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Article ; Online: Effects of the essential oil of Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm. on healing and tissue repair after partial Achilles tenotomy in rats.

Santos-Júnior, Luciano / Oliveira, Tassia Virgínia de Carvalho / Cândido, Janaína Farias / Santana, Danielle Souza de / Pereira, Rose Nely / Pereyra, Beatriz Benny Sungaila / Gomes, Margarete Zanardo / Lima, Sônia Oliveira / Albuquerque-Júnior, Ricardo Luiz Cavalcanti de / Cândido, Edna Aragão Farias

Acta cirurgica brasileira

2017 Volume 32, Issue 6, Page(s) 449–458

Abstract: Purpose:: To investigate the cellular response to injury, analyzing histopathologic changes associated with increased cellularity, degeneration and disorganization of collagen fibers.: Methods:: Thirty wistar rats were divided in two groups after ... ...

Abstract	Purpose:: To investigate the cellular response to injury, analyzing histopathologic changes associated with increased cellularity, degeneration and disorganization of collagen fibers. Methods:: Thirty wistar rats were divided in two groups after partial Achilles tenotomy: the right hind paw were treated with the essential oil of Alpinia zerumbet (EOAz), diluted to 33% (0.3 mL kg-1), and the left hind paw received sunflower oil for 3, 14, 30 and 90 days. Statistical significance was determined using a Chi-square and Pearson Correlation qualitative variables test. Moreover, Mann-Whitney U-test test for comparison between different groups of the same cell, one-way ANOVA, and Tukey's test of quantitative measurement. Results:: A decrease hyperemia (p < 0.001) was observed in the acute phase of inflammatory cell number (p < 0.001), whereas sub-acute phase was marked by significant correlation with macrophages in fibroblasts (r = 0.17, p = 0.03), with probable induction a dense and modeled tissue. At chronic phase, it was found an increase in the number of fibroblasts and a higher percentage of type I collagen fibers (78%) compared with control collagen fibers (55%). Conclusion:: Oil of Alpinia zerumbet stimulated the process of maturation, organization and tissue repair which gave it greater resistance.
MeSH term(s)	Achilles Tendon/pathology ; Achilles Tendon/surgery ; Alpinia/chemistry ; Animals ; Collagen/drug effects ; Male ; Oils, Volatile/therapeutic use ; Rats ; Rats, Wistar ; Tenotomy ; Wound Healing/drug effects
Chemical Substances	Oils, Volatile ; Collagen (9007-34-5)
Language	English
Publishing date	2017-03-27
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2012156-8
ISSN	1678-2674 ; 1678-2674
ISSN (online)	1678-2674
ISSN	1678-2674
DOI	10.1590/s0102-865020170060000005
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Article ; Online: Impact of formulary-related pharmacy claim rejections of cariprazine on health care utilization and treatment patterns among patients with bipolar I disorder.

Laliberté, François / Zanardo, Enrico / MacKnight, Sean D / Urosevic, Ana / Wade, Sally W / Parikh, Mousam

Journal of managed care & specialty pharmacy

2024 Volume 30, Issue 2, Page(s) 118–128

Abstract: Background: Formulary restrictions, intended to limit inappropriate medication use and decrease pharmacy costs, may prevent or delay patients with bipolar I disorder from initiating cariprazine, a dopamine D: Objective: To evaluate the impact of ... ...

Abstract	Background: Formulary restrictions, intended to limit inappropriate medication use and decrease pharmacy costs, may prevent or delay patients with bipolar I disorder from initiating cariprazine, a dopamine D Objective: To evaluate the impact of formulary-related cariprazine claim rejections on health care resource utilization (HCRU) and treatment patterns among patients newly prescribed cariprazine for bipolar I disorder. Methods: Symphony Health Integrated Dataverse was used to identify commercially insured adults (aged ≥18 years) with bipolar I disorder and at least 1 pharmacy claim for cariprazine (rejected because of formulary restrictions or approved; date of the first claim is the index date) from March 2015 through October 2020. Formulary-related rejection reasons included noncoverage, prior authorization requirement, and step therapy requirement. Baseline characteristics were evaluated during the 12 months pre-index and balanced between rejected and approved cohorts using 1:2 propensity score matching. HCRU outcomes included all-cause and mental health (MH)-related hospitalizations, emergency department (ED) visits, and outpatient visits. Treatment patterns were analyzed descriptively and included treatment delay and atypical antipsychotic use. HCRU was reported per patient-year and compared between cohorts using rate ratios; 95% CIs and Results: The matched rejected and approved cohorts comprised 1,554 and 3,108 patients, respectively. The rejected cohort had 22% more all-cause and 24% more MH-related hospitalizations per patient-year vs the approved cohort (rate ratio [95% CI], all-cause: 1.22 [1.01-1.48], Conclusions: Patients with bipolar I disorder and formulary-related cariprazine claim rejections experienced significantly more hospitalizations than patients whose initial claim was approved; ED and outpatient visits were similar between cohorts. Less than a quarter of patients whose initial claim was rejected later received cariprazine, and more than one-third never received any atypical antipsychotic. To our knowledge, this is the first study to evaluate the impact of formulary-related rejections of cariprazine on HCRU and treatment patterns in patients with bipolar I disorder.
MeSH term(s)	Adult ; Humans ; Adolescent ; Bipolar Disorder/drug therapy ; Antipsychotic Agents/adverse effects ; Patient Acceptance of Health Care ; Pharmacy ; Retrospective Studies ; Piperazines
Chemical Substances	Antipsychotic Agents ; cariprazine (F6RJL8B278) ; Piperazines
Language	English
Publishing date	2024-02-03
Publishing country	United States
Document type	Journal Article
ISSN	2376-1032
ISSN (online)	2376-1032
DOI	10.18553/jmcp.2024.30.2.118
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Article ; Online: The environmental impact of energy consumption and carbon emissions in radiology departments: a systematic review.

Roletto, Andrea / Zanardo, Moreno / Bonfitto, Giuseppe Roberto / Catania, Diego / Sardanelli, Francesco / Zanoni, Simone

European radiology experimental

2024 Volume 8, Issue 1, Page(s) 35

Abstract: Objectives: Energy consumption and carbon emissions from medical equipment like CT/MRI scanners and workstations contribute to the environmental impact of healthcare facilities. The aim of this systematic review was to identify all strategies to reduce ... ...

Abstract	Objectives: Energy consumption and carbon emissions from medical equipment like CT/MRI scanners and workstations contribute to the environmental impact of healthcare facilities. The aim of this systematic review was to identify all strategies to reduce energy use and carbon emissions in radiology. Methods: In June 2023, a systematic review (Medline/Embase/Web of Science) was performed to search original articles on environmental sustainability in radiology. The extracted data include environmental sustainability topics (e.g., energy consumption, carbon footprint) and radiological devices involved. Sustainable actions and environmental impact in radiology settings were analyzed. Study quality was assessed using the QualSyst tool. Results: From 918 retrieved articles, 16 met the inclusion criteria. Among them, main topics were energy consumption (10/16, 62.5%), life-cycle assessment (4/16, 25.0%), and carbon footprint (2/16, 12.5%). Eleven studies reported that 40-91% of the energy consumed by radiological devices can be defined as "nonproductive" (devices "on" but not working). Turning-off devices during idle periods 9/16 (56.2%) and implementing workflow informatic tools (2/16, 12.5%) were the sustainable actions identified. Energy-saving strategies were reported in 8/16 articles (50%), estimating annual savings of thousand kilowatt-hours (14,180-171,000 kWh). Cost-savings were identified in 7/16 (43.7%) articles, ranging from US $9,225 to 14,328 per device. Study quality was over or equal the 80% of high-quality level in 14/16 (87.5%) articles. Conclusion: Energy consumption and environmental sustainability in radiology received attention in literature. Sustainable actions include turning-off radiological devices during idle periods, favoring the most energy-efficient imaging devices, and educating radiological staff on energy-saving practices, without compromising service quality. Relevance statement: A non-negligible number of articles - mainly coming from North America and Europe - highlighted the need for energy-saving strategies, attention to equipment life-cycle assessment, and carbon footprint reduction in radiology, with a potential for cost-saving outcome. Key points: • Energy consumption and environmental sustainability in radiology received attention in the literature (16 articles published from 2010 to 2023). • A substantial portion (40-91%) of the energy consumed by radiological devices was classified as "non-productive" (devices "on" but not working). • Sustainable action such as shutting down devices during idle periods was identified, with potential annual energy savings ranging from 14,180 to 171,000 kWh.
MeSH term(s)	Humans ; Carbon Footprint ; Radiology ; Tomography Scanners, X-Ray Computed ; Magnetic Resonance Imaging ; Europe
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ISSN	2509-9280
ISSN (online)	2509-9280
DOI	10.1186/s41747-024-00424-6
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Article ; Online: Reply to Letter to Editor: Abdominal CT: a radiologist-driven adjustment of the dose of iodinated contrast agent approaches a calculation per lean body weight.

Zanardo, Moreno / Di Leo, Giovanni

European radiology experimental

2020 Volume 4, Issue 1, Page(s) 46

Language	English
Publishing date	2020-09-22
Publishing country	England
Document type	Letter ; Comment
ISSN	2509-9280
ISSN (online)	2509-9280
DOI	10.1186/s41747-020-00179-w
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Article ; Online: Ultrasonic Pocket Doppler, novel technology for fetal and neonatal heart rate assessment.

Zanardo, Vincenzo / Parotto, Matteo

Resuscitation

2019 Volume 145, Page(s) 91–92

MeSH term(s)	Female ; Heart Rate ; Humans ; Infant, Newborn ; Pregnancy ; Prenatal Care ; Ultrasonics ; Ultrasonography ; Ultrasonography, Doppler
Language	English
Publishing date	2019-11-06
Publishing country	Ireland
Document type	Letter ; Comment
ZDB-ID	189901-6
ISSN	1873-1570 ; 0300-9572
ISSN (online)	1873-1570
ISSN	0300-9572
DOI	10.1016/j.resuscitation.2019.09.037
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Zs.A 1048: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Treatment Patterns, Healthcare Resource Utilization, and Costs of Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma in the US.

Yang, Xiaoqin / Zanardo, Enrico / Lejeune, Dominique / De Nigris, Enrico / Sarpong, Eric / Farooqui, Mohammed / Laliberté, François

The oncologist

2024 Volume 29, Issue 3, Page(s) e360–e371

Abstract: Background: Chronic lymphocytic leukemia (CLL) is the most common type of leukemia among US adults and has experienced a rapidly evolving treatment landscape; yet current data on treatment patterns in clinical practice and economic burden are limited. ... ...

Abstract	Background: Chronic lymphocytic leukemia (CLL) is the most common type of leukemia among US adults and has experienced a rapidly evolving treatment landscape; yet current data on treatment patterns in clinical practice and economic burden are limited. This study aimed to provide an up-to-date description of real-world characteristics, treatments, and costs of patients with CLL or small lymphocytic lymphoma (SLL). Materials and methods: Using retrospective data from the Optum Clinformatics DataMart database (January 2013 to December 2021), adults with diagnosis codes for CLL/SLL on two different dates were selected. An adapted algorithm identified lines of therapy (LOT). Treatment patterns were stratified by the index year pre- and post-2018. Healthcare resource utilization and costs were evaluated per patient-years. Results: A total of 18 418 patients with CLL/SLL were identified, 5226 patients (28%) were treated with ≥1 LOT and 1728 (9%) with ≥2 LOT. Among patients diagnosed with CLL in 2014-2017 and ≥1 LOT (N = 2585), 42% used targeted therapy and 30% used chemoimmunotherapy in first line (1L). The corresponding proportions of patients diagnosed with CLL in 2018-2021 (N = 2641) were 54% and 16%, respectively. Total costs were numerically 3.5 times higher and 4.9 times higher compared with baseline costs among patients treated with 1L+ and 3L+, respectively. Conclusion: This study documented the real-world change in CLL treatment landscape and the substantial economic burden of patients with CLL/SLL. Specifically, targeted therapies were increasingly used as 1L treatments and they were part of more than half of 1L regimens in recent years (2018-2021).
MeSH term(s)	Adult ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology ; Leukemia, Lymphocytic, Chronic, B-Cell/therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Retrospective Studies ; Delivery of Health Care
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1409038-7
ISSN	1549-490X ; 1083-7159
ISSN (online)	1549-490X
ISSN	1083-7159
DOI	10.1093/oncolo/oyad324
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Zs.A 4845: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 494: Show issues

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Article: Dual Energy X-ray Absorptiometry: Radiographer'S Role in Assessing Fracture Risk Assessment Tool (FRAX) Questionnaire Variables.

Zanardo, Moreno / Mennini, Cinzia / Glielmo, Pierluigi / Fusco, Stefano / Albano, Domenico / Messina, Carmelo

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

2023 Volume 27, Issue 1, Page(s) 101458

Abstract: Background: The FRAX® algorithm is a tool used to calculate the 10-year probability of fracture in patients with osteoporosis and is based the assessment of several risk factors. We assessed the performance and accuracy of the completion of the FRAX® ... ...

Abstract	Background: The FRAX® algorithm is a tool used to calculate the 10-year probability of fracture in patients with osteoporosis and is based the assessment of several risk factors. We assessed the performance and accuracy of the completion of the FRAX® anamnestic questionnaire by the radiographer without impact on the clinical workflow. Methodology: We evaluated the accuracy of fracture risk calculation by the radiographer using the FRAX® algorithm before and after specific training. A total of 100 women were enrolled in the study. The radiographer preliminarily administered the FRAX® questionnaire to all subjects before the execution of the DXA examination. After the end of the examination, a radiologist administered the questionnaire to the patient. Women were divided into two groups: group A (pre-training) and group B (post-training). The radiographer in group A completed the FRAX® questionnaire for the patients before training. For group B, the same radiographer completed the FRAX® questionnaire after training. The results of the FRAX® questionnaire completed by radiographer were compared with that completed by the referring physician. Results: Before training, radiographer's accuracy ranged from 92% (question 7, alcohol consumption) to 36% (question 6, secondary osteoporosis). After training, accuracy values improved substantially, ranging from 100% to 92%. Analysis of the absolute values of FRAX® showed that in the pre-training group data tended to be overestimated by the radiographer, with both major and fractures probabilities being significantly higher when assessed by the radiographer (12% and 5.8%, respectively). After the training, there was a marked decrease in the variation between the FRAX® data calculated by the radiographer and the radiologist. Conclusions: The accuracy of fracture risk calculation by the radiographer using the FRAX® algorithm is significantly improved after a specific training period. This study demonstrates the importance of dedicated training radiographers on the FRAX® algorithm.
MeSH term(s)	Humans ; Female ; Absorptiometry, Photon ; Bone Density ; Risk Assessment/methods ; Osteoporosis/complications ; Fractures, Bone ; Risk Factors ; Surveys and Questionnaires ; Osteoporotic Fractures/diagnostic imaging ; Osteoporotic Fractures/etiology
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2040951-5
ISSN	1094-6950
ISSN	1094-6950
DOI	10.1016/j.jocd.2023.101458
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Zs.A 5425: Show issues

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Article ; Online: An investigation into academic career pathways across Radiography education centres internationally.

Zanardo, M / Rainford, L / McGee, A / Dowley, A / McNulty, J P / Buissink, C / O'Connor, M

Radiography (London, England : 1995)

2023 Volume 29, Issue 6, Page(s) 992–999

Abstract: Introduction: Robust academic pathways are critical to support of radiography faculty within third level education. As the profession of Radiography grows its' research activity, it is important that academic opportunities meet the needs of the ... ...

Abstract	Introduction: Robust academic pathways are critical to support of radiography faculty within third level education. As the profession of Radiography grows its' research activity, it is important that academic opportunities meet the needs of the profession. The purpose of this research was to investigate current academic career pathways across radiography education centres internationally. Methods: An online survey was developed and administered to radiography academics and clinical/academic staff members internationally. The survey questions (n = 28) include demographic data; teaching and research requirements; academic promotion criteria; identification of the challenges and benefits of being an academic, including equality, diversity and inclusion (EDI) matters. Results: A total of 175 responses were obtained (6 continents and 39 countries), with a variety of experience levels amongst academics that primarily held permanent work contracts. Regarding the highest qualifications held, 31.4% (n = 55) had a Doctorate and 45.7% (n = 80) a Master's degree, and most respondents were employed as academic lecturers (40.6%; n = 71), with 17.7% (n = 31) employed at professorial level. The minimum time requirement to achieve a permanent contract was variable, ranging from no delay (5.7%; n = 10) to more than 10 years (12.6%; n = 22). Doctorate qualification is currently not necessary in order to career progression for 126 (72%) respondents, while 52% (n = 91) provided specific research requirements. 106 (60.6%) respondents indicated that their institution has EDI policy. Conclusion: This study has captured details related to academic pathways across international radiography education centres. Whilst some heterogeneity exists, there are numerous differences impacting standardised academic career opportunities for Radiography academics. These may challenge academic career opportunities and discourage those interested in an academic career. Implications for practice: The profile and educational background of these academics has been highlighted as well as the perceived barriers and advantages of a career in academic.
MeSH term(s)	Humans ; Career Choice ; Educational Status ; Surveys and Questionnaires ; Radiography
Language	English
Publishing date	2023-08-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1289102-2
ISSN	1532-2831 ; 1078-8174
ISSN (online)	1532-2831
ISSN	1078-8174
DOI	10.1016/j.radi.2023.07.010
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Zs.A 4438: Show issues

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Article ; Online: Bringing radiology to patient's home using mobile equipment: A weapon to fight COVID-19 pandemic.

Zanardo, Moreno / Schiaffino, Simone / Sardanelli, Francesco

Clinical imaging

2020 Volume 68, Page(s) 99–101

Abstract: Because of coronavirus disease 2019 (COVID-19) high contagiousness, it is crucial to identify and promptly isolate COVID-19 patients. In this context, chest imaging examinations, in particular chest x-ray (CXR), can play a pivotal role in different ... ...

Abstract	Because of coronavirus disease 2019 (COVID-19) high contagiousness, it is crucial to identify and promptly isolate COVID-19 patients. In this context, chest imaging examinations, in particular chest x-ray (CXR), can play a pivotal role in different settings, to triage in case of unavailability, delay of or first negative result of reverse transcriptase-polymerase chain reaction (RT-PCR), and to stratify disease severity. Considering the need to reduce, as much as possible, hospital admission of patients with suspected or confirmed infection, the use of mobile x-ray equipment could represent a safe approach. We picture a potential sequence of events, involving a team composed by a radiographer and a nurse, going to patient's home to perform CXR, nasopharyngeal swab (and, if needed, also a blood sample), with fast radiologist tele-reporting, and resulting patient management approach (home isolation or emergency room admission, when needed). This approach brings healthcare to patient's home, reducing the risk of infected subjects referring to family doctors' office or emergency departments, and strengthening community medicine while maintaining a strong connection with radiology departments.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; House Calls ; Humans ; Pandemics ; Pneumonia, Viral ; Radiography, Thoracic/methods ; SARS-CoV-2 ; Telemedicine
Keywords	covid19
Language	English
Publishing date	2020-06-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2020.06.031
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Zs.A 1469: Show issues

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Article ; Online: Contrast-enhanced Mammography: A Systematic Review and Meta-Analysis of Diagnostic Performance.

Cozzi, Andrea / Magni, Veronica / Zanardo, Moreno / Schiaffino, Simone / Sardanelli, Francesco

Radiology

2021 Volume 302, Issue 3, Page(s) 568–581

Abstract: Background Contrast-enhanced mammography (CEM) is a promising technique for breast cancer detection, but conflicting results have been reported in previous meta-analyses. Purpose To perform a systematic review and meta-analysis of CEM diagnostic ... ...

Abstract	Background Contrast-enhanced mammography (CEM) is a promising technique for breast cancer detection, but conflicting results have been reported in previous meta-analyses. Purpose To perform a systematic review and meta-analysis of CEM diagnostic performance considering different interpretation methods and clinical settings. Materials and Methods The MEDLINE, EMBASE, Web of Science, and Cochrane Library databases were systematically searched up to July 15, 2021. Prospective and retrospective studies evaluating CEM diagnostic performance with histopathology and/or follow-up as the reference standard were included. Study quality was assessed with the Quality Assessment of Diagnostic Accuracy Studies 2 tool. Summary diagnostic odds ratio and area under the receiver operating characteristic curve were estimated with the hierarchical summary receiver operating characteristic (HSROC) model. Summary estimates of sensitivity and specificity were obtained with the hierarchical bivariate model, pooling studies with the same image interpretation approach or focused on the same findings. Heterogeneity was investigated through meta-regression and subgroup analysis. Results Sixty studies (67 study parts, 11 049 CEM examinations in 10 605 patients) were included. The overall area under the HSROC curve was 0.94 (95% CI: 0.91, 0.96). Pooled diagnostic odds ratio was 55.7 (95% CI: 42.7, 72.7) with high heterogeneity (τ
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Contrast Media ; Female ; Humans ; Mammography/methods
Chemical Substances	Contrast Media
Language	English
Publishing date	2021-12-14
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.211412
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