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  1. Article ; Online: Allogeneic stem cell transplantation for high-risk acute leukemia and maintenance therapy: no time to waste.

    Scott, Bart L

    Blood advances

    2020  Volume 4, Issue 13, Page(s) 3200–3204

    Abstract: This article has a companion Counterpoint by Soiffer. ...

    Abstract This article has a companion Counterpoint by Soiffer.
    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia, Myeloid, Acute/therapy
    Language English
    Publishing date 2020-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2019000388
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    Zs.A 7153: Show issues Location:
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  2. Article ; Online: Existing agents, novel agents, or transplantation for high-risk MDS.

    Scott, Bart L

    Hematology. American Society of Hematology. Education Program

    2020  Volume 2020, Issue 1, Page(s) 411–417

    Abstract: The decision algorithm for treatment of advanced myelodysplastic syndrome (MDS) (intermediate- to very high-risk by the revised International Prognostic Scoring System [IPSS-R]) is complex. Often, the appropriate choice is unknown and not currently ... ...

    Abstract The decision algorithm for treatment of advanced myelodysplastic syndrome (MDS) (intermediate- to very high-risk by the revised International Prognostic Scoring System [IPSS-R]) is complex. Often, the appropriate choice is unknown and not currently addressed by available clinical evidence. Although allogeneic hematopoietic cell transplantation (alloHCT) is curative for some patients with MDS, there is a concurrent high risk of mortality and morbidity. Alternatively, although hypomethylating agents (HMAs) have low toxicity, they are not thought to be curative, with a median increase in overall survival of only 9 months. Initial attempts to improve outcomes with HMAs through addition of novel agents failed, but there is hope that newer combination strategies will improve outcomes. Challenging clinical questions include who should be considered for alloHCT, appropriate timing and preparation for alloHCT, and appropriate therapeutic choices for patients who are not candidates for alloHCT. Given the interplay between alloHCT and non-alloHCT approaches, a unified coordinated approach is optimal for patients with advanced MDS. When possible, patients with advanced MDS should be encouraged to enroll into clinical trials that include alloHCT and non-alloHCT approaches.
    MeSH term(s) Aged ; Antineoplastic Agents/therapeutic use ; Clinical Trials as Topic ; Disease Management ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Male ; Middle Aged ; Myelodysplastic Syndromes/etiology ; Myelodysplastic Syndromes/therapy ; Risk Factors ; Transplantation, Homologous/methods
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2020-12-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/hematology.2020000125
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  3. Article ; Online: It's Not All in the Conditioning or the Perils of Early Trial Cessation.

    Scott, Bart L

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2018  Volume 24, Issue 10, Page(s) 1957–1958

    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Propensity Score
    Language English
    Publishing date 2018-08-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2018.08.014
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  4. Article ; Online: Erratum

    Verstovsek, Srdan / Mesa, Ruben / Talpaz, Moshe / Kiladjian, Jean-Jacques / Harrison, Claire N / Oh, Stephen T / Vannucchi, Alessandro M / Rampal, Raajit / Scott, Bart L / Buckley, Sarah A / Craig, Adam R / Roman-Torres, Karisse / Mascarenhas, John O

    Haematologica

    2024  Volume 109, Issue 4, Page(s) 3010

    Language English
    Publishing date 2024-04-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.284815
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  5. Article ; Online: Allogeneic transplantation for myelofibrosis with adverse risk karyotype: Attack on the clones?

    Cooper, Jason P / Scott, Bart L

    American journal of hematology

    2018  Volume 93, Issue 5, Page(s) 603–604

    MeSH term(s) Humans ; Karyotype ; Karyotyping ; Primary Myelofibrosis ; Transplantation Conditioning ; Transplantation, Homologous
    Language English
    Publishing date 2018-03-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.25078
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  6. Article ; Online: Structure of an ancestral mammalian family 1B1 cytochrome P450 with increased thermostability.

    Bart, Aaron G / Harris, Kurt L / Gillam, Elizabeth M J / Scott, Emily E

    The Journal of biological chemistry

    2020  Volume 295, Issue 17, Page(s) 5640–5653

    Abstract: Mammalian cytochrome P450 enzymes often metabolize many pharmaceuticals and other xenobiotics, a feature that is valuable in a biotechnology setting. However, extant P450 enzymes are typically relatively unstable, ... ...

    Abstract Mammalian cytochrome P450 enzymes often metabolize many pharmaceuticals and other xenobiotics, a feature that is valuable in a biotechnology setting. However, extant P450 enzymes are typically relatively unstable, with
    MeSH term(s) Amino Acid Sequence ; Animals ; Benzoflavones/metabolism ; Crystallography, X-Ray ; Cytochrome P-450 CYP1B1/chemistry ; Cytochrome P-450 CYP1B1/metabolism ; Enzyme Stability ; Estradiol/metabolism ; Humans ; Models, Molecular ; Protein Binding ; Protein Conformation ; Temperature
    Chemical Substances Benzoflavones ; Estradiol (4TI98Z838E) ; alpha-naphthoflavone (604-59-1) ; CYP1B1 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP1B1 (EC 1.14.14.1)
    Language English
    Publishing date 2020-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.RA119.010727
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    Uc I Zs.108: Show issues Location:
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  7. Article ; Online: Bidirectional Comorbid Associations between Back Pain and Major Depression in US Adults

    Haiou Yang / Eric L. Hurwitz / Jian Li / Katie de Luca / Patricia Tavares / Bart Green / Scott Haldeman

    International Journal of Environmental Research and Public Health, Vol 20, Iss 4217, p

    2023  Volume 4217

    Abstract: Low back pain and depression have been globally recognized as key public health problems and they are considered co-morbid conditions. This study explores both cross-sectional and longitudinal comorbid associations between back pain and major depression ... ...

    Abstract Low back pain and depression have been globally recognized as key public health problems and they are considered co-morbid conditions. This study explores both cross-sectional and longitudinal comorbid associations between back pain and major depression in the adult population in the United States. We used data from the Midlife in the United States survey (MIDUS), linking MIDUS II and III with a sample size of 2358. Logistic regression and Poisson regression models were used. The cross-sectional analysis showed significant associations between back pain and major depression. The longitudinal analysis indicated that back pain at baseline was prospectively associated with major depression at follow-up (PR 1.96, CI: 1.41, 2.74), controlling for health behavioral and demographic variables. Major depression at baseline was also prospectively associated with back pain at follow-up (PR 1.48, CI: 1.04, 2.13), controlling for a set of related confounders. These findings of a bidirectional comorbid association fill a gap in the current understanding of these comorbid conditions and could have clinical implications for the management and prevention of both depression and low back pain.
    Keywords low back pain ; depression ; comorbidity ; Medicine ; R
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Spinal Pain, Chronic Health Conditions and Health Behaviors

    Katie de Luca / Patricia Tavares / Haiou Yang / Eric L. Hurwitz / Bart N. Green / Hannah Dale / Scott Haldeman

    International Journal of Environmental Research and Public Health, Vol 20, Iss 5369, p

    Data from the 2016–2018 National Health Interview Survey

    2023  Volume 5369

    Abstract: Spinal pain and chronic health conditions are highly prevalent, burdensome, and costly conditions, both in the United States and globally. Using cross-sectional data from the 2016 through 2018 National Health Interview Survey (n = 26,926), we explored ... ...

    Abstract Spinal pain and chronic health conditions are highly prevalent, burdensome, and costly conditions, both in the United States and globally. Using cross-sectional data from the 2016 through 2018 National Health Interview Survey (n = 26,926), we explored associations between spinal pain and chronic health conditions and investigated the influence that a set of confounders may have on the associations between spinal pain and chronic health conditions. Variance estimation method was used to compute weighted descriptive statistics and measures of associations with multinomial logistic regression models. All four chronic health conditions significantly increased the prevalence odds of spinal pain; cardiovascular conditions by 58%, hypertension by 40%, diabetes by 25% and obesity by 34%, controlling for all the confounders. For all chronic health conditions, tobacco use (45–50%), being insufficiently active (17–20%), sleep problems (180–184%), cognitive impairment (90–100%), and mental health conditions (68–80%) significantly increased the prevalence odds of spinal pain compared to cases without spinal pain. These findings provide evidence to support research on the prevention and treatment of non-musculoskeletal conditions with approaches of spinal pain management.
    Keywords back pain ; low back pain ; neck pain ; cardiovascular diseases ; hypertension ; diabetes mellitus ; Medicine ; R
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  9. Article ; Online: Relative prognostic value of flow cytometric measurable residual disease before allogeneic hematopoietic cell transplantation for adults with MDS/AML or AML.

    Orvain, Corentin / Ali, Naveed / Othus, Megan / Rodríguez-Arbolí, Eduardo / Milano, Filippo / Le, Calvin M / Sandmaier, Brenda M / Scott, Bart L / Appelbaum, Frederick R / Walter, Roland B

    American journal of hematology

    2024  Volume 99, Issue 5, Page(s) 862–870

    Abstract: Multiparameter flow cytometry (MFC) measurable residual disease (MRD) before allogeneic hematopoietic cell transplantation (HCT) independently predicts poor outcomes in acute myeloid leukemia (AML). Conversely, its prognostic value in the newly defined ... ...

    Abstract Multiparameter flow cytometry (MFC) measurable residual disease (MRD) before allogeneic hematopoietic cell transplantation (HCT) independently predicts poor outcomes in acute myeloid leukemia (AML). Conversely, its prognostic value in the newly defined disease entity, myelodysplastic neoplasm (MDS)/AML is unknown. To assess the relationship between disease type, pre-HCT MRD, and post-HCT outcomes, we retrospectively analyzed 1265 adults with MDS/AML (n = 151) or AML (n = 1114) who received a first allograft in first or second morphologic remission at a single institution between April 2006 and March 2023. At 3 years, relapse rates (29% for MDS/AML vs. 29% for AML, p = .98), relapse-free survival (RFS; 50% vs. 55%, p = .22), overall survival (OS; 52% vs. 60%, p = .073), and non-relapse mortality (22% vs. 16%, p = .14) were not statistically significantly different. However, a significant interaction was found between pre-HCT MFC MRD and disease type (MDS/AML vs. AML) for relapse (p = .009), RFS (p = .011), and OS (p = .039). The interaction models indicated that the hazard ratios (HRs) for the association between pre-HCT MRD and post-HCT outcomes were lower in patients with MDS/AML (for relapse: HR = 1.75 [0.97-3.15] in MDS/AML vs. 4.13 [3.31-5.16] in AML; for RFS: HR = 1.58 [1.02-2.45] vs. 2.98 [2.48-3.58]; for OS: HR = 1.50 [0.96-2.35] vs. 2.52 [2.09-3.06]). On the other hand, residual cytogenetic abnormalities at the time of HCT were equally informative in MDS/AML as in AML patients. Our data indicate that MFC-based pre-HCT MRD testing, but not testing for residual cytogenetic abnormalities, is less informative for MDS/AML than AML patients when used for prognostication of post-HCT outcomes.
    MeSH term(s) Adult ; Humans ; Prognosis ; Flow Cytometry ; Retrospective Studies ; Recurrence ; Chromosome Aberrations ; Hematopoietic Stem Cell Transplantation ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/therapy ; Neoplasm, Residual ; Chronic Disease
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27259
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  10. Article ; Online: Results from a phase I study of continuous infusion cladribine, high-dose cytarabine, and mitoxantrone for relapsed/refractory high-grade myeloid neoplasms.

    Kopmar, Noam E / Gooley, Ted / Curley, Niall / Russell, Kathryn / Shaw, Carole / Schonhoff, Kelda / Lim, John / Halpern, Anna B / Walter, Roland B / Scott, Bart L / Appelbaum, Jacob / Hendrie, Paul C / Estey, Elihu H / Percival, Mary-Elizabeth M

    Leukemia & lymphoma

    2023  Volume 64, Issue 5, Page(s) 1057–1059

    MeSH term(s) Humans ; Mitoxantrone ; Cladribine ; Cytarabine ; Neoplasm Recurrence, Local/drug therapy ; Leukemia, Myeloid, Acute/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
    Chemical Substances Mitoxantrone (BZ114NVM5P) ; Cladribine (47M74X9YT5) ; Cytarabine (04079A1RDZ)
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Clinical Trial, Phase I ; Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2023.2185087
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