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  1. Article ; Online: The prevalence of gastroesophageal reflux disease and laryngopharyngeal reflux in patients with dysphagia after radiotherapy for nasopharyngeal carcinoma.

    Ku, Peter K M / Vlantis, Alexander C / Hui, Thomas S C / Yeung, Zenon W C / Cho, Ryan H W / Wong, Marc H K / Lee, Alex K F / Yeung, David C M / Chan, Simon Y P / Chan, Becky Y T / Chang, Wai-Tsz / Mok, Florence / Wong, Kam-Hung / Wong, Jeffrey K T / Abdullah, Victor / van Hasselt, Andrew / Wu, Justin C Y / Tong, Michael C F

    Head & neck

    2024  

    Abstract: Background: The prevalence of gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR) in post-irradiated patients with nasopharyngeal carcinoma (NPC) is unknown.: Materials and methods: In a cross-sectional study, 31 NPC and 12 ... ...

    Abstract Background: The prevalence of gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR) in post-irradiated patients with nasopharyngeal carcinoma (NPC) is unknown.
    Materials and methods: In a cross-sectional study, 31 NPC and 12 control patients completed questionnaires for GERD/LPR before esophageal manometry and 24-h pH monitoring. The DeMeester score and reflux finding score (RFS) were used to define GERD and LPR, respectively. Risk factors were identified.
    Results: 51.6% of NPC and 8.3% of control patients, and 77.4% of NPC and 33% of control patients, were GERD-positive and LPR-positive, respectively. The GERD/LPR questionnaire failed to identify either condition in patients with NPC. No parameter differences in esophageal manometry or pneumonia incidence were noted between GERD/LPR-positive and GERD/LPR-negative patients. Post radiotherapy duration, high BMI, lack of chemotherapy, and dysphagia were positive risk factors for GERD/LPR.
    Conclusions: A high prevalence of GERD/LPR in patients with post-irradiated NPC exists, but reflux symptoms are inadequate for diagnosis.
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27645
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  2. Article ; Online: Salvage stereotactic body radiation therapy re-irradiation for unresectable locally recurrent nasopharyngeal rhabdomyosarcoma in a young adult: A case report.

    Buchberger, David S / Cook, Samantha K / Anderson, Peter M / Shepard, Dale R / Ku, Jamie A / Fritz, Michael A / Sindwani, Raj / Recinos, Pablo / Murphy, Erin S / Koyfman, Shlomo A

    Pediatric blood & cancer

    2023  Volume 70, Issue 10, Page(s) e30548

    MeSH term(s) Humans ; Young Adult ; Re-Irradiation ; Neoplasm Recurrence, Local/radiotherapy ; Radiosurgery ; Rhabdomyosarcoma/radiotherapy ; Salvage Therapy ; Nasopharyngeal Neoplasms/radiotherapy ; Treatment Outcome
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.30548
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    Zs.A 1131: Show issues Location:
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  3. Article ; Online: Rhinoplasty outcomes and trends.

    Ho, Osan Y M / Ku, Peter K M / Tong, Michael C F

    Current opinion in otolaryngology & head and neck surgery

    2019  Volume 27, Issue 4, Page(s) 280–286

    Abstract: Purpose of review: This article reviewed studies that support the use of implants for nasal valve surgery and augmentation rhinoplasty.: Recent findings: For nasal valve collapse, there is a trend for rhinoplasty surgeons to use Monarch nasal implant, ...

    Abstract Purpose of review: This article reviewed studies that support the use of implants for nasal valve surgery and augmentation rhinoplasty.
    Recent findings: For nasal valve collapse, there is a trend for rhinoplasty surgeons to use Monarch nasal implant, absorbable valve implant and titanium butterfly implant rather than traditional cartilaginous grafts. For augmentation rhinoplasty, it is still a gold standard to use autologous cartilage. However, alloplastic implants are still very popular for Asian rhinoplasty. A combination of implant materials for augmentation rhinoplasty can improve outcomes while minimizing complications.
    Summary: Application of implants and newer techniques in nasal valve surgery and augmentation rhinoplasty are important to enhance the outcome in rhinoplasty.
    MeSH term(s) Absorbable Implants ; Cartilage/transplantation ; Humans ; Outcome and Process Assessment, Health Care ; Prostheses and Implants ; Rhinoplasty/trends ; Transplantation, Autologous
    Language English
    Publishing date 2019-06-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000554
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    Zs.A 4814: Show issues Location:
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  4. Article: Quality of life and swallowing outcomes after early proactive swallowing rehabilitation by either transcutaneous neuromuscular electrical stimulation or exercise-based swallowing training in patients with nasopharyngeal carcinoma after radiotherapy.

    Ku, Peter K M / Vlantis, Alexander C / Wong, Rita W M / Hui, Thomas S C / Law, Thomas / Ng, Louisa K Y / Wong, Eddy W Y / Chang, W T / Johnson, David R / Mok, Florence S T / Wong, K H / Abdullah, Victor / van Hasselt, Andrew / Lee, Kathy Y S / Tong, Michael C F

    Laryngoscope investigative otolaryngology

    2023  Volume 8, Issue 6, Page(s) 1532–1546

    Abstract: Background: Exercise-based swallowing training (EBST) and transcutaneous neuromuscular electrical stimulation (TNMES) are common modalities used to treat late dysphagia after radiotherapy for nasopharyngeal carcinoma (NPC). We aimed to investigate and ... ...

    Abstract Background: Exercise-based swallowing training (EBST) and transcutaneous neuromuscular electrical stimulation (TNMES) are common modalities used to treat late dysphagia after radiotherapy for nasopharyngeal carcinoma (NPC). We aimed to investigate and compare the efficacies of EBST and TNMES as proactive treatments administered early after radiotherapy.
    Methods: Patients with early post-radiotherapy NPC (
    Results: Three months after radiotherapy, 31 and 34 patients underwent TNMES and EBST, respectively, and completed swallowing assessments at all four assessment timepoints. All patients showed post-radiotherapy impairments in the SFS, PAS, DIGEST, PMI, and PFI. Compared with the EBST group, the TNMES group showed significant improvements in the PFI and PMI scores, with small-to-medium effect sizes. Additionally, compared with the EBST group, the TNMES group demonstrated a trend toward slightly better improvements in the PAS, DIGEST, FOIS, and SPSS scores immediately and 6 months after the intervention. The SFS scores improved from baseline in both groups; however, the TNMES group showed an earlier improvement. Finally, the TNMES group showed better QOL according to the FACT-NP than the EBST group.
    Conclusion: Proactive TMNES and EBST are safe and feasible modalities for improving swallowing in patients with NPC when administered early after radiotherapy. Although TNMES showed better results than EBST, these results should be interpreted with caution given the study limitations.
    Level of evidence: 1B.
    Language English
    Publishing date 2023-10-14
    Publishing country United States
    Document type Journal Article
    ISSN 2378-8038
    ISSN 2378-8038
    DOI 10.1002/lio2.1162
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  5. Article ; Online: A Hybrid Auricular Framework of Autologous Rib Cartilage and a Porous Polyethylene Implant for Reconstruction of Congenital Microtia: A Modification of Nagata's Technique.

    Ku, Peter K M / Vlantis, Alexander C / Tong, Marcus C / Chan, Trevor T T / Yeung, Zenon W C / Cho, Ryan H W / Hui, Thomas S C / Ho, Osan Y M / Leung, Iris O S / Tsang, Willis S S / Lai, Nelson K L / Chang, Wai-Tsz / Abdullah, Victor / van Hasselt, Andrew / Tong, Michael C F

    Facial plastic surgery & aesthetic medicine

    2023  Volume 26, Issue 1, Page(s) 15–22

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Plastic Surgery Procedures ; Congenital Microtia/surgery ; Polyethylene ; Porosity ; Cartilage/transplantation ; Ribs/surgery
    Chemical Substances Polyethylene (9002-88-4)
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3006458-2
    ISSN 2689-3622 ; 2689-3614
    ISSN (online) 2689-3622
    ISSN 2689-3614
    DOI 10.1089/fpsam.2022.0152
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    Zs.A 5869: Show issues Location:
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  6. Article ; Online: Safety Endpoints With Vadadustat Versus Darbepoetin Alfa in Patients With Non-Dialysis-Dependent CKD: A Post Hoc Regional Analysis of the PRO

    Winkelmayer, Wolfgang C / Arnold, Susan / Burke, Steven K / Chertow, Glenn M / Eckardt, Kai-Uwe / Jardine, Alan G / Lewis, Eldrin F / Luo, Wenli / Matsushita, Kunihiro / McCullough, Peter A / Minga, Todd / Parfrey, Patrick S

    Kidney medicine

    2023  Volume 5, Issue 7, Page(s) 100666

    Abstract: ... glomerular filtration rate (eGFR) level of ≤10 mL/min/1.73 m: Limitations: Different regional treatment patterns ...

    Abstract Rationale & objective: Prespecified analyses of the PRO
    Study design: Phase 3, global, open-label, randomized, active-controlled clinical trial.
    Setting and participants: Erythropoiesis-stimulating agent-untreated patients with anemia and NDD-CKD.
    Intervention: Eligible patients were randomized 1:1 to receive vadadustat or darbepoetin alfa.
    Outcomes: The primary safety end point was time to first MACE. Secondary safety end points included time to first expanded MACE (MACE plus hospitalization for heart failure or thromboembolic event, excluding vascular access thrombosis).
    Results: In the non-US/non-Europe region, there was a higher proportion of patients with baseline estimated glomerular filtration rate (eGFR) level of ≤10 mL/min/1.73 m
    Limitations: Different regional treatment patterns of patients with NDD-CKD.
    Conclusions: The higher MACE rate in the non-US/non-Europe vadadustat group may have been partly because of imbalances in the baseline eGFR level in countries where dialysis was not uniformly available resulting in many kidney-related deaths.
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article
    ISSN 2590-0595
    ISSN (online) 2590-0595
    DOI 10.1016/j.xkme.2023.100666
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  7. Article ; Online: Safety Endpoints With Vadadustat Versus Darbepoetin Alfa in Patients With Non

    Parfrey, Patrick S / Burke, Steven K / Chertow, Glenn M / Eckardt, Kai-Uwe / Jardine, Alan G / Lewis, Eldrin F / Luo, Wenli / Matsushita, Kunihiro / McCullough, Peter A / Minga, Todd / Winkelmayer, Wolfgang C

    Kidney medicine

    2023  Volume 5, Issue 7, Page(s) 100667

    Abstract: Rationale & objective: In the PRO: Study design: Phase 3, global, open-label, randomized, active-controlled clinical trial.: Setting & participants: A total of 1,725 erythropoiesis-stimulating agent (ESA)-treated patients with anemia and NDD-CKD.!# ...

    Abstract Rationale & objective: In the PRO
    Study design: Phase 3, global, open-label, randomized, active-controlled clinical trial.
    Setting & participants: A total of 1,725 erythropoiesis-stimulating agent (ESA)-treated patients with anemia and NDD-CKD.
    Intervention: 1:1 randomization to receive vadadustat or darbepoetin alfa.
    Outcomes: The primary safety end point was the time to first MACE.
    Results: At baseline, patients in Europe (n=444) were primarily treated with darbepoetin alfa, showed higher proportions on low ESA doses (<90 U/kg/wk epoetin alfa equivalents) with a hemoglobin concentration of ≥10 g/dL compared with patients in the US (n=665) and non-US/non-Europe (n=614) regions. The MACE rates per 100 person-years in the 3 vadadustat groups across regions were 14.5 in the US, 11.6 in Europe, and 10.0 in the non-US/non-Europe groups, whereas event rates in the darbepoetin alfa group were considerably lower in Europe than in the US and non-US/non-Europe groups (6.7 vs 13.3 and 10.5, respectively). The overall hazard ratio for MACE for vadadustat vs darbepoetin alpha was 1.16; 95% CI, 0.93-1.45, but varied by geographical region, with a greater hazard ratio seen in Europe (US, 1.07; 95% CI, 0.78-1.46; Europe, 2.05; 95% CI, 1.24-3.39; non-US/non-Europe, 0.91; 95% CI, 0.60-1.37); interaction between study treatment and geographical region,
    Limitations: Several analyses are exploratory.
    Conclusions: In this trial, there was a low risk of MACE in the darbepoetin alfa group in Europe. Patients in Europe were generally on low doses of ESA, with hemoglobin already within target range. The low risk of MACE may have been related to a limited need to switch and titrate darbepoetin alfa compared with the non-US/non-Europe group.
    Funding: Akebia Therapeutics, Inc.
    Trial registration: ClinicalTrials.gov identifier: NCT02680574.
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article
    ISSN 2590-0595
    ISSN (online) 2590-0595
    DOI 10.1016/j.xkme.2023.100667
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  8. Article ; Online: Management of dysphagia in the patient with head and neck cancer during COVID-19 pandemic: Practical strategy.

    Ku, Peter K M / Holsinger, Floyd Christopher / Chan, Jason Y K / Yeung, Zenon W C / Chan, Becky Y T / Tong, Michael C F / Starmer, Heather M

    Head & neck

    2020  Volume 42, Issue 7, Page(s) 1491–1496

    Abstract: The global pandemic of 2019 novel coronavirus disease (COVID-19) has tremendously altered routine medical service provision and imposed unprecedented challenges to the health care system. This impacts patients with dysphagia complications caused by head ... ...

    Abstract The global pandemic of 2019 novel coronavirus disease (COVID-19) has tremendously altered routine medical service provision and imposed unprecedented challenges to the health care system. This impacts patients with dysphagia complications caused by head and neck cancers. As this pandemic of COVID-19 may last longer than severe acute respiratory syndrome (SARS) in 2003, a practical workflow for managing dysphagia is crucial to ensure a safe and efficient practice to patients and health care personnel. This document provides clinical practice guidelines based on available evidence to date to balance the risks of SARS-CoV-2 exposure with the risks associated with dysphagia. Critical considerations include reserving instrumental assessments for urgent cases only, optimizing the noninstrumental swallowing evaluation, appropriate use of personal protective equipment (PPE), and use of telehealth when appropriate. Despite significant limitations in clinical service provision during the pandemic of COVID-19, a safe and reasonable dysphagia care pathway can still be implemented with modifications of setup and application of newer technologies.
    MeSH term(s) Air Filters ; Barium Sulfate ; Betacoronavirus ; COVID-19 ; Contrast Media ; Coronavirus Infections ; Deglutition Disorders/diagnosis ; Deglutition Disorders/etiology ; Environmental Exposure/prevention & control ; Esophagoscopy ; Fluoroscopy ; Head and Neck Neoplasms/complications ; Humans ; Infection Control/organization & administration ; Occupational Exposure/prevention & control ; Pandemics ; Personal Protective Equipment ; Pneumonia, Viral ; Quarantine ; SARS-CoV-2 ; Telemedicine ; Video Recording
    Chemical Substances Contrast Media ; Barium Sulfate (25BB7EKE2E)
    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.26224
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    Zs.A 1493: Show issues Location:
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  9. Article ; Online: Exposure to airborne polychlorinated biphenyls and type 2 diabetes in a Danish cohort.

    Deen, Laura / Clark, Alice / Hougaard, Karin Sørig / Petersen, Kajsa Ugelvig / Frederiksen, Marie / Wise, Lauren A / Wesselink, Amelia K / Meyer, Harald William / Bonde, Jens Peter / Tøttenborg, Sandra Søgaard

    Environmental research

    2023  Volume 237, Issue Pt 2, Page(s) 117000

    Abstract: ... incident T2D cases during the follow-up. Exposure to ≥3300 ng/m: Discussion: We observed a marginally ...

    Abstract Background: Previous research indicates an association between higher-chlorinated polychlorinated biphenyls (PCBs) and type 2 diabetes (T2D). However, less is known about the extent to which PCB exposure in indoor air, composed primarily of lower-chlorinated PCBs, affects T2D risk. We assessed the association between indoor air exposure to PCBs in residential buildings and T2D incidence.
    Methods: The register-based 'Health Effects of PCBs in Indoor Air' (HESPAIR) cohort comprises 51,921 Danish residents of two residential areas with apartments built with and without PCB-containing materials (reference apartments). We assessed exposure status by combining register-based information on relocation history with extrapolated values of exposure based on PCB-measurements in indoor air from subsets of the apartments. T2D cases were identified in the Danish registers during 1977-2018. We estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression analyses with time-varying exposure.
    Results: We identified 2737 incident T2D cases during the follow-up. Exposure to ≥3300 ng/m
    Discussion: We observed a marginally higher risk of T2D, but there was no evidence of an exposure-response relationship. The results should be interpreted with caution until confirmed in other independent studies of PCB exposure in indoor air.
    Language English
    Publishing date 2023-08-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2023.117000
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    Zs.A 726: Show issues Location:
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  10. Article ; Online: Tumor-derived biomarkers predict efficacy of B7H3 antibody-drug conjugate treatment in metastatic prostate cancer models.

    Agarwal, Supreet / Fang, Lei / McGowen, Kerry / Yin, JuanJuan / Bowman, Joel / Ku, Anson T / Alilin, Aian Neil / Corey, Eva / Roudier, Martine P / True, Lawrence D / Dumpit, Ruth / Coleman, Ilsa / Lee, John K / Nelson, Peter S / Capaldo, Brian J / Mariani, Aida / Hoover, Clare / Senatorov, Ilya S / Beshiri, Michael /
    Sowalsky, Adam G / Hurt, Elaine M / Kelly, Kathleen

    The Journal of clinical investigation

    2023  Volume 133, Issue 22

    Abstract: Antibody-drug conjugates (ADCs) are a promising targeted cancer therapy; however, patient selection based solely on target antigen expression without consideration for cytotoxic payload vulnerabilities has plateaued clinical benefits. Biomarkers to ... ...

    Abstract Antibody-drug conjugates (ADCs) are a promising targeted cancer therapy; however, patient selection based solely on target antigen expression without consideration for cytotoxic payload vulnerabilities has plateaued clinical benefits. Biomarkers to capture patients who might benefit from specific ADCs have not been systematically determined for any cancer. We present a comprehensive therapeutic and biomarker analysis of a B7H3-ADC with pyrrolobenzodiazepine(PBD) payload in 26 treatment-resistant, metastatic prostate cancer (mPC) models. B7H3 is a tumor-specific surface protein widely expressed in mPC, and PBD is a DNA cross-linking agent. B7H3 expression was necessary but not sufficient for B7H3-PBD-ADC responsiveness. RB1 deficiency and/or replication stress, characteristics of poor prognosis, and conferred sensitivity were associated with complete tumor regression in both neuroendocrine (NEPC) and androgen receptor positive (ARPC) prostate cancer models, even with low B7H3 levels. Non-ARPC models, which are currently lacking efficacious treatment, demonstrated the highest replication stress and were most sensitive to treatment. In RB1 WT ARPC tumors, SLFN11 expression or select DNA repair mutations in SLFN11 nonexpressors governed response. Importantly, WT TP53 predicted nonresponsiveness (7 of 8 models). Overall, biomarker-focused selection of models led to high efficacy of in vivo treatment. These data enable a paradigm shift to biomarker-driven trial designs for maximizing clinical benefit of ADC therapies.
    MeSH term(s) Male ; Humans ; Immunoconjugates/pharmacology ; Immunoconjugates/therapeutic use ; Biomarkers, Tumor/genetics ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics ; Antineoplastic Agents/therapeutic use ; Nuclear Proteins
    Chemical Substances Immunoconjugates ; Biomarkers, Tumor ; Antineoplastic Agents ; SLFN11 protein, human ; Nuclear Proteins
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI162148
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