LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1737

Search options

  1. Article: An evaluation of the brain distribution of [(11)C]GSK1034702, a muscarinic-1 (M 1) positive allosteric modulator in the living human brain using positron emission tomography.

    Ridler, Khanum / Cunningham, Vincent / Huiban, Mickael / Martarello, Laurent / Pampols-Maso, Sabina / Passchier, Jan / Gunn, Roger N / Searle, Graham / Abi-Dargham, Anissa / Slifstein, Mark / Watson, Jeanette / Laruelle, Marc / Rabiner, Eugenii A

    EJNMMI research

    2014  Volume 4, Issue 1, Page(s) 66

    Abstract: ... radiolabelled with (11)C, and the brain distribution of [(11)C]GSK1034702 was investigated in two anaesthetised ... of [(11)C]GSK1034702) at baseline and after a single oral 5-mg dose of GSK1034702. The in vitro brain and ... Results: The distribution of [(11)C]GSK1034702 in the primate brain was homogenous and the whole brain ...

    Abstract Background: The ability to quantify the capacity of a central nervous system (CNS) drug to cross the human blood-brain barrier (BBB) provides valuable information for de-risking drug development of new molecules. Here, we present a study, where a suitable positron emission tomography (PET) ligand was not available for the evaluation of a potent muscarinic acetylcholine receptor type-1 (M1) allosteric agonist (GSK1034702) in the primate and human brain. Hence, direct radiolabelling of the novel molecule was performed and PET measurements were obtained and combined with in vitro equilibrium dialysis assays to enable assessment of BBB transport and estimation of the free brain concentration of GSK1034702 in vivo.
    Methods: GSK1034702 was radiolabelled with (11)C, and the brain distribution of [(11)C]GSK1034702 was investigated in two anaesthetised baboons and four healthy male humans. In humans, PET scans were performed (following intravenous injection of [(11)C]GSK1034702) at baseline and after a single oral 5-mg dose of GSK1034702. The in vitro brain and plasma protein binding of GSK1034702 was determined across a range of species using equilibrium dialysis.
    Results: The distribution of [(11)C]GSK1034702 in the primate brain was homogenous and the whole brain partition coefficient (V T) was 3.97. In contrast, there was mild regional heterogeneity for GSK1034702 in the human brain. Human whole brain V T estimates (4.9) were in broad agreement with primate V T and the f P/f ND ratio (3.97 and 2.63, respectively), consistent with transport by passive diffusion across the BBB.
    Conclusion: In primate and human PET studies designed to evaluate the transport of a novel M1 allosteric agonist (GSK1034702) across the BBB, we have demonstrated good brain uptake and BBB passage consistent with passive diffusion or active influx. These studies discharged some of the perceived development risks for GSK1034702 and provided information to progress the molecule into the next stage of clinical development.
    Trial registration: Clinical trial details: 'Brain Uptake of GSK1034702: a Positron Emission Tomography (PET) Scan Study.'; clinicaltrial.gov identifier: NCT00937846 .
    Language English
    Publishing date 2014-12-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2619892-7
    ISSN 2191-219X
    ISSN 2191-219X
    DOI 10.1186/s13550-014-0066-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Psoas muscle metastatic disease mimicking a psoas abscess on imaging.

    Gunn, Christopher / Fani, Mazyar

    BMJ case reports

    2022  Volume 15, Issue 8

    Abstract: Here, we report a case of malignant psoas syndrome presented to us during the second peak of the COVID-19 pandemic. Our patient had a medical history of hypertension, recently diagnosed with left iliac deep vein thrombosis and previous breast and ... ...

    Abstract Here, we report a case of malignant psoas syndrome presented to us during the second peak of the COVID-19 pandemic. Our patient had a medical history of hypertension, recently diagnosed with left iliac deep vein thrombosis and previous breast and endometrial cancers. She presented with exquisite pain and a fixed flexion deformity of the left hip. A rim-enhancing lesion was seen within the left psoas muscle and was initially deemed to be a psoas abscess. This failed to respond to medical management and attempts at drainage. Subsequent further imaging revealed the mass was of a malignant nature; histology revealing a probable carcinomatous origin. Following diagnosis, palliative input was obtained and, unfortunately, our patient passed away in a hospice shortly after discharge. We discuss the aetiology, radiological findings and potential treatments of this condition and learning points to prompt clinicians to consider this diagnosis in those with a personal history of cancer.
    MeSH term(s) COVID-19 ; Female ; Humans ; Neoplasms ; Pandemics ; Psoas Abscess/diagnostic imaging ; Psoas Abscess/etiology ; Psoas Muscles/diagnostic imaging ; Psoas Muscles/pathology
    Language English
    Publishing date 2022-08-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-250654
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Book ; Conference proceedings: Proceedings of the 2017 Annual Meetings of the International Plant Propagators' Society

    Heuser, C. W. / Roberts, W. G. / Larkman, C. / Gunn, S. / Tomita, M. / Foulds, H. / Davies, F. T. / Blythe, E.

    Southern Africa Region, March 1 to 4, 2017, Tzaneen, South Africa : Australian Region, May 11 to 14, 2017, Perth, Western Australia, Australia : New Zealand Region, May 18 to 21, 2017, Pukekohe, New Zealand : European Region, July 10 to 14, 2017, Alphen a/d Rijn, Netherlands : Eastern Region, North America, October 11 to 14, 2017, Grand Rapids, Michigan, USA : Western Region, North America, October 17 to 20, 2017, Wilsonville, Oregon, USA : Southern Region, North America, October 28 to 31, 2017, Dallas, Texas, USA : IPPS Japan Region, November 18 to 19, 2017, Nishihara Town, Okinawa Pref., Japan

    (Acta horticulturae ; 1212)

    2018  

    Title variant 2017 Annual Meetings of the International Plant Propagators' Society
    Institution International Plant Propagators' Society
    Event/congress International Plant Propagators' Society (20., 2017, Tzaneen, Southern Africa Region) ; International Plant Propagators' Society (45., 2017, PerthWesternAustralia, Australian Region) ; International Plant Propagators' Society (46., 2017, Pukekohe, New Zealand Region) ; International Plant Propagators' Society (50., 2017, AlphenaandenRijn, European Region) ; International Plant Propagators' Society (67., 2017, GrandRapidsMich., Eastern Region, North America) ; International Plant Propagators' Society (58., 2017, WilsonvilleOr., Western Region, North America) ; International Plant Propagators' Society (42., 2017, DallasTex., Southern Region, North America)
    Author's details editors and editorial board: C. W. Heuser, Jr., W. G. Roberts, C. Larkman, S. Gunn, M. Tomita, H. Foulds, F. T. Davies, E. Blythe
    Series title Acta horticulturae ; 1212
    Collection
    Language English
    Size xiv, 390 Seiten, Illustrationen, Diagramme, 24 cm
    Publisher ISHS Secretariat
    Publishing place Leuven
    Publishing country Belgium
    Document type Book ; Conference proceedings
    HBZ-ID HT019872573
    ISBN 978-94-6261-209-9 ; 94-6261-209-9
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

    More links

    Kategorien

  4. Article ; Online: Yours, mine, or ours? Dyadic sleep hygiene and associations with sleep quality, emotional distress, and conflict frequency in mixed-gender, bed-sharing couples.

    Novak, Josh R / Miller, Kaleigh C / Gunn, Heather E / Troxel, Wendy M

    Journal of sleep research

    2023  , Page(s) e14047

    Abstract: ... men's (M = 14.45, SD = 7.41) and women's total score self-report sleep hygiene ([M = 17.67, SD = 8.27 ...

    Abstract Although prior research demonstrates the interdependence of sleep quality within couples (i.e., the sleep of one partner affects the sleep of the other), little is known about the degree to which couples' sleep hygiene behaviours are concordant or discordant, and if one's own sleep hygiene or their report of their partners' sleep hygiene is related to worse relational, psychological, and sleep outcomes. In a sample of 143 mixed-gender, bed-sharing couples, each partner completed an online questionnaire consisting of the Sleep Hygiene Index (for themselves and their partner), PROMIS sleep disturbance scale, conflict frequency, PHQ-4 for anxiety and depressive symptoms, and the Perceived Stress Scale. Paired samples t-tests between partners were conducted using total and individual-item Sleep Hygiene Index scores to examine similarities and differences. Intraclass correlation coefficient (ICC) scores of dyadic reports were conducted to examine the level of agreement between each partner's sleep hygiene. Finally, we examined associations between one's own sleep hygiene and their report of their partner's sleep hygiene with both partner's sleep quality, emotional distress, and conflict frequency in a dyadic structural equation model with important covariates and alternative model tests. The results revealed a significant difference between men's (M = 14.45, SD = 7.41) and women's total score self-report sleep hygiene ([M = 17.67, SD = 8.27]; t(142) = -5.06, p < 0.001) and partners only had similar sleep hygiene for 5 out of the 13 items. Examining dyadic reports of sleep hygiene revealed that partners had moderate agreement on their partners' sleep hygiene (0.69-0.856). The results from the dyadic structural equation model revealed that poorer sleep hygiene was associated with one's own poor sleep quality, higher emotional distress, and more frequent relational conflict. For both men and women a poorer report of a partner's sleep hygiene was associated with one's own report of higher relationship conflict. Finally, men's poorer report of a partner's sleep hygiene was related better to their own sleep quality but was related to poorer sleep quality for their partners. These results have implications for sleep promotion and intervention efforts as well as for couple relationship functioning.
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1122722-9
    ISSN 1365-2869 ; 0962-1105
    ISSN (online) 1365-2869
    ISSN 0962-1105
    DOI 10.1111/jsr.14047
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Book ; Conference proceedings: Proceedings of the 2016 Annual Meetings of the International Plant Propagators' Society

    Heuser, C. W. / Roberts, W. G. / Larkman, C. / Gunn, S. / Tomita, M. / Foulds, H. / Davies, F. T. / Blythe, E.

    Southern Africa Region, Region March 1 to 3, 2016, Lambert's Bay, West Coast, South Africa ; New Zealand Region, April 21 to 24, 2016, Christ Church, New Zealand ; Australian Region, May 19 to 22, 2016, Adelaide, SA, Australia ; IPPS Japan Region, September 24 to 25, 2016, Kochi City, Kochi Prefecture, Japan ; Western Region, North America, October 19 to 22, 2016, Phoenix, Arizona, USA ; Eastern Region, North America, September 21 to 24, 2016, Hartford, Connecticut, USA ; European Region, September 28 to 30, 2016, Shifnal, England, UK ; Southern Region, North America, October 23 to 26, 2016, Virginia Beach, Virginia, USA

    (Acta horticulturae ; 1174)

    2017  

    Title variant 2016 Annual Meetings of the International Plant Propagators' Society ; IPPS
    Institution International Plant Propagators' Society
    Event/congress International Plant Propagators' Society (19., 2016, Southern Africa Region) ; International Plant Propagators' Society (45., 2016, Christchurch, New Zealand Region) ; International Plant Propagators' Society (44., 2016, Adelaide, Australian Region) ; International Plant Propagators' Society (23., 2016, Kōchi, Japan Region) ; International Plant Propagators' Society (57., 2016, Phoenix, Western Region, North America)
    Author's details editors C. W. Heuser, Jr., W. G. Roberts, C. Larkman, S. Gunn, M. Tomita, H. Foulds, F. T. Davies, E. Blythe
    Series title Acta horticulturae ; 1174
    Collection
    Language English
    Size xii, 376 Seiten, Illustrationen, Diagramme, 24 cm
    Publisher ISHS Secretariat
    Publishing place Leuven
    Publishing country Belgium
    Document type Book ; Conference proceedings
    HBZ-ID HT019536825
    ISBN 978-94-6261-170-2 ; 94-6261-170-X
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

    More links

    Kategorien

  6. Article ; Online: Development and initial psychometric evaluation of the Perceptions of Parental Illness Questionnaire for Cancer.

    Fletcher, Chloe M E / Flight, Ingrid / Gunn, Kate M / Patterson, Pandora / Wilson, Carlene

    Psycho-oncology

    2023  Volume 32, Issue 7, Page(s) 1130–1141

    Abstract: ... Questionnaire for Cancer (PPIQ-C) among adolescents and young adults (AYAs).: Methods: A sample of 372 AYAs ... aged 12-24 years) who had a parent diagnosed with cancer completed the PPIQ-C and the Kessler ... structure of the PPIQ-C. Scale reliability was evaluated using Cronbach's alpha (α) and McDonald's omega (ω ...

    Abstract Objective: To evaluate the psychometric properties of the Perceptions of Parental Illness Questionnaire for Cancer (PPIQ-C) among adolescents and young adults (AYAs).
    Methods: A sample of 372 AYAs (aged 12-24 years) who had a parent diagnosed with cancer completed the PPIQ-C and the Kessler Psychological Distress Scale (K10). Exploratory factor analyses were conducted to examine the dimensional structure of the PPIQ-C. Scale reliability was evaluated using Cronbach's alpha (α) and McDonald's omega (ω). Pearson correlation analyses were conducted to assess construct validity by examining correlations between PPIQ-C subscale scores and K10 total scores.
    Results: The PPIQ-C is organised into three sections, each with a separate factor structure for items representing identity, core (emotional representations, coherence, timeline, consequences, and controllability), and cause dimensions of the Common-Sense Model of Self-Regulation. Exploratory factor analyses determined the structure of each section: identity items comprised two subscales (12 items), core items comprised 10 subscales (38 items), and cause items comprised three subscales (11 items). Scale reliability was acceptable for all subscales, except the cause subscale chance or luck attributions (α = 0.665). Correlations between PPIQ-C subscale scores and K10 total scores provided support for construct validity.
    Conclusions: Preliminary evidence suggests that the PPIQ-C is a reliable, valid, and useful tool for assessing illness perceptions among AYAs with a parent with cancer. The PPIQ-C may be a useful addition to both clinical practice and future research, however further evaluation work is needed to confirm its structure and robustness prior to use.
    MeSH term(s) Adolescent ; Young Adult ; Humans ; Psychometrics ; Reproducibility of Results ; Surveys and Questionnaires ; Neoplasms/psychology ; Parents
    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1118536-3
    ISSN 1099-1611 ; 1057-9249
    ISSN (online) 1099-1611
    ISSN 1057-9249
    DOI 10.1002/pon.6168
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: 'Being a farmer, I mostly always think there is something more important to do': A mixed methods analysis of the skin cancer detection practices of Australian farmers.

    Fletcher, Chloe M E / Trenerry, Camilla / Wilson, Carlene / Gunn, Kate M

    Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals

    2023  

    Abstract: Issue addressed: Farmers experience skin cancer and die from melanoma at significantly higher rates than the general Australian population. This study examined Australian farmers' engagement with self-skin examinations (SSE), participation in clinical ... ...

    Abstract Issue addressed: Farmers experience skin cancer and die from melanoma at significantly higher rates than the general Australian population. This study examined Australian farmers' engagement with self-skin examinations (SSE), participation in clinical skin examinations (CSE) by a health professional, and self-reported barriers to engagement with these important skin cancer detection practices.
    Methods: A cross-sectional, mixed-methods design was used. Australian farmers were recruited through an industry-based organisation representing livestock farmers. Farmers (N = 498; 22-89 years; 83.1% male) responded to a paper-based survey that included closed- and open-ended questions.
    Results: Farmers reported engagement with self-conducted SSE and routine CSE that was comparable to findings in the general population, but 29.4% of farmers reported that they had not sought a CSE as soon as possible after noticing changes to their skin. Farmers reported a range of barriers to SSE, including physical difficulties examining their skin, difficulties identifying changes in their skin, forgetfulness, and lack of motivation. Barriers to CSE included accessibility, cost, difficulties finding the right doctor, and avoidance and complacency.
    Conclusions: There is a need to make clinical skin cancer detection more accessible to farmers, in addition to promoting self-skin examination and help-seeking behaviours within this at risk population. SO WHAT?: Novel approaches are needed to address systemic barriers faced by Australian farmers. These may include the use of teledermatology or artificial intelligence to assist with CSE. Remote training delivery methods may be also utilised to teach SSE skills to farmers who may be otherwise unable to access such opportunities.
    Language English
    Publishing date 2023-08-23
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2250864-8
    ISSN 2201-1617 ; 1036-1073
    ISSN (online) 2201-1617
    ISSN 1036-1073
    DOI 10.1002/hpja.796
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Agricultural insect pests as models for studying stress-induced evolutionary processes.

    Gunn, Joe C / Christensen, Blair M / Bueno, Erika M / Cohen, Zachary P / Kissonergis, Alexander S / Chen, Yolanda H

    Insect molecular biology

    2024  

    Abstract: Agricultural insect pests (AIPs) are widely successful in adapting to natural and anthropogenic stressors, repeatedly overcoming population bottlenecks and acquiring resistance to intensive management practices. Although they have been largely overlooked ...

    Abstract Agricultural insect pests (AIPs) are widely successful in adapting to natural and anthropogenic stressors, repeatedly overcoming population bottlenecks and acquiring resistance to intensive management practices. Although they have been largely overlooked in evolutionary studies, AIPs are ideal systems for understanding rapid adaptation under novel environmental conditions. Researchers have identified several genomic mechanisms that likely contribute to adaptive stress responses, including positive selection on de novo mutations, polygenic selection on standing allelic variation and phenotypic plasticity (e.g., hormesis). However, new theory suggests that stress itself may induce epigenetic modifications, which may confer heritable physiological changes (i.e., stress-resistant phenotypes). In this perspective, we discuss how environmental stress from agricultural management generates the epigenetic and genetic modifications that are associated with rapid adaptation in AIPs. We summarise existing evidence for stress-induced evolutionary processes in the context of insecticide resistance. Ultimately, we propose that studying AIPs offers new opportunities and resources for advancing our knowledge of stress-induced evolution.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 33602-6
    ISSN 1365-2583 ; 0962-1075
    ISSN (online) 1365-2583
    ISSN 0962-1075
    DOI 10.1111/imb.12915
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: The Effect of Immediacy of Expected Goal Feedback on Persistence in a Physical Task.

    Gunn, Christopher P / Englert, Chris / Ennigkeit, Fabienne / Taylor, Ian M

    Journal of sport & exercise psychology

    2023  Volume 45, Issue 1, Page(s) 41–48

    Abstract: Minimizing the temporal gap between behavior and reward enhances persistence, but the effect of other outcomes is unknown. Two concurrently run studies aimed to investigate whether persistence on a physical task would be influenced according to whether ... ...

    Abstract Minimizing the temporal gap between behavior and reward enhances persistence, but the effect of other outcomes is unknown. Two concurrently run studies aimed to investigate whether persistence on a physical task would be influenced according to whether participants expected immediate versus delayed goal feedback. Furthermore, whether this effect occurs via intrinsic motivation (Studies 1 and 2) or delaying the desire-goal conflict (Study 2) was examined. Using a counterbalanced within-person design, 34 participants in each study (Study 1: 16 males, 18 females; Study 2: 15 males, 19 females) completed two wall-sit persistence tasks, one with immediate feedback expected (regarding the participant's position on a leader board) and the other with feedback expected to be provided 1 week later. A two-way mixed analysis of variance found no significant differences in persistence between conditions in either study. Furthermore, no indirect effects were found via intrinsic motivation or delayed desire-goal conflict. Study findings did not support the hypothesis that the timing of expected feedback enhances persistence.
    MeSH term(s) Male ; Female ; Humans ; Motivation ; Goals ; Feedback ; Attention ; Reward
    Language English
    Publishing date 2023-01-12
    Publishing country United States
    Document type Journal Article
    ISSN 1543-2904
    ISSN (online) 1543-2904
    DOI 10.1123/jsep.2022-0038
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Factors Associated with Suicide Risk Behavior Outcomes Among Black High School Adolescents.

    Richardson, Sonyia C / Gunn, Laura H / Phipps, Margaret / Azasu, Enoch

    Journal of community health

    2023  Volume 49, Issue 3, Page(s) 466–474

    Abstract: There is an urgent need for youth suicide research, particularly among Black adolescents, for whom there have been significant increases over time. This study examines associations between eight covariates and suicide ideation, planning, and attempts ... ...

    Abstract There is an urgent need for youth suicide research, particularly among Black adolescents, for whom there have been significant increases over time. This study examines associations between eight covariates and suicide ideation, planning, and attempts among a national sample of Black high school adolescents to inform prevention efforts. Utilizing the 2019 National Youth Risk Behavior Survey data, a sample of N = 6225 Black high school participants was analyzed. A weighted classification tree and network analysis were used to visualize data features, and weighted multinomial ordered logistic regression analyses with multiple imputation pooled using Rubin's rules were performed. Suicide ideation rates of 16% were found in the sample and a higher reported rate of suicide attempts (56%) for those who have reported both ideation and planning. Interpersonal and multilevel factors, including suffering from bullying/cyberbullying, carrying a weapon, or being a sexual minority, were significantly associated with all three suicide behaviors. Findings support an interrelated and multilevel nature of suicide risk factors. Prevention programs for Black adolescents should consider the intersectionality of identities and experiences.
    MeSH term(s) Humans ; Adolescent ; Suicide, Attempted ; Suicidal Ideation ; Risk-Taking ; Schools ; Bullying ; Risk Factors
    Language English
    Publishing date 2023-12-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 426631-6
    ISSN 1573-3610 ; 0094-5145
    ISSN (online) 1573-3610
    ISSN 0094-5145
    DOI 10.1007/s10900-023-01312-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top