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  1. Article ; Online: Harnessing big data for identifying atrial fibrillation.

    Altman, Robert K / Steinberg, Jonathan S

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2019  Volume 21, Issue 9, Page(s) 1283

    MeSH term(s) Atrial Fibrillation ; Big Data ; Cohort Studies ; Humans
    Language English
    Publishing date 2019-05-16
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/euz129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Should the force be with us?

    Steinberg, Jonathan S / Altman, Robert K

    Heart rhythm

    2017  Volume 15, Issue 2, Page(s) 209–210

    Language English
    Publishing date 2017-10-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2017.10.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Don't Neglect the Electrocardiogram: P-Wave Proves a Potent Predictor.

    Steinberg, Jonathan S / Altman, Robert K

    JACC. Clinical electrophysiology

    2017  Volume 4, Issue 4, Page(s) 544–546

    MeSH term(s) Atrial Appendage ; Atrial Fibrillation ; Electrocardiography ; Heart Atria ; Humans ; Pulmonary Veins
    Language English
    Publishing date 2017-12-20
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2018.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Validation of continuous measures of peer social interaction with self- and teacher-reports of friendship and social engagement.

    Altman, Robert L / Laursen, Brett / Perry, Lynn K / Messinger, Daniel S

    The European journal of developmental psychology

    2020  Volume 17, Issue 5, Page(s) 773–785

    Abstract: The present study validates a new procedure that combines continuous measures of proximity (Ubisense) and vocalization (LENA) into measures of peer social interaction. The data were collected from 4 boys and 5 girls (ages 2-3 at the outset) on 8 separate ...

    Abstract The present study validates a new procedure that combines continuous measures of proximity (Ubisense) and vocalization (LENA) into measures of peer social interaction. The data were collected from 4 boys and 5 girls (ages 2-3 at the outset) on 8 separate days (3-4 hours per day) over the course of an academic year. Teacher reports of friendship were positively correlated with continuous measures of dyadic social interaction (i.e., the amount of time two children spent in proximity to one another, talking). Self-reports of reciprocated friendship were marginally correlated with continuous measures of dyadic social interaction, but only in the spring semester (when children were older and their reports of friendship more reliable). At the individual level, peer nominations of likeability, and teacher ratings of sociability and withdrawal were correlated with continuous measures of social interaction (i.e., the amount of time a child spent in proximity to other children, talking).
    Language English
    Publishing date 2020-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2145762-1
    ISSN 1740-5610 ; 1740-5629
    ISSN (online) 1740-5610
    ISSN 1740-5629
    DOI 10.1080/17405629.2020.1716724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Paclitaxel-Coated Balloon vs Uncoated Balloon for Coronary In-Stent Restenosis: The AGENT IDE Randomized Clinical Trial.

    Yeh, Robert W / Shlofmitz, Richard / Moses, Jeffrey / Bachinsky, William / Dohad, Suhail / Rudick, Steven / Stoler, Robert / Jefferson, Brian K / Nicholson, William / Altman, John / Bateman, Cinthia / Krishnaswamy, Amar / Grantham, J Aaron / Zidar, Frank J / Marso, Steven P / Tremmel, Jennifer A / Grines, Cindy / Ahmed, Mustafa I / Latib, Azeem /
    Tehrani, Behnam / Abbott, J Dawn / Batchelor, Wayne / Underwood, Paul / Allocco, Dominic J / Kirtane, Ajay J

    JAMA

    2024  Volume 331, Issue 12, Page(s) 1015–1024

    Abstract: Importance: Drug-coated balloons offer a potentially beneficial treatment strategy for the management of coronary in-stent restenosis. However, none have been previously evaluated or approved for use in coronary circulation in the United States.: ... ...

    Abstract Importance: Drug-coated balloons offer a potentially beneficial treatment strategy for the management of coronary in-stent restenosis. However, none have been previously evaluated or approved for use in coronary circulation in the United States.
    Objective: To evaluate whether a paclitaxel-coated balloon is superior to an uncoated balloon in patients with in-stent restenosis undergoing percutaneous coronary intervention.
    Design, setting, and participants: AGENT IDE, a multicenter randomized clinical trial, enrolled 600 patients with in-stent restenosis (lesion length <26 mm and reference vessel diameter >2.0 mm to ≤4.0 mm) at 40 centers across the United States between May 2021 and August 2022. One-year clinical follow-up was completed on October 2, 2023.
    Interventions: Participants were randomized in a 2:1 allocation to undergo treatment with a paclitaxel-coated (n = 406) or an uncoated (n = 194) balloon.
    Main outcomes and measures: The primary end point of 1-year target lesion failure-defined as the composite of ischemia-driven target lesion revascularization, target vessel-related myocardial infarction, or cardiac death-was tested for superiority.
    Results: Among 600 randomized patients (mean age, 68 years; 157 females [26.2%]; 42 Black [7%], 35 Hispanic [6%] individuals), 574 (95.7%) completed 1-year follow-up. The primary end point at 1 year occurred in 17.9% in the paclitaxel-coated balloon group vs 28.6% in the uncoated balloon group, meeting the criteria for superiority (hazard ratio [HR], 0.59 [95% CI, 0.42-0.84]; 2-sided P = .003). Target lesion revascularization (13.0% vs 24.7%; HR, 0.50 [95% CI, 0.34-0.74]; P = .001) and target vessel-related myocardial infarction (5.8% vs 11.1%; HR, 0.51 [95% CI, 0.28-0.92]; P = .02) occurred less frequently among patients treated with paclitaxel-coated balloon. The rate of cardiac death was 2.9% vs 1.6% (HR, 1.75 [95% CI, 0.49-6.28]; P = .38) in the coated vs uncoated balloon groups, respectively.
    Conclusions and relevance: Among patients undergoing coronary angioplasty for in-stent restenosis, a paclitaxel-coated balloon was superior to an uncoated balloon with respect to the composite end point of target lesion failure. Paclitaxel-coated balloons are an effective treatment option for patients with coronary in-stent restenosis.
    Trial registration: ClinicalTrials.gov Identifier: NCT04647253.
    MeSH term(s) Female ; Humans ; Aged ; Paclitaxel ; Coronary Restenosis/etiology ; Coronary Restenosis/therapy ; Stents ; Treatment Outcome ; Myocardial Infarction ; Death
    Chemical Substances Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2024.1361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: TP53-altered acute myeloid leukemia and myelodysplastic syndrome with excess blasts should be approached as a single entity.

    Shallis, Rory M / Daver, Naval G / Altman, Jessica K / Hasserjian, Robert P / Kantarjian, Hagop M / Platzbecker, Uwe / Santini, Valeria / Wei, Andrew H / Sallman, David A / Zeidan, Amer M

    Cancer

    2022  Volume 129, Issue 2, Page(s) 175–180

    Abstract: TP53-altered myelodysplastic syndrome with excess blasts and TP53-altered acute myeloid leukemia should be considered under one unifying classification term for their study in clinical trials. Ultimately, such a unification would simplify the screening ... ...

    Abstract TP53-altered myelodysplastic syndrome with excess blasts and TP53-altered acute myeloid leukemia should be considered under one unifying classification term for their study in clinical trials. Ultimately, such a unification would simplify the screening processes for clinical trials and allow a focus on treating the patient for a genetically defined disorder rather than one based on an arbitrary blast threshold.
    MeSH term(s) Humans ; Myelodysplastic Syndromes/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/drug therapy ; Leukocytes ; Tumor Suppressor Protein p53/genetics
    Chemical Substances TP53 protein, human ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.34535
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  7. Article ; Online: Modulating β-arrestin 2 recruitment at the δ- and μ-opioid receptors using peptidomimetic ligands.

    Sharma, Krishna K / Cassell, Robert J / Meqbil, Yazan J / Su, Hongyu / Blaine, Arryn T / Cummins, Benjamin R / Mores, Kendall L / Johnson, David K / van Rijn, Richard M / Altman, Ryan A

    RSC medicinal chemistry

    2021  Volume 12, Issue 11, Page(s) 1958–1967

    Abstract: μ-Opioid receptor agonists provide potent and effective acute analgesia; however, their therapeutic window narrows considerably upon repeated administration, such as required for treating chronic pain. In contrast, bifunctional μ/δ opioid agonists, such ... ...

    Abstract μ-Opioid receptor agonists provide potent and effective acute analgesia; however, their therapeutic window narrows considerably upon repeated administration, such as required for treating chronic pain. In contrast, bifunctional μ/δ opioid agonists, such as the endogenous enkephalins, have potential for treating both acute and chronic pain. However, enkephalins recruit β-arrestins, which correlate with certain adverse effects at μ- and δ-opioid receptors. Herein, we identify the C-terminus of Tyr-ψ[(
    Language English
    Publishing date 2021-08-16
    Publishing country England
    Document type Journal Article
    ISSN 2632-8682
    ISSN (online) 2632-8682
    DOI 10.1039/d1md00025j
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  8. Article ; Online: Chronic Myeloid Leukemia, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology.

    Shah, Neil P / Bhatia, Ravi / Altman, Jessica K / Amaya, Maria / Begna, Kebede H / Berman, Ellin / Chan, Onyee / Clements, Joan / Collins, Robert H / Curtin, Peter T / DeAngelo, Daniel J / Drazer, Michael / Maness, Lori / Metheny, Leland / Mohan, Sanjay / Moore, Joseph O / Oehler, Vivian / Pratz, Keith / Pusic, Iskra /
    Rose, Michal G / Shomali, William / Smith, B Douglas / Styler, Michael / Talpaz, Moshe / Tanaka, Tiffany N / Tantravahi, Srinivas / Thompson, James / Tsai, Steven / Vaughn, Jennifer / Welborn, Jeanna / Yang, David T / Sundar, Hema / Gregory, Kristina

    Journal of the National Comprehensive Cancer Network : JNCCN

    2024  Volume 22, Issue 1, Page(s) 43–69

    Abstract: Chronic myeloid leukemia (CML) is defined by the presence of Philadelphia chromosome resulting from a reciprocal translocation between chromosomes 9 and 22 [t9;22] that gives rise to a BCR::ABL1 fusion gene. CML occurs in 3 different phases (chronic, ... ...

    Abstract Chronic myeloid leukemia (CML) is defined by the presence of Philadelphia chromosome resulting from a reciprocal translocation between chromosomes 9 and 22 [t9;22] that gives rise to a BCR::ABL1 fusion gene. CML occurs in 3 different phases (chronic, accelerated, and blast phase) and is usually diagnosed in the chronic phase in developed countries. Tyrosine kinase inhibitor (TKI) therapy is a highly effective treatment option for patients with chronic phase-CML. The primary goal of TKI therapy in patients with chronic phase-CML is to prevent disease progression to accelerated phase-CML or blast phase-CML. Discontinuation of TKI therapy with careful monitoring is feasible in selected patients. This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnosis and management of patients with chronic phase-CML.
    MeSH term(s) Humans ; Blast Crisis/chemically induced ; Blast Crisis/drug therapy ; Blast Crisis/genetics ; Protein Kinase Inhibitors/adverse effects ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/diagnosis ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Philadelphia Chromosome ; Leukemia, Myeloid, Chronic-Phase/drug therapy ; Fusion Proteins, bcr-abl/genetics
    Chemical Substances Protein Kinase Inhibitors ; Fusion Proteins, bcr-abl (EC 2.7.10.2)
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2250759-0
    ISSN 1540-1413 ; 1540-1405
    ISSN (online) 1540-1413
    ISSN 1540-1405
    DOI 10.6004/jnccn.2024.0007
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  9. Article ; Online: CML and the WHO: Why?

    Berman, Ellin / Shah, Neil P / Deninger, Michael / Altman, Jessica K / Amaya, Maria / Begna, Kebede / Bhatia, Ravi / Chan, Onyee / Collins, Robert / Curtin, Peter / DeAngelo, Daniel J / Drazer, Michael / Maness, Lori / Metheny, Leland / Mohan, Sanjay / Moore, Joseph / Oehler, Vivian / Pratz, Keith / Pusic, Iskra /
    Rose, Michal / Shomali, William / Smith, B Douglas / Styler, Michael / Sweet, Kendra / Talpaz, Moshe / Tanaka, Tiffany / Tantravahi, Srinivas / Tsai, Steven / Vaughn, Jennifer / Welborn, Jeanna / Yang, David / Mauro, Michael / Cortes, Jorge / Radich, Jerald / Druker, Brian

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 42, Issue 9, Page(s) 984–986

    MeSH term(s) Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; World Health Organization
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.01689
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  10. Article ; Online: High Complication Rate After Percutaneous Screw Fixation for Valgus-Impacted Femoral Neck Fractures Without Sagittal Malalignment.

    Gaski, Greg E / Altman, Kyle / Lear, Taylor / Prodoehl, Julia / Tanner, Stephanie / Wang, Angela / Hymes, Robert A / Hunter, Brett / Adams, John D

    Journal of orthopaedic trauma

    2022  Volume 37, Issue 9, Page(s) 440–443

    Abstract: Objectives: To evaluate the rate of reoperation in patients without sagittal plane malalignment who underwent percutaneous screw fixation of a valgus-impacted femoral neck fracture.: Design: Retrospective case series.: Setting: Two Level 1 ... ...

    Abstract Objectives: To evaluate the rate of reoperation in patients without sagittal plane malalignment who underwent percutaneous screw fixation of a valgus-impacted femoral neck fracture.
    Design: Retrospective case series.
    Setting: Two Level 1 academic trauma centers.
    Patients and intervention: Two hundred seven patients >50 years of age with valgus-impacted femoral neck fractures treated with at least 3 large-diameter (>6.5 mm) cancellous screws from 2013 to 2019. Patients were excluded if there was a sagittal plane fracture deformity.
    Main outcome measurements: The primary outcome was reoperation. Secondary outcomes considered "major complications" included: avascular necrosis, varus collapse or implant cutout, nonunion, deep infection, and hematoma requiring reoperation. Surgical fixation strategies (screw configuration, aim) and implant type (partial vs. fully threaded cancellous screws) were secondarily compared.
    Results: Average patient age was 77 years, and median clinical follow-up was 658 days. Thirty-one patients (15%) required reoperation, and the major complication rate was 17.3% (36 complications in 33 patients). Logistic regression analysis demonstrated a higher risk of reoperation with constructs consisting of all partially threaded screws (17.0%) compared with the use of at least 1 fully threaded screw (7.5%) when an inverted triangle configuration was used (odds ratio, 2.50; 95% CI, 0.81-7.77).
    Conclusions: This study demonstrated a relatively high rate of reoperation and major complications in patients with valgus-impacted femoral neck fractures without sagittal malalignment treated with in situ percutaneous screw fixation.
    Level of evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
    MeSH term(s) Humans ; Aged ; Retrospective Studies ; Fracture Fixation, Internal/adverse effects ; Femoral Neck Fractures/surgery ; Bone Screws/adverse effects ; Reoperation ; Treatment Outcome
    Language English
    Publishing date 2022-05-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639099-7
    ISSN 1531-2291 ; 0890-5339
    ISSN (online) 1531-2291
    ISSN 0890-5339
    DOI 10.1097/BOT.0000000000002621
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