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  1. Article ; Online: Management of multiple myeloma during COVID-19 pandemic

    Jethava, YS / Fonseca, Rafael / Landgren, Ola

    Leukemia Research Reports

    2020  Volume 14, Page(s) 100212

    Keywords Oncology ; Hematology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2706248-X
    ISSN 2213-0489
    ISSN 2213-0489
    DOI 10.1016/j.lrr.2020.100212
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Management of multiple myeloma during COVID-19 pandemic

    YS Jethava / Rafael Fonseca / Ola Landgren

    Leukemia Research Reports, Vol 14, Iss , Pp 100212- (2020)

    2020  

    Abstract: At the end of 2019, a novel coronavirus was identified as the cause of pneumonia cases in Wuhan, a city in the Hubei Province of China. On January 30, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a public health emergency of ... ...

    Abstract At the end of 2019, a novel coronavirus was identified as the cause of pneumonia cases in Wuhan, a city in the Hubei Province of China. On January 30, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a public health emergency of international concern and, in March 2020, began to characterize it as a pandemic. The virus that causes COVID-19 is designated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) In February 2020, the World Health Organization designated the disease COVID-19, which stands for coronavirus disease 2019.
    Keywords Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; covid19
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Management of multiple myeloma during COVID-19 pandemic.

    Jethava, Y S / Fonseca, Rafael / Landgren, Ola

    Leukemia research reports

    2020  Volume 14, Page(s) 100212

    Abstract: At the end of 2019, a novel coronavirus was identified as the cause of pneumonia cases in Wuhan, a city in the Hubei Province of China. On January 30, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a public health emergency of ... ...

    Abstract At the end of 2019, a novel coronavirus was identified as the cause of pneumonia cases in Wuhan, a city in the Hubei Province of China. On January 30, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a public health emergency of international concern and, in March 2020, began to characterize it as a pandemic. The virus that causes COVID-19 is designated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) In February 2020, the World Health Organization designated the disease COVID-19, which stands for coronavirus disease 2019.
    Keywords covid19
    Language English
    Publishing date 2020-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2706248-X
    ISSN 2213-0489
    ISSN 2213-0489
    DOI 10.1016/j.lrr.2020.100212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Management of multiple myeloma during COVID-19 pandemic

    Jethava, Y. S. / Fonseca, Rafael / Landgren, Ola

    Leuk. Res. Rep.

    Abstract: At the end of 2019, a novel coronavirus was identified as the cause of pneumonia cases in Wuhan, a city in the Hubei Province of China. On January 30, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a public health emergency of ... ...

    Abstract At the end of 2019, a novel coronavirus was identified as the cause of pneumonia cases in Wuhan, a city in the Hubei Province of China. On January 30, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a public health emergency of international concern and, in March 2020, began to characterize it as a pandemic. The virus that causes COVID-19 is designated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) In February 2020, the World Health Organization designated the disease COVID-19, which stands for coronavirus disease 2019.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #597784
    Database COVID19

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  5. Article ; Online: Drug Combinations with Transplantation for Myeloma.

    Jethava, Yogesh S / Barlogie, Bart / Tricot, Guido J

    The New England journal of medicine

    2017  Volume 377, Issue 1, Page(s) 91–92

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols ; Drug Combinations ; Hematopoietic Stem Cell Transplantation ; Humans ; Multiple Myeloma ; Transplantation, Autologous
    Chemical Substances Drug Combinations
    Language English
    Publishing date 2017--06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1705671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Transplantation for Multiple Myeloma.

    Jethava, Yogesh S / van Rhee, Frits

    Cancer treatment and research

    2016  Volume 169, Page(s) 227–250

    Abstract: Multiple myeloma is a disorder characterized by accumulation of malignant plasma cells in the bone marrow, hypercalcemia, monoclonal protein, and end organ damage. Recently newer generation proteosome inhibitors, monoclonal antibodies and novel agents ... ...

    Abstract Multiple myeloma is a disorder characterized by accumulation of malignant plasma cells in the bone marrow, hypercalcemia, monoclonal protein, and end organ damage. Recently newer generation proteosome inhibitors, monoclonal antibodies and novel agents have been approved by FDA, which is undoubtedly increasing life expectancy of the patients. However, hematopoietic stem cell transplantation still remains the cornerstone of the treatment. In this chapter, we are discussing the autologous stem cell transplant, allogeneic stem cell transplant and total therapy trials with outcomes.
    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Humans ; Multiple Myeloma/therapy
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 0927-3042
    ISSN 0927-3042
    DOI 10.1007/978-3-319-40320-5_13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Bloodless tandem autologous transplant in Jehovah's Witness patients.

    Khan, Rafiullah / Mott, Sarah L / Schultz, Allyson / Jethava, Y S / Tricot, Guido

    Bone marrow transplantation

    2018  Volume 53, Issue 11, Page(s) 1428–1433

    Abstract: Tandem autologous transplants are generally the preferred therapy for newly diagnosed intermediate- and high-risk myeloma patients. More Jehovah's Witnesses (JW) are receiving single autologous peripheral blood stem cell transplants (PBSCTs). However, ... ...

    Abstract Tandem autologous transplants are generally the preferred therapy for newly diagnosed intermediate- and high-risk myeloma patients. More Jehovah's Witnesses (JW) are receiving single autologous peripheral blood stem cell transplants (PBSCTs). However, tandem autologous transplants have not been reported in JW patients. We performed a retrospective study of 54 patients, including four JW patients who received tandem autologous transplants between August 2000 and January 2017 and the last 50 consecutive tandem autologous transplants performed between August 2014 and August 2016. The bleeding complications, number, and cost of transfusions of blood products were compared. The median number of CD34 cells infused in non-JW patients was 8.16 million cells/kg versus 9.44 million cells/kg in JW patients. During the first 30 days, one JW experienced Grade III pulmonary hemorrhage, while none of the non-JW patients had a Grade III or higher bleeding problem. After tandem autologous transplants, complete remission was achieved in 88% of non-JW, compared with 75% in JW patients. In the first 30 days post-transplant, median platelet and packed red blood cell (PRBC) transfusions in non-JW patients was 2 (range: 0-40) and 1 (range: 0-11), respectively. Total cost of PRBC and platelet transfusions for the 50 non-JW was $214,664 (average $2147/transplant). Tandem autologous transplants can thus be performed safely without a single blood transfusion.
    MeSH term(s) Adult ; Aged ; Blood Transfusion/methods ; Female ; Humans ; Jehovah's Witnesses ; Male ; Middle Aged ; Retrospective Studies ; Transplantation, Autologous/methods
    Language English
    Publishing date 2018-05-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-018-0132-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2168: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: The impact of prior malignancies on second malignancies and survival in MM patients: a population-based study.

    Jonsdottir, Gudbjörg / Lund, Sigrún H / Björkholm, Magnus / Turesson, Ingemar / Hultcrantz, Malin / Porwit, Anna / Jethava, Yogesh S / Landgren, Ola / Kristinsson, Sigurdur Y

    Blood advances

    2017  Volume 1, Issue 25, Page(s) 2392–2398

    Abstract: In the present study, we aimed to evaluate 2 hypotheses. First, we hypothesize that prior malignancy is a proxy for genetic susceptibility that could be a risk factor for subsequent malignancy development in multiple myeloma (MM) patients. Second, we ... ...

    Abstract In the present study, we aimed to evaluate 2 hypotheses. First, we hypothesize that prior malignancy is a proxy for genetic susceptibility that could be a risk factor for subsequent malignancy development in multiple myeloma (MM) patients. Second, we hypothesize that survival after MM is influenced by a prior malignancy. All patients diagnosed with MM from 1 January 1973 to 31 December 2010 were identified from the Swedish Cancer Register. Cox regression model was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) where prior malignancy was compared in MM patients who developed a subsequent malignancy and MM patients who did not. In another Cox regression model, survival was compared in MM patients with and without a prior malignancy diagnosis. A total of 19 791 patients were diagnosed with MM. Patients with a prior malignancy diagnosis had a significantly increased risk of developing a subsequent malignancy compared with MM patients without (HR 1.42, 95% CI 1.23-1.65,
    Language English
    Publishing date 2017-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2876449-3
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2017007930
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  9. Article ; Online: Conditioning regimens for allogeneic hematopoietic stem cell transplants in acute myeloid leukemia.

    Jethava, Y S / Sica, S / Savani, B / Socola, F / Jagasia, M / Mohty, M / Nagler, A / Bacigalupo, A

    Bone marrow transplantation

    2017  Volume 52, Issue 11, Page(s) 1504–1511

    Abstract: AML is currently the first indication for allogeneic hematopoietic stem cell transplantation (allo-HSCT), as shown by international transplant registries. The conditioning regimens are classified as myeloablative conditioning, non-myeloablative or ... ...

    Abstract AML is currently the first indication for allogeneic hematopoietic stem cell transplantation (allo-HSCT), as shown by international transplant registries. The conditioning regimens are classified as myeloablative conditioning, non-myeloablative or reduced intensity conditioning. Targeted radioimmunotherapy such as anti-CD45 antibody have also been added to the conditioning regimen in an attempt to improve tumor cell kill. Refinement of standard regimens has led to a reduction of non-relapse mortality, also in the older age group over 60 or 70 years of age. Relapse post allo-HSCT remains an important issue, especially for patients who undergo transplant with residual or refractory disease. In these patients, pre- and post-transplant interventions need to be considered.
    MeSH term(s) Hematopoietic Stem Cell Transplantation/methods ; Humans ; Leukemia, Myeloid, Acute/therapy ; Transplantation Conditioning/methods ; Transplantation, Homologous
    Language English
    Publishing date 2017-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/bmt.2017.83
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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Adverse Metaphase Cytogenetics Can Be Overcome by Adding Bortezomib and Thalidomide to Fractionated Melphalan Transplants.

    Jethava, Yogesh S / Mitchell, Alan / Epstein, Joshua / Zangari, Maurizio / Yaccoby, Shmuel / Tian, Erming / Waheed, Sarah / Khan, Rashid / Papanikolaou, Xenofon / Grazziutti, Monica / Cottler-Fox, Michele / Petty, Nathan / Steward, Douglas / Panozzo, Susan / Bailey, Clyde / Hoering, Antje / Crowley, John / Sawyer, Jeffrey / Morgan, Gareth /
    Barlogie, Bart / van Rhee, Frits

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2017  Volume 23, Issue 11, Page(s) 2665–2672

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Bortezomib/administration & dosage ; Bortezomib/adverse effects ; Chromosome Aberrations/drug effects ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Male ; Melphalan/administration & dosage ; Melphalan/adverse effects ; Metaphase/drug effects ; Middle Aged ; Multiple Myeloma/drug therapy ; Multiple Myeloma/genetics ; Multiple Myeloma/pathology ; Neoplasm Proteins/genetics ; Prognosis ; Prospective Studies ; Thalidomide/administration & dosage ; Thalidomide/adverse effects
    Chemical Substances Neoplasm Proteins ; Thalidomide (4Z8R6ORS6L) ; Bortezomib (69G8BD63PP) ; Melphalan (Q41OR9510P)
    Language English
    Publishing date 2017-06-01
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-15-2620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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