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Article: Sedation/Analgesia Administration Practice Varies according to Endoscopy Facility (Hospital- or Office-Based) Setting: Results from a Nationwide Survey in Greece.

Tziatzios, Georgios / Samonakis, Dimitrios N / Tsionis, Theocharis / Goulas, Spyridon / Christodoulou, Dimitrios / Triantafyllou, Konstantinos

Gastroenterology research and practice

2020 Volume 2020, Page(s) 8701791

Abstract: Objectives: To examine the impact of endoscopy setting (hospital-based vs. office-based) on sedation/analgesia administration and to provide nationwide data on monitoring practices among Greek gastroenterologists in real-world settings. : Results: ... ...

Abstract	Objectives: To examine the impact of endoscopy setting (hospital-based vs. office-based) on sedation/analgesia administration and to provide nationwide data on monitoring practices among Greek gastroenterologists in real-world settings. Results: 211 individuals responded (response rate: 40.3%). Propofol use was significantly higher in the private hospital compared to the public hospital and the office-based setting for esophagogastroduodenoscopy (EGD) (85.8% vs. 19.5% vs. 10.5%, Conclusion: The private hospital-based setting is associated with higher propofol sedation administration both for EGD and for colonoscopy. Greek endoscopists are adequately trained in airway management techniques.
Language	English
Publishing date	2020-10-05
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2435460-0
ISSN	1687-630X ; 1687-6121
ISSN (online)	1687-630X
ISSN	1687-6121
DOI	10.1155/2020/8701791
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Article: Transcatheter arterial chemoembolization combined with radiofrequency or microwave ablation for hepatocellular carcinoma: a review.

Galanakis, Nikolaos / Kehagias, Elias / Matthaiou, Nikolas / Samonakis, Dimitrios / Tsetis, Dimitrios

Hepatic oncology

2018 Volume 5, Issue 2, Page(s) HEP07

Abstract: Hepatocellular carcinoma (HCC) is the sixth most common type of malignancy. Several therapies are available for HCC and are determined by stage of presentation, patient clinical status and liver function. Local-regional treatment options, including ... ...

Abstract	Hepatocellular carcinoma (HCC) is the sixth most common type of malignancy. Several therapies are available for HCC and are determined by stage of presentation, patient clinical status and liver function. Local-regional treatment options, including transcatheter arterial chemoembolization, radiofrequency ablation or microwave ablation, are safe and effective for HCC but are accompanied by limitations. The synergistic effects of combined transcatheter arterial chemoembolization and radiofrequency ablation/microwave ablation may overcome these limitations and improve the therapeutic outcome. The purpose of this article is to review the current literature on these combined therapies and examine their efficacy, safety and influence on the overall and recurrence-free survival in patients with HCC.
Language	English
Publishing date	2018-09-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2756098-3
ISSN	2045-0931 ; 2045-0923
ISSN (online)	2045-0931
ISSN	2045-0923
DOI	10.2217/hep-2018-0001
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Article ; Online: Liver Transplantation for Familial Amyloid Polyneuropathy (Val30Met): Long-Term Follow-up Prospective Study in a Nontransplant Center.

Kavousanaki, M / Tzagournissakis, Μ / Zaganas, I / Stylianou, K G / Patrianakos, A P / Tsilimbaris, M K / Mantaka, A / Samonakis, D N

Transplantation proceedings

2019 Volume 51, Issue 2, Page(s) 429–432

Abstract: Background: Familial amyloidosis polyneuropathy (FAP) is a rare, progressive, and life-threatening disease inherited in the autosomal dominant pattern. Liver transplantation is the only proven disease-modifying treatment to date.: Aim: To study the ... ...

Abstract	Background: Familial amyloidosis polyneuropathy (FAP) is a rare, progressive, and life-threatening disease inherited in the autosomal dominant pattern. Liver transplantation is the only proven disease-modifying treatment to date. Aim: To study the long-term outcomes of patients transplanted for FAP under a multidisciplinary team care. Methods: We included adult patients who were transplanted for FAP indication and were followed up in a relevant clinic or admitted in our department. Results: Twelve patients (6 male) with a mean age of 43 years and mean follow-up post-transplant of 100 months were included. Three patients died in this period, 1 due to a disease-related cause. All patients had peripheral neuropathy (25% severe). Eighty-three percent had autonomic nervous system dysfunction; all men, except one, erectile dysfunction; and half of the patients several genitourinary manifestations. Gastrointestinal involvement was present in 75% of the patients. The severity of several complications related to FAP was found to be associated with waiting on the transplant list for more than 12 months. Conclusions: Patients transplanted for FAP have a long survival. Prolonged stay on the transplant waiting list is associated with frequency and severity of disease complications. These patients are best managed in the context of multidisciplinary team care.
MeSH term(s)	Adult ; Aged ; Amyloid Neuropathies, Familial/surgery ; Female ; Follow-Up Studies ; Humans ; Liver Transplantation/methods ; Male ; Middle Aged ; Prospective Studies ; Treatment Outcome
Language	English
Publishing date	2019-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2019.01.071
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Article: Ultrasound-guided direct intrahepatic portosystemic shunt in patients with Budd-Chiari syndrome: Short- and long-term results.

Hatzidakis, Adam / Galanakis, Nikolaos / Kehagias, Elias / Samonakis, Dimitrios / Koulentaki, Mairi / Matrella, Erminia / Tsetis, Dimitrios

Interventional medicine & applied science

2017 Volume 9, Issue 2, Page(s) 86–93

Abstract: Background and aims: Budd-Chiari syndrome (BCS) is treated with anticoagulation therapy, transjugular intrahepatic portosystemic shunt (TIPS), angioplasty, and liver transplantation. TIPS is not always technically feasible, due to the complete hepatic ... ...

Abstract	Background and aims: Budd-Chiari syndrome (BCS) is treated with anticoagulation therapy, transjugular intrahepatic portosystemic shunt (TIPS), angioplasty, and liver transplantation. TIPS is not always technically feasible, due to the complete hepatic venous thrombosis. Direct intrahepatic portosystemic shunt (DIPS) is an alternative method for decompression of portal hypertension. This is a retrospective, single-center study aiming to evaluate the outcome of ultrasound (US)-guided DIPS in patients with BCS. Materials and methods: Between 2003 and 2016, six patients with BCS were treated with US-guided DIPS. Polytetrafluoroethylene (PTFE)-covered stents were used in two patients and bare-metal stents in four patients. Mean follow-up time was 71.4 months (range: 21-164). Technical/clinical success, technical difficulties, and complications of DIPS were analyzed. Results: Technical success without complications was achieved in all patients (100%). In one patient, DIPS was performed through the right femoral vein, without significant amelioration of portal hypertension (clinical success 83.3%). In four out of five patients, ascites and variceal bleeding resolved completely and in the other one ascites was relieved. Six- and 12-month primary patency rates were 100% in PTFE-covered stent group when compared with bare-metal stent group, the rates were 33% and 0%, respectively. Conclusion: US-guided DIPS is a safe and effective alternative technique for patients with BCS, with significant clinical improvement.
Keywords	covid19
Language	English
Publishing date	2017-08-30
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	2573851-3
ISSN	2061-5094 ; 2061-1617
ISSN (online)	2061-5094
ISSN	2061-1617
DOI	10.1556/1646.9.2017.2.14
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Article: Endotoxin Translocation and Gut Barrier Dysfunction Are Related to Variceal Bleeding in Patients With Liver Cirrhosis.

Triantos, Christos / Kalafateli, Maria / Assimakopoulos, Stelios F / Karaivazoglou, Katerina / Mantaka, Aikaterini / Aggeletopoulou, Ioanna / Spantidea, Panagiota I / Tsiaoussis, Georgios / Rodi, Maria / Kranidioti, Hariklia / Goukos, Dimitrios / Manolakopoulos, Spilios / Gogos, Charalambos / Samonakis, Dimitrios N / Daikos, Georgios L / Mouzaki, Athanasia / Thomopoulos, Konstantinos

Frontiers in medicine

2022 Volume 9, Page(s) 836306

Abstract: Background: Bacterial infections are associated with the risk of variceal bleeding through complex pathophysiologic pathways.: Objectives: The primary objective of the present case-control study was to investigate the role of bacterial translocation ... ...

Abstract	Background: Bacterial infections are associated with the risk of variceal bleeding through complex pathophysiologic pathways. Objectives: The primary objective of the present case-control study was to investigate the role of bacterial translocation and intestinal barrier dysfunction in the pathogenesis of variceal bleeding. A secondary objective was to determine independent predictors of key outcomes in variceal bleeding, including bleeding-related mortality. Methods: Eighty-four ( Results: Child-Pugh (CP) score (OR: 1.868; Conclusions: Bacterial translocation and gut barrier impairment are directly related to the risk of variceal bleeding. Microbiota-modulating interventions and anti-endotoxin agents may be promising strategies to prevent variceal bleeding.
Language	English
Publishing date	2022-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.836306
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Article ; Online: HERACLIS-TAF: a multi-centre prospective cohort study on 2-year safety and efficacy of tenofovir alafenamide in patients with chronic hepatitis B with renal and/or bone disorders or risks.

Papatheodoridis, George V / Mimidis, Kostas / Manolakopoulos, Spilios / Gatselis, Nikolaos / Goulis, John / Kapatais, Andreas / Manesis, Emanuel / Vasiliadis, Themistoklis / Triantos, Christos / Samonakis, Dimitrios / Sevastianos, Vasilios / Karatapanis, Stelios / Elefsiniotis, Ioannis / Deutsch, Melanie / Mylopoulou, Theodora / Papatheodoridi, Margarita / Kranidioti, Hariklia / Agorastou, Polyxeni / Karaoulani, Theofani /

Kyriazidou, Anastasia / Zisimopoulos, Konstantinos / Dalekos, George N

Alimentary pharmacology & therapeutics

2022 Volume 56, Issue 4, Page(s) 702–712

Abstract: ... were prospectively included. Main exclusion criteria were hepatitis D, active malignancy and ...

Abstract	Background: Tenofovir alafenamide (TAF) has exhibited a favourable safety profile on estimated glomerular filtration (eGFR) and bone mineral density (BMD), but has not been extensively studied in patients with renal impairment and/or BMD disorders. Aims: To assess predictors of eGFR changes and other safety and efficacy outcomes during 24-month TAF therapy in patients with chronic hepatitis B with renal and/or BMD disorders/risks. Methods: Adult patients who started TAF at 13 clinics throughout Greece were prospectively included. Main exclusion criteria were hepatitis D, active malignancy and bisphosphonates recent use. MDRD formula was used for eGFR estimation. Results: TAF was initiated in 176 patients (91% switched from another agent). At 12 and 24 months, HBV DNA was undetectable in 97% and 100%, and ALT was normal in 96% and 95% of patients. Median ALT decreased from baseline to month 12/24 (p < 0.001). Mean eGFR decreased from previous treatment initiation to baseline (p < 0.001), increased at 12 months and remained stable at 24 months (p ≤ 0.001). An increase in eGFR of >3 ml/min at 12 month was observed in 50% of patients and was associated mainly with baseline eGFR 30-60 ml/min. In patients with baseline phosphate <2.5 mg/dl, mean serum phosphate increased at month-12/24 (p < 0.001). Median BMD did not change significantly from baseline to 12 months but improved at 24 months (p = 0.001). Conclusions: In mostly switched patients with renal and/or BMD disorders/risks, eGFR improved after 12-24 months of TAF treatment, especially in patients with baseline eGFR 30-60 ml/min. TAF may also improve low serum phosphate, BMD and ALT, whereas it maintains or induces virological suppression.
MeSH term(s)	Adenine/adverse effects ; Adult ; Alanine/adverse effects ; HIV Infections ; Hepatitis B, Chronic/drug therapy ; Humans ; Phosphates ; Prospective Studies ; Tenofovir/adverse effects ; Tenofovir/analogs & derivatives
Chemical Substances	Phosphates ; Tenofovir (99YXE507IL) ; tenofovir alafenamide (EL9943AG5J) ; Adenine (JAC85A2161) ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2022-06-23
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17093
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Zs.A 2206: Show issues

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Article: Spontaneous bacterial peritonitis: a prospective Greek multicenter study of its epidemiology, microbiology, and outcomes.

Samonakis, Dimitrios N / Gatselis, Nikolaos / Bellou, Aristea / Sifaki-Pistolla, Dimitra / Mela, Maria / Demetriou, George / Thalassinos, Evangelos / Rigopoulou, Eirini I / Kevrekidou, Polyxeni / Tziortziotis, Ioannis / Azariadi, Kalliopi / Kavousanaki, Melina / Digenakis, Emmanuel / Vassiliadis, Themistoklis / Kouroumalis, Elias A / Dalekos, George N

Annals of gastroenterology

2021 Volume 35, Issue 1, Page(s) 80–87

Abstract: Background: Spontaneous bacterial peritonitis (SBP) is an ominous complication of decompensated cirrhosis. This study aimed to assess several epidemiological, clinical, microbiological and outcome characteristics in Greek patients with SBP, as no solid ... ...

Abstract	Background: Spontaneous bacterial peritonitis (SBP) is an ominous complication of decompensated cirrhosis. This study aimed to assess several epidemiological, clinical, microbiological and outcome characteristics in Greek patients with SBP, as no solid representative nationwide data of this type was available. Methods: During a 3-year period, 77 consecutive patients with SBP (61 male; median age: 67 years; model for end-stage liver disease [MELD] score: 20), diagnosed and followed in 5 tertiary liver units, were prospectively recruited and studied. Various prognostic factors for disease outcome were studied. Results: Thirty-eight patients had alcohol-related cirrhosis, 17 viral hepatitis, 6 non-alcoholic steatohepatitis, 6 autoimmune liver diseases, and 10 cryptogenic cirrhosis. Hepatocellular carcinoma (HCC) was present in 23 (29.9%), whereas 10 (13%) had portal vein thrombosis. The first SBP episode at baseline was community-acquired in 53 (68.8%), while in 24 (31.1%) was hospital-acquired, with predominant symptoms abdominal pain and encephalopathy. A positive ascitic culture was documented in 36% of patients in the initial episode, with almost equal gram (+) and gram (-) pathogens, including 3 multidrug-resistant pathogens. Significant factors for 6-month survival were: higher MELD score, previous b-blocker use, lower serum albumin, higher lactate on admission and need for vasopressors, while factors for 12-month survival were MELD score and lactate. For overall survival, higher MELD score and lactate along with HCC presence were negative predictive factors. Conclusions: MELD score, lactate, albumin, HCC and treatment with vasopressors were predictive of survival in SBP patients. In hospital-acquired SBP the prevalence of difficult-to-treat pathogens was higher.
Language	English
Publishing date	2021-11-10
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2032850-3
ISSN	1108-7471
ISSN	1108-7471
DOI	10.20524/aog.2021.0674
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Zs.A 2455: Show issues

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Article ; Online: HERACLIS-HDV cohort for the factors of underdiagnosis and prevalence of hepatitis D virus infection in HBsAg-positive patients.

Papatheodoridis, George / Mimidis, Konstantinos / Manolakopoulos, Spilios / Triantos, Christos / Vlachogiannakos, Ioannis / Veretanos, Christos / Deutsch, Melanie / Karatapanis, Stylianos / Goulis, Ioannis / Elefsiniotis, Ioannis / Cholongitas, Evangelos / Sevastianos, Vassilios / Christodoulou, Dimitrios / Samonakis, Dimitrios / Manesis, Emanuel / Kapatais, Andreas / Papadopoulos, Nikolaos / Ioannidou, Panagiota / Germanidis, Georgios /

Liver international : official journal of the International Association for the Study of the Liver

2023 Volume 43, Issue 9, Page(s) 1879–1889

Abstract: Background and aims: Hepatitis D virus (HDV) underdiagnosis remains common. We assessed the HDV ...

Abstract	Background and aims: Hepatitis D virus (HDV) underdiagnosis remains common. We assessed the HDV screening and prevalence rates in HBsAg-positive patients seen at tertiary liver centres throughout Greece as well as factors affecting HDV diagnosis. Methods: All adult HBsAg-positive patients seen within the last 5 years were included. Non-screened patients who visited or could be recalled to the clinics over a 6-month period were prospectively tested for anti-HDV. Results: Of 5079 HBsAg-positive patients, 53% had anti-HDV screening (41% before and 12% after study initiation). Pre-study (8%-88%) and total screening rates (14%-100%) varied widely among centres. Screening rates were associated with older age, known risk group, elevated ALT, centre location and size and period of first visit. Anti-HDV prevalence was 5.8% without significant difference in patients screened before (6.1%) or after study initiation (4.7%, p = 0.240). Anti-HDV positivity was associated with younger age, parenteral drug use, born abroad, advanced liver disease and centre location. Overall, HDV RNA detectability rate was 71.6% being more frequent in anti-HDV-positive patients with elevated ALT, advanced liver disease and hepatitis B therapy. Conclusions: Anti-HDV screening rates and recall capabilities vary widely among Greek liver clinics being higher in HBsAg-positive patients of known risk group with active/advanced liver disease seen at smaller centres, while non-medical factors are also important. Anti-HDV prevalence varies throughout Greece being higher in patients born abroad with younger age, parenteral drug use and advanced liver disease. Viremia is more frequently but not exclusively detected in anti-HDV-positive patients with elevated ALT and advanced liver disease.
MeSH term(s)	Adult ; Humans ; Hepatitis Delta Virus/genetics ; Hepatitis B Surface Antigens ; Prevalence ; Hepatitis D/diagnosis ; Hepatitis D/epidemiology ; Hepatitis D/complications ; Hepatitis B/diagnosis ; Hepatitis B/epidemiology ; Hepatitis B/complications ; Liver Diseases/complications ; Substance-Related Disorders/complications
Chemical Substances	Hepatitis B Surface Antigens
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/liv.15638
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Zs.A 1632: Show issues

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Article ; Online: Screening for Hepatopulmonary Syndrome in Cirrhotic Patients Using Technetium 99m-macroaggregated Albumin Perfusion Lung Scan (Tc-MAA): Diagnostic Approach and Clinical Correlations.

Fragaki, Maria / Sifaki-Pistolla, Dimitra / Samonakis, Dimitrios N / Koulentaki, Mairi / Koukouraki, Sofia / Stathaki, Maria / Kouroumalis, Elias

Journal of clinical gastroenterology

2017 Volume 52, Issue 9, Page(s) 828–834

Abstract: Background and aims: The aims of this study were to prospectively screen cirrhotic patients with arterial blood gas test and albumin perfusion scan, identify those fulfilling the classic hepatopulmonary syndrome (HPS) criteria, correlate with clinical ... ...

Abstract	Background and aims: The aims of this study were to prospectively screen cirrhotic patients with arterial blood gas test and albumin perfusion scan, identify those fulfilling the classic hepatopulmonary syndrome (HPS) criteria, correlate with clinical parameters, and evaluate the survival of patients with HPS compared with those without HPS in a genetically homogenous Cretan cirrhotic population. Materials and methods: Data on consecutive 102 patients within 1 year were collected and analyzed. All patients underwent a technetium 99m-macroaggregated albumin perfusion lung scan (Tc-MAA). Diagnosis of HPS was based on the presence of the quantitative index Tc-MAA≥6% and a [P(A-a)O2]≥15 mm Hg (≥20 mm Hg for patients over >64 y). Results: In 94/102 patients, complete scintigraphic data were available. In total, 24 (26%) patients fulfilled the diagnostic criteria of HPS; 95.8% of them had mild-to-moderate HPS. In 8 patients the Tc-MAA scintigraphy could not be interpreted. There was no difference in HPS between decompensated (24.6%) and compensated cirrhosis (27.3%). In the multivariate analysis only the quantitative index was significant for the diagnosis of HPS (P=0.001, odds ratio; 95% confidence interval, 7.05; 2.27-21.87). Kaplan- Meier survival curves indicated a similar overall prognosis for patients diagnosed with HPS (P=0.105). Conclusions: HPS is a frequent complication of cirrhosis. Mild-to-moderate HPS has no significant effect on survival of cirrhotic patients. The quantitative Tc-MAA test is a reliable tool for diagnosis.
MeSH term(s)	Blood Gas Analysis/methods ; Female ; Follow-Up Studies ; Hepatopulmonary Syndrome/diagnostic imaging ; Hepatopulmonary Syndrome/etiology ; Hepatopulmonary Syndrome/physiopathology ; Humans ; Kaplan-Meier Estimate ; Liver Cirrhosis/complications ; Male ; Mass Screening/methods ; Middle Aged ; Prognosis ; Prospective Studies ; Radionuclide Imaging/methods ; Radiopharmaceuticals/administration & dosage ; Severity of Illness Index ; Technetium Tc 99m Aggregated Albumin/administration & dosage
Chemical Substances	Radiopharmaceuticals ; Technetium Tc 99m Aggregated Albumin
Language	English
Publishing date	2017-09-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	448460-5
ISSN	1539-2031 ; 0192-0790
ISSN (online)	1539-2031
ISSN	0192-0790
DOI	10.1097/MCG.0000000000000926
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Article ; Online: The tale of an unexpected SVR

D.N. Samonakis / E. Xenaki / A. Dermitzaki / E.A. Kouroumalis

Annals of Gastroenterology, Vol 21, Iss 4, Pp 240-

2009 Volume 241

Abstract: A case of a “difficult to treat” patient with chronic hepatitis C is presented, who experienced multiple problems, leading to significant drug reductions or discontinuations. Nevertheless, after an initial response, ribavirin monotherapy for a ... ...

Abstract	A case of a “difficult to treat” patient with chronic hepatitis C is presented, who experienced multiple problems, leading to significant drug reductions or discontinuations. Nevertheless, after an initial response, ribavirin monotherapy for a significant period proved be an important factor in achieving sustained virological response.
Keywords	Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Gastroenterology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2009-04-01T00:00:00Z
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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