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  1. Article ; Online: A change of paradigm in PBC: Pursuing normal alkaline phosphatase.

    Lleo, Ana

    EBioMedicine

    2022  Volume 82, Page(s) 104150

    MeSH term(s) Alkaline Phosphatase ; Humans ; Liver Cirrhosis, Biliary ; Ursodeoxycholic Acid
    Chemical Substances Ursodeoxycholic Acid (724L30Y2QR) ; Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2022-07-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2022.104150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The COSMIC-312 study: will it shape future combination therapies for advanced hepatocellular carcinoma?

    Saborowski, Anna / Lleo, Ana

    The lancet. Gastroenterology & hepatology

    2024  Volume 9, Issue 4, Page(s) 275–276

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Sorafenib ; Combined Modality Therapy
    Chemical Substances Sorafenib (9ZOQ3TZI87)
    Language English
    Publishing date 2024-02-13
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(24)00007-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A change of paradigm in PBC

    Ana Lleo

    EBioMedicine, Vol 82, Iss , Pp 104150- (2022)

    Pursuing normal alkaline phosphatase

    2022  

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Survival After Liver Transplantation for Autoimmune Hepatitis: Are We Messing With the Immune System?

    Lleo, Ana

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2020  Volume 26, Issue 7, Page(s) 861–862

    MeSH term(s) Hepatitis, Autoimmune/surgery ; Humans ; Immune System ; Liver Transplantation/adverse effects ; Registries
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.25782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4702: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Tumor-Infiltrating B Lymphocytes: Promising Immunotherapeutic Targets for Primary Liver Cancer Treatment.

    Milardi, Giulia / Lleo, Ana

    Cancers

    2023  Volume 15, Issue 7

    Abstract: Hepatocellular carcinoma and cholangiocarcinoma are the fourth most lethal primary cancers worldwide. Therefore, there is an urgent need for therapeutic strategies, including immune cell targeting therapies. The heterogeneity of liver cancer is partially ...

    Abstract Hepatocellular carcinoma and cholangiocarcinoma are the fourth most lethal primary cancers worldwide. Therefore, there is an urgent need for therapeutic strategies, including immune cell targeting therapies. The heterogeneity of liver cancer is partially explained by the characteristics of the tumor microenvironment (TME), where adaptive and innate immune system cells are the main components. Pioneering studies of primary liver cancers revealed that tumor-infiltrating immune cells and their dynamic interaction with cancer cells significantly impacted carcinogenesis, playing an important role in cancer immune evasion and responses to immunotherapy treatment. In particular, B cells may play a prominent role and have a controversial function in the TME. In this work, we highlight the effect of B lymphocytes as tumor infiltrates in relation to primary liver cancers and their potential prognostic value. We also present the key pathways underlying B-cell interactions within the TME, as well as the way that a comprehensive characterization of B-cell biology can be exploited to develop novel immune-based therapeutic approaches.
    Language English
    Publishing date 2023-04-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15072182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Immune checkpoint inhibitors in malignancies after liver transplantation: Better safe or sorry?

    Vogel, Arndt / Lleo, Ana

    Liver international : official journal of the International Association for the Study of the Liver

    2022  Volume 43, Issue 1, Page(s) 6–7

    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/adverse effects ; Liver Transplantation ; Carcinoma, Hepatocellular/drug therapy ; Liver Neoplasms/drug therapy ; Immunotherapy
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2022-12-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15474
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1632: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: PPAR agonists for the treatment of primary biliary cholangitis: Old and new tales.

    Colapietro, Francesca / Gershwin, M Eric / Lleo, Ana

    Journal of translational autoimmunity

    2023  Volume 6, Page(s) 100188

    Abstract: Introduction: Primary biliary cholangitis (PBC) is an autoimmune liver disease involving the small intrahepatic bile ducts; when untreated or undertreated, it may evolve to liver fibrosis and cirrhosis. Ursodeoxycholic Acid (UDCA) is the standard of ... ...

    Abstract Introduction: Primary biliary cholangitis (PBC) is an autoimmune liver disease involving the small intrahepatic bile ducts; when untreated or undertreated, it may evolve to liver fibrosis and cirrhosis. Ursodeoxycholic Acid (UDCA) is the standard of care treatment, Obeticholic Acid (OCA) has been approved as second-line therapy for those non responder or intolerant to UDCA. However, due to moderate rate of UDCA-non responders and to warnings recently issued against OCA use in patients with cirrhosis, further therapies are needed.Areas covered. Deep investigations into the pathogenesis of PBC is leading to proposal of new therapeutic agents, among which peroxisome proliferator-activated receptor (PPAR) ligands seem to be highly promising given the preliminary, positive results in Phase 2 and 3 trials. Bezafibrate, the most evaluated, is currently used in clinical practice in combination with UDCA in referral centers. We herein describe completed and ongoing trials involving PPAR agonists use in PBC, analyzing pits and falls.
    Expert opinion: Testing new therapeutic opportunities in PBC is challenging due to its low prevalence and slow progression. However, new drugs including PPAR agonists, are currently under investigation and should be considered for at-risk PBC patients.
    Language English
    Publishing date 2023-01-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2589-9090
    ISSN (online) 2589-9090
    DOI 10.1016/j.jtauto.2023.100188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Targeting the RANK/RANKL pathway in autoimmune disease and malignancy: future perspectives.

    Lleo, Ana / Gershwin, M Eric

    Expert review of clinical immunology

    2021  Volume 17, Issue 9, Page(s) 933–936

    MeSH term(s) Autoimmune Diseases ; Humans ; Neoplasms ; RANK Ligand/metabolism
    Chemical Substances RANK Ligand
    Language English
    Publishing date 2021-08-27
    Publishing country England
    Document type Editorial
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2021.1971972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6661: Show issues Location:
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  9. Article ; Online: Letter to the Editor: Are We Confident That Primary Biliary Cholangitis Liver-Related Mortality Is Higher in Males?

    Lleo, Ana / Hirschfield, Gideon M

    Hepatology (Baltimore, Md.)

    2021  Volume 74, Issue 4, Page(s) 2307

    MeSH term(s) Cholagogues and Choleretics/therapeutic use ; Humans ; Liver Cirrhosis, Biliary/drug therapy ; Male
    Chemical Substances Cholagogues and Choleretics
    Language English
    Publishing date 2021-06-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.31882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Diabetes and Familial Hypercholesterolemia: Interplay between Lipid and Glucose Metabolism.

    González-Lleó, Ana M / Sánchez-Hernández, Rosa María / Boronat, Mauro / Wägner, Ana M

    Nutrients

    2022  Volume 14, Issue 7

    Abstract: Familial hypercholesterolemia (FH) is a genetic disease characterized by high low-density lipoprotein (LDL) cholesterol (LDL-c) concentrations that increase cardiovascular risk and cause premature death. The most frequent cause of the disease is a ... ...

    Abstract Familial hypercholesterolemia (FH) is a genetic disease characterized by high low-density lipoprotein (LDL) cholesterol (LDL-c) concentrations that increase cardiovascular risk and cause premature death. The most frequent cause of the disease is a mutation in the LDL receptor (
    MeSH term(s) Cholesterol ; Diabetes Mellitus ; Glucose ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hyperlipoproteinemia Type II/complications ; Hyperlipoproteinemia Type II/genetics ; Phenotype ; Receptors, LDL/genetics
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Receptors, LDL ; Cholesterol (97C5T2UQ7J) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-04-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14071503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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