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Article ; Online: Response.

Cavaliere, Kimberly / Trindade, Arvind J

2021 Volume 93, Issue 5, Page(s) 1193–1194

MeSH term(s)	COVID-19 ; Humans ; SARS-CoV-2
Language	English
Publishing date	2021-04-19
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2021.01.015
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Article: Identifying Visceral Kaposi Sarcoma (KS): A Responsibility to Avoid Anchoring on the Diagnosis of a Crohn's Flare.

Seltzer, Emily S / Shenoy, Shabari M / Yoon, Bo Hyung / Rozenshteyn, Frederick / Cavaliere, Kimberly

Cureus

2023 Volume 15, Issue 2, Page(s) e34986

Abstract: The initial evaluation of reported inflammatory bowel disease (IBD) should include an assessment for immunosuppression which can broaden the differential diagnosis to include opportunistic infection as well as other processes. Here we present an ... ...

Abstract	The initial evaluation of reported inflammatory bowel disease (IBD) should include an assessment for immunosuppression which can broaden the differential diagnosis to include opportunistic infection as well as other processes. Here we present an exceedingly rare case of a patient with a self-reported history of Crohn's disease presenting with frequent diarrhea presumed to be a Crohn's flare, however, after further workup was found to have extensive visceral Kaposi sarcoma (KS).
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.34986
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Article ; Online: Digital Rectal Exams Are Infrequently Performed Prior to Anorectal Manometry.

Menand, Joseph A / Sandhu, Robinderpal / Israel, Yonatan / Reford, Emma / Zafar, Ahmun / Singh, Priyanka / Cavaliere, Kimberly / Saleh, Jean / Smith, Michael S / Jodorkovsky, Daniela / Luo, Yuying

Digestive diseases and sciences

2024 Volume 69, Issue 3, Page(s) 728–731

Abstract: Background: Digital rectal examination should be performed prior to anorectal manometry; however, real-world data is lacking.: Aims: Characterize real world rates of digital rectal and their sensitivity for detecting dyssynergia compared to anorectal ...

Abstract	Background: Digital rectal examination should be performed prior to anorectal manometry; however, real-world data is lacking. Aims: Characterize real world rates of digital rectal and their sensitivity for detecting dyssynergia compared to anorectal manometry and balloon expulsion test. Methods: A retrospective single-center study was conducted to examine all patients who underwent anorectal manometry for chronic constipation between 2021 and 2022 at one tertiary center with motility expertise. Primary outcomes consisted of the rate of digital rectal exam prior to anorectal manometry; and secondary outcomes included the sensitivity of digital rectal exam for dyssynergic defecation. Results: Only 42.3% of 142 patients had digital rectal examinations prior to anorectal manometry. Overall sensitivity for detecting dyssynergic defecation was 46.4%, but significantly higher for gastroenterology providers (p = .004), and highest for gastroenterology attendings (82.6%). Conclusions: Digital rectal examination is infrequently performed when indicated for chronic constipation. Sensitivity for detecting dyssynergic defecation may be impacted by discipline and level of training.
MeSH term(s)	Humans ; Defecation ; Retrospective Studies ; Manometry ; Rectum ; Constipation/diagnosis ; Digital Rectal Examination ; Ataxia ; Anal Canal
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-023-08243-2
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Article ; Online: Management of upper GI bleeding in patients with COVID-19 pneumonia.

Cavaliere, Kimberly / Levine, Calley / Wander, Praneet / Sejpal, Divyesh V / Trindade, Arvind J

Gastrointestinal endoscopy

2020 Volume 92, Issue 2, Page(s) 454–455

MeSH term(s)	Aged ; Aged, 80 and over ; COVID-19 ; Coronavirus Infections/complications ; Female ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/therapy ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Upper Gastrointestinal Tract
Keywords	covid19
Language	English
Publishing date	2020-04-20
Publishing country	United States
Document type	Letter
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2020.04.028
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Article: Management of upper GI bleeding in patients with COVID-19 pneumonia

Cavaliere, Kimberly / Levine, Calley / Wander, Praneet / Sejpal, Divyesh V / Trindade, Arvind J

Gastrointest Endosc

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #88504
Database	COVID19

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Article ; Online: Management of upper GI bleeding in patients with COVID-19 pneumonia

Cavaliere, Kimberly / Levine, Calley / Wander, Praneet / Sejpal, Divyesh V. / Trindade, Arvind J.

Gastrointestinal Endoscopy

2020 Volume 92, Issue 2, Page(s) 454–455

Keywords	Gastroenterology ; Radiology Nuclear Medicine and imaging ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2020.04.028
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Article ; Online: Longitudinal and Circumferential Distributions of Dysplasia and Early Neoplasia in Barrett's Esophagus: A Pooled Analysis of Three Prospective Studies.

Raphael, Kara L / Inamdar, Sumant / McKinley, Matthew J / Martinez, Nichol / Cavaliere, Kimberly / Kahn, Allon / Leggett, Cadman L / Iyer, Prasad / Wang, Kenneth K / Trindade, Arvind J

Clinical and translational gastroenterology

2021 Volume 12, Issue 2, Page(s) e00311

Abstract: Introduction: Studies have shown that dysplasia in Barrett's esophagus (BE) has a predilection for the right hemisphere. There is limited information on the longitudinal distribution. The aim was to determine both the longitudinal and circumferential ... ...

Abstract	Introduction: Studies have shown that dysplasia in Barrett's esophagus (BE) has a predilection for the right hemisphere. There is limited information on the longitudinal distribution. The aim was to determine both the longitudinal and circumferential distributions of dysplasia and early neoplasia from 3 prospective studies. Methods: This is a pooled analysis from 3 prospective studies of patients with treatment-naive BE. Both circumferential and longitudinal locations (for BE segments greater than 1 cm) of dysplastic and early neoplastic lesions were recorded. Results: A total of 177 dysplastic and early neoplastic lesions from 91 patients were included in the pooled analysis; of which 59.3% (n = 105) were seen on high-definition white light endoscopy, 29.4% (n = 52) on advanced imaging, and 11.2% (n = 20) with random biopsies. The average Prague score was C3M5. Of 157 lesions within BE segments greater than 1 cm, 49 (34.8%) lesions were in the proximal half, whereas 92 lesions (65.2%) were in the distal half (P < 0.001). The right hemisphere of the esophagus contained 55% (86/157) of the total lesions compared with 45% (71/157) for the left hemisphere (P = 0.02). This was because of the presence of high-grade dysplasia being concentrated in the right hemisphere compared with the left hemisphere (60% vs 40%, P = 0.002). Discussion: In this pooled analysis of prospective studies, both low-grade dysplasia and high-grade dysplasia are more frequently found in the distal half of the Barrett's segment. This study confirms that the right hemisphere is a hot spot for high-grade dysplasia. Careful attention to these locations is important during surveillance endoscopy.
MeSH term(s)	Barrett Esophagus/diagnostic imaging ; Barrett Esophagus/pathology ; Biopsy ; Data Interpretation, Statistical ; Esophageal Neoplasms/diagnostic imaging ; Esophageal Neoplasms/pathology ; Esophagoscopy ; Female ; Humans ; Male ; Microscopy, Confocal
Language	English
Publishing date	2021-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2581516-7
ISSN	2155-384X ; 2155-384X
ISSN (online)	2155-384X
ISSN	2155-384X
DOI	10.14309/ctg.0000000000000311
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Article ; Online: Identification of molecular motors in the Woods Hole squid, Loligo pealei: an expressed sequence tag approach.

DeGiorgis, Joseph A / Cavaliere, Kimberly R / Burbach, J Peter H

Cytoskeleton (Hoboken, N.J.)

2011 Volume 68, Issue 10, Page(s) 566–577

Abstract: The squid giant axon and synapse are unique systems for studying neuronal function. While a few nucleotide and amino acid sequences have been obtained from squid, large scale genetic and proteomic information is lacking. We have been particularly ... ...

Abstract	The squid giant axon and synapse are unique systems for studying neuronal function. While a few nucleotide and amino acid sequences have been obtained from squid, large scale genetic and proteomic information is lacking. We have been particularly interested in motors present in axons and their roles in transport processes. Here, to obtain genetic data and to identify motors expressed in squid, we initiated an expressed sequence tag project by single-pass sequencing mRNAs isolated from the stellate ganglia of the Woods Hole Squid, Loligo pealei. A total of 22,689 high quality expressed sequence tag (EST) sequences were obtained and subjected to basic local alignment search tool analysis. Seventy six percent of these sequences matched genes in the National Center for Bioinformatics databases. By CAP3 analysis this library contained 2459 contigs and 7568 singletons. Mining for motors successfully identified six kinesins, six myosins, a single dynein heavy chain, as well as components of the dynactin complex, and motor light chains and accessory proteins. This initiative demonstrates that EST projects represent an effective approach to obtain sequences of interest.
MeSH term(s)	Amino Acid Sequence ; Animals ; Axonal Transport ; Axons/metabolism ; Axons/physiology ; Decapodiformes/enzymology ; Decapodiformes/genetics ; Dyneins/genetics ; Dyneins/metabolism ; Expressed Sequence Tags ; Kinesin/genetics ; Kinesin/metabolism ; Molecular Motor Proteins/genetics ; Molecular Motor Proteins/metabolism ; Molecular Sequence Data ; Myosins/genetics ; Myosins/metabolism ; Sequence Alignment ; Stellate Ganglion/chemistry ; Stellate Ganglion/physiology ; Transcriptome
Chemical Substances	Molecular Motor Proteins ; Myosins (EC 3.6.4.1) ; Dyneins (EC 3.6.4.2) ; Kinesin (EC 3.6.4.4)
Language	English
Publishing date	2011-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2534372-5
ISSN	1949-3592 ; 1949-3584
ISSN (online)	1949-3592
ISSN	1949-3584
DOI	10.1002/cm.20531
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Article ; Online: Escalation of Immunosuppressive Therapy for Inflammatory Bowel Disease Is Not Associated With Adverse Outcomes After Infection With Clostridium difficile.

Lukin, Dana J / Lawlor, Garrett / Hudesman, David P / Durbin, Laura / Axelrad, Jordan E / Passi, Monica / Cavaliere, Kimberly / Coburn, Elliot / Loftus, Michelle / Jen, Henry / Feathers, Alexandra / Rosen, Melissa H / Malter, Lisa B / Swaminath, Arun

Inflammatory bowel diseases

2018 Volume 25, Issue 4, Page(s) 775–781

Abstract: Background: Clostridium difficile infection (CDI) is common in patients with inflammatory bowel disease (IBD), often leading to diagnostic confusion and delays in IBD therapy escalation. This study sought to assess outcomes after CDI in IBD patients ... ...

Abstract	Background: Clostridium difficile infection (CDI) is common in patients with inflammatory bowel disease (IBD), often leading to diagnostic confusion and delays in IBD therapy escalation. This study sought to assess outcomes after CDI in IBD patients exposed to new or escalated immunosuppressive therapy. Methods: This multicenter retrospective cohort study included IBD patients with documented CDI at 4 academic medical centers. Data were abstracted from clinical databases at each institution. Outcomes at 30 and 90 days were compared between patients undergoing new or intensified immunosuppressive therapy and those without therapy escalation. Continuous variables were compared using t tests, and proportions using chi-square tests. Multivariable logistic regression was used to determine the association of individual variables with severe outcomes (including death, sepsis, and/or colectomy) within 90 days. Secondary outcomes included CDI recurrence, rehospitalization, worsening of IBD, and severe outcomes within 30 days. Results: A total of 207 adult patients with IBD and CDI were included, of whom 62 underwent escalation to biologic or corticosteroid therapy (median time to escalation, 13 days). Severe outcomes within 90 days occurred in 21 (15.6%) nonescalated and 1 (1.8%) therapy-escalated patients. Serum albumin <2.5 mg/dL, lactate >2.2 mg/dL, intensive care unit admission, hypotension, and comorbid disease were associated with severe outcomes. Likelihood of severe outcomes was decreased in patients undergoing escalation of IBD therapy after CDI (adjusted odds ratio [aOR], 0.12) and increased among patients aged >65 years (aOR, 4.55). Conclusions: Therapy escalation for IBD within 90 days of CDI was not associated with worse clinical outcomes. Initiation of immunosuppression for active IBD may therefore be appropriate in carefully selected patients after treatment of CDI.
MeSH term(s)	Adolescent ; Adult ; Clostridium Infections/complications ; Clostridium Infections/drug therapy ; Clostridium Infections/microbiology ; Clostridium difficile/drug effects ; Clostridium difficile/isolation & purification ; Female ; Follow-Up Studies ; Hospitalization ; Humans ; Immunosuppressive Agents/therapeutic use ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/microbiology ; Male ; Prognosis ; Retrospective Studies
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2018-10-11
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izy308
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Article ; Online: Myocardial involvement in children with post-COVID multisystem inflammatory syndrome: a cardiovascular magnetic resonance based multicenter international study-the CARDOVID registry.

Aeschlimann, Florence A / Misra, Nilanjana / Hussein, Tarique / Panaioli, Elena / Soslow, Jonathan H / Crum, Kimberly / Steele, Jeremy M / Huber, Steffen / Marcora, Simona / Brambilla, Paolo / Jain, Supriya / Navallas, Maria / Giuli, Valentina / Rücker, Beate / Angst, Felix / Patel, Mehul D / Azarine, Arshid / Caro-Domínguez, Pablo / Cavaliere, Annachiara /

Di Salvo, Giovanni / Ferroni, Francesca / Agnoletti, Gabriella / Bonnemains, Laurent / Martins, Duarte / Boddaert, Nathalie / Wong, James / Pushparajah, Kuberan / Raimondi, Francesca

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

2021 Volume 23, Issue 1, Page(s) 140

Abstract: Background: Recent evidence shows an association between coronavirus disease 2019 (COVID-19) infection and a severe inflammatory syndrome in children. Cardiovascular magnetic resonance (CMR) data about myocardial injury in children are limited to small ... ...

Abstract	Background: Recent evidence shows an association between coronavirus disease 2019 (COVID-19) infection and a severe inflammatory syndrome in children. Cardiovascular magnetic resonance (CMR) data about myocardial injury in children are limited to small cohorts. The aim of this multicenter, international registry is to describe clinical and cardiac characteristics of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 using CMR so as to better understand the real extent of myocardial damage in this vulnerable cohort. Methods and results: Hundred-eleven patients meeting the World Health Organization criteria for MIS-C associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), having clinical cardiac involvement and having received CMR imaging scan were included from 17 centers. Median age at disease onset was 10.0 years (IQR 7.0-13.8). The majority of children had COVID-19 serology positive (98%) with 27% of children still having both, positive serology and polymerase chain reaction (PCR). CMR was performed at a median of 28 days (19-47) after onset of symptoms. Twenty out of 111 (18%) patients had CMR criteria for acute myocarditis (as defined by the Lake Louise Criteria) with 18/20 showing subepicardial late gadolinium enhancement (LGE). CMR myocarditis was significantly associated with New York Heart Association class IV (p = 0.005, OR 6.56 (95%-CI 1.87-23.00)) and the need for mechanical support (p = 0.039, OR 4.98 (95%-CI 1.18-21.02)). At discharge, 11/111 (10%) patients still had left ventricular systolic dysfunction. Conclusion: No CMR evidence of myocardial damage was found in most of our MIS-C cohort. Nevertheless, acute myocarditis is a possible manifestation of MIS-C associated with SARS-CoV-2 with CMR evidence of myocardial necrosis in 18% of our cohort. CMR may be an important diagnostic tool to identify a subset of patients at risk for cardiac sequelae and more prone to myocardial damage. Clinical trial registration: The study has been registered on ClinicalTrials.gov, Identifier NCT04455347, registered on 01/07/2020, retrospectively registered.
MeSH term(s)	COVID-19/complications ; Child ; Contrast Media ; Gadolinium ; Humans ; Magnetic Resonance Spectroscopy ; Myocarditis/diagnostic imaging ; Myocarditis/epidemiology ; Predictive Value of Tests ; Registries ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2021-12-30
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	1458034-2
ISSN	1532-429X ; 1097-6647
ISSN (online)	1532-429X
ISSN	1097-6647
DOI	10.1186/s12968-021-00841-1
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