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Article: Challenges in Screening and Diagnosing Frailty Syndrome: Which Tool to be used?

Laksmi, Purwita W

2015 Volume 47, Issue 3, Page(s) 181–182

MeSH term(s)	Aged ; Frail Elderly ; Geriatric Assessment/methods ; Health Status Indicators ; Humans ; Phenotype ; Practice Guidelines as Topic
Language	English
Publishing date	2015-07
Publishing country	Indonesia
Document type	Editorial
ZDB-ID	2474707-5
ISSN	2338-2732 ; 0125-9326
ISSN (online)	2338-2732
ISSN	0125-9326
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Frailty syndrome: an emerging geriatric syndrome calling for its potential intervention.

Laksmi, Purwita W

Acta medica Indonesiana

2014 Volume 46, Issue 3, Page(s) 173–174

MeSH term(s)	Aged ; Aged, 80 and over ; Frail Elderly ; Geriatric Assessment ; Health Status Indicators ; Humans ; Syndrome
Language	English
Publishing date	2014-07
Publishing country	Indonesia
Document type	Editorial
ZDB-ID	2474707-5
ISSN	2338-2732 ; 0125-9326
ISSN (online)	2338-2732
ISSN	0125-9326
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Challenges in Screening and Diagnosing Frailty Syndrome

Purwita W Laksmi

Acta Medica Indonesiana, Vol 47, Iss

Which Tool to be used?

2016 Volume 3

Abstract: Frailty syndrome has become one of the geriatric syndromes with an increasing risk of debilitating clinical outcome. Accordingly, the current treatment guidelines have been focusing in viewing frailty syndrome as an important aspect to be considered. The ...

Abstract	Frailty syndrome has become one of the geriatric syndromes with an increasing risk of debilitating clinical outcome. Accordingly, the current treatment guidelines have been focusing in viewing frailty syndrome as an important aspect to be considered. The International Diabetes Federation (IDF) classifies the guideline for managing the elderly with type 2 diabetes mellitus based on their functional status, whether it is functionally independent or dependent. Functionally dependent group is further classified as subgroup of frail and/or demented people. Special consideration on older people has also been discussed as a topic on the treatment algorithm for hypertension and dyslipidemia.
Keywords	Internal medicine ; RC31-1245
Language	English
Publishing date	2016-05-01T00:00:00Z
Publisher	Interna Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Factors Associated with Physical Frailty in Elderly Women with Low Socioeconomic Status in Urban Communities: A Cross-Sectional Study.

Rensa, Rensa / Setiati, Siti / Laksmi, Purwita W / Rinaldi, Ikhwan

Acta medica Indonesiana

2019 Volume 51, Issue 3, Page(s) 220–229

Abstract: Background: there are differences in factors associated with frailty syndrome in elderly population. The aim of this research was to determine frailty status (fit, pre-frail and frail) and to identify factors associated with physical frailty in urban ... ...

Abstract	Background: there are differences in factors associated with frailty syndrome in elderly population. The aim of this research was to determine frailty status (fit, pre-frail and frail) and to identify factors associated with physical frailty in urban community-dwelling elderly women. Methods: a cross-sectional study of community-dwelling women aged 60 years and older was conducted in West and Central Jakarta regions, Indonesia, from July until September 2017. The Cardiovascular Health Study (CHS) score was used to determine frailty status (fit/ pre-frail/ frail). Chi-Square Test and logistic regression analysis were used to determine association between independent variables and physical frailty. Results: there were 325 female subjects with a median age of 67 (60-94) years; 95.7% had income below the Provincial Minimum Income of DKI Jakarta in 2017 (<3.3 million IDR≈238 USD/month), and 92.6% had a level of education ≤9 years. Subjects were classified into this following groups: fit (12.6%), pre-frail (63.4%) and frail (24%). Factors associated with physical frailty were age above 70 years old with OR 5.27, lower Barthel Index for Activities of Daily Living (B-ADL) with OR 2.85, depressive symptoms with OR 6.79, and Euro Quality of Life-5 Dimensions (EQ-5D) index with OR 1.96. Conclusion: elderly women in the urban community with low socioeconomic status were classified as fit (12.6%), pre-frail (63.4%) and frail (24%). Factors associated with physical frailty were age above 70 years old, depressive symptoms, lower functional status and health-related quality of life index.
MeSH term(s)	Activities of Daily Living ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Depression/complications ; Female ; Frail Elderly/psychology ; Frailty/epidemiology ; Geriatric Assessment ; Humans ; Independent Living/psychology ; Indonesia/epidemiology ; Logistic Models ; Middle Aged ; Quality of Life/psychology ; Social Class ; Urban Population
Language	English
Publishing date	2019-11-07
Publishing country	Indonesia
Document type	Journal Article
ZDB-ID	2474707-5
ISSN	2338-2732 ; 0125-9326
ISSN (online)	2338-2732
ISSN	0125-9326
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Factors Associated with Physical Frailty in Elderly Women with Low Socioeconomic Status in Urban Communities

Rensa Rensa / Siti Setiati / Purwita W Laksmi / Ikhwan Rinaldi

Acta Medica Indonesiana, Vol 51, Iss

A Cross-Sectional Study

2019 Volume 3

Abstract	Background: there are differences in factors associated with frailty syndrome in elderly population. The aim of this research was to determine frailty status (fit, pre-frail and frail) and to identify factors associated with physical frailty in urban community-dwelling elderly women. Methods: a cross-sectional study of community-dwelling women aged 60 years and older was conducted in West and Central Jakarta regions, Indonesia, from July until September 2017. The Cardiovascular Health Study (CHS) score was used to determine frailty status (fit/ pre-frail/ frail). Chi-Square Test and logistic regression analysis were used to determine association between independent variables and physical frailty. Results: there were 325 female subjects with a median age of 67 (60–94) years; 95.7% had income below the Provincial Minimum Income of DKI Jakarta in 2017 (<3.3 million IDR≈238 USD/month), and 92.6% had a level of education ≤9 years. Subjects were classified into this following groups: fit (12.6%), pre-frail (63.4%) and frail (24%). Factors associated with physical frailty were age above 70 years old with OR 5.27, lower Barthel Index for Activities of Daily Living (B-ADL) with OR 2.85, depressive symptoms with OR 6.79, and Euro Quality of Life-5 Dimensions (EQ-5D) index with OR 1.96. Conclusion: elderly women in the urban community with low socioeconomic status were classified as fit (12.6%), pre-frail (63.4%) and frail (24%). Factors associated with physical frailty were age above 70 years old, depressive symptoms, lower functional status and health-related quality of life index.
Keywords	elderly women ; low socioeconomic status ; physical frailty ; urban community ; Internal medicine ; RC31-1245
Subject code	796
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	Interna Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Need for a New Cut-off Value to Increase Diagnostic Performance of Bioelectrical Impedance Analysis Compared with Dual-Energy X-ray Absorptiometry to Measure Muscle Mass in Indonesian Elderly.

Laksmi, Purwita W / Sukma, Fragma Ady / Setyohadi, Bambang / Nugroho, P / Ariane, A / Tirtarahardja, Gunawan

Acta medica Indonesiana

2019 Volume 51, Issue 2, Page(s) 95–101

Abstract: Background: the use of bioelectrical impedance analysis (BIA) is affected by the population setting, the type of BIA, and the cut-off point being used. The aim of this study was to determine the diagnostic performance of BIA to measure muscle mass in ... ...

Abstract	Background: the use of bioelectrical impedance analysis (BIA) is affected by the population setting, the type of BIA, and the cut-off point being used. The aim of this study was to determine the diagnostic performance of BIA to measure muscle mass in Indonesian elderly outpatients aged 60 years or more. Methods: a cross-sectional study was conducted at the Geriatric Clinic of Cipto Mangunkusumo Hospital from April to June 2018. The muscle mass was measured using BIA Tanita MC-780MA (Tokyo, Japan) with dual-energy x-ray absorptiometry (DXA) as the reference test. Analysis on the cut-off point was performed based on the Asian Working Group of Sarcopenia (AWGS) criteria and the new cut-off point. Results: from 120 subjects, 74 were female (61.7%). The diagnostic performance of BIA based on AWGS criteria only showed sensitivity and specificity of 79.2% and 66.7%. The diagnostic performance of BIA based on the new cut-off point showed sensitivity and specificity of 75% and 92.7%. The new cut-off point using BIA was found to be <6.9 kg/m2 in males (sensitivity 70.6%; specificity 82.8%) and <5 kg/m2 in females (sensitivity 85.7%; specificity 97%). Conclusion: the diagnostic performance of BIA Tanita MC-780MA (Tokyo, Japan) was good to measure muscle mass in Indonesian elderly outpatients using a new cut-off point of <6.9 kg/m2 for males and <5 kg/m2 for females.
MeSH term(s)	Absorptiometry, Photon/standards ; Aged ; Aged, 80 and over ; Body Composition ; Cross-Sectional Studies ; Electric Impedance ; Female ; Hand Strength ; Humans ; Indonesia ; Male ; Middle Aged ; Muscle, Skeletal/diagnostic imaging ; Predictive Value of Tests ; ROC Curve ; Reference Values ; Reproducibility of Results ; Sarcopenia/diagnostic imaging ; Sarcopenia/ethnology
Language	English
Publishing date	2019-08-02
Publishing country	Indonesia
Document type	Comparative Study ; Journal Article
ZDB-ID	2474707-5
ISSN	2338-2732 ; 0125-9326
ISSN (online)	2338-2732
ISSN	0125-9326
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Need for a New Cut-off Value to Increase Diagnostic Performance of Bioelectrical Impedance Analysis Compared with Dual-Energy X-ray Absorptiometry to Measure Muscle Mass in Indonesian Elderly

Purwita W Laksmi / Fragma Ady Sukma / Bambang Setyohadi / P Nugroho / A Ariane / Gunawan Tirtarahardja

Acta Medica Indonesiana, Vol 51, Iss

2019 Volume 2

Abstract	Background: the use of bioelectrical impedance analysis (BIA) is affected by the population setting, the type of BIA, and the cut-off point being used. The aim of this study was to determine the diagnostic performance of BIA to measure muscle mass in Indonesian elderly outpatients aged 60 years or more. Methods: a cross-sectional study was conducted at the Geriatric Clinic of Cipto Mangunkusumo Hospital from April to June 2018. The muscle mass was measured using BIA Tanita MC-780MA (Tokyo, Japan) with dual-energy x-ray absorptiometry (DXA) as the reference test. Analysis on the cut-off point was performed based on the Asian Working Group of Sarcopenia (AWGS) criteria and the new cut-off point. Results: from 120 subjects, 74 were female (61.7%). The diagnostic performance of BIA based on AWGS criteria only showed sensitivity and specificity of 79.2% and 66.7%. The diagnostic performance of BIA based on the new cut-off point showed sensitivity and specificity of 75% and 92.7%. The new cut-off point using BIA was found to be <6.9 kg/m2 in males (sensitivity 70.6%; specificity 82.8%) and <5 kg/m2 in females (sensitivity 85.7%; specificity 97%). Conclusion: the diagnostic performance of BIA Tanita MC-780MA (Tokyo, Japan) was good to measure muscle mass in Indonesian elderly outpatients using a new cut-off point of <6.9 kg/m2 for males and <5 kg/m2 for females.
Keywords	BIA Tanita MC-780MA ; elderly ; Indonesia ; muscle mass ; sarcopenia ; Internal medicine ; RC31-1245
Subject code	796
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	Interna Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Factors Related with Handgrip Strength in Elderly Patients.

Riviati, Nur / Setiati, Siti / Laksmi, Purwita W / Abdullah, Murdani

Acta medica Indonesiana

2017 Volume 49, Issue 3, Page(s) 215–219

Abstract: Background: the aging process causes decreasing in the function of various organs. Skletal muscle is one of the organs affected by aging process. It is known as sarcopenia. Sarcopenia is defined as a syndrome characterized by progressive loss of muscle ... ...

Abstract	Background: the aging process causes decreasing in the function of various organs. Skletal muscle is one of the organs affected by aging process. It is known as sarcopenia. Sarcopenia is defined as a syndrome characterized by progressive loss of muscle mass and strength. The handgrip strength examination is often applied as a sarcopenia filtering technique. This study aimed to determine the relationship between age, nutritional status, and chronic diseases such as stroke, hypertension (HT), diabetes mellitus (DM), coronary heart disease (CHD), and chronic obstructive pulmonary disease (COPD) with handgrip strength. Methods: a cross-sectional study to determine factors related to the handgrip strength in elderly patients was conducted in Geriatric outpatient clinic of Cipto Mangunkusumo Hospital and Mohammad Hoesin Hospital from August to October 2015. There were 352 eligible subjects in this study recruited with consecutive sampling. The independent variables in the study consisted of age, sex, nutritional status, chronic disease (stroke, hypertension (HT), diabetes mellitus (DM), coronary heart disease (CHD) and chronic obstructive pulmonary disease (COPD)), waist circumference while the dependent variable was handgrip strength. Results: age of more than 75 years old and malnutriton were risk factors that affected hangrip strength. Age of >75 years increase the risk for having low handgrip strength by 2,3-fold. Malnutrition increased risk for low handgrip strength for 1,9-fold. Conclusion: ages of >75 years old and malnutrition will increase the risk of low handgrip strength in elderly patients.
MeSH term(s)	Activities of Daily Living ; Age Factors ; Aged ; Aging/physiology ; Chronic Disease/epidemiology ; Cross-Sectional Studies ; Female ; Geriatric Assessment ; Hand Strength/physiology ; Humans ; Indonesia ; Male ; Malnutrition/epidemiology ; Middle Aged ; Nutritional Status ; Risk Factors ; Sarcopenia/physiopathology ; Sex Factors
Language	English
Publishing date	2017-07
Publishing country	Indonesia
Document type	Journal Article ; Multicenter Study
ZDB-ID	2474707-5
ISSN	2338-2732 ; 0125-9326
ISSN (online)	2338-2732
ISSN	0125-9326
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Factors Related with Handgrip Strength in Elderly Patients

Nur Riviati / Siti Setiati / Purwita W Laksmi / Murdani Abdullah

Acta Medica Indonesiana, Vol 49, Iss

2017 Volume 3

Abstract	Background: the aging process causes decreasing in the function of various organs. Skletal muscle is one of the organs affected by aging process. It is known as sarcopenia. Sarcopenia is defined as a syndrome characterized by progressive loss of muscle mass and strength. The handgrip strength examination is often applied as a sarcopenia filtering technique. This study aimed to determine the relationship between age, nutritional status, and chronic diseases such as stroke, hypertension (HT), diabetes mellitus (DM), coronary heart disease (CHD), and chronic obstructive pulmonary disease (COPD) with handgrip strength. Methods: a cross-sectional study to determine factors related to the handgrip strength in elderly patients was conducted in Geriatric outpatient clinic of Cipto Mangunkusumo Hospital and Mohammad Hoesin Hospital from August to October 2015. There were 352 eligible subjects in this study recruited with consecutive sampling. The independent variables in the study consisted of age, sex, nutritional status, chronic disease (stroke, hypertension (HT), diabetes mellitus (DM), coronary heart disease (CHD) and chronic obstructive pulmonary disease (COPD)), waist circumference while the dependent variable was handgrip strength. Results: age of more than 75 years old and malnutriton were risk factors that affected hangrip strength. Age of >75 years increase the risk for having low handgrip strength by 2,3-fold. Malnutrition increased risk for low handgrip strength for 1,9-fold. Conclusion: ages of >75 years old and malnutrition will increase the risk of low handgrip strength in elderly patients.
Keywords	handgrip strength ; elderly ; factor ; Internal medicine ; RC31-1245
Subject code	610
Language	English
Publishing date	2017-11-01T00:00:00Z
Publisher	Interna Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Extended Dual Antiplatelet for Diabetic Elderly Patients After Drug-eluting Stent Implantation: an Evidence-based Clinical Review.

Suwita, Benedicta M / Laksmi, Purwita W / Wijaya, Ika P

Acta medica Indonesiana

2015 Volume 47, Issue 3, Page(s) 253–264

Abstract: Antiplatelet is an important drug for patients with coronary heart disease undergoing drug-eluting stent implantation. Current guidelines recommend dual antiplatelet with aspirin and a P2Y12 inhibitor for at least 12 months. Continuation of DAPT beyond ... ...

Abstract	Antiplatelet is an important drug for patients with coronary heart disease undergoing drug-eluting stent implantation. Current guidelines recommend dual antiplatelet with aspirin and a P2Y12 inhibitor for at least 12 months. Continuation of DAPT beyond 12 months may be considered for preventing very late stent thrombosis. Several patient-related factors that contribute to stent thrombosis have been recognized, including diabetes and advanced age, but the optimal DAPT duration for these patients is still controversial. This article reviews the efficacy of extended (>12 months) compared to standard (12 months) DAPT for reducing myocardial infarction and stent thrombosis rates, especially in diabetic elderly patients. Literature screening was conducted at PubMed and Cochrane database using "dual antiplatelet", "duration", "adult-onset diabetes mellitus", "elderly" and, "drug-eluting stent" as keywords. Article types were limited to meta-analysis, systematic review, randomized clinical trial, or clinical trial that compared the efficacy of extended to standard duration of DAPT. Clinical outcomes used were myocardial infarction and stent thrombosis. The initial search was done to find relevant studies specifically assessing diabetic and elderly patients, then widened to diabetic and non-diabetic patients of any age above eighteen years. A total of 5 clinical trials and 1 meta-analysis were reviewed, showing an overall risk reduction of stent thrombosis and myocardial infarction. This review has several limitations, such as its potential selection bias and under-represented proportion of diabetic and elderly patients. High-risk subgroups like diabetes mellitus has a tendency of increased ischemic risk, while advanced age could have both increased ischemic risk and bleeding risk. This review suggests that it is better to reserve extended dual antiplatelet therapy for patients with high ischemic risk and low bleeding risk (tailored therapy).
MeSH term(s)	Aged ; Aspirin/therapeutic use ; Coronary Disease/complications ; Coronary Disease/therapy ; Diabetes Complications/complications ; Drug Therapy, Combination ; Drug-Eluting Stents/adverse effects ; Evidence-Based Medicine ; Humans ; Myocardial Infarction/prevention & control ; Platelet Aggregation Inhibitors/administration & dosage ; Platelet Aggregation Inhibitors/therapeutic use ; Purinergic P2Y Receptor Antagonists/therapeutic use ; Thrombosis/prevention & control ; Time Factors
Chemical Substances	Platelet Aggregation Inhibitors ; Purinergic P2Y Receptor Antagonists ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2015-07
Publishing country	Indonesia
Document type	Journal Article ; Review
ZDB-ID	2474707-5
ISSN	2338-2732 ; 0125-9326
ISSN (online)	2338-2732
ISSN	0125-9326
Database	MEDical Literature Analysis and Retrieval System OnLINE

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