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Article: Missed Opportunities? A Retrospective Study Into Adults Hospitalized With Invasive Infection From Airway Pathogens.

Smith, Emma L / Tan, Bryan / Bastas, Alysia / Kotsanas, Despina / Dendle, Claire / Ojaimi, Samar

2022 Volume 9, Issue 7, Page(s) ofac330

Abstract: Background: Invasive disease caused by airway pathogens, including : Methods: A retrospective analysis was conducted at a large tertiary Australian health service, comprising multiple centers. Patients aged 18 years or older, in whom the above ... ...

Abstract	Background: Invasive disease caused by airway pathogens, including Methods: A retrospective analysis was conducted at a large tertiary Australian health service, comprising multiple centers. Patients aged 18 years or older, in whom the above pathogens were isolated from sterile sites, were included as identified through a microbiology database, between 2015 and 2020. Using electronic medical records, patient demographics, medical history, outcomes of admission, and pathology results were captured and reviewed to address the aims. Results: In 252 patients, Conclusions: Immunodeficiency is common in this patient population. Screening should be undertaken to ensure timely diagnosis and treatment of the underlying condition to avoid future morbidity and mortality.
Language	English
Publishing date	2022-07-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofac330
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Article ; Online: Survey of treatment practices for immunocompromised patients with COVID-19 in Australasia.

Moso, Michael A / Sasadeusz, Joe / Morrissey, Catherine O / Bond, Katherine / Guy, Stephen / Slavin, Monica A / Dendle, Claire

Internal medicine journal

2023 Volume 53, Issue 4, Page(s) 619–624

Abstract: Coronavirus disease 2019 (COVID-19) in immunocompromised patients can lead to severe and prolonged illness. Data are limited with regard to management of COVID-19 in this setting, particularly in persistent or recrudescent infection. The authors ... ...

Abstract	Coronavirus disease 2019 (COVID-19) in immunocompromised patients can lead to severe and prolonged illness. Data are limited with regard to management of COVID-19 in this setting, particularly in persistent or recrudescent infection. The authors conducted an online survey among infectious diseases doctors to determine current approaches to treatment across Australasia. There was marked variability in responses relating to the diagnostic modalities and use of antiviral agents in patients with immunocompromise, highlighting the need for high-quality studies to guide treatment decisions in this group.
MeSH term(s)	Humans ; COVID-19 ; Antiviral Agents/therapeutic use ; Immunocompromised Host ; Surveys and Questionnaires ; Australasia/epidemiology
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2023-04-03
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.16064
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Zs.A 792: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: SARS-COV-2 vaccine acceptance in patients with rheumatic diseases: a cross-sectional study.

Ko, Tina / Dendle, Claire / Woolley, Ian / Morand, Eric / Antony, Anna

Human vaccines & immunotherapeutics

2021 Volume 17, Issue 11, Page(s) 4048–4056

Abstract: Objectives: To evaluate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine acceptance among patients with rheumatic diseases (RMD).: Methods: All rheumatology patients attending a large suburban health network were invited to ... ...

Abstract	Objectives: To evaluate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine acceptance among patients with rheumatic diseases (RMD). Methods: All rheumatology patients attending a large suburban health network were invited to participate in an anonymized online survey. The primary outcome of interest was SARS-COV-2 vaccine acceptance. Results: The mean (SD) age of respondents (n = 641) was 52.7 (15.1) years and 74.4% (n = 474) were female. Sixty-five percent were willing to have a SARS-COV-2 vaccine, while 34.4% were vaccine-hesitant (unwilling or undecided). On multivariate analysis, vaccine acceptance was associated with smoking (OR: 2.25 [95% CI: 1.22-4.15; Conclusion: SARS-COV-2 vaccine hesitancy is prevalent amongst RMD patients and associated with concerns regarding vaccine safety, efficacy, side effects and RMD flare. Clinician recommendation, vaccine choice and communications targeting patient concerns could facilitate vaccine acceptance.
MeSH term(s)	COVID-19 ; COVID-19 Vaccines ; Cross-Sectional Studies ; Female ; Humans ; Influenza Vaccines ; Middle Aged ; Rheumatic Diseases ; SARS-CoV-2 ; Vaccination ; Vaccination Hesitancy ; Vaccine Efficacy
Chemical Substances	COVID-19 Vaccines ; Influenza Vaccines
Language	English
Publishing date	2021-08-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2021.1958611
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Zs.A 6967: Show issues

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Article ; Online: Kidney transplant recipients' attitudes toward COVID-19 vaccination and barriers and enablers to vaccine acceptance.

Tharmaraj, Dhakshayini / Dendle, Claire / Polkinghorne, Kevan R / Mulley, William R

Transplant infectious disease : an official journal of the Transplantation Society

2021 Volume 24, Issue 1, Page(s) e13749

Abstract: Objective: To identify barriers and enablers to COVID-19 vaccination in renal transplant recipients who are undecided about vaccination.: Methods: An online survey was distributed to 876 adult kidney transplant recipients at a tertiary referral ... ...

Abstract	Objective: To identify barriers and enablers to COVID-19 vaccination in renal transplant recipients who are undecided about vaccination. Methods: An online survey was distributed to 876 adult kidney transplant recipients at a tertiary referral service, who had not been vaccinated against COVID-19. The survey assessed willingness to be vaccinated, attitudes toward COVID-19 vaccines, and barriers and enablers to proceeding with vaccination. Results: The survey response rate was 54% (473/876). Three hundred and forty-six (73.1%) participants planned to receive vaccination (yes group), 105 (22.2%) were undecided, and 22 (4.7%) refused vaccination. The undecided group were younger but were not different in other demographic characteristics to the yes group. The undecided group were less positive toward (34.29% vs. 91.3%, p < .001) and more concerned about (93.3% vs. 25.1%, p < .001) vaccination than the yes group. Their concerns related to vaccine safety (including harm to their transplant), poor efficacy, and a lack of rigorous testing in transplant recipients. Undecided recipients had received less vaccine-specific information from medical specialists than the yes group. Most undecided participants (95.1%) were willing to proceed with vaccination with appropriate supports. The most desired supports were information and a recommendation to proceed with vaccination from their treating transplant specialist and team. Conclusion(s): Concerns about vaccine safety (including harm to transplant), poor vaccine efficacy, and lack of rigorous testing were barriers to vaccine uptake. Most undecided recipients would proceed with vaccination with specific recommendations and vaccine information provided by their transplant specialist/team. These simple interventions can be readily implemented to optimize vaccine uptake.
MeSH term(s)	Adult ; Attitude ; COVID-19 ; COVID-19 Vaccines ; Humans ; Kidney Transplantation/adverse effects ; SARS-CoV-2 ; Transplant Recipients ; Vaccination ; Vaccines
Chemical Substances	COVID-19 Vaccines ; Vaccines
Language	English
Publishing date	2021-11-03
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.13749
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Zs.A 5100: Show issues

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Article ; Online: High risk of infection in 'real-world' patients receiving ibrutinib, idelalisib or venetoclax for mature B-cell leukaemia/lymphoma.

Tey, Amanda / Schwarer, James / Raffa, Robert / Shi, Emily / Paul, Eldho / Opat, Stephen / Dendle, Claire / Shortt, Jake

European journal of haematology

2023 Volume 110, Issue 5, Page(s) 540–547

Abstract: Objective: The infection risk in patients receiving ibrutinib, idelalisib or venetoclax for chronic lymphocytic leukaemia (CLL) or B-cell lymphoma treated outside of clinical trials is incompletely defined. We sought to identify the severe infection ... ...

Abstract	Objective: The infection risk in patients receiving ibrutinib, idelalisib or venetoclax for chronic lymphocytic leukaemia (CLL) or B-cell lymphoma treated outside of clinical trials is incompletely defined. We sought to identify the severe infection rate and associated risk factors in a 'real-world' cohort. Methods: We conducted a retrospective cohort study of adult patients with CLL or lymphoma treated with ibrutinib, idelalisib or venetoclax. Results: Of 67 patients identified (ibrutinib n = 53, idelalisib n = 8 and venetoclax n = 6), 32 (48%) experienced severe infection. Severe infection occurred at a rate of 65 infections per 100 person-years, with a median of 17.8 months of therapy. Median time to first infection (IQR) was 5.4 months (1.4-15.9). Poor baseline Eastern Cooperative Oncology Group (ECOG) performance status and high Charlson Comorbidity Index (CCI) score associated with increased risk of severe infection [hazard ratios (95% CI) 1.57 (1.07-2.31, p = .018) and 1.3 (1.05-1.62, p = .016) respectively]. Conclusion: The severe infection rate for patients receiving ibrutinib, idelalisib or venetoclax for lymphoma and CLL exceeded those reported in clinical trials. Patients with poor ECOG or high CCI should be closely monitored for early signs of infection and prevention strategies actively pursued. Further prospective research is required to define optimal antimicrobial prophylaxis recommendations.
MeSH term(s)	Adult ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Retrospective Studies ; Lymphoma, B-Cell/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
Chemical Substances	idelalisib (YG57I8T5M0) ; ibrutinib (1X70OSD4VX) ; venetoclax (N54AIC43PW)
Language	English
Publishing date	2023-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/ejh.13928
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Zs.A 323: Show issues

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Article ; Online: Persistently positive culture of antimicrobial-susceptible

Rafiei, Nastaran / Shaw, Briony / Dendle, Claire / Opat, Stephen / Williamson, Deborah / Graham, Maryza

Access microbiology

2020 Volume 2, Issue 5, Page(s) acmi000113

Abstract: Legionella ... ...

Abstract	Legionella pneumophila
Language	English
Publishing date	2020-03-02
Publishing country	England
Document type	Case Reports
ISSN	2516-8290
ISSN (online)	2516-8290
DOI	10.1099/acmi.0.000113
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Article ; Online: Disseminated Lomentospora prolificans infection in a patient on idelalisib-rituximab therapy for relapsed chronic lymphocytic leukaemia.

Tey, Amanda / Mohan, Bianca / Cheah, Ron / Dendle, Claire / Gregory, Gareth

Annals of hematology

2020 Volume 99, Issue 10, Page(s) 2455–2456

MeSH term(s)	Antifungal Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cyclophosphamide/administration & dosage ; Cyclophosphamide/adverse effects ; Drug Resistance, Multiple, Fungal ; Drug Substitution ; Fatal Outcome ; Febrile Neutropenia/complications ; Febrile Neutropenia/drug therapy ; Female ; Filgrastim/therapeutic use ; Fluconazole/therapeutic use ; Humans ; Immunocompromised Host ; Invasive Fungal Infections/drug therapy ; Invasive Fungal Infections/etiology ; Invasive Fungal Infections/microbiology ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Middle Aged ; Piperacillin, Tazobactam Drug Combination/therapeutic use ; Purines/administration & dosage ; Purines/adverse effects ; Quinazolinones/administration & dosage ; Quinazolinones/adverse effects ; Recurrence ; Rituximab/administration & dosage ; Rituximab/adverse effects ; Scedosporium/drug effects ; Scedosporium/isolation & purification ; Triazoles/therapeutic use ; Valacyclovir/therapeutic use ; Vidarabine/administration & dosage ; Vidarabine/adverse effects ; Vidarabine/analogs & derivatives
Chemical Substances	Antifungal Agents ; Purines ; Quinazolinones ; Triazoles ; Piperacillin, Tazobactam Drug Combination (157044-21-8) ; Rituximab (4F4X42SYQ6) ; posaconazole (6TK1G07BHZ) ; Cyclophosphamide (8N3DW7272P) ; Fluconazole (8VZV102JFY) ; Vidarabine (FA2DM6879K) ; Valacyclovir (MZ1IW7Q79D) ; fludarabine (P2K93U8740) ; Filgrastim (PVI5M0M1GW) ; idelalisib (YG57I8T5M0)
Language	English
Publishing date	2020-05-25
Publishing country	Germany
Document type	Case Reports ; Letter
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-020-04087-2
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Article ; Online: A Description of the Type, Frequency and Severity of Infections Among Sixteen Patients Treated for T-Cell Lymphoma.

Ko, Tina / Seah, Crystal / Gilbertson, Michael / McQuilten, Zoe / Opat, Stephen / Dendle, Claire

Journal of hematology

2021 Volume 10, Issue 3, Page(s) 123–129

Abstract: Background: Infections are an important cause of morbidity and mortality in T-cell lymphomas. Factors contributing to increased risk of infection include the nature of the underlying disease, as well as treatment-associated immunosuppression. Currently ... ...

Abstract	Background: Infections are an important cause of morbidity and mortality in T-cell lymphomas. Factors contributing to increased risk of infection include the nature of the underlying disease, as well as treatment-associated immunosuppression. Currently there are few reports describing the types of infections, including preventable infections, in this cohort of patients. The aim of the study was to identify the type, frequency and severity of infection in patients with T-cell lymphoma undergoing treatment. Methods: A case series was performed on all patients with T-cell lymphoma over a 5-year period from 2011 to 2016 at a tertiary Australian hospital. Information was collected from medical record review regarding patient demographics, lymphoma treatment and outcomes, and infectious outcomes. Severe infections were recorded, defined as infection requiring hospitalization. Results: Sixteen patients were identified with a diagnosis of T-cell lymphoma who received treatment at our institution. There were 42 discrete episodes of severe infections in total. Severe infections occurred in 81% of patients, with over 40% having more than one infection. The median length of hospital stay was 13 days, 33% required intensive care admission and 14% of infectious episodes resulted in death. Only 50% of infectious episodes were microbiologically proven, with the most common etiology being bacterial. The most commonly isolated organism overall was Conclusion: Infections are frequent, opportunistic and severe in patients with T-cell lymphoma. Our data suggests that fungal prophylaxis may be indicated with T-cell lymphoma.
Language	English
Publishing date	2021-06-16
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2662519-2
ISSN	1927-1220 ; 1927-1220
ISSN (online)	1927-1220
ISSN	1927-1220
DOI	10.14740/jh838
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Article ; Online: Occupational Legionella pneumophila Exposure in a Street Sweeper with a Renal Transplant.

Tedjaseputra, Aditya / Manzoor, Momena / Dendle, Claire / Kanellis, John

Nephrology (Carlton, Vic.)

2018 Volume 23, Issue 5, Page(s) 493–494

MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/adverse effects ; Job Description ; Kidney Transplantation/adverse effects ; Legionella pneumophila/drug effects ; Legionella pneumophila/immunology ; Legionella pneumophila/pathogenicity ; Legionnaires' Disease/diagnosis ; Legionnaires' Disease/drug therapy ; Legionnaires' Disease/immunology ; Legionnaires' Disease/microbiology ; Male ; Middle Aged ; Occupational Diseases/diagnosis ; Occupational Diseases/drug therapy ; Occupational Diseases/immunology ; Occupational Diseases/microbiology ; Occupational Exposure ; Opportunistic Infections/diagnosis ; Opportunistic Infections/drug therapy ; Opportunistic Infections/immunology ; Opportunistic Infections/microbiology ; Sanitation ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Immunosuppressive Agents
Language	English
Publishing date	2018-04-25
Publishing country	Australia
Document type	Case Reports ; Letter
ZDB-ID	1303661-0
ISSN	1440-1797 ; 1320-5358
ISSN (online)	1440-1797
ISSN	1320-5358
DOI	10.1111/nep.13092
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Zs.A 4822: Show issues

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Article ; Online: Can immune biomarkers predict infections in solid organ transplant recipients? A review of current evidence.

Dendle, Claire / Mulley, William R / Holdsworth, Stephen

Transplantation reviews (Orlando, Fla.)

2018 Volume 33, Issue 2, Page(s) 87–98

Abstract: Despite improvements in graft survival, solid organ transplantation is still associated with considerable infection induced morbidity and mortality. If we were able to show that serious infection risk was associated with excessive suppression of immune ... ...

Abstract	Despite improvements in graft survival, solid organ transplantation is still associated with considerable infection induced morbidity and mortality. If we were able to show that serious infection risk was associated with excessive suppression of immune capacity, we would be justified in "personalizing" the extent of immunosuppression by carefully monitored reduction to see if we can improve immune compromize without increasing the risk of rejection. Reliable biomarkers are needed to identify this patients at an increased risk of infection. This review focuses on the currently available evidence in solid organ transplant recipients for immune non-pathogen specific biomarkers to predict severe infections with the susceptibility to particular pathogens according to the component of the immune system that is suppressed. This review is categorized into immune biomarkers representative of the humoral, cellular, phagocytic, natural killer cell and complement system. Biomarkers humoral and cellular systems of the that have demonstrated an association with infections include immunoglobulins, lymphocyte number, lymphocyte subsets, intracellular concentrations of adenosine triphosphate in stimulated CD4
MeSH term(s)	Adenosine Triphosphate/immunology ; Biomarkers/analysis ; CD4-Positive T-Lymphocytes/immunology ; Female ; Graft Rejection/immunology ; Humans ; Immunocompromised Host ; Infection/etiology ; Infection/immunology ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; Killer Cells, Natural/immunology ; Male ; Organ Transplantation/adverse effects ; Organ Transplantation/methods ; Organ Transplantation/mortality ; Postoperative Complications/epidemiology ; Postoperative Complications/microbiology ; Postoperative Complications/physiopathology ; Predictive Value of Tests ; Risk Assessment ; Survival Analysis ; Transplantation Immunology/physiology ; Treatment Outcome
Chemical Substances	Biomarkers ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2018-10-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639400-0
ISSN	1557-9816 ; 0955-470X
ISSN (online)	1557-9816
ISSN	0955-470X
DOI	10.1016/j.trre.2018.10.001
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