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Article ; Online: The anatomical distribution of lentiginous melanoma (lentigo maligna and lentigo maligna melanoma): Differences according to sex.

Punchihewa, Nisal / Wee, Edmund / Kelly, John W / Mclean, Catriona / Mar, Victoria J / Pan, Yan

2023 Volume 64, Issue 3, Page(s) e277–e280

MeSH term(s)	Humans ; Hutchinson's Melanotic Freckle ; Melanoma ; Skin Neoplasms
Language	English
Publishing date	2023-04-20
Publishing country	Australia
Document type	Journal Article
ZDB-ID	138052-7
ISSN	1440-0960 ; 0004-8380
ISSN (online)	1440-0960
ISSN	0004-8380
DOI	10.1111/ajd.14058
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Article ; Online: 'It makes you not want to eat': Perceptions of anti-obesity public health campaigns in individuals diagnosed with an eating disorder.

Bristow, Claire / Simmonds, Janette / Allen, Kelly-Ann / McLean, Louise

European eating disorders review : the journal of the Eating Disorders Association

2022 Volume 31, Issue 1, Page(s) 166–177

Abstract: Objective: Recent research has highlighted the potentially deleterious effects of anti-obesity public health campaigns on vulnerable audiences such as those at risk of, or diagnosed with, eating disorders (ED). The qualitative experiences of campaigns ... ...

Abstract	Objective: Recent research has highlighted the potentially deleterious effects of anti-obesity public health campaigns on vulnerable audiences such as those at risk of, or diagnosed with, eating disorders (ED). The qualitative experiences of campaigns in this population group have been little explored. Methods: Twelve interviews were conducted with participants either currently or previously diagnosed with an ED using the Interpretative Phenomenological Analysis approach. Participants were shown a series of real-world public health campaigns and, using a semi-structured interview guide, asked about their responses to the images used. Results: Several themes emerged from the data, including the effect of campaigns on participants, perceived effect on others, and general campaign attributes. It was evident that participants felt that anti-obesity campaigns had the potential to confirm ED thoughts and behaviours, and could act as potential triggers. Participants also felt that they could impact vulnerable groups (e.g., young audiences) and stigmatise those living in larger bodies. Conclusion: Campaigns addressing overweight and obesity should consider reframing these conditions and care must be taken to avoid causing potential harm to vulnerable audiences.
MeSH term(s)	Humans ; Health Promotion ; Feeding and Eating Disorders
Language	English
Publishing date	2022-09-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1159507-3
ISSN	1099-0968 ; 1067-1633 ; 1072-4133
ISSN (online)	1099-0968
ISSN	1067-1633 ; 1072-4133
DOI	10.1002/erv.2950
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Zs.A 3760: Show issues

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Article ; Online: Neoadjuvant Immune Checkpoint Inhibition in Metastatic Conjunctival Melanoma.

Fan, Kelly / Waninger, Jessica J / Yentz, Sarah / McLean, Scott / Demirci, Hakan

Ophthalmic plastic and reconstructive surgery

2023 Volume 39, Issue 5, Page(s) e152–e155

Abstract: The development of immune checkpoint inhibitors (ICI) has transformed the treatment of advanced-stage cutaneous melanoma; however, most trials did not include patients with conjunctival melanoma. Herein the authors describe a patient with recurrent ... ...

Abstract	The development of immune checkpoint inhibitors (ICI) has transformed the treatment of advanced-stage cutaneous melanoma; however, most trials did not include patients with conjunctival melanoma. Herein the authors describe a patient with recurrent conjunctival melanoma who developed locally advanced, b-raf and v-raf murine sarcoma viral oncogene homolog B1-negative melanoma in her nasal cavity and extensive, metabolically active, bilateral lymphadenopathy in her thorax. Her nasal mass measured 4.3 × 1.7 cm and was determined to be unresectable. She was treated with 4 cycles of combination ipilimumab and nivolumab therapy followed by maintenance nivolumab. She experienced a dramatic treatment response with a reduction in the size of her nasal mass to 3.0 × 1.1 cm and a complete resolution of her adenopathy. She then underwent complete surgical resection of her residual mass (approximately 75% of her original tumor size) and remains melanoma-free at 1 year of follow-up. Given the underlying genetic similarities of conjunctival melanoma to cutaneous melanoma, providers should consider the use of neoadjuvant immune checkpoint inhibitors for patients with locally advanced or limited metastatic disease.
MeSH term(s)	Humans ; Female ; Mice ; Animals ; Melanoma/pathology ; Nivolumab/therapeutic use ; Skin Neoplasms/pathology ; Immune Checkpoint Inhibitors/therapeutic use ; Antineoplastic Agents, Immunological/therapeutic use ; Neoadjuvant Therapy ; Neoplasm Recurrence, Local/drug therapy ; Ipilimumab/therapeutic use ; Lymphadenopathy ; Antineoplastic Combined Chemotherapy Protocols ; Melanoma, Cutaneous Malignant
Chemical Substances	Nivolumab (31YO63LBSN) ; Immune Checkpoint Inhibitors ; Antineoplastic Agents, Immunological ; Ipilimumab
Language	English
Publishing date	2023-05-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	632830-1
ISSN	1537-2677 ; 0740-9303
ISSN (online)	1537-2677
ISSN	0740-9303
DOI	10.1097/IOP.0000000000002407
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Zs.A 2159: Show issues

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Article ; Online: Online student culture as site for negotiating assessment in medical education.

Underman, Kelly / Kochunilathil, Merlin / McLean, Lauren / Vinson, Alexandra H

Social science & medicine (1982)

2022 Volume 310, Page(s) 115270

Abstract: Classic studies of medical education have examined how professional socialization reproduces the prevailing professional culture, as well as how students actively negotiate their place in educational processes. However, sociological research has not re- ... ...

Abstract	Classic studies of medical education have examined how professional socialization reproduces the prevailing professional culture, as well as how students actively negotiate their place in educational processes. However, sociological research has not re-examined student culture in light of structural transformations in medical education, such as the introduction of new assessment types and their use as modes of commensuration. In this paper, we examine data from two studies of online forums where medical trainees and applicants to medical school discuss their experiences preparing for tests of professional skills, including judgment, empathy, and communication. Examining how medical students talk about these tests on such forums allows us to understand the meaning-making processes at work as students negotiate the commensuration processes such tests enable. We examine how these negotiations take place in online forums, where participants confront common challenges, form common perspectives, and share common solutions, all hallmarks of student culture. Through qualitative analysis, we find that online communities are spaces where students grapple with these new forms of commensuration, interrogate the standards and quantifications that underlie them, and collectively negotiate how to approach these assessments. Using the case of online forum communities, our findings advance past work on student culture in medical sociology by theorizing student culture as an extra-organizational phenomenon that spans multiple career stages. In so doing, we highlight the importance of online forum data for studying social processes.
MeSH term(s)	Communication ; Education, Medical ; Empathy ; Humans ; Negotiating ; Students, Medical
Language	English
Publishing date	2022-08-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4766-1
ISSN	1873-5347 ; 0037-7856 ; 0277-9536
ISSN (online)	1873-5347
ISSN	0037-7856 ; 0277-9536
DOI	10.1016/j.socscimed.2022.115270
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Zs.A 625: Show issues

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Article ; Online: Society for Maternal-Fetal Medicine Special Statement: A maternal transport briefing form and checklist.

Gibson, Kelly S / McLean, David

American journal of obstetrics and gynecology

2020 Volume 223, Issue 5, Page(s) B12–B15

Abstract: When performing a maternal transport between two facilities, numerous pieces of information must be communicated between physicians, nurses, and transport personnel, including the health status of 2 patients (mother and fetus), availability of bed space ... ...

Abstract	When performing a maternal transport between two facilities, numerous pieces of information must be communicated between physicians, nurses, and transport personnel, including the health status of 2 patients (mother and fetus), availability of bed space and personnel in 2 units at the receiving facility (labor and delivery unit and neonatal intensive care unit), arrangements for transportation, and inpatient and outpatient records. The amount and complexity of information creates a risk of medical error due to communication lapses. A cognitive aid such as a standardized form can help the team prepare for a transfer and provide a consistent framework for a handoff briefing among healthcare professionals. SMFM presents a sample briefing form to ensure that key elements are communicated for every maternal transport. Practical suggestions are given to help facilities customize the form and implement it on their units.
MeSH term(s)	Checklist ; Delivery Rooms ; Female ; Fetal Membranes, Premature Rupture ; Forms as Topic ; Humans ; Intensive Care Units, Neonatal ; Medical Errors/prevention & control ; Obstetric Labor, Premature ; Patient Handoff ; Patient Transfer/methods ; Pregnancy ; Transportation of Patients/methods
Language	English
Publishing date	2020-08-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2020.08.065
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Article: Responses of largemouth bass (Micropterus salmoides, Lacépède, 1802) to fishmeal‐, and fish oil‐free diets

McLean, Ewen / Alfrey, Kelly B. / Gatlin, Delbert M., III / Barrows, Frederick T.

Aquaculture research. 2022 June, v. 53, no. 8

2022

Abstract: Largemouth bass (LMB; ~15.2 g initial weight) was fed one of the five experimental, and a fishmeal (FM)/fish oil (FO) control diet and two commercial (Xinxin, Coppens) LMB feeds for 10 weeks. Fish were dispersed into 24, 110‐L aquaria (n = 20/tank) ... ...

Abstract	Largemouth bass (LMB; ~15.2 g initial weight) was fed one of the five experimental, and a fishmeal (FM)/fish oil (FO) control diet and two commercial (Xinxin, Coppens) LMB feeds for 10 weeks. Fish were dispersed into 24, 110‐L aquaria (n = 20/tank) configured as a recirculating system. Aquaria were arbitrarily allocated to dietary treatments in triplicate (n = 60/fish diet). The FM component of experimental diets was replaced using poultry by‐product meal and soy protein concentrate. One experimental diet contained FO, whereas in others, FO was replaced with canola, flax and/or algal oil or combinations thereof. At trial end, there were no differences among fish‐fed various diets in terms of feed conversion or protein efficiency ratios. Weight gain and survival were similar for experimental groups, and LMB fed the Xinxin commercial feed, but the Coppens feed returned inferior (p < 0.05) weights and higher mortality. Condition factor, fillet yield and intraperitoneal fat ratios were unaffected by diet but hepatosomatic index varied. The Coppens feed caused greatest differences in whole‐body protein, lipid and ash contents (p < 0.001). Whole‐body fatty acid profiles reflected those of the diet, with algal oil enriched feed illustrating enhanced DHA:EPA ratios.
Keywords	Micropterus salmoides ; algal oils ; aquaculture ; canola ; condition factor ; experimental diets ; fatty acids ; feed conversion ; fillets ; fish ; fish meal ; flax ; hepatosomatic index ; mortality ; poultry meal ; research ; soy protein concentrate ; weight gain
Language	English
Dates of publication	2022-06
Size	p. 3036-3047.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1227359-4
ISSN	1355-557X
ISSN	1355-557X
DOI	10.1111/are.15815
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Early Melanoma Diagnosis With Sequential Dermoscopic Images.

Yu, Zhen / Nguyen, Jennifer / Nguyen, Toan D / Kelly, John / Mclean, Catriona / Bonnington, Paul / Zhang, Lei / Mar, Victoria / Ge, Zongyuan

IEEE transactions on medical imaging

2022 Volume 41, Issue 3, Page(s) 633–646

Abstract: Dermatologists often diagnose or rule out early melanoma by evaluating the follow-up dermoscopic images of skin lesions. However, existing algorithms for early melanoma diagnosis are developed using single time-point images of lesions. Ignoring the ... ...

Abstract	Dermatologists often diagnose or rule out early melanoma by evaluating the follow-up dermoscopic images of skin lesions. However, existing algorithms for early melanoma diagnosis are developed using single time-point images of lesions. Ignoring the temporal, morphological changes of lesions can lead to misdiagnosis in borderline cases. In this study, we propose a framework for automated early melanoma diagnosis using sequential dermoscopic images. To this end, we construct our method in three steps. First, we align sequential dermoscopic images of skin lesions using estimated Euclidean transformations, extract the lesion growth region by computing image differences among the consecutive images, and then propose a spatio-temporal network to capture the dermoscopic changes from aligned lesion images and the corresponding difference images. Finally, we develop an early diagnosis module to compute probability scores of malignancy for lesion images over time. We collected 179 serial dermoscopic imaging data from 122 patients to verify our method. Extensive experiments show that the proposed model outperforms other commonly used sequence models. We also compared the diagnostic results of our model with those of seven experienced dermatologists and five registrars. Our model achieved higher diagnostic accuracy than clinicians (63.69% vs. 54.33%, respectively) and provided an earlier diagnosis of melanoma (60.7% vs. 32.7% of melanoma correctly diagnosed on the first follow-up images). These results demonstrate that our model can be used to identify melanocytic lesions that are at high-risk of malignant transformation earlier in the disease process and thereby redefine what is possible in the early detection of melanoma.
MeSH term(s)	Dermoscopy/methods ; Diagnostic Imaging ; Early Diagnosis ; Humans ; Melanoma/diagnostic imaging ; Skin Neoplasms/diagnostic imaging
Language	English
Publishing date	2022-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	622531-7
ISSN	1558-254X ; 0278-0062
ISSN (online)	1558-254X
ISSN	0278-0062
DOI	10.1109/TMI.2021.3120091
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Zs.A 2546: Show issues

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Article: Is It Time to Redefine Lidocaine Administration Guidelines in Mohs Surgery?

Flanagan, Kelly / McLean, Riley / Goldberg, Dori

Journal of drugs in dermatology : JDD

2019 Volume 19, Issue 4, Page(s) 433

MeSH term(s)	Anesthesia, Local/methods ; Anesthesia, Local/standards ; Anesthetics, Local/administration & dosage ; Anesthetics, Local/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Half-Life ; Humans ; Lidocaine/administration & dosage ; Lidocaine/pharmacokinetics ; Mohs Surgery/adverse effects ; Pain, Procedural/etiology ; Pain, Procedural/prevention & control ; Practice Guidelines as Topic ; Skin Neoplasms/surgery ; Time Factors ; United States ; United States Food and Drug Administration/standards
Chemical Substances	Anesthetics, Local ; Lidocaine (98PI200987)
Language	English
Publishing date	2019-09-17
Publishing country	United States
Document type	Letter
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
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Zs.A 5931: Show issues

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Article ; Online: Evaluation of dynamic dermoscopic features of melanoma and benign naevi by sequential digital dermoscopic imaging and total body photography in a high-risk Australian cohort.

Nguyen, Jennifer / Doolan, Brent J / Pan, Yan / Vestergaard, Tine / Paul, Eldho / McLean, Catriona / Haskett, Martin / Kelly, John / Mar, Victoria / Chamberlain, Alexander

The Australasian journal of dermatology

2023 Volume 64, Issue 1, Page(s) 67–79

Abstract: Background/objectives: Sequential digital dermoscopic imaging (SDDI) and total body photography (TBP) are recommended as a two-step surveillance method for individuals at high-risk of developing cutaneous melanoma. Dermoscopic features specific to ... ...

Abstract	Background/objectives: Sequential digital dermoscopic imaging (SDDI) and total body photography (TBP) are recommended as a two-step surveillance method for individuals at high-risk of developing cutaneous melanoma. Dermoscopic features specific to melanoma have been well described, however, dynamic changes on serial imaging are less understood. This study aims to identify and compare dermoscopic features in developing melanomas and benign naevi that underwent SDDI and TBP to understand which dermoscopic features may be associated with a malignant change. Method: Histopathology reports from a private specialist dermatology clinic from January 2007 to December 2019 were reviewed. Histopathologically confirmed melanoma and benign naevi that underwent SDDI and TBP with a minimum follow-up interval of 3 months were included. Results: Eighty-nine melanomas (38.2% invasive, median Breslow thickness 0.35 mm, range: 0.2-1.45 mm) and 48 benign naevi were evaluated by three experienced dermatologists for dermoscopic changes. Features most strongly associated with melanoma included the development of neovascularisation, asymmetry and growth in pigment network, additional colours, shiny white structures, regression, structureless areas and change to a multi-component pattern. The presence of atypical vessels (p = 0.02) and shiny white structures (p = 0.02) were significantly associated with invasive melanoma. Conclusion: Evaluation for certain evolving dermoscopic features in melanocytic lesions monitored by SDDI and TBP is efficient in assisting clinical decision making. SDDI with TBP is an effective tool for early detection of melanoma.
MeSH term(s)	Humans ; Melanoma/pathology ; Skin Neoplasms/pathology ; Dermoscopy/methods ; Australia ; Nevus, Pigmented/diagnostic imaging ; Nevus, Pigmented/pathology ; Photography ; Melanoma, Cutaneous Malignant
Language	English
Publishing date	2023-01-18
Publishing country	Australia
Document type	Journal Article
ZDB-ID	138052-7
ISSN	1440-0960 ; 0004-8380
ISSN (online)	1440-0960
ISSN	0004-8380
DOI	10.1111/ajd.13975
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Zs.A 236: Show issues

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Article ; Online: Early-life exposure to analgesia and 18-month neurodevelopmental outcomes in very preterm infants.

Selvanathan, Thiviya / Zaki, Pearl / McLean, Mia A / Au-Young, Stephanie H / Chau, Cecil M Y / Chau, Vann / Synnes, Anne R / Ly, Linh G / Kelly, Edmond / Grunau, Ruth E / Miller, Steven P

Pediatric research

2023 Volume 94, Issue 2, Page(s) 738–746

Abstract: Background: We assessed variability of analgesic use across three tertiary neonatal intensive care units (NICUs) accounting for early-life pain, quantified as number of invasive procedures. We also determined whether analgesia exposure modifies ... ...

Abstract	Background: We assessed variability of analgesic use across three tertiary neonatal intensive care units (NICUs) accounting for early-life pain, quantified as number of invasive procedures. We also determined whether analgesia exposure modifies associations between early-life pain and neurodevelopment. Methods: Multicenter prospective study of 276 very preterm infants (born <24-32 weeks' gestational age [GA]). Detailed data of number of invasive procedures and duration of analgesia exposure were collected in initial weeks after birth. Eighteen-month neurodevelopmental assessments were completed in 215 children with Bayley Scales for Infant Development-Third edition. Results: Multivariable linear regressions revealed significant differences in morphine use across sites, for a given exposure to early-life pain (interaction p < 0.001). Associations between early-life pain and motor scores differed by duration of morphine exposure (interaction p = 0.01); greater early-life pain was associated with poorer motor scores in infants with no or long (>7 days) exposure, but not short exposure (≤7 days). Conclusions: Striking cross-site differences in morphine exposure in very preterm infants are observed even when accounting for early-life pain. Negative associations between greater early-life pain and adverse motor outcomes were attenuated in infants with short morphine exposure. These findings emphasize the need for further studies of optimal analgesic approaches in preterm infants. Impact: In very preterm neonates, both early-life exposure to pain and analgesia are associated with adverse neurodevelopment and altered brain maturation, with no clear guidelines for neonatal pain management in this population. We found significant cross-site variability in morphine use across three tertiary neonatal intensive care units in Canada. Morphine use modified associations between early-life pain and motor outcomes. In infants with no or long durations of morphine exposure, greater early-life pain was associated with lower motor scores, this relationship was attenuated in those with short morphine exposure. Further trials of optimal treatment approaches with morphine in preterm infants are warranted.
MeSH term(s)	Infant ; Child ; Humans ; Infant, Newborn ; Infant, Premature ; Pain Management ; Prospective Studies ; Pain/drug therapy ; Analgesia ; Morphine/adverse effects ; Analgesics ; Gestational Age
Chemical Substances	Morphine (76I7G6D29C) ; Analgesics
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-023-02536-y
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Zs.A 564: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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