hemorrhage in childhood potentially leading to intra-articular iron deposition, synovia proliferation, neoangiogenesis, and eventual damage to articular ... ...

    Abstract (1) Background: Around 50% of hemophilia patients develop severe arthropathy, with even subclinical hemorrhage in childhood potentially leading to intra-articular iron deposition, synovia proliferation, neoangiogenesis, and eventual damage to articular cartilage and subchondral bone. Treatments typically include coagulation factor substitution, radiosynoviorthesis, and joint replacement for advanced cases. This study aims to elucidate programmed cell death mechanisms in hemophilic arthropathy (HA) to identify novel treatments. (2) Methods: Human chondrocytes were exposed to lysed/non-lysed erythrocytes, ferroptosis inducer ML-162, cytokines (IL-1ß, TNFα), and ferric citrate, then assessed for metabolic activity, DNA content, and cell death using Alamar Blue, cyQUANT, and Sytox assays. Three-dimensional spheroids served as a cartilage model to study the effects of erythrocytes and ML-162. (3) Results: Erythrocytes caused significant cell death in 2D cultures (
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020559
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  2. Article ; Online: Influences of lumbo-sacral transitional vertebrae for anterior lumbar interbody fusion.

    Becker, Luis / Mihalache, Tim Victor / Schmidt, Hendrik / Putzier, Michael / Pumberger, Matthias / Schömig, Friederike

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2746

    Abstract: Lumbo-sacral transitional vertebrae (LSTV) are frequent congenital variances of the spine and are associated with increased spinal degeneration. Nevertheless, there is a lack of data whether bony alterations associated with LSTV result in reduced ... ...

    Abstract Lumbo-sacral transitional vertebrae (LSTV) are frequent congenital variances of the spine and are associated with increased spinal degeneration. Nevertheless, there is a lack of data whether bony alterations associated with LSTV result in reduced segmental restoration of lordosis when performing ALIF. 58 patients with monosegmental stand-alone ALIF in the spinal segment between the 24th and 25th vertebra (L5/S1)/(L5/L6) where included. Of these, 17 patients had LSTV and were matched to a control population by age and sex. Pelvic incidence, pelvic tilt, sagittal vertical axis, lumbar lordosis, segmental lordosis, disc height and depth were compared. LSTV-patients had a significantly reduced segmental lordosis L4/5 (p = 0.028) and L5/S1/(L5/L6) (p = 0.041) preoperatively. ALIF resulted in a significant increase in segmental lordosis L5/S1 (p < 0.001). Postoperatively, the preoperatively reduced segmental lordosis was no longer significantly different in segments L4/5 (p = 0.349) and L5/S1/(L5/6) (p = 0.576). ALIF is associated with a significant increase in segmental lordosis in the treated segment even in patients with LSTV. Therefore, ALIF is a sufficient intervention for restoring the segmental lordosis in these patients as well.
    MeSH term(s) Humans ; Lordosis/diagnostic imaging ; Lordosis/surgery ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Retrospective Studies ; Pelvis/diagnostic imaging ; Pelvis/surgery ; Lumbosacral Region/surgery ; Spinal Fusion/methods
    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53179-w
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  3. Article ; Online: Schober test is not a valid assessment tool for lumbar mobility.

    Taheri, Nima / Becker, Luis / Reitmaier, Sandra / Muellner, Maximilian / Schömig, Friederike / Pumberger, Matthias / Schmidt, Hendrik

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5451

    Abstract: The Schober test is considered reliable in evaluating lumbar mobility and its impairment. Especially in patients with chronic low back pain (cLBP) identification of functional restriction is important. We aimed to investigate whether the 5 cm Schober cut- ...

    Abstract The Schober test is considered reliable in evaluating lumbar mobility and its impairment. Especially in patients with chronic low back pain (cLBP) identification of functional restriction is important. We aimed to investigate whether the 5 cm Schober cut-off provides a valid distinction between unrestricted and restricted mobility in participants with and without cLBP (18-65 years). cLBP is defined as LBP persisting for ≥ 12 weeks. We analyzed agreement between the Schober test with two measurement devices (Epionics SPINE
    MeSH term(s) Animals ; Humans ; Lumbosacral Region ; Spine
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54787-2
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  4. Article ; Online: Adolescent idiopathic scoliosis is associated with muscle area asymmetries in the lumbar spine.

    Becker, Luis / Li, Zhao / Wang, Zhen / Pumberger, Matthias / Schömig, Friederike

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2023  Volume 32, Issue 11, Page(s) 3979–3986

    Abstract: Purpose: While the etiopathogenesis of adolescent idiopathic scoliosis (AIS) remains unclear, it is assumed that muscular asymmetries contribute to curve progression. As previous studies have found asymmetries of the thoracic paraspinal muscles in AIS ... ...

    Abstract Purpose: While the etiopathogenesis of adolescent idiopathic scoliosis (AIS) remains unclear, it is assumed that muscular asymmetries contribute to curve progression. As previous studies have found asymmetries of the thoracic paraspinal muscles in AIS patients, our study's aim was to analyze differences in the erector spinae, multifidus, quadratus lumborum, and psoas muscles of the lumbar spine depending on the curve's radiographic characteristics.
    Methods: We retrospectively included all patients who received posterior reposition spondylodesis for AIS treatment at our institution. Patients were classified according to the Lenke classification. Muscle cross-sectional areas were obtained from magnetic resonance imaging of the lumbar spine. Data were analyzed with the Wilcoxon rank sum test, the Kruskal-Wallis test with post hoc testing, or the Spearman's correlation coefficient.
    Results: Seventy-four (14 males and 60 females) AIS patients with a median age of 16 (IQR ± 4) years and a mean Cobb angle of 56.0° (± 18.0°) were included. In curve types Lenke 1 and 2 (n = 45), the erector spinae (p < 0.001) and multifidus (p < 0.001) muscles had a significantly larger cross-sectional area on the convex side, whereas the quadratus lumborum (p = 0.034) and psoas (p < 0.001) muscles each had a significantly larger cross-sectional area on the lumbar contralateral side.
    Conclusion: Our results show an asymmetry of the lumbar spine's muscles which depends on both the convexity and the extent of the scoliotic curve. While our results cannot prove whether these differences are the deformity's cause or effect, they may contribute to a better understanding of AIS pathogenesis and may allow for more specific preoperative physiotherapy.
    MeSH term(s) Male ; Female ; Humans ; Adolescent ; Child, Preschool ; Scoliosis/diagnostic imaging ; Scoliosis/surgery ; Scoliosis/pathology ; Retrospective Studies ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Lumbar Vertebrae/pathology ; Kyphosis ; Psoas Muscles/diagnostic imaging
    Language English
    Publishing date 2023-09-12
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-023-07921-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3437: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Thesis: Erhöhtes Atheroskleroserisiko chronischer Hämodialyse-Patienten mit Diabetes mellitus Typ II

    Schömig, Michael

    die Rolle modifizierter, triglyzeridreicher Low-density-Lipoproteine

    1996  

    Author's details vorgelegt von Michael Schömig
    Language German
    Size 115 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 1998
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT009419768
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 MB 2523 order for loan Magazin

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  6. Article: Clinical presentation and diagnosis of delayed postoperative spinal implant infection.

    Schömig, Friederike / Putzier, Michael

    Journal of spine surgery (Hong Kong)

    2020  Volume 6, Issue 4, Page(s) 772–776

    Language English
    Publishing date 2020-12-28
    Publishing country China
    Document type Editorial
    ZDB-ID 2874556-5
    ISSN 2414-4630 ; 2414-469X
    ISSN (online) 2414-4630
    ISSN 2414-469X
    DOI 10.21037/jss-20-499
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  7. Article: Komplikationsmanagement im Rahmen von Zementaugmentation an der Wirbelsäule

    Schömig, Friederike / Müllner, Maximilian / Pumberger, Matthias

    Die Wirbelsäule

    2023  Volume 07, Issue 04, Page(s) 221–226

    Abstract: Die Herausforderungen durch Osteoporose-assoziierte spinale Pathologien nehmen insbesondere aufgrund der steigenden Zahl betroffener Patient:innen zu. Der Einsatz von Knochenzement ist inzwischen essenzieller Bestandteil in der Versorgung dieses ... ...

    Abstract Die Herausforderungen durch Osteoporose-assoziierte spinale Pathologien nehmen insbesondere aufgrund der steigenden Zahl betroffener Patient:innen zu. Der Einsatz von Knochenzement ist inzwischen essenzieller Bestandteil in der Versorgung dieses herausfordernden Patientenkollektivs und wird in der Behandlung sowohl von pathologischen sowie traumatischen Frakturen als auch vereinzelt bei degenerativen Erkrankungen eingesetzt. Nichtsdestotrotz ist er bis heute mit einem hohen Komplikationsrisiko assoziiert: neben den häufig asymptomatischen, jedoch teilweise auch lebensbedrohlichen Zementleckagen führt die Zementaugmentation zu biomechanischen Veränderungen der Wirbelsäule, welche den behandelnden Operateur:innen in der präoperativen Planung und intraoperativen Umsetzung zwingend bewusst sein müssen. Gleichzeitig ist die Anwendung spezifischer Strategien zur Vermeidung dieser Komplikationen essenziell.
    Keywords Wirbelsäulenchirurgie ; Komplikationen ; Zementaugmentation ; spine surgery ; complications ; cement augmentation
    Language German
    Publishing date 2023-10-24
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2509-825X ; 2509-8241
    ISSN (online) 2509-825X
    ISSN 2509-8241
    DOI 10.1055/a-1926-0718
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  8. Article ; Online: Operative Strategien bei der Versorgung neuromuskulärer Skoliosen.

    Schömig, Friederike / Fussi, Jasmin / Pumberger, Matthias / Putzier, Michael

    Der Orthopade

    2021  Volume 50, Issue 8, Page(s) 633–637

    Abstract: As part of the underlying condition, neuromuscular scoliosis occurs in early childhood. Compared to idiopathic scoliosis, neuromuscular scoliosis shows a more rapid progress of deformity, which continues even after the end of growth. This progress and ... ...

    Title translation Surgical strategies in the treatment of neuromuscular scoliosis.
    Abstract As part of the underlying condition, neuromuscular scoliosis occurs in early childhood. Compared to idiopathic scoliosis, neuromuscular scoliosis shows a more rapid progress of deformity, which continues even after the end of growth. This progress and the associated complications can only be prevented by surgical treatment. Depending on the patient's age and the extent of the deformity, different strategies have been established: in early childhood, so-called "growing implants" are used, while between the ages of 10 to 12, definitive treatment by reposition and fusion of the deformity is the treatment of choice. In this review, we present different surgical strategies as well as indications for surgery and discuss challenges in the treatment of these complex deformities.
    MeSH term(s) Child ; Child, Preschool ; Humans ; Scoliosis/diagnostic imaging ; Scoliosis/surgery ; Spinal Fusion ; Treatment Outcome
    Language German
    Publishing date 2021-07-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 121792-6
    ISSN 1433-0431 ; 0085-4530
    ISSN (online) 1433-0431
    ISSN 0085-4530
    DOI 10.1007/s00132-021-04128-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 822: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Microbial spectrum, patient-specific factors, and diagnostics in implant-related postoperative spondylodiscitis.

    Pichler, Lorenz / Li, Zhao / Khakzad, Thilo / Perka, Carsten / Pumberger, Matthias / Schömig, Friederike

    Bone & joint open

    2023  Volume 4, Issue 11, Page(s) 832–838

    Abstract: Aims: Implant-related postoperative spondylodiscitis (IPOS) is a severe complication in spine surgery and is associated with high morbidity and mortality. With growing knowledge in the field of periprosthetic joint infection (PJI), equivalent ... ...

    Abstract Aims: Implant-related postoperative spondylodiscitis (IPOS) is a severe complication in spine surgery and is associated with high morbidity and mortality. With growing knowledge in the field of periprosthetic joint infection (PJI), equivalent investigations towards the management of implant-related infections of the spine are indispensable. To our knowledge, this study provides the largest description of cases of IPOS to date.
    Methods: Patients treated for IPOS from January 2006 to December 2020 were included. Patient demographics, parameters upon admission and discharge, radiological imaging, and microbiological results were retrieved from medical records. CT and MRI were analyzed for epidural, paravertebral, and intervertebral abscess formation, vertebral destruction, and endplate involvement. Pathogens were identified by CT-guided or intraoperative biopsy, intraoperative tissue sampling, or implant sonication.
    Results: A total of 32 cases of IPOS with a mean patient age of 68.7 years (37.6 to 84.1) were included. Diabetes, age > 60 years, and history of infection were identified as risk factors. Patient presentation upon admission included a mean body temperature of 36.7°C (36.1 to 38.0), back pain at rest (mean visual analogue scale (VAS) mean 5/10) and when mobile (mean VAS 6/10), as well as elevated levels of CRP (mean 76.8 mg/l (0.4 to 202.9)) and white blood cell count (mean 9.2 units/nl (2.6 to 32.8)). Pathogens were identified by CT-guided or conventional biopsy, intraoperative tissue sampling, or sonication, and Gram-positive cocci presented as the most common among them. Antibiotic therapy was established in all cases with pathogen-specific treatment in 23 (71.9%) subjects. Overall 27 (84.4%) patients received treatment by debridement, decompression, and fusion of the affected segment.
    Conclusion: Cases of IPOS are rare and share similarities with spontaneous spondylodiscitis. While procedures such as CT-guided biopsy and sonication are valuable tools in the diagnosis of IPOS, MRI and intraoperative tissue sampling remain the gold standard. Research on known principles of PJI such as implant retention versus implant exchange need to be expanded to the field of spine surgery.
    Language English
    Publishing date 2023-11-03
    Publishing country England
    Document type Journal Article
    ISSN 2633-1462
    ISSN (online) 2633-1462
    DOI 10.1302/2633-1462.411.BJO-2023-0087.R1
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  10. Article: Finger-Floor Distance Is Not a Valid Parameter for the Assessment of Lumbar Mobility.

    Becker, Luis / Schömig, Friederike / Cordes, Lea Marie-Sophie / Duda, Georg N / Pumberger, Matthias / Schmidt, Hendrik

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 4

    Abstract: Low back pain (LBP) could be associated with a reduced lumbar mobility. For the evaluation of lumbar flexibility, parameters such as finger-floor distance (FFD) are historically established. However, the extent of the correlation of FFD to lumbar ... ...

    Abstract Low back pain (LBP) could be associated with a reduced lumbar mobility. For the evaluation of lumbar flexibility, parameters such as finger-floor distance (FFD) are historically established. However, the extent of the correlation of FFD to lumbar flexibility or other involved joint kinematics such as pelvic motion, as well as the influence of LBP, is not yet known. We conducted a prospective cross-sectional observation study with 523 participants included (167 with LBP > 12 weeks, 356 asymptomatic). LBP-participants were matched for sex, age, height, and body-mass-index with an asymptomatic control cohort, resulting in two cohorts with 120 participants each. The FFD in maximal trunk flexion was measured. The Epionics-SPINE measurement-system was used to evaluate the pelvic and lumbar Range-of-Flexion (RoF), and the correlation of FFD to pelvic- and lumbar-RoF was evaluated. In an asymptomatic sub-cohort of 12 participants, we examined the individual correlation of FFD to pelvic- and lumbar-RoF under gradual trunk flexion. Participants with LBP showed a significantly reduced pelvic-RoF (
    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13040638
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