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  1. Article ; Online: What Is Childhood Leukemia?

    Ruiz, Jenny / Mathews, Colleen / Friehling, Erika

    JAMA

    2024  Volume 331, Issue 9, Page(s) 808

    MeSH term(s) Child ; Humans ; Leukemia/diagnosis ; Leukemia/therapy
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Patient Education Handout
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.24648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: The locus coeruleus directs sensory-motor reflex amplitude across environmental contexts.

    Witts, Emily C / Mathews, Miranda A / Murray, Andrew J

    Current biology : CB

    2023  Volume 33, Issue 21, Page(s) 4679–4688.e3

    Abstract: Purposeful movement across unpredictable environments requires quick, accurate, and contextually appropriate motor corrections in response to disruptions in balance and posture. ...

    Abstract Purposeful movement across unpredictable environments requires quick, accurate, and contextually appropriate motor corrections in response to disruptions in balance and posture.
    MeSH term(s) Humans ; Mice ; Animals ; Locus Coeruleus/physiology ; Reflex/physiology ; Spinal Cord/physiology ; Norepinephrine
    Chemical Substances Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.08.085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3208: Show issues Location:
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  3. Article ; Online: Palliative Care Is the Umbrella, Not the Rain-A Metaphor to Guide Conversations in Advanced Cancer.

    Zimmermann, Camilla / Mathews, Jean

    JAMA oncology

    2022  Volume 8, Issue 5, Page(s) 681–682

    MeSH term(s) Communication ; Humans ; Metaphor ; Neoplasms/therapy ; Palliative Care
    Language English
    Publishing date 2022-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2021.8210
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  4. Article ; Online: Critical Action and Ethnic-Racial Identity: Tools of Racial Resistance at the College Transition.

    Mathews, Channing J / Durkee, Myles / Hope, Elan C

    Journal of research on adolescence : the official journal of the Society for Research on Adolescence

    2022  Volume 32, Issue 3, Page(s) 1083–1097

    Abstract: This study examines the reciprocal relationship between critical action and ethnic-racial identity (ERI) exploration in Black college students using a longitudinal cross-lagged model. Participants were Black students (N = 237; ... ...

    Abstract This study examines the reciprocal relationship between critical action and ethnic-racial identity (ERI) exploration in Black college students using a longitudinal cross-lagged model. Participants were Black students (N = 237; M
    MeSH term(s) Adolescent ; Ethnicity ; Female ; Humans ; Longitudinal Studies ; Male ; Racial Groups ; Social Identification ; Universities
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2017369-6
    ISSN 1532-7795 ; 1050-8392
    ISSN (online) 1532-7795
    ISSN 1050-8392
    DOI 10.1111/jora.12790
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  5. Article ; Online: Prescribing in pregnancy: navigating risks and benefits.

    Dobson, Ruth / Ovadia, Caroline / Mathews, Joela / Brex, Peter

    Practical neurology

    2023  Volume 23, Issue 5, Page(s) 366–367

    MeSH term(s) Pregnancy ; Female ; Humans ; Pregnancy Complications/drug therapy ; Risk Assessment ; Drug Prescriptions
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Editorial
    ZDB-ID 2170881-2
    ISSN 1474-7766 ; 1474-7758
    ISSN (online) 1474-7766
    ISSN 1474-7758
    DOI 10.1136/pn-2023-003812
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    Zs.A 6001: Show issues Location:
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  6. Article ; Online: "I'll meet you at our bench": adaptation, innovation and resilience among VCSE organisations who supported marginalised and minoritised communities during the Covid-19 pandemic in Northern England - a qualitative focus group study.

    Scott, S / McGowan, V J / Wildman, J / Bidmead, E / Hartley, J / Mathews, C / James, B / Sullivan, C / Bambra, C / Sowden, S

    BMC health services research

    2024  Volume 24, Issue 1, Page(s) 7

    Abstract: Background: The Covid-19 pandemic has exacerbated pre-existing inequalities and increased adversity and challenges for vulnerable and marginalised communities worldwide. In the UK, the Voluntary Community and Social Enterprise (VCSE) sector play a vital ...

    Abstract Background: The Covid-19 pandemic has exacerbated pre-existing inequalities and increased adversity and challenges for vulnerable and marginalised communities worldwide. In the UK, the Voluntary Community and Social Enterprise (VCSE) sector play a vital role in supporting the health and wellbeing of people who are marginalised or experiencing multiple complex needs. However, only a small number of studies have focused on the impact that Covid-19 had on the VCSE sector.
    Methods: As part of a Health Inequalities Impact Assessment (HIIA), we conducted qualitative focus groups with staff and volunteers from five organisations to examine short, medium and longer-term impacts of Covid-19 upon the VCSE sector in Northern England. Nine online focus groups were conducted between March and July 2021.
    Findings: Focus group transcripts were analysed using Framework Analysis and yielded three central themes: (1) exacerbation of pre-existing inequalities, adversity and challenges for vulnerable and marginalised populations; (2) the 'price' of being flexible, innovative and agile for VCSE staff and volunteers; and (3) the voluntary sector as a 'lifeline' - organisational pride and resilience.
    Conclusions: While the voluntary sector 'adapted at pace' to provide support during Covid-19 and in its continued aftermath, this resilience has potentially come at the cost of workforce and volunteer wellbeing, compounded by political obstacles and chronic shortage in funding and support. The VCSE sector has a vital role to play in the post-lockdown 'levelling up' agenda. The expertise, capacity and resilience of VCSE organisations, and their ability to respond to Covid-19, should be celebrated, recognised and supported adequately to maintain its resilience. To not do so threatens the sector's sustainability and risks jeopardising attempts to involve the sector in addressing the social determinants of health.
    MeSH term(s) Humans ; Focus Groups ; COVID-19/epidemiology ; Pandemics ; Resilience, Psychological ; Communicable Disease Control ; England/epidemiology
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-023-10435-5
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  7. Article: Computing the inducibility of B cell lineages under a context-dependent model of affinity maturation: Applications to sequential vaccine design.

    Mathews, Joseph / Van Itallie, Elizabeth / Wiehe, Kevin / Schmidler, Scott C

    bioRxiv : the preprint server for biology

    2023  

    Abstract: A key challenge in B cell lineage-based vaccine design is understanding ... ...

    Abstract A key challenge in B cell lineage-based vaccine design is understanding the
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.13.562156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Correlated signatures of social behavior in cerebellum and anterior cingulate cortex.

    Hur, Sung Won / Safaryan, Karen / Yang, Long / Blair, Hugh T / Masmanidis, Sotiris C / Mathews, Paul J / Aharoni, Daniel / Golshani, Peyman

    eLife

    2024  Volume 12

    Abstract: The cerebellum has been implicated in the regulation of social behavior. Its influence is thought to arise from communication, via the thalamus, to forebrain regions integral in the expression of social interactions, including the anterior cingulate ... ...

    Abstract The cerebellum has been implicated in the regulation of social behavior. Its influence is thought to arise from communication, via the thalamus, to forebrain regions integral in the expression of social interactions, including the anterior cingulate cortex (ACC). However, the signals encoded or the nature of the communication between the cerebellum and these brain regions is poorly understood. Here, we describe an approach that overcomes technical challenges in exploring the coordination of distant brain regions at high temporal and spatial resolution during social behavior. We developed the E-Scope, an electrophysiology-integrated miniature microscope, to synchronously measure extracellular electrical activity in the cerebellum along with calcium imaging of the ACC. This single coaxial cable device combined these data streams to provide a powerful tool to monitor the activity of distant brain regions in freely behaving animals. During social behavior, we recorded the spike timing of multiple single units in cerebellar right Crus I (RCrus I) Purkinje cells (PCs) or dentate nucleus (DN) neurons while synchronously imaging calcium transients in contralateral ACC neurons. We found that during social interactions a significant subpopulation of cerebellar PCs were robustly inhibited, while most modulated neurons in the DN were activated, and their activity was correlated with positively modulated ACC neurons. These distinctions largely disappeared when only non-social epochs were analyzed suggesting that cerebellar-cortical interactions were behaviorally specific. Our work provides new insights into the complexity of cerebellar activation and co-modulation of the ACC during social behavior and a valuable open-source tool for simultaneous, multimodal recordings in freely behaving mice.
    MeSH term(s) Mice ; Animals ; Gyrus Cinguli ; Calcium ; Cerebellum ; Social Behavior ; Prosencephalon
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.88439
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  9. Article ; Online: Contraceptive Service Uptake and Delivery Preferences in Perinatally and Horizontally Infected Female Adolescents Living with HIV: Results from a South Africa-Based Mixed-Methods Study'.

    Olagbuji, Biodun / Cooper, Diane / Mathews, Catherine / Moodley, Jennifer

    Journal of pediatric and adolescent gynecology

    2022  Volume 35, Issue 6, Page(s) 692–701

    Abstract: Study objective: To investigate whether contraceptive service uptake (including current contraceptive use), unmet need for contraception, unintended pregnancy, preferences for service provision, and providers among female adolescents living with HIV ( ... ...

    Abstract Study objective: To investigate whether contraceptive service uptake (including current contraceptive use), unmet need for contraception, unintended pregnancy, preferences for service provision, and providers among female adolescents living with HIV (ALHIV) vary with HIV-acquisition route, that is, perinatal HIV acquisition vs horizontal HIV acquisition.
    Design: Mixed methods including exit and in-depth interviews SETTING: Multicenter, public sector primary health care facilities, Cape Town, South Africa PARTICIPANTS: Sexually experienced female ALHIV aged 14-19 years (n = 303) including both peri/postnatally infected ALHIV (pALHIV) and horizontally infected ALHIV (hALHIV) and health care providers involved in HIV care and treatment services (n = 19) MAIN OUTCOME MEASURES: Current contraceptive use, unintended pregnancy, and preferences for service provision and providers RESULTS: The association between HIV-acquisition route and current use of any contraceptive method (aOR = 1.23; 95% CI, 0.52-2.92) and unintended pregnancy (aOR = 1.02; 95% CI, 0.39-2.67) was not significant. In contrast, pALHIV had significantly decreased odds of receiving dual-method contraception (aOR = 0.02; 95% CI, 0.00-0.38) and significantly increased odds of preferences for younger providers (aOR = 4.45; 95% CI, 2.84-6.97), female providers (aOR = 5.11; 95% CI, 1.25-20.91), and standalone youth clinics (aOR = 7.01; 95% CI, 2.39-20.55) compared with female hALHIV. Qualitative findings indicate that provider positive attitudes, as opposed to judgmental attitudes, encourage pALHIV acceptance of care from any provider regardless of, for example, the provider's age.
    Conclusions: Current contraceptive use and unintended pregnancies were similar between pALHIV and hALHIV, but the 2 distinct groups of ALHIV were heterogeneous in terms of dual-method contraception and preferences for type of clinic model and providers. Promoting positive provider attitudes could improve ALHIV's contraceptive uptake.
    MeSH term(s) Pregnancy ; Adolescent ; Female ; Humans ; Contraceptive Agents ; South Africa ; HIV Infections ; Contraception/methods ; Contraception Behavior ; Family Planning Services
    Chemical Substances Contraceptive Agents
    Language English
    Publishing date 2022-05-20
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1325079-6
    ISSN 1873-4332 ; 1083-3188
    ISSN (online) 1873-4332
    ISSN 1083-3188
    DOI 10.1016/j.jpag.2022.05.001
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  10. Article: Comparison of ZETA Fast (PTS) (Optopol Technology) and Humphrey SITA Fast (SFA) (Carl Zeiss Meditec) Perimetric Strategies.

    Mathews, Basil / Laux, Jeff / Barnhart, Cassandra / Fleischman, David

    Journal of ophthalmology

    2022  Volume 2022, Page(s) 5675793

    Abstract: Purpose: To compare two threshold strategies for visual field assessment, ZETA Fast (Optopol Technology) and Humphrey SITA Fast (Carl Zeiss Meditec), in controls and subjects with glaucoma. : Results: The difference in MD values (Optopol-Zeiss) was ... ...

    Abstract Purpose: To compare two threshold strategies for visual field assessment, ZETA Fast (Optopol Technology) and Humphrey SITA Fast (Carl Zeiss Meditec), in controls and subjects with glaucoma.
    Results: The difference in MD values (Optopol-Zeiss) was within the margin for controls (difference = 0.36,
    Conclusions: Both strategies enable effective identification of glaucomatous defects within 6 minutes; they also offer high sensitivity with a high correlation in global indices between the two strategies. The Optopol strategy is an alternative to the Zeiss counterpart with the limitation of a marginally longer testing protocol but a higher sensitivity of detecting glaucomatous defects.
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2546525-9
    ISSN 2090-0058 ; 2090-004X
    ISSN (online) 2090-0058
    ISSN 2090-004X
    DOI 10.1155/2022/5675793
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