LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 131

Search options

  1. Article ; Online: Students' intelligence test results after six and sixteen months of irregular schooling due to the COVID-19 pandemic.

    Breit, Moritz / Scherrer, Vsevolod / Blickle, Joshua / Preckel, Franzis

    PloS one

    2023  Volume 18, Issue 3, Page(s) e0281779

    Abstract: The COVID-19 pandemic has affected schooling worldwide. In many places, schools closed for weeks or months, only part of the student body could be educated at any one time, or students were taught online. Previous research discloses the relevance of ... ...

    Abstract The COVID-19 pandemic has affected schooling worldwide. In many places, schools closed for weeks or months, only part of the student body could be educated at any one time, or students were taught online. Previous research discloses the relevance of schooling for the development of cognitive abilities. We therefore compared the intelligence test performance of 424 German secondary school students in Grades 7 to 9 (42% female) tested after the first six months of the COVID-19 pandemic (i.e., 2020 sample) to the results of two highly comparable student samples tested in 2002 (n = 1506) and 2012 (n = 197). The results revealed substantially and significantly lower intelligence test scores in the 2020 sample than in both the 2002 and 2012 samples. We retested the 2020 sample after another full school year of COVID-19-affected schooling in 2021. We found mean-level changes of typical magnitude, with no signs of catching up to previous cohorts or further declines in cognitive performance. Perceived stress during the pandemic did not affect changes in intelligence test results between the two measurements.
    MeSH term(s) Humans ; Female ; Male ; Pandemics ; COVID-19/epidemiology ; Students/psychology ; Schools ; Intelligence Tests
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0281779
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Change of glucometabolic activity per PSMA expression predicts survival in mCRPC patients non-responding to PSMA radioligand therapy: introducing a novel dual imaging biomarker.

    Burgard, Caroline / Engler, Jakob / Blickle, Arne / Bartholomä, Mark / Maus, Stephan / Schaefer-Schuler, Andrea / Khreish, Fadi / Ezziddin, Samer / Rosar, Florian

    Frontiers in medicine

    2024  Volume 10, Page(s) 1339160

    Abstract: Purpose: The value of [: Methods: Twenty-three mCRPC patients of a prospective registry (NCT04833517), who were treated with [: Results: Kaplan-Meier analyses showed no significant association with OS for each tested cGA (cGA: Conclusion: The ... ...

    Abstract Purpose: The value of [
    Methods: Twenty-three mCRPC patients of a prospective registry (NCT04833517), who were treated with [
    Results: Kaplan-Meier analyses showed no significant association with OS for each tested cGA (cGA
    Conclusion: The novel biomarker cGAP
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1339160
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Meglitinide analogues: a review of clinical data focused on recent trials.

    Blicklé, J F

    Diabetes & metabolism

    2006  Volume 32, Issue 2, Page(s) 113–120

    Abstract: Glinides represent a chemically heterogeneous new class of insulin-secreting agents characterized by a rapid onset and short duration of action. They act by closure of the ATP-dependant K channel. Repaglinide, the only glinide available in France, has an ...

    Abstract Glinides represent a chemically heterogeneous new class of insulin-secreting agents characterized by a rapid onset and short duration of action. They act by closure of the ATP-dependant K channel. Repaglinide, the only glinide available in France, has an equivalent HbA1c lowering effect to conventional sulfonylureas but reduces predominantly postprandial glucose levels. Several studies indicate a decreased risk of hypoglycaemias, particularly nocturnal or in case of a shift or omission of a meal. This drug appears particularly useful in early stage type 2 diabetes or in combination with metformin. The only significant drug-drug interaction concerns gemfibrozil. Due to its hepatic metabolism and biliary elimination, repaglinide can be used in patients with renal insufficiency. Nateglinide has a even shorter duration of action and has almost no effect on fasting plasma glucose levels. For this reason, this drug is only indicated in combination with metformin in the countries where it is licensed. Several experimental data suggest that glinides could preserve B cell function over time better than hypoglycaemic sulfonylureas, and that the improvement of post-prandial glucose levels could exert a long term protective cardiovascular effect.
    MeSH term(s) Benzamides/pharmacokinetics ; Benzamides/therapeutic use ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Clinical Trials as Topic ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/drug therapy ; Humans ; Hypoglycemic Agents/pharmacokinetics ; Hypoglycemic Agents/therapeutic use ; Insulin/metabolism ; Insulin Secretion
    Chemical Substances Benzamides ; Blood Glucose ; Hypoglycemic Agents ; Insulin ; meglitinide (8V6OK1I088)
    Language English
    Publishing date 2006-02-16
    Publishing country France
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 1315751-6
    ISSN 1262-3636 ; 0338-1684
    ISSN 1262-3636 ; 0338-1684
    DOI 10.1016/s1262-3636(07)70257-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1267: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Management of hypertension in elderly diabetic patients.

    Blicklé, J F

    Diabetes & metabolism

    2005  Volume 31 Spec No 2, Page(s) 5S82–5S91

    Abstract: Hypertension is a major vascular risk factor in the elderly diabetic. The benefit of proper management is well recognized, even if treatment has no influence on overall mortality or might even tend to increase it in very elderly subjects. Globally, the ... ...

    Abstract Hypertension is a major vascular risk factor in the elderly diabetic. The benefit of proper management is well recognized, even if treatment has no influence on overall mortality or might even tend to increase it in very elderly subjects. Globally, the efficacy of the major classes of antihypertensive drugs, diuretics, beta-blockers, calcium channel blockers, angiotensin converting enzyme inhibitors, or angiotensin II receptor antagonists appears to be equivalent so that the therapeutic choice depends on the type of hypertension, systolic or systolic-diastolic, and the rapidity of the desired effect, co-morbid conditions, particularly coronary or renal disease, or drug tolerance. Blood pressure goals are similar to those in middle-aged persons, except in very old, frail or sick subjects.
    MeSH term(s) Aged ; Aging/physiology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Clinical Trials as Topic ; Diabetic Angiopathies/drug therapy ; Diabetic Angiopathies/physiopathology ; Humans ; Hypertension/drug therapy ; Hypertension/physiopathology
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents
    Language English
    Publishing date 2005-12
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 1315751-6
    ISSN 1262-3636 ; 0338-1684
    ISSN 1262-3636 ; 0338-1684
    DOI 10.1016/s1262-3636(05)73656-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1267: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Physiopathologie du diabète de type 2 : quelles implications thérapeutiques ?

    Blicklé, J-F

    La Revue de medecine interne

    2003  Volume 24, Issue 11, Page(s) 709–710

    Title translation Type 2 diabetes mellitus pathogenesis: new therapeutic managements?.
    MeSH term(s) Carbamates/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/physiopathology ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/metabolism ; Insulin Resistance ; Insulin Secretion ; Piperidines/therapeutic use ; Treatment Outcome
    Chemical Substances Carbamates ; Hypoglycemic Agents ; Insulin ; Piperidines ; repaglinide (668Z8C33LU)
    Language French
    Publishing date 2003-08-28
    Publishing country France
    Document type Editorial
    ZDB-ID 604679-4
    ISSN 1768-3122 ; 0248-8663
    ISSN (online) 1768-3122
    ISSN 0248-8663
    DOI 10.1016/s0248-8663(03)00249-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2451: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Les études de prévention médicamenteuse du diabète de type 2 doivent-elles nous amener à changer nos prescriptions?

    Blicklé, J F

    Diabetes & metabolism

    2003  Volume 29, Issue 5, Page(s) 547–553

    Abstract: Type 2 diabetes (T2D), a major public health problem in all parts of the world, is preceded by an identifiable phase of impaired glucose tolerance (IGT) during which a therapeutic intervention aimed at preventing the glycaemic decompensation can be ... ...

    Title translation Should type 2 diabetes prevention pharmacological studies prompt us to change our prescription habits?.
    Abstract Type 2 diabetes (T2D), a major public health problem in all parts of the world, is preceded by an identifiable phase of impaired glucose tolerance (IGT) during which a therapeutic intervention aimed at preventing the glycaemic decompensation can be considered. The efficacy of a diet resulting in a weight loss and even more of an exercise program has been clearly established, but the long term continuation of these measures is difficult in real life conditions. So, pharmacological interventions on insulin resistance and B cell dysfunction, the major pathophysiologic components of the disease have been tested. A relative risk reduction of conversion from IG to T2D has been obtained with metformin in the Diabetes Prevention Program, but this effect seems to be directly linked to the antihyperglycaemic effect of the drug. Likewise, the relative risk reduction of 25% with acarbose in the Stop-NIDDM trial results more from a short term therapeutic effect than from an action in depth on the mechanisms leading to the glycaemic decompensation. This might does not be the case with troglitazone in the TRIPOD trial, since the protection conferred by this drug largely exceeds the treatment period and the B cell function appears to be preserved. However, these results should be confirmed in larger and more common populations of IGT. Finally, the practical carrying out of a prevention program at the scale of a whole population raises several unsolved problems.
    MeSH term(s) Chromans/therapeutic use ; Diabetes Mellitus, Type 2/prevention & control ; Drug Prescriptions/statistics & numerical data ; France ; Humans ; Hypoglycemic Agents/therapeutic use ; Thiazolidinediones/therapeutic use ; Troglitazone
    Chemical Substances Chromans ; Hypoglycemic Agents ; Thiazolidinediones ; Troglitazone (I66ZZ0ZN0E)
    Language French
    Publishing date 2003-11-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 1315751-6
    ISSN 1262-3636 ; 0338-1684
    ISSN 1262-3636 ; 0338-1684
    DOI 10.1016/s1262-3636(07)70070-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1267: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Thiazolidinediones: données cliniques et perspectives.

    Blicklé, J F

    Diabetes & metabolism

    2001  Volume 27, Issue 2 Pt 2, Page(s) 279–285

    Abstract: This brief review realizes a synthesis of the main clinical studies of the three thiazolidinediones (TZDs) which have been launched elsewhere, troglitazone, rosiglitazone and pioglitazone. At optimal dose, the three molecules have a similar effect, ... ...

    Title translation Thiazolidinediones: clinical data and perspectives.
    Abstract This brief review realizes a synthesis of the main clinical studies of the three thiazolidinediones (TZDs) which have been launched elsewhere, troglitazone, rosiglitazone and pioglitazone. At optimal dose, the three molecules have a similar effect, although slightly weaker for the first, on the fasting plasma glucose and HbA1c levels. They exhibit identical activity, or even higher for troglitazone, in combination with sulfonylureas, metformine and insulin. On the contrary, the three TZDs seem to differentiate according to their effects on lipid metabolism. While rosiglitazone only moderately and inconstantly reduces plasma triglycerides, troglitazone and pioglitazone decreases them by 15 to 25%. LDL-cholesterol levels are almost unaffected by pioglitazone while they increase by 6 to 8% with troglitazone and by more than 10% with rosiglitazone. On the other hand, HDL-cholesterol strongly increases with rosiglitazone and pioglitazone and only slightly on troglitazone. Besides these metabolic effects, TZDs have several properties which could be of therapeutical interest, particularly a possible beta cell protective effect. Except for the severe problems of hepatotoxicity which appear specific to troglitazone and have led to its withdrawal, TZDs are well tolerated. They share as major undesirable effects a risk of peripheral oedema, of anemia due to plasma volume expansion and of weight gain due to the development of subcutaneous adipose tissue. Until now, the European Product licence of rosiglitazone and pioglitazone is limited to the combination with metformin in case of failure of a monotherapy with metformin in obese type 2 diabetic patients and to the combination with a sulphonylurea only in case of intolerance or contra-indication to metformin in type 2 diabetics insufficiently controlled by sulphonylurea therapy at maximal tolerated dose. These indications will probably be enlarged to earlier treatments when long term study results will be available.
    MeSH term(s) Animals ; Blood Glucose/metabolism ; Chromans/adverse effects ; Chromans/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Glycated Hemoglobin A/analysis ; Humans ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/therapeutic use ; Lipids/blood ; Thiazoles/adverse effects ; Thiazoles/therapeutic use ; Thiazolidinediones
    Chemical Substances Blood Glucose ; Chromans ; Glycated Hemoglobin A ; Hypoglycemic Agents ; Lipids ; Thiazoles ; Thiazolidinediones ; rosiglitazone (05V02F2KDG) ; troglitazone (I66ZZ0ZN0E) ; pioglitazone (X4OV71U42S)
    Language French
    Publishing date 2001-04
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 1315751-6
    ISSN 1262-3636 ; 0338-1684
    ISSN 1262-3636 ; 0338-1684
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1267: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Conference proceedings: Effects of Early Intervention on Educational Achievement of Children with Cyanotic Congenital Heart Disease after Neonatal Cardiac Surgery

    Buchdunger, L.A. / Pfitzer, C. / Helm, P. / Blickle, M. / Photiadis, J. / Ferentzi, H. / Berger, F. / Bauer, U. / Schmitt, K.

    The Thoracic and Cardiovascular Surgeon

    2021  Volume 69, Issue S 02

    Event/congress 53rd Annual Meeting of the German Society for Pediatric Cardiology (DGPK), Online, 2021-02-26
    Language English
    Publishing date 2021-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 800050-5
    ISSN 1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
    ISSN (online) 1439-1902
    ISSN 0171-6425 ; 0946-4778 ; 0172-6137
    DOI 10.1055/s-0041-1725902
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.186: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Detrimental action of thiazolidinediones on bone (rebuttal).

    Elte, J W F / Blicklé, J F

    European journal of internal medicine

    2007  Volume 18, Issue 5, Page(s) 448

    Language English
    Publishing date 2007-09
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 0953-6205
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2007.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Rosiglitazone: les éléments cliniques.

    Blickle, J F

    Annales d'endocrinologie

    2002  Volume 63, Issue 2 Pt 2, Page(s) 1S27–33

    Title translation Rosiglitazone: clinical data.
    MeSH term(s) Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Drug Therapy, Combination ; Humans ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/therapeutic use ; Metformin/administration & dosage ; Metformin/therapeutic use ; Sulfonylurea Compounds/administration & dosage ; Sulfonylurea Compounds/therapeutic use ; Thiazoles/adverse effects ; Thiazoles/therapeutic use ; Thiazolidinediones
    Chemical Substances Blood Glucose ; Hypoglycemic Agents ; Sulfonylurea Compounds ; Thiazoles ; Thiazolidinediones ; rosiglitazone (05V02F2KDG) ; Metformin (9100L32L2N)
    Language French
    Publishing date 2002-04
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 299-9
    ISSN 2213-3941 ; 0003-4266
    ISSN (online) 2213-3941
    ISSN 0003-4266
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top