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  1. Article: A comparative evaluation of the analytical performances of Capillarys 2 Flex Piercing, Tosoh HLC-723 G8, Premier Hb9210, and Roche Cobas c501 Tina-quant Gen 2 analyzers for HbA

    Wu, Xiaobin / Chao, Yan / Wan, Zemin / Wang, Yunxiu / Ma, Yan / Ke, Peifeng / Wu, Xinzhong / Xu, Jianhua / Zhuang, Junhua / Huang, Xianzhang

    Biochemia medica

    2016  Volume 26, Issue 3, Page(s) 353–364

    Abstract: Introduction: Haemoglobin A: Materials and methods: A comparative evaluation of the analytical performances (precision, linearity, accuracy, method comparison, and interferences including bilirubin, triglyceride, cholesterol, labile HbA: Results: ... ...

    Abstract Introduction: Haemoglobin A
    Materials and methods: A comparative evaluation of the analytical performances (precision, linearity, accuracy, method comparison, and interferences including bilirubin, triglyceride, cholesterol, labile HbA
    Results: A good precision was shown at both low and high HbA
    Conclusions: The four HbA
    MeSH term(s) Artifacts ; Chromatography, High Pressure Liquid/instrumentation ; Electrophoresis, Capillary/instrumentation ; Glycated Hemoglobin A/analysis ; Humans ; Limit of Detection ; Reproducibility of Results
    Chemical Substances Glycated Hemoglobin A ; hemoglobin A1c protein, human
    Language English
    Publishing date 2016-10-15
    Publishing country Croatia
    Document type Comparative Study ; Journal Article
    ZDB-ID 1208725-7
    ISSN 1846-7482 ; 1330-0962
    ISSN (online) 1846-7482
    ISSN 1330-0962
    DOI 10.11613/BM.2016.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Capecitabine-Induced Genital Hand-Foot Syndrome Treated With Topical Tacrolimus.

    Chan, Bryan L / Wang, Tina

    Cureus

    2024  Volume 16, Issue 4, Page(s) e57570

    Abstract: We describe a rare case of capecitabine-induced palmar-plantar erythrodysesthesia (PPE), or hand-foot syndrome (HFS), involving the genitals, which resolved with tacrolimus therapy, in a patient with cT3dN3 stage IIIc moderately differentiated proximal ... ...

    Abstract We describe a rare case of capecitabine-induced palmar-plantar erythrodysesthesia (PPE), or hand-foot syndrome (HFS), involving the genitals, which resolved with tacrolimus therapy, in a patient with cT3dN3 stage IIIc moderately differentiated proximal rectal adenocarcinoma who was undergoing neoadjuvant chemotherapy. Given its severe impact on the quality of life, HFS often requires independent local anti-inflammatory treatment and subsequent dose delay and/or modification of the patient's chemotherapy. We believe that our findings in this report can aid clinicians in the early recognition and management of capecitabine-associated HFS resulting in balanitis, as prompt treatment may reduce morbidity and avoid prolonged interruption of chemotherapy in these patients.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.57570
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  3. Book ; Online: TinaFace

    Zhu, Yanjia / Cai, Hongxiang / Zhang, Shuhan / Wang, Chenhao / Xiong, Yichao

    Strong but Simple Baseline for Face Detection

    2020  

    Abstract: Face detection has received intensive attention in recent years. Many works present lots of special methods for face detection from different perspectives like model architecture, data augmentation, label assignment and etc., which make the overall ... ...

    Abstract Face detection has received intensive attention in recent years. Many works present lots of special methods for face detection from different perspectives like model architecture, data augmentation, label assignment and etc., which make the overall algorithm and system become more and more complex. In this paper, we point out that \textbf{there is no gap between face detection and generic object detection}. Then we provide a strong but simple baseline method to deal with face detection named TinaFace. We use ResNet-50 \cite{he2016deep} as backbone, and all modules and techniques in TinaFace are constructed on existing modules, easily implemented and based on generic object detection. On the hard test set of the most popular and challenging face detection benchmark WIDER FACE \cite{yang2016wider}, with single-model and single-scale, our TinaFace achieves 92.1\% average precision (AP), which exceeds most of the recent face detectors with larger backbone. And after using test time augmentation (TTA), our TinaFace outperforms the current state-of-the-art method and achieves 92.4\% AP. The code will be available at \url{https://github.com/Media-Smart/vedadet}.
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 006
    Publishing date 2020-11-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: FDA experiences with a centralized statistical monitoring tool.

    Wang, Xiaofeng Tina / Schuette, Paul / Kam, Matilde

    Journal of biopharmaceutical statistics

    2024  , Page(s) 1–7

    Abstract: The U.S. Food and Drug Administration (FDA) has broadly supported quality by design initiatives for clinical trials - including monitoring and data validation - by releasing two related guidance documents (FDA 2013 and 2019). Centralized statistical ... ...

    Abstract The U.S. Food and Drug Administration (FDA) has broadly supported quality by design initiatives for clinical trials - including monitoring and data validation - by releasing two related guidance documents (FDA 2013 and 2019). Centralized statistical monitoring (CSM) can be a component of a quality by design process. In this article, we describe our experience with a CSM platform as part of a Cooperative Research and Development Agreement between CluePoints and FDA. This agreement's approach to CSM is based on many statistical tests performed on all relevant subject-level data submitted to identify outlying sites. An overall data inconsistency score is calculated to assess the inconsistency of data from one site compared to data from all sites. Sites are ranked by the data inconsistency score (
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1131763-2
    ISSN 1520-5711 ; 1054-3406
    ISSN (online) 1520-5711
    ISSN 1054-3406
    DOI 10.1080/10543406.2024.2330210
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  5. Article ; Online: A Modular Scaffold for Controlling Transcriptional Activation via Homomeric Protein-Protein Interactions.

    Lee, ByungUk / Wang, Tina

    ACS synthetic biology

    2022  Volume 11, Issue 10, Page(s) 3198–3206

    Abstract: Protein-protein interactions (PPIs) have been extensively utilized in synthetic biology to construct artificial gene networks. However, synthetic regulation of gene expression by PPIs ... ...

    Abstract Protein-protein interactions (PPIs) have been extensively utilized in synthetic biology to construct artificial gene networks. However, synthetic regulation of gene expression by PPIs in
    MeSH term(s) Transcriptional Activation/genetics ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Ligands ; Transcription Factors/metabolism ; Synthetic Biology
    Chemical Substances Ligands ; Transcription Factors
    Language English
    Publishing date 2022-10-10
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2161-5063
    ISSN (online) 2161-5063
    DOI 10.1021/acssynbio.2c00501
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  6. Article ; Online: Cost-effectiveness of medication therapy management among Medicare population and across racial/ethnic groups.

    Tsang, Chi Chun Steve / Wang, Junling / Shih, Ya-Chen Tina

    Medicine

    2024  Volume 103, Issue 18, Page(s) e37935

    Abstract: Background: Inappropriate medication utilization among older adults is a pressing concern in the United States, owing to its high prevalence and the consequential detrimental impact it engenders. The adverse effects stemming from the inappropriate use ... ...

    Abstract Background: Inappropriate medication utilization among older adults is a pressing concern in the United States, owing to its high prevalence and the consequential detrimental impact it engenders. The adverse effects stemming from the inappropriate use of medication may be unequally borne by racial/ethnic minority populations, calling for greater efforts towards promoting equity in healthcare. The study objective was to assess the cost-effectiveness of Medication Therapy Management (MTM) services among Medicare beneficiaries and across racial/ethnic groups.
    Methods: Medicare administrative data from 2016 to 2017 linked to Area Health Resources Files were used to analyze Medicare fee-for-service patients aged 65 or above with continuous Parts A/B/D coverage. The intervention group included new MTM enrollees in 2017; the control group referred to patients who met the general MTM eligible criteria but did not enroll in 2016 or 2017. The 2 groups were matched using a propensity score method. Effectiveness was evaluated as the proportion of appropriate medication utilization based on performance measures developed by the Pharmacy Quality Alliance. Costs were computed as total healthcare costs from Medicare perspective. A multivariable net benefit regressions with a classic linear model and Bayesian analysis were utilized. Net benefit was calculated based on willingness-to-pay thresholds at various multiples of the gross domestic product in 2017. Three-way interaction terms among dummy variables for MTM enrollment, 2017, and racial/ethnic minority groups were incorporated in a difference-in-differences study design.
    Results: After adjusting for patient characteristics, the findings indicate that MTM receipt was associated with incremental net benefit among each race and ethnicity. For instance, the net benefit of MTM among the non-Hispanic White patients was $2498 (95% confidence interval = $1609, $3386) at a willingness-to-pay value of $59,908. The study found no significant difference in net benefits for MTM services between minority and White patients.
    Conclusion: The study provides evidence that MTM is a cost-effective tool for managing medication utilization among the Medicare population. However, MTM may not be cost-effective in reducing racial/ethnic disparities in medication utilization in the short term. Further research is needed to understand the long-term cost-effectiveness of MTM on racial/ethnic disparities.
    MeSH term(s) Humans ; United States ; Medication Therapy Management/economics ; Medication Therapy Management/statistics & numerical data ; Aged ; Medicare/economics ; Male ; Female ; Cost-Benefit Analysis ; Aged, 80 and over ; Ethnicity/statistics & numerical data ; Racial Groups/statistics & numerical data
    Language English
    Publishing date 2024-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037935
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  7. Article ; Online: Congratulatory remarks from Wiley, the publishing partner of Integrative Zoology.

    Wang, Tina

    Integrative zoology

    2016  Volume 11, Issue 6, Page(s) 426

    Language English
    Publishing date 2016-11
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2570656-1
    ISSN 1749-4877 ; 1749-4869
    ISSN (online) 1749-4877
    ISSN 1749-4869
    DOI 10.1111/1749-4877.12233
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  8. Article ; Online: Response to Wheeler and Colleagues. Re: Flexibility in APPEs but at What Cost.

    Kanmaz, Tina / Newman, Kate / Skrabal, Maryann / Smith, Mary Douglass / Wang, Ying / Stultz, Kimberly

    American journal of pharmaceutical education

    2023  Volume 87, Issue 11, Page(s) 100600

    MeSH term(s) Humans ; Education, Pharmacy ; Problem-Based Learning ; Curriculum
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603807-4
    ISSN 1553-6467 ; 0002-9459
    ISSN (online) 1553-6467
    ISSN 0002-9459
    DOI 10.1016/j.ajpe.2023.100600
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  9. Article ; Online: Cardiovascular Health in People with Psoriasis: A Population-Based Study in the United States.

    Wang, Sonia / Shin, Daniel B / Bhutani, Tina / Garshick, Michael S / Gelfand, Joel M

    The Journal of investigative dermatology

    2023  Volume 143, Issue 10, Page(s) 2075–2078

    MeSH term(s) Humans ; United States/epidemiology ; Psoriasis/epidemiology ; Cardiovascular Diseases/epidemiology ; Risk Factors
    Language English
    Publishing date 2023-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2023.04.006
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  10. Article: Integrating clinical access limitations into iPDT treatment planning with PDT-SPACE.

    Wang, Shuran / Saeidi, Tina / Lilge, Lothar / Betz, Vaughn

    Biomedical optics express

    2023  Volume 14, Issue 2, Page(s) 714–738

    Abstract: PDT-SPACE is an open-source software tool that automates interstitial photodynamic therapy treatment planning by providing patient-specific placement of light sources to destroy a tumor while minimizing healthy tissue damage. This work extends PDT-SPACE ... ...

    Abstract PDT-SPACE is an open-source software tool that automates interstitial photodynamic therapy treatment planning by providing patient-specific placement of light sources to destroy a tumor while minimizing healthy tissue damage. This work extends PDT-SPACE in two ways. The first enhancement allows specification of clinical access constraints on light source insertion to avoid penetrating critical structures and to minimize surgical complexity. Constraining fiber access to a single burr hole of adequate size increases healthy tissue damage by 10%. The second enhancement generates an initial placement of light sources as a starting point for refinement, rather than requiring entry of a starting solution by the clinician. This feature improves productivity and also leads to solutions with 4.5% less healthy tissue damage. The two features are used in concert to perform simulations of various surgery options of virtual glioblastoma multiforme brain tumors.
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.478217
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