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  1. Article: COVID-19 emergency: from a general hospital to a covid hospital in one week, an Italian experience.

    Azzolini, E / Furia, G / Cerquetani, F / Speranza, F / Chiaradia, S / Marchianò, V / Mainelli, M T / Vescia, M / Zoppegno, A / Quintili, M / Chierchini, P

    Annali di igiene : medicina preventiva e di comunita

    2022  Volume 34, Issue 6, Page(s) 659–663

    Abstract: Abstract: Aim of this letter is to describe the reconversion process of our general hospital, in just one week, into a COVID-19 Hospital. The working strategy allowed to quickly find the spaces, identify the working group, reshape the hospital ... ...

    Abstract Abstract: Aim of this letter is to describe the reconversion process of our general hospital, in just one week, into a COVID-19 Hospital. The working strategy allowed to quickly find the spaces, identify the working group, reshape the hospital organizational structure, redesign the flows and patient/health workers pathways. The hospital provided for a progressive activation of COVID-19 beds following the philosophy of the intensity of care. The main results were on management, flows, PPE and hygiene areas. Although some problems came out in the beginning, this fast hospital reconversion model may be replicated in the future to face similar epidemic or pandemic outbreaks.
    MeSH term(s) COVID-19 ; Health Personnel ; Hospitals, General ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-08-30
    Publishing country Italy
    Document type Letter
    ZDB-ID 1018045-x
    ISSN 1120-9135 ; 0029-6287
    ISSN 1120-9135 ; 0029-6287
    DOI 10.7416/ai.2022.2496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Synthesis and Antimycobacterial Activity of 3-Phenyl-1

    Jardim Etchart, Renata / Rambo, Raoní S / Lopes Abbadi, Bruno / Sperotto, Nathalia / Ev Neves, Christiano / Fries Silva, Fernanda / Dornelles, Maiele / Duarte, Lovaine / Souza Macchi, Fernanda / Alberton Perelló, Marcia / Vescia Lourega, Rogério / Valim Bizarro, Cristiano / Basso, Luiz Augusto / Machado, Pablo

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 17

    Abstract: Tuberculosis has been described as a global health crisis since the 1990s, with an estimated 1.4 million deaths in the last year. Herein, a series of 20 ... ...

    Abstract Tuberculosis has been described as a global health crisis since the 1990s, with an estimated 1.4 million deaths in the last year. Herein, a series of 20 1
    MeSH term(s) Animals ; Antitubercular Agents/chemical synthesis ; Antitubercular Agents/pharmacology ; Cell Line, Tumor ; Chlorocebus aethiops ; Hep G2 Cells ; Humans ; Indoles/chemical synthesis ; Indoles/pharmacology ; Microbial Sensitivity Tests/methods ; Mycobacterium tuberculosis/drug effects ; Structure-Activity Relationship ; Tuberculosis/drug therapy ; Vero Cells
    Chemical Substances Antitubercular Agents ; Indoles
    Language English
    Publishing date 2021-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26175148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Translational Aspects of Epithelioid Sarcoma: Current Consensus.

    Grünewald, Thomas G P / Postel-Vinay, Sophie / Nakayama, Robert T / Berlow, Noah E / Bolzicco, Andrea / Cerullo, Vincenzo / Dermawan, Josephine K / Frezza, Anna Maria / Italiano, Antoine / Jin, Jia Xiang / Le Loarer, Francois / Martin-Broto, Javier / Pecora, Andrew / Perez-Martinez, Antonio / Tam, Yuen Bun / Tirode, Franck / Trama, Annalisa / Pasquali, Sandro / Vescia, Mariagrazia /
    Wortmann, Lukas / Wortmann, Michael / Yoshida, Akihiko / Webb, Kim / Huang, Paul H / Keller, Charles / Antonescu, Cristina R

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2023  Volume 30, Issue 6, Page(s) 1079–1092

    Abstract: Epithelioid sarcoma (EpS) is an ultra-rare malignant soft-tissue cancer mostly affecting adolescents and young adults. EpS often exhibits an unfavorable clinical course with fatal outcome in ∼50% of cases despite aggressive multimodal therapies combining ...

    Abstract Epithelioid sarcoma (EpS) is an ultra-rare malignant soft-tissue cancer mostly affecting adolescents and young adults. EpS often exhibits an unfavorable clinical course with fatal outcome in ∼50% of cases despite aggressive multimodal therapies combining surgery, chemotherapy, and irradiation. EpS is traditionally classified in a more common, less aggressive distal (classic) type and a rarer aggressive proximal type. Both subtypes are characterized by a loss of nuclear INI1 expression, most often following homozygous deletion of its encoding gene, SMARCB1-a core subunit of the SWI/SNF chromatin remodeling complex. In 2020, the EZH2 inhibitor tazemetostat was the first targeted therapy approved for EpS, raising new hopes. Still, the vast majority of patients did not benefit from this drug or relapsed rapidly. Further, other recent therapeutic modalities, including immunotherapy, are only effective in a fraction of patients. Thus, novel strategies, specifically targeted to EpS, are urgently needed. To accelerate translational research on EpS and eventually boost the discovery and development of new diagnostic tools and therapeutic options, a vibrant translational research community has formed in past years and held two international EpS digital expert meetings in 2021 and 2023. This review summarizes our current understanding of EpS from the translational research perspective and points to innovative research directions to address the most pressing questions in the field, as defined by expert consensus and patient advocacy groups.
    MeSH term(s) Adolescent ; Young Adult ; Humans ; Transcription Factors/genetics ; DNA-Binding Proteins/genetics ; Chromosomal Proteins, Non-Histone/genetics ; Homozygote ; Consensus ; Sequence Deletion ; SMARCB1 Protein/genetics ; SMARCB1 Protein/metabolism ; Sarcoma/diagnosis ; Sarcoma/genetics ; Sarcoma/therapy
    Chemical Substances Transcription Factors ; DNA-Binding Proteins ; Chromosomal Proteins, Non-Histone ; SMARCB1 Protein
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-23-2174
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  4. Article ; Online: Synthesis and Antimycobacterial Activity of 3-Phenyl-1 H -indoles

    Renata Jardim Etchart / Raoní S. Rambo / Bruno Lopes Abbadi / Nathalia Sperotto / Christiano Ev Neves / Fernanda Fries Silva / Maiele Dornelles / Lovaine Duarte / Fernanda Souza Macchi / Marcia Alberton Perelló / Rogério Vescia Lourega / Cristiano Valim Bizarro / Luiz Augusto Basso / Pablo Machado

    Molecules, Vol 26, Iss 5148, p

    2021  Volume 5148

    Abstract: Tuberculosis has been described as a global health crisis since the 1990s, with an estimated 1.4 million deaths in the last year. Herein, a series of 20 1 H -indoles were synthesized and evaluated as in vitro inhibitors of Mycobacterium tuberculosis (Mtb) ...

    Abstract Tuberculosis has been described as a global health crisis since the 1990s, with an estimated 1.4 million deaths in the last year. Herein, a series of 20 1 H -indoles were synthesized and evaluated as in vitro inhibitors of Mycobacterium tuberculosis (Mtb) growth. Furthermore, the top hit compounds were active against multidrug-resistant strains, without cross-resistance with first-line drugs. Exposing HepG2 and Vero cells to the molecules for 72 h showed that one of the evaluated structures was devoid of apparent toxicity. In addition, this 3-phenyl-1 H -indole showed no genotoxicity signals. Finally, time-kill and pharmacodynamic model analyses demonstrated that this compound has bactericidal activity at concentrations close to the Minimum Inhibitory Concentration, coupled with a strong time-dependent behavior. To the best of our knowledge, this study describes the activity of 3-phenyl-1 H -indole against Mtb for the first time.
    Keywords 1 H -indoles ; Mycobacterium tuberculosis ; mammalian cellular viability ; genotoxicity ; time-kill ; pharmacodynamic model ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Conference proceedings: Verminderung von Komplikationen sowie Pflege implantierter Portkatheter bei Tumorpatienten

    Baumgärtner, AK / Vescia, S / Harbeck, N / Loibl, S

    Senologie - Zeitschrift für Mammadiagnostik und -therapie

    2006  

    Abstract: Die Behandlung von Patienten mit onkologischen Erkrankungen hat in den letzten Jahrzehnten einen wesentlichen Wandel erfahren. Neue standardisierte Schemata mit zytostatischen Kombinationstherapien haben an Bedeutung gewonnen und die Applikationsmuster ... ...

    Event/congress 26. Jahrestagung der - Deutschen Gesellschaft für Senologie, Dresden, 2006
    Abstract Die Behandlung von Patienten mit onkologischen Erkrankungen hat in den letzten Jahrzehnten einen wesentlichen Wandel erfahren. Neue standardisierte Schemata mit zytostatischen Kombinationstherapien haben an Bedeutung gewonnen und die Applikationsmuster sind deutlich komplexer geworden. Als sicherer, zentraler Gefäßzugang zur Zytostatika-Applikation sowie Gabe von Blutprodukten oder parenteraler Ernährung sind implantierte Portkatheter aus dem Alltag der Onkologie nicht mehr wegzudenken. Sachgerecht implantiert, richtig genutzt und sorgfältig gewartet stellen sie eine wesentliche Erleichterung für Patienten, Ärzte und Pflegepersonal dar. Die häufigsten Komplikationen dieser Portsysteme sind Infektionen, Thrombosen (3–37%), Okklusion, Dislokation, Membrandefekt und Penetration durch die Haut. Verschiedene Arbeitsgruppen haben sich sowohl mit dem prophylaktischen Einsatz von niedermolekularen Heparinen und Cumarinderivaten zur Vermeidung von katheterassoziierten Thrombosen beschäftigt, als auch Übersichtsartikel über die sachgerechte Handhabung von Portsystemen veröffentlicht. Diese Arbeit soll eine Zusammenfassung über die aktuelle Literatur geben und Empfehlungen für den Umgang mit Portsystemen unter laufender Chemotherapie sowie in der Nachsorge zusammenstellen. Zukünftiges Ziel muss die Entwicklung von Leitlinien sein, die den Umgang mit Portsystemen standardisieren und die Komplikationsrate durch gezielte Maßnahmen senken.
    Language German
    Publishing date 2006-10-09
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2174147-5
    ISSN 1611-647X ; 1611-6453
    ISSN (online) 1611-647X
    ISSN 1611-6453
    DOI 10.1055/s-2006-953748
    Database Thieme publisher's database

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  6. Article ; Online: Management of venous port systems in oncology: a review of current evidence.

    Vescia, S / Baumgärtner, A K / Jacobs, V R / Kiechle-Bahat, M / Rody, A / Loibl, S / Harbeck, N

    Annals of oncology : official journal of the European Society for Medical Oncology

    2007  Volume 19, Issue 1, Page(s) 9–15

    Abstract: Background: Over the last decades, many changes have occurred in oncology with new chemotherapy combinations and more complex application schemes becoming available. Central venous catheters and implantable venous port systems have become widely used ... ...

    Abstract Background: Over the last decades, many changes have occurred in oncology with new chemotherapy combinations and more complex application schemes becoming available. Central venous catheters and implantable venous port systems have become widely used and have facilitated the problem of vascular access. However, important complications are associated with permanent central venous catheters.
    Material and methods: This review summarizes evidence on venous port system use published in Medline up to February 2007. Moreover, recent guidelines for the prevention and management of catheter-related infections issued by the Infectious Diseases Society of America, the American College of Critical Care Medicine, the Society for Healthcare Epidemiology of America, the Center for Disease Control and Prevention, Atlanta, and the Infectious Diseases Working Party of the German Society of Hematology and Oncology are included.
    Results: Sterile precautions are essential when implanting and accessing port systems. Infections must be treated with adequate antimicrobial therapy. Catheter-related thromboembolic complications were found at a rate of 12-64% in retrospective studies. Five current clinical trials investigated the effect of prophylactic anticoagulation with either low molecular weight heparin or warfarin in cancer patients with central venous devices. On the basis of these results, routine anticoagulation cannot be recommended.
    Conclusions: This article reviews the current literature on long-term complications of venous port systems, focusing on infection and thrombosis. In addition, it summarizes the evidence regarding routine maintenance of port systems in follow-up care.
    MeSH term(s) Antibiotic Prophylaxis ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Antineoplastic Agents/administration & dosage ; Bacteremia/epidemiology ; Bacteremia/etiology ; Bacteremia/prevention & control ; Catheterization, Central Venous/adverse effects ; Catheterization, Central Venous/instrumentation ; Catheterization, Central Venous/methods ; Catheters, Indwelling/adverse effects ; Clinical Trials as Topic/statistics & numerical data ; Equipment Contamination ; Evidence-Based Medicine ; Fungemia/epidemiology ; Fungemia/etiology ; Fungemia/prevention & control ; Humans ; Infection Control/methods ; Neoplasms/drug therapy ; Thromboembolism/etiology ; Thromboembolism/prevention & control
    Chemical Substances Anticoagulants ; Antineoplastic Agents
    Language English
    Publishing date 2007-09-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1093/annonc/mdm272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Waking EEG power spectra in the rat: correlations with training performance.

    Mandile, Paola / Giuditta, Antonio / Romano, Fabio / Montagnese, Paola / Piscopo, Stefania / Cotugno, Mario / Vescia, Stefania

    Brain research. Cognitive brain research

    2003  Volume 17, Issue 1, Page(s) 94–105

    Abstract: Adult rats chronically implanted with supradural electrodes were telemetrically EEG recorded during a baseline session, a training session for a two-way active avoidance task, and a retention session. Rats were assigned to a fast learning (FL), slow ... ...

    Abstract Adult rats chronically implanted with supradural electrodes were telemetrically EEG recorded during a baseline session, a training session for a two-way active avoidance task, and a retention session. Rats were assigned to a fast learning (FL), slow learning (SL) and non learning (NL) group if they achieved criterion during the training session, the retention session, or in neither session. High-resolution EEG analyses indicated that intergroup differences were present in the low frequency range of waking baseline power spectra. Moreover, baseline delta emissions directly correlated with freezings, and inversely correlated with avoidances, while emissions at 7-10 Hz directly correlated with avoidances and inversely correlated with freezings. Interestingly, during the first training period, waking delta emission selectively increased in FL rats in concomitance with a marked performance improvement; instead, SL and NL rats displayed increments at 7-9 Hz. In addition, freezings scored during the first two training periods directly correlated with post-training waking emission at 2 Hz, and inversely correlated with emission at 7-10 Hz. Conversely, escapes and avoidances directly correlated with waking emission at 7-10 Hz. The data indicate that (i) waking baseline power spectra differ among behavioral groups, and correlate with behavioral performance the following day; (ii) selective modifications of waking power spectra occur in each behavioral group during training; and (iii) behavioral responses during training correlate with post-training waking power spectra. Notably, the delta increment selectively occurring in training FL rats is assumed to reflect online memory processing leading to better performance. The latter observation supports the primary involvement of delta waves in learning.
    MeSH term(s) Animals ; Avoidance Learning/physiology ; Electroencephalography/methods ; Male ; Rats ; Rats, Wistar ; Retention (Psychology)/physiology ; Wakefulness/physiology
    Language English
    Publishing date 2003-04-24
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1120380-8
    ISSN 1872-6348 ; 0926-6410
    ISSN (online) 1872-6348
    ISSN 0926-6410
    DOI 10.1016/s0926-6410(03)00084-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Trains of sleep sequences are indices of learning capacity in rats.

    Piscopo, S / Mandile, P / Montagnese, P / Cotugno, M / Giuditta, A / Vescia, S

    Behavioural brain research

    2000  Volume 120, Issue 1, Page(s) 13–21

    Abstract: ... W and SS-->TS-->PS) in the baseline session of adult male Wistar rats [Mandile P, Vescia S ... of transition sleep (TS) strongly correlate with the number of avoidances scored the following day [Vescia S ... A, Vescia S. Identification of trains of sleep sequences in adult rats, Behav Brain Res, this volume], and ...

    Abstract In previous work dealing with the identification of four sleep sequences (SS-->W, SS-->PS, SS-->TS-->W and SS-->TS-->PS) in the baseline session of adult male Wistar rats [Mandile P, Vescia S, Montagnese P, Romano F, Giuditta A. Characterization of transition sleep episodes in baseline EEG recordings of adults rats, Physiol Behav 1996;60:1435-1439], we have shown that those containing an intervening episode of transition sleep (TS) strongly correlate with the number of avoidances scored the following day [Vescia S, Mandile P, Montagnese P, Romano F, Cataldo G, Cotugno M, Giuditta A. Baseline transition sleep and associated sleep episodes are related to the learning ability of rats, Physiol Behav 1996;60:1513-152]. More recently, clusters of sleep sequences (trains) separated by waking intervals longer than 60 s have been identified in the baseline session of the same rats [Piscopo S, Mandile P, Montagnese P, Cotugno M, Giuditta A, Vescia S. Identification of trains of sleep sequences in adult rats, Behav Brain Res, this volume], and distinguished in homogeneous or mixed trains according to the presence of a single sleep sequence or more than one sequence. Mixed trains have been further separated into trains containing the SS-->TS-->W sequence (+TSW trains) and trains lacking it (-TSW trains). Analysis of the distribution of variables of baseline trains (and of their sleep sequences and components) among fast learning (FL), slow learning (SL), or non-learning (NL) rats, indicates that variables of +TSW trains prevail in FL rats, while variables of -TSW trains prevail in NL rats. In addition, variables of +TSW trains correlate with the number of avoidances of the training session, while variables of -TSW trains do not significantly correlate, or show inverse correlations. Interestingly, sleep sequences such as SS-->W or SS-->TS-->W show direct or inverse correlations with avoidances depending on whether they are included in +TSW trains or in -TSW trains. The data are interpreted to suggest that the outcome of brain operations performed during a sleep sequence may selectively condition the appearance of later sequences within a time interval shorter than a given threshold. An analogous mechanism may be responsible for the aggregation of sleep components in sleep sequences.
    MeSH term(s) Analysis of Variance ; Animals ; Avoidance Learning/physiology ; Conditioning, Classical ; Electroencephalography ; Learning/physiology ; Male ; Memory/physiology ; Models, Neurological ; Random Allocation ; Rats ; Rats, Wistar ; Sleep Stages/physiology
    Language English
    Publishing date 2000-12-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 449927-x
    ISSN 1872-7549 ; 0166-4328
    ISSN (online) 1872-7549
    ISSN 0166-4328
    DOI 10.1016/s0166-4328(00)00360-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Identification of trains of sleep sequences in adult rats.

    Piscopo, S / Mandile, P / Montagnese, P / Cotugno, M / Giuditta, A / Vescia, S

    Behavioural brain research

    2000  Volume 119, Issue 1, Page(s) 93–101

    Abstract: ... We have now used waking periods longer than 60 s to separate clusters of baseline sleep sequences (trains ...

    Abstract In previous studies based on high resolution EEG analyses of the 7 h baseline session of 18 adult male Wistar rats [6,14], we have identified four sleep sequences initiating with slow wave sleep (SS) and terminating with waking (W) or paradoxical sleep (PS). Two of these sequences contained an intervening episode of transition sleep (TS). Several variables of these sequences (SS-->W, SS-->TS-->W, SS-->TS-->PS, and SS-->PS) were selectively correlated with the capacity of rats to learn a two-way active avoidance task the following day, and were differently distributed in fast learning, slow learning and non learning rats [21]. The temporal organization of different sleep components in sequences suggested that a comparable temporal organization might concern the different sleep sequences, albeit on a longer time scale. We have now used waking periods longer than 60 s to separate clusters of baseline sleep sequences (trains) in the same rats. Trains containing the same sleep sequence (homogeneous trains) have been distinguished from trains containing different sleep sequences (mixed trains). In addition, mixed trains including the SS-->TS-->W sequence (+TSW trains) have been separated from mixed trains lacking that sequence (-TSW trains). Mixed trains of the +TSW type were longest and most numerous, while homogeneous trains were shortest and least abundant. Mixed trains of the -TSW type displayed intermediate values. Several variables of sleep sequences and sleep components differed within mixed trains and among mixed and homogeneous trains. The data indicate that baseline sleep sequences aggregate in relatively long strings in a non random fashion. The mechanism of this association is discussed.
    MeSH term(s) Animals ; Electroencephalography ; Male ; Rats ; Rats, Wistar ; Sleep/physiology ; Sleep Stages/physiology ; Wakefulness/physiology
    Language English
    Publishing date 2000-12-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 449927-x
    ISSN 1872-7549 ; 0166-4328
    ISSN (online) 1872-7549
    ISSN 0166-4328
    DOI 10.1016/s0166-4328(00)00339-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The GISS trial: a phase II prevention trial of screening plus goserelin, ibandronate, versus screening alone in premenopausal women at increased risk of breast cancer.

    von Minckwitz, Gunter / Loibl, Sibylle / Jackisch, Christian / Paepke, Stefan / Nestle-Kraemling, Caroline / Lux, Michael P / Maass, Nico / Schmutzler, Rita / du Bois, Andreas / Wallwiener, Diethelm / Vescia, Sabine / Budischewski, Kai / Kaufmann, Manfred

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

    2011  Volume 20, Issue 10, Page(s) 2141–2149

    Abstract: Background: Genetic testing for inherited mutations in breast cancer genes provides valuable information for disease prevention. Today, premenopausal women with increased risk for breast cancer have only limited nonsurgical options to reduce their risk.! ...

    Abstract Background: Genetic testing for inherited mutations in breast cancer genes provides valuable information for disease prevention. Today, premenopausal women with increased risk for breast cancer have only limited nonsurgical options to reduce their risk.
    Methods: The GISS trial, a randomized, multicenter, open-label phase II trial, assessed the feasibility of a preventive treatment with goserelin and ibandronate for premenopausal women at increased risk for breast cancer. The primary endpoints were refusal to undergo randomization and discontinuation of treatment. Safety and quality of life were also evaluated.
    Results: Between the years 2001 and 2003, 31 of 322 eligible women participated in the trial; 15 received goserelin/ibandronate plus screening, 15 screening only, and 1 withdrew her consent after randomization. The treatment duration was 24 months. Here, mainly the results from the first 12 months were evaluated because of the low compliance thereafter. Hot flushes, headache, and vaginal dryness/discharge occurred more often in the goserelin arm. No difference was observed between the two arms in the agreement to randomization, compliance, or any other endpoints.
    Conclusions: Acceptance of chemoprevention with goserelin and ibandronate was low. Premenopausal women at increased risk for breast cancer should be better informed about chemoprevention through physician counseling and a more feasible study design (e.g., oral medication) should be provided.
    Impact: This is the first chemoprevention trial in premenopausal women at increased risk for breast cancer.
    MeSH term(s) Adult ; Antineoplastic Agents, Hormonal/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols ; Bone Density Conservation Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/etiology ; Breast Neoplasms/prevention & control ; Diphosphonates/therapeutic use ; Feasibility Studies ; Female ; Goserelin/therapeutic use ; Hot Flashes ; Humans ; Mass Screening/utilization ; Middle Aged ; Premenopause ; Prognosis ; Risk Factors
    Chemical Substances Antineoplastic Agents, Hormonal ; Bone Density Conservation Agents ; Diphosphonates ; Goserelin (0F65R8P09N) ; ibandronic acid (UMD7G2653W)
    Language English
    Publishing date 2011-10
    Publishing country United States
    Document type Clinical Trial, Phase II ; Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 1153420-5
    ISSN 1538-7755 ; 1055-9965
    ISSN (online) 1538-7755
    ISSN 1055-9965
    DOI 10.1158/1055-9965.EPI-11-0222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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