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Book: Core topics in mechanical ventilation

Mackenzie, Iain

(Cambridge medicine)

2008

Author's details	ed. by Iain Mackenzie
Series title	Cambridge medicine
Keywords	Respiration, Artificial ; Artificial respiration
Subject code	615.8362
Language	English
Size	XIV, 425 S. : Ill., graph. Darst.
Publisher	Cambridge Univ. Press
Publishing place	Cambridge u.a.
Publishing country	Great Britain
Document type	Book
Note	Includes bibliographical references and index
HBZ-ID	HT015581018
ISBN	978-0-521-86781-8 ; 0-521-86781-9
Database	Catalogue ZB MED Medicine, Health

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2008 A 6130	order for loan	Magazin

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Book: Orain Iain Luim

Mackenzie, Annie M

songs of John MacDonald, Bard of Keppoch

(Scottish Gaelic texts ; 8)

1964

Author's details	ed. by Annie M. Mackenzie
Series title	Scottish Gaelic texts ; 8
Language	English ; Scottish Gaelic
Size	XLVII, 439 S, Kt
Publisher	Oliver & Boyd
Publishing place	Edinburgh
Document type	Book
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Quantification and uncertainty of root growth stimulation by elevated CO

Ziegler, Clare / Kulawska, Aleksandra / Kourmouli, Angeliki / Hamilton, Liz / Shi, Zongbo / MacKenzie, A Rob / Dyson, Rosemary J / Johnston, Iain G

The Science of the total environment

2022 Volume 854, Page(s) 158661

Abstract: Increasing ... ...

Abstract	Increasing CO
MeSH term(s)	Ecosystem ; Carbon Dioxide/analysis ; Uncertainty ; Forests ; Biomass ; Soil
Chemical Substances	Carbon Dioxide (142M471B3J) ; Soil
Language	English
Publishing date	2022-09-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.158661
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Article ; Online: Development of the chicken skull: A complement to the external staging table of Hamburger and Hamilton.

Arnaout, Bassel / Lantigua, Kayla E / MacKenzie, Erin M / McKinnell, Iain W / Maddin, Hillary C

Anatomical record (Hoboken, N.J. : 2007)

2021 Volume 304, Issue 12, Page(s) 2726–2740

Abstract: Embryonic staging tables provide a standard of developmental stages that can be used by individual investigators and provide approximate time points for the study of developmental phenomena. Surprisingly, despite the presence of a plethora of studies on ... ...

Abstract	Embryonic staging tables provide a standard of developmental stages that can be used by individual investigators and provide approximate time points for the study of developmental phenomena. Surprisingly, despite the presence of a plethora of studies on the chicken skull and its role as a model species in developmental research, a staging table of the development of the chicken skull remains lacking. A detailed photographic staging table of the osseous portion of the chicken skull is thus presented here based on cleared and stained HH stages spanning HH 35 (first appearance of skull ossification) to the final stage before hatching (HH 45). This table documents the development of most of the cranial elements in the skull from the start of ossification until the element takes its final shape. The table shows that the elements of the lower jaw and ventral side of the skull begin ossifying before the skull roof and that most elements take roughly 5 days to reach their final shape, whereas others take up to 9 days (e.g., the frontal). The obtained results lead to several hypotheses about chicken skull development and provide a timeframe for future studies on chicken skull development.
MeSH term(s)	Animals ; Chickens ; Head ; Mandible ; Skull
Language	English
Publishing date	2021-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2269667-2
ISSN	1932-8494 ; 1932-8486
ISSN (online)	1932-8494
ISSN	1932-8486
DOI	10.1002/ar.24603
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Article ; Online: Quantification and uncertainty of root growth stimulation by elevated CO2 in a mature temperate deciduous forest

Ziegler, Clare / Kulawska, Aleksandra / Kourmouli, Angeliki / Hamilton, Liz / Shi, Zongbo / MacKenzie, A. Rob / Dyson, Rosemary J. / Johnston, Iain G.

Science of the Total Environment. 2023 Jan., v. 854 p.158661-

2023

Abstract: Increasing CO₂ levels are a major global challenge, and the potential mitigation of anthropogenic CO₂ emissions by natural carbon sinks remains poorly understood. The uptake of elevated CO₂ (eCO₂) by the terrestrial biosphere, and subsequent ... ...

Abstract	Increasing CO₂ levels are a major global challenge, and the potential mitigation of anthropogenic CO₂ emissions by natural carbon sinks remains poorly understood. The uptake of elevated CO₂ (eCO₂) by the terrestrial biosphere, and subsequent sequestration as biomass in ecosystems, remain hard to quantify in natural ecosystems. Here, we combine field observations of fine root stocks and flows, derived from belowground imaging and soil cores, with image analysis, stochastic modelling, and statistical inference, to elucidate belowground root dynamics in a mature temperate deciduous forest under free-air eCO₂ to 150 ppm above ambient levels. eCO₂ led to relatively faster root production (a peak volume fold change of 4.52 ± 0.44 eCO₂ versus 2.58 ± 0.21 control), with increased root elongation relative to decay the likely causal mechanism for this acceleration. Physical analysis of 552 root systems from soil cores support this picture, with lengths and widths of fine roots significantly increasing under eCO₂. Estimated fine root contributions to belowground net primary productivity increase under eCO₂ (mean annual 204 ± 93 g dw m⁻² yr⁻¹ eCO₂ versus 140 ± 60 g dw m⁻² yr⁻¹ control). This multi-faceted approach thus sheds quantitative light on the challenging characterisation of the eCO₂ response of root biomass in mature temperate forests.
Keywords	biomass ; biosphere ; carbon ; carbon dioxide ; carbon dioxide enrichment ; deciduous forests ; fine roots ; image analysis ; net primary productivity ; root growth ; soil ; statistical inference ; uncertainty ; Elevated CO2 ; Belowground NPP ; Mature temperate woodland ; Mathematical modelling
Language	English
Dates of publication	2023-01
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Creative Commons Attribution 4.0 Generic (CC BY 4.0) ; Resource is Open Access
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.158661
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Addressing the need for patient-friendly medical communications: adaptation of the 2019 recommendations for the management of MPS VI and MPS IVA.

Bruce, Iain A / Ezgü, Fatih S / Kampmann, Christoph / Kenis, Vladimir / Mackenzie, William / Stevens, Bob / Walker, Robert / Hendriksz, Christian

Orphanet journal of rare diseases

2022 Volume 17, Issue 1, Page(s) 91

Abstract: Background: Patients are the most important stakeholders in the care of any disease and have an educational need to learn about their condition and the treatment they should receive. Considering this need for patient-focused materials, we present a ... ...

Abstract	Background: Patients are the most important stakeholders in the care of any disease and have an educational need to learn about their condition and the treatment they should receive. Considering this need for patient-focused materials, we present a directed approach for mucopolysaccharidosis (MPS) VI and MPS IVA, a pair of rare, inherited diseases that affects multiple organs and parts of the body. Independent guidelines on the treatment of these diseases were recently published, providing evidence- and expertise-driven recommendations to optimize patient management. However, while healthcare providers may have the training and knowledge to understand these guidelines, patients and their caregivers can find the technical content challenging. Hence, we aimed to develop plain language summaries (PLS) of the MPS VI and MPS IVA guidelines with patients as the primary audience. Results: A review of the guidelines by an expert team identified six domains of information relevant to patients: The multidisciplinary team, regular tests and check-ups, disease-modifying and supportive treatments, general anesthetics, ear-nose-throat/respiratory care, and surgeries. This information was adapted into a series of infographics specific to either MPS VI or MPS IVA, designed to appeal to patients and clearly present information in a concise manner. Conclusions: The use of patient-friendly materials, like the infographics we have developed, has the potential to better inform patients and engage them in their care. We issue a "call to arms" to the medical community for the development of similar PLS materials in rare diseases intended to inform and empower patients.
MeSH term(s)	Humans ; Mucopolysaccharidosis IV ; Mucopolysaccharidosis VI ; Patient Education as Topic
Language	English
Publishing date	2022-03-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2225857-7
ISSN	1750-1172 ; 1750-1172
ISSN (online)	1750-1172
ISSN	1750-1172
DOI	10.1186/s13023-022-02219-7
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Article ; Online: Disseminated Mucocutaneous Histoplasmosis Diagnosed in the United Kingdom, Presumably as a Result of Recrudescence Decades After Primary Infection Following Immunosuppressive Treatment of Its Mimic, Sarcoidosis: A Multidisciplinary Cautionary Tale.

Earp, Eleanor / Gordon, Patricia M / Tan, Adrian / Page, Iain / Thum, Chee K / Mackenzie, Andrew I / Johnson, Elizabeth / Biswas, Asok

The American Journal of dermatopathology

2022 Volume 44, Issue 12, Page(s) 984–988

Abstract: Abstract: Histoplasmosis is a dimorphic fungal infection, which is rare outside endemic pockets in North, Central, and South America, Asia, and Africa. Herein, we describe a woman in her 80s living in the Scottish Borders region of the United Kingdom ... ...

Abstract	Abstract: Histoplasmosis is a dimorphic fungal infection, which is rare outside endemic pockets in North, Central, and South America, Asia, and Africa. Herein, we describe a woman in her 80s living in the Scottish Borders region of the United Kingdom with a recent diagnosis of granulomatous rosacea, who on receiving escalating immunosuppression for suspected sarcoidosis, and long-standing rheumatoid arthritis developed a striking eruption involving her eyelids along with painful ulceration of the oral and nasal mucosa. Histopathologic examination of the skin and mucosal lesions demonstrated granulomatous inflammation with numerous yeast forms of fungal organisms with morphological characteristics of Histoplasma species. This was confirmed to be H. capsulatum on fungal culture and direct panfungal polymerase chain reaction assay. Although the patient had not left the United Kingdom for more than 20 years, she gave a travel history involving multiple trips to countries where histoplasmosis is known to occur, before that. This case exemplifies the challenges involved in making a diagnosis of histoplasmosis in nonendemic regions for both clinicians and pathologists alike. In this particular patient, the diagnostic difficulties were compounded by the clinicopathological overlap with other cutaneous and systemic granulomatous disorders like granulomatous rosacea and suspected sarcoidosis and also the exceptionally long latency period between the purported historical primary infection and recent recrudescence. We highlight this unusual case to increase an awareness of histoplasmosis, which is very rare in nonendemic regions like the United Kingdom and involves cases acquired during residence in or travel to endemic areas, to ensure its prompt recognition and treatment.
MeSH term(s)	Humans ; Female ; Histoplasmosis/diagnosis ; Histoplasmosis/drug therapy ; Sarcoidosis/diagnosis ; United Kingdom ; Immunosuppressive Agents/adverse effects ; Recurrence ; Rosacea
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2022-09-27
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	448469-1
ISSN	1533-0311 ; 0193-1091
ISSN (online)	1533-0311
ISSN	0193-1091
DOI	10.1097/DAD.0000000000002235
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Normal development in Xenopus laevis: A complementary staging table for the skull based on cartilage and bone.

MacKenzie, Erin M / Atkins, Jade B / Korneisel, Dana E / Cantelon, Alanna S / McKinnell, Iain W / Maddin, Hillary C

Developmental dynamics : an official publication of the American Association of Anatomists

2022 Volume 251, Issue 8, Page(s) 1340–1356

Abstract: Background: Xenopus laevis is a widely used model organism in the fields of genetics and development, and more recently evolution. At present, the most widely used staging table for X. laevis is based primarily on external features and does not describe ...

Abstract	Background: Xenopus laevis is a widely used model organism in the fields of genetics and development, and more recently evolution. At present, the most widely used staging table for X. laevis is based primarily on external features and does not describe the corresponding skull development in detail. Here, we describe skull development in X. laevis, complete with labeled figures, for each relevant stage in the most widely used staging table. Results: We find skull development in X. laevis is, for the most part, distinct at each of the previously established stages based on external anatomy. However, variation does exist in the timing of onset of ossification of certain bones in the skull, which results in a range of stages where a skull element first ossifies. The overall sequence of ossification is less variable than the timing of ossification onset. Conclusions: While events in skull development vary somewhat between specimens, and in comparison, to external events, this staging table is useful in showing both when bones first appear and for documenting the range of temporal variance in X. laevis skull development more accurately than previously done. Furthermore, when only skull data are available, the approximate stage of a specimen can now be determined.
MeSH term(s)	Animals ; Cartilage ; Head ; Osteogenesis ; Skull/anatomy & histology ; Xenopus laevis
Language	English
Publishing date	2022-03-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1102541-4
ISSN	1097-0177 ; 1058-8388
ISSN (online)	1097-0177
ISSN	1058-8388
DOI	10.1002/dvdy.465
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Article ; Online: Addressing the need for patient-friendly medical communications

Iain A. Bruce / Fatih S. Ezgü / Christoph Kampmann / Vladimir Kenis / William Mackenzie / Bob Stevens / Robert Walker / Christian Hendriksz

Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-

adaptation of the 2019 recommendations for the management of MPS VI and MPS IVA

2022 Volume 18

Abstract: Abstract Background Patients are the most important stakeholders in the care of any disease and have an educational need to learn about their condition and the treatment they should receive. Considering this need for patient-focused materials, we present ...

Abstract	Abstract Background Patients are the most important stakeholders in the care of any disease and have an educational need to learn about their condition and the treatment they should receive. Considering this need for patient-focused materials, we present a directed approach for mucopolysaccharidosis (MPS) VI and MPS IVA, a pair of rare, inherited diseases that affects multiple organs and parts of the body. Independent guidelines on the treatment of these diseases were recently published, providing evidence- and expertise-driven recommendations to optimize patient management. However, while healthcare providers may have the training and knowledge to understand these guidelines, patients and their caregivers can find the technical content challenging. Hence, we aimed to develop plain language summaries (PLS) of the MPS VI and MPS IVA guidelines with patients as the primary audience. Results A review of the guidelines by an expert team identified six domains of information relevant to patients: The multidisciplinary team, regular tests and check-ups, disease-modifying and supportive treatments, general anesthetics, ear-nose-throat/respiratory care, and surgeries. This information was adapted into a series of infographics specific to either MPS VI or MPS IVA, designed to appeal to patients and clearly present information in a concise manner. Conclusions The use of patient-friendly materials, like the infographics we have developed, has the potential to better inform patients and engage them in their care. We issue a “call to arms” to the medical community for the development of similar PLS materials in rare diseases intended to inform and empower patients.
Keywords	Rare diseases ; Mucopolysaccharidosis ; MPS IVA ; MPS VI ; Management guidelines ; Enzyme replacement therapy ; Medicine ; R
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Core topics in mechanical ventilation

Mackenzie, Iain

2008

Title variant	Mechanical ventilation
Author's details	edited by Iain Mackenzie
MeSH term(s)	Respiration, Artificial
Language	English
Size	xiv, 425 p. :, ill., port.
Publisher	Cambridge University Press
Publishing place	Cambridge ; New York
Document type	Book
ISBN	9780521867818 ; 0521867819
Database	Catalogue of the US National Library of Medicine (NLM)

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