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Article: Forward neutral pion production in p + p and d + Au collisions at square root sNN=200 GeV.

Adams, J / Aggarwal, M M / Ahammed, Z / Amonett, J / Anderson, B D / Arkhipkin, D / Averichev, G S / Badyal, S K / Bai, Y / Balewski, J / Barannikova, O / Barnby, L S / Baudot, J / Bekele, S / Belaga, V V / Bellingeri-Laurikainen, A / Bellwied, R / Berger, J / Bezverkhny, B I /

Bharadwaj, S / Bhasin, A / Bhati, A K / Bhatia, V S / Bichsel, H / Bielcik, J / Bielcikova, J / Billmeier, A / Bland, L C / Blyth, C O / Blyth, S-L / Bonner, B E / Botje, M / Boucham, A / Bouchet, J / Brandin, A V / Bravar, A / Bystersky, M / Cadman, R V / Cai, X Z / Caines, H / Sánchez, M Calderón de la Barca / Catu, O / Cebra, D / Chajecki, Z / Chaloupka, P / Chattopadhyay, S / Chen, H F / Chen, J H / Chen, Y / Cheng, J / Cherney, M / Chikanian, A / Choi, H A / Christie, W / Coffin, J P / Cormier, T M / Cosentino, M R / Cramer, J G / Crawford, H J / Das, D / Das, S / Daugherity, M / de Moura, M M / Dedovich, T G / Dephillips, M / Derevschikov, A A / Didenko, L / Dietel, T / Dogra, S M / Dong, W J / Dong, X / Draper, J E / Du, F / Dubey, A K / Dunin, V B / Dunlop, J C / Mazumdar, M R Dutta / Eckardt, V / Edwards, W R / Efimov, L G / Emelianov, V / Engelage, J / Eppley, G / Erazmus, B / Estienne, M / Fachini, P / Faivre, J / Fatemi, R / Fedorisin, J / Filimonov, K / Filip, P / Finch, E / Fine, V / Fisyak, Y / Fornazier, K S F / Fox, B D / Fu, J / Gagliardi, C A / Gaillard, L / Gans, J / Ganti, M S / Geurts, F / Ghazikhanian, V / Ghosh, P / Gonzalez, J E / Gorbunov, Y G / Gos, H / Grachov, O / Grebenyuk, O / Grosnick, D / Guertin, S M / Guo, Y / Gupta, A / Gupta, N / Gutierrez, T D / Hallman, T J / Hamed, A / Harris, J W / Heinz, M / Henry, T W / Hepplemann, S / Hippolyte, B / Hirsch, A / Hjort, E / Hoffmann, G W / Horner, M J / Huang, H Z / Huang, S L / Hughes, E W / Humanic, T J / Igo, G / Ishihara, A / Jacobs, P / Jacobs, W W / Jiang, H / Jones, P G / Judd, E G / Kabana, S / Kang, K / Kaplan, M / Keane, D / Kechechyan, A / Khodyrev, V Yu / Kim, B C / Kiryluk, J / Kisiel, A / Kislov, E M / Klein, S R / Koetke, D D / Kollegger, T / Kopytine, M / Kotchenda, L / Kowalik, K L / Kramer, M / Kravtsov, P / Kravtsov, V I / Krueger, K / Kuhn, C / Kulikov, A I / Kumar, A / Kutuev, R Kh / Kuznetsov, A A / Lamb, R / Lamont, M A C / Landgraf, J M / Lange, S / Laue, F / Lauret, J / Lebedev, A / Lednicky, R / Lee, C-H / Lehocka, S / Levine, M J / Li, C / Li, Q / Li, Y / Lin, G / Lindenbaum, S J / Lisa, M A / Liu, F / Liu, H / Liu, J / Liu, L / Liu, Q J / Liu, Z / Ljubicic, T / Llope, W J / Long, H / Longacre, R S / Lopez-Noriega, M / Love, W A / Lu, Y / Ludlam, T / Lynn, D / Ma, G L / Ma, J G / Ma, Y G / Magestro, D / Mahajan, S / Mahapatra, D P / Majka, R / Mangotra, L K / Manweiler, R / Margetis, S / Markert, C / Martin, L / Marx, J N / Matis, H S / Matulenko, Yu A / McClain, C J / McShane, T S / Melnick, Yu / Meschanin, A / Miller, M L / Minaev, N G / Mironov, C / Mischke, A / Mishra, D K / Mitchell, J / Mioduszewski, S / Mohanty, B / Molnar, L / Moore, C F / Morozov, D A / Munhoz, M G / Nandi, B K / Nayak, S K / Nayak, T K / Nelson, J M / Netrakanti, P K / Nikitin, V A / Nogach, L V / Nurushev, S B / Odyniec, G / Ogawa, A / Okorokov, V / Oldenburg, M / Olson, D / Pal, S K / Panebratsev, Y / Panitkin, S Y / Pavlinov, A I / Pawlak, T / Peitzmann, T / Perevoztchikov, V / Perkins, C / Peryt, W / Petrov, V A / Phatak, S C / Picha, R / Planinic, M / Pluta, J / Porile, N / Porter, J / Poskanzer, A M / Potekhin, M / Potrebenikova, E / Potukuchi, B V K S / Prindle, D / Pruneau, C / Putschke, J / Rakness, G / Raniwala, R / Raniwala, S / Ravel, O / Ray, R L / Razin, S V / Reichhold, D / Reid, J G / Reinnarth, J / Renault, G / Retiere, F / Ridiger, A / Ritter, H G / Roberts, J B / Rogachevskiy, O V / Romero, J L / Rose, A / Roy, C / Ruan, L / Russcher, M J / Sahoo, R / Sakrejda, I / Salur, S / Sandweiss, J / Sarsour, M / Savin, I / Sazhin, P S / Schambach, J / Scharenberg, R P / Schmitz, N / Schweda, K / Seger, J / Selyuzhenkov, I / Seyboth, P / Shabetai, A / Shahaliev, E / Shao, M / Shao, W / Sharma, M / Shen, W Q / Shestermanov, K E / Shimanskiy, S S / Sichtermann, E / Simon, F / Singaraju, R N / Smirnov, N / Snellings, R / Sood, G / Sorensen, P / Sowinski, J / Speltz, J / Spinka, H M / Srivastava, B / Stadnik, A / Stanislaus, T D S / Stock, R / Stolpovsky, A / Strikhanov, M / Stringfellow, B / Suaide, A A P / Sugarbaker, E / Sumbera, M / Surrow, B / Swanger, M / Symons, T J M / de Toledo, A Szanto / Tai, A / Takahashi, J / Tang, A H / Tarnowsky, T / Thein, D / Thomas, J H / Timmins, A R / Timoshenko, S / Tokarev, M / Trainor, T A / Trentalange, S / Tribble, R E / Tsai, O D / Ulery, J / Ullrich, T / Underwood, D G / Buren, G Van / van der Kolk, N / van Leeuwen, M / Molen, A M Vander / Varma, R / Vasilevski, I M / Vasiliev, A N / Vernet, R / Vigdor, S E / Viyogi, Y P / Vokal, S / Voloshin, S A / Waggoner, W T / Wang, F / Wang, G / Wang, X L / Wang, Y / Wang, Z M / Ward, H / Watson, J W / Webb, J C / Westfall, G D / Wetzler, A / Whitten, C / Wieman, H / Wissink, S W / Witt, R / Wood, J / Wu, J / Xu, N / Xu, Q H / Xu, Z / Xu, Z Z / Yepes, P / Yoo, I-K / Yurevich, V I / Zborovsky, I / Zhang, H / Zhang, W M / Zhang, Y / Zhang, Z P / Zhong, C / Zoulkarneev, R / Zoulkarneeva, Y / Zubarev, A N / Zuo, J X

Physical review letters

2006 Volume 97, Issue 15, Page(s) 152302

Abstract: Measurements of the production of forward pi0 mesons from p + p and d + Au collisions at square ... in p + p that is suppressed in d + Au at low pion energy. These observations are qualitatively ... root sNN=200 GeV are reported. The p + p yield generally agrees with next-to-leading order perturbative ...

Abstract	Measurements of the production of forward pi0 mesons from p + p and d + Au collisions at square root sNN=200 GeV are reported. The p + p yield generally agrees with next-to-leading order perturbative QCD calculations. The d + Au yield per binary collision is suppressed as eta increases, decreasing to approximately 30% of the p + p yield at eta =4.00, well below shadowing expectations. Exploratory measurements of azimuthal correlations of the forward pi0 with charged hadrons at eta approximately 0 show a recoil peak in p + p that is suppressed in d + Au at low pion energy. These observations are qualitatively consistent with a saturation picture of the low-x gluon structure of heavy nuclei.
Language	English
Publishing date	2006-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.97.152302
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Article: alpha 1-Antitrypsin: Referenzwerte in Serum und Plasma mit Benzoyl-D,L-arginin-p-nitroanilid, einem chromogenen Substrat.

Witt, I / Tritschler, W

Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie

1982 Volume 20, Issue 8, Page(s) 587–591

Abstract: Reference values for alpha 1-antitrypsin were determined using a commercially available kit for continuous assay at 25 degrees C. With a population of 100 probands aged between 20 and 60 years, a reference range of 1.4-2.4 kIU/l (1.9-3.4 g/l) was ... ...

Title translation	alpha 1-antitrypsin: reference values in serum and plasma with benzoyl-D,L-arginine-p-nitroanilide, a chromogenic substrate.
Abstract	Reference values for alpha 1-antitrypsin were determined using a commercially available kit for continuous assay at 25 degrees C. With a population of 100 probands aged between 20 and 60 years, a reference range of 1.4-2.4 kIU/l (1.9-3.4 g/l) was obtained for serum, and 1.4-2.1 kIU/l (1.9-3.0 g/l) for plasma. In each case, these ranges correspond to the 5th to 95th percentile. No variations according to age or sex were observed, or was any difference noted between preprandial and postprandial activities, or between values in smokers and nonsmokers. Significantly different values were found in the group of women taking oral steroid contraceptives and the group not taking such contraceptives. If the dilution of the blood sample with citrate solution is taken into account in calculating the activity in citrated plasma, it is apparent that higher values are found in plasma than in serum (median 13%): Hence, the in vivo-alpha 1-antitrypsin activity can most probably be better determined using a plasma sample.
MeSH term(s)	Adult ; Arginine ; Chromogenic Compounds ; Citrates ; Citric Acid ; Contraceptives, Oral, Hormonal ; Female ; Humans ; Male ; Middle Aged ; Plasma/enzymology ; Reagent Kits, Diagnostic ; Reference Values ; alpha 1-Antitrypsin/analysis
Chemical Substances	Chromogenic Compounds ; Citrates ; Contraceptives, Oral, Hormonal ; Reagent Kits, Diagnostic ; alpha 1-Antitrypsin ; Citric Acid (2968PHW8QP) ; Arginine (94ZLA3W45F)
Language	German
Publishing date	1982-08
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	130387-9
ISSN	0340-076X
ISSN	0340-076X
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Article: Effects Induced by the Temperature and Chemical Environment on the Fluorescence of Water-Soluble Gold Nanoparticles Functionalized with a Perylene-Derivative Dye.

Lindstaedt, Agnieszka / Doroszuk, Justyna / Machnikowska, Aneta / Dziadosz, Alicja / Barski, Piotr / Raffa, Vittoria / Witt, Dariusz

Materials (Basel, Switzerland)

2024 Volume 17, Issue 5

Abstract: We developed a fluorescent molecular probe based on gold nanoparticles functionalized ... ...

Abstract	We developed a fluorescent molecular probe based on gold nanoparticles functionalized with
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17051097
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Article ; Online: Effect of different brushing parameters on erosive tooth wear in primary bovine enamel and dentin.

Kanzow, Philipp / Witt, Corinna / Lechte, Clemens / Barke, Sarah / Rohland, Bianca / Schmidt, Alexandra / Wiegand, Annette

PloS one

2024 Volume 19, Issue 4, Page(s) e0302261

Abstract: ... 60 s/d, citric acid, pH 2.4) and brushed with children's toothbrushes (2 × 15 s/d) over 5 days ... followed by Scheffe's (enamel) or Tamhane's (dentin) post-hoc tests (p < 0.05). Brushing ...

Abstract	This in-vitro study aimed to analyse the effect of brushing and different brushing parameters (kind of toothpaste, kind of toothbrush, brushing force) on erosive tooth wear of primary bovine enamel and dentin. Specimens were prepared from primary bovine enamel or dentin (each group n = 12) and cyclically eroded (6 × 60 s/d, citric acid, pH 2.4) and brushed with children's toothbrushes (2 × 15 s/d) over 5 days. The brushing parameters under investigation were: toothpaste (fluoridated, fluoride-free), toothbrush (manual; rotating-oscillating and sonic, each at two different activation modes) and brushing force (1 N, 2 N). Specimens that were only eroded and not brushed served as controls. Enamel and dentin wear was quantified using widefield confocal microscopy. Statistical analysis was performed using three- and one-way ANOVAs followed by Scheffe's (enamel) or Tamhane's (dentin) post-hoc tests (p < 0.05). Brushing with the fluoridated toothpaste was able to significantly reduce erosive wear in enamel (by 15 to 37%, 6 of 10 groups) and in dentin (by 58 to 72%, all groups), while brushing with the fluoride-free toothpaste was not different from the controls. Considering the kind of toothpaste and brushing force, slight differences between the toothbrushes were observed in enamel, but not in dentin. Within the same toothbrush and activation mode, almost no differences between 1 and 2 N brushing force were detected. In conclusion, erosive tooth wear on primary bovine dental hard tissue mainly depends on the kind of toothpaste, rather than on the kind of toothbrush and the brushing force.
MeSH term(s)	Child ; Cattle ; Animals ; Humans ; Tooth Erosion ; Tooth Abrasion/etiology ; Toothpastes/pharmacology ; Toothbrushing ; Dentin ; Dental Enamel ; Tooth Wear
Chemical Substances	Toothpastes
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0302261
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Article ; Online: Promotion of an Algorithm-Based Tool for Pregnancy Prevention by Instagram Influencers.

Laestadius, Linnea I / Van Hoorn, Kelsey / Wahl, Megan / Witt, Alice / Carlyle, Kellie E / Guidry, Jeanine P D

Journal of women's health (2002)

2023 Volume 33, Issue 2, Page(s) 141–151

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Pregnancy ; Female ; Humans ; United States ; Pregnancy, Unplanned ; Public Health ; Social Media
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1139774-3
ISSN	1931-843X ; 1059-7115 ; 1540-9996
ISSN (online)	1931-843X
ISSN	1059-7115 ; 1540-9996
DOI	10.1089/jwh.2023.0251
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Article ; Online: A conceptual framework for return to work for clients with major depressive disorder.

Franzsen, Denise / de Witt, Patricia / Saohatse, Lebohang / van Niekerk, Matty

Work (Reading, Mass.)

2022

Abstract: Background: Return to work (RTW) may be a lengthy and complex process for individuals with major depressive disorder (MDD) especially when not well managed. This increases the risk of isolation and loss of routine which negatively influences their ... ...

Abstract	Background: Return to work (RTW) may be a lengthy and complex process for individuals with major depressive disorder (MDD) especially when not well managed. This increases the risk of isolation and loss of routine which negatively influences their mental health. However, for clients with MDD, a comprehensive overview of all the factors that influence RTW based on a model of occupation, is lacking. Objective: To develop a conceptual framework to guide an occupation-based process of RTW for clients with MDD, treated in the private sector in South Africa. Methods: This paper describes the development of a conceptual framework using literature and thematic synthesis of a qualitative descriptive study based on interviews with eight participants diagnosed with MDD which were linked to constructs of Kielhofner's Model of Human Occupation (MOHO). Results: Qualitative data from key informant interviews were deductively analysed according to the subsystems of MOHO for waiting to RTW and experience of RTW. The conceptual framework developed included the constructs of Person and Occupational Setting from MOHO as well as the components of Occupational Identity and Competence central to intervention to achieve successful RTW. Conclusion: A successful RTW process for clients with MDD is dependent on the person and the occupational setting. The role of the occupational therapist in the RTW can be facilitated by the occupation-based conceptual framework developed on MOHO.
Language	English
Publishing date	2022-10-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1394194-x
ISSN	1875-9270 ; 1051-9815
ISSN (online)	1875-9270
ISSN	1051-9815
DOI	10.3233/WOR-210520
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Article ; Online: Genetic analysis of pancreatic phospholipase A2 (PLA2G1B) in patients with chronic pancreatitis.

Ewers, Maren / Epple, Denise / Bugert, Peter / Rosendahl, Jonas / Witt, Heiko

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

2022 Volume 22, Issue 2, Page(s) 244–247

Abstract: ... Results: We detected 2 frequent synonymous variants in exon 3: c.222T>C (p.Y74 = ) and c.294G>A (p.S98 ... in controls; c.294AA: 2.4% in NACP vs. 1.1% in controls). All p-values were non-significant. In addition ... we found one synonymous variant, c.138C>T (p.N46 = ) and one non-synonymous variant, c.244A>G (p.S82G ...

Abstract	Background: Genetic mutations in various pancreatic enzymes or their counteracting proteins have been linked to chronic pancreatitis. In particular, variants in the genes encoding pancreatic lipase (PNLIP) and carboxyl ester lipase (CEL) have been associated with pancreatitis. Therefore, we investigated pancreatic phospholipase A2 (PLA2G1B) as a promising candidate gene in patients with chronic pancreatitis. Methods: We analyzed all coding exons and adjacent intronic regions of PLA2G1B in 416 German patients with non-alcoholic chronic pancreatitis (NACP) and 186 control subjects by direct DNA sequencing. Results: We detected 2 frequent synonymous variants in exon 3: c.222T>C (p.Y74 = ) and c.294G>A (p.S98 = ). The genotype and allele frequencies of these variants were similar between patients and controls (c.222 TC: 9.6% in NACP vs. 9.7% in controls; c.222CC: 0.2% in NACP vs. 0% in controls; c.294 GA: 31.3% in NACP vs. 28.0% in controls; c.294AA: 2.4% in NACP vs. 1.1% in controls). All p-values were non-significant. In addition, we found one synonymous variant, c.138C>T (p.N46 = ) and one non-synonymous variant, c.244A>G (p.S82G), in a single case each. Conclusions: Our results suggest that genetic alterations in PLA2G1B do not predispose to the development of non-alcoholic chronic pancreatitis.
MeSH term(s)	Gene Frequency ; Genetic Testing ; Group IB Phospholipases A2/genetics ; Humans ; Pancreatitis, Alcoholic/genetics ; Pancreatitis, Chronic/genetics ; Sequence Analysis, DNA
Chemical Substances	Group IB Phospholipases A2 (EC 3.1.1.4) ; PLA2G1B protein, human (EC 3.1.1.4)
Language	English
Publishing date	2022-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2056680-3
ISSN	1424-3911 ; 1424-3903
ISSN (online)	1424-3911
ISSN	1424-3903
DOI	10.1016/j.pan.2022.01.003
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Zs.A 5553: Show issues

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Article ; Online: Extreme elevational migration spurred cryptic speciation in giant hummingbirds.

Williamson, Jessie L / Gyllenhaal, Ethan F / Bauernfeind, Selina M / Bautista, Emil / Baumann, Matthew J / Gadek, Chauncey R / Marra, Peter P / Ricote, Natalia / Valqui, Thomas / Bozinovic, Francisco / Singh, Nadia D / Witt, Christopher C

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 21, Page(s) e2313599121

Abstract: The ecoevolutionary drivers of species niche expansion or contraction are critical for biodiversity but challenging to infer. Niche expansion may be promoted by local adaptation or constrained by physiological performance trade-offs. For birds, ... ...

Abstract	The ecoevolutionary drivers of species niche expansion or contraction are critical for biodiversity but challenging to infer. Niche expansion may be promoted by local adaptation or constrained by physiological performance trade-offs. For birds, evolutionary shifts in migratory behavior permit the broadening of the climatic niche by expansion into varied, seasonal environments. Broader niches can be short-lived if diversifying selection and geography promote speciation and niche subdivision across climatic gradients. To illuminate niche breadth dynamics, we can ask how "outlier" species defy constraints. Of the 363 hummingbird species, the giant hummingbird (
MeSH term(s)	Animals ; Animal Migration/physiology ; Birds/genetics ; Birds/physiology ; Birds/classification ; Genetic Speciation ; Ecosystem ; Altitude ; Biological Evolution
Language	English
Publishing date	2024-05-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2313599121
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Zs.A 1148: Show issues

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Article ; Online: Missed chances? Sequestration and non-sequestration of alkaloids by moths (Lepidoptera)

Petzel-Witt, Silvana / Wunder, Cora / Pogoda, Werner / Toennes, Stefan W. / Mebs, D.

Toxicon. 2023 May, v. 227 p.107098-

2023

Abstract: ... sulfate was added to the alkaloid-free diet of the larvae, A. atropos and D. nerii were found to be unable ...

Abstract	Some butterflies and moths sequester and retain noxious phytochemicals for defence against predators. In the present study, three moth species, the garden tiger moth, Arctia caja, the death hawk moth, Acherontia atropos, and the oleander hawk moth, Daphnis nerii, were tested whether they sequester alkaloids from their host plants. Whereas A. caja consistently sequestered atropine from Atropa belladonna, also when atropine sulfate was added to the alkaloid-free diet of the larvae, A. atropos and D. nerii were found to be unable to sequester alkaloids, neither atropine nor eburnamenine from Vinca major, respectively. Instead of acquiring toxicity as chemical defence, nocturnal lifestyle and cryptic attitudes may improve their chances of survival.
Keywords	Acherontia atropos ; Arctia caja ; Atropa belladonna ; Daphnis nerii ; Vinca major ; atropine ; chemical defenses ; death ; diet ; moths ; nocturnal activity ; phytochemicals ; sulfates ; toxicity ; Alkaloid sequestration ; Eburnamenine
Language	English
Dates of publication	2023-05
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2023.107098
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 501: Show issues

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Article: Three-Dimensional Quantification of Collagen Microstructure During Tensile Mechanical Loading of Skin.

Woessner, Alan E / Jones, Jake D / Witt, Nathan J / Sander, Edward A / Quinn, Kyle P

Frontiers in bioengineering and biotechnology

2021 Volume 9, Page(s) 642866

Abstract: Skin is a heterogeneous tissue that can undergo substantial structural and functional changes with age, disease, or following injury. Understanding how these changes impact the mechanical properties of skin requires three-dimensional (3D) quantification ... ...

Abstract	Skin is a heterogeneous tissue that can undergo substantial structural and functional changes with age, disease, or following injury. Understanding how these changes impact the mechanical properties of skin requires three-dimensional (3D) quantification of the tissue microstructure and its kinematics. The goal of this study was to quantify these structure-function relationships
Language	English
Publishing date	2021-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2021.642866
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