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  1. Article ; Online: Complete sequence of the closed circular extrachromosomal element of

    Nguyen, Brian T / Chapman, Nora M / Johnson, Niklas / Stessman, Holly A F / Tracy, Steven / Drescher, Kristen M

    Microbiology resource announcements

    2024  Volume 13, Issue 4, Page(s) e0080623

    Abstract: The DNA encoding the ribosomal RNA ... ...

    Abstract The DNA encoding the ribosomal RNA in
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00806-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Ovarian Hormones and Binge Eating in Adulthood: Summary of Findings and Implications for Individual Differences in Risk in Women.

    Klump, Kelly L / Culbert, Kristen M / Johnson, Alexander W / Sisk, Cheryl L

    Current directions in psychological science

    2023  Volume 32, Issue 6, Page(s) 471–478

    Abstract: Ovarian hormone influences on general food intake have been studied in animals for 60+ years. Yet, extensions of these data to key eating disorder symptoms in humans (e.g., binge eating (BE)) have only recently occurred. In this article, we summarize ... ...

    Abstract Ovarian hormone influences on general food intake have been studied in animals for 60+ years. Yet, extensions of these data to key eating disorder symptoms in humans (e.g., binge eating (BE)) have only recently occurred. In this article, we summarize findings from studies examining the effects of ovarian hormones on BE. Findings suggest ovarian hormones contribute to BE in animals and humans, although studies are few in number, and effects are not present in all women or all animals exposed to high-risk hormonal milieus. Differences in susceptibility may be due to gene x hormone interactions that can explain why some, but not all, women/females develop BE in the presence of risky hormonal environments.
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2026362-4
    ISSN 1467-8721 ; 0963-7214
    ISSN (online) 1467-8721
    ISSN 0963-7214
    DOI 10.1177/09637214231192835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Complete sequence of the closed circular extrachromosomal element (CERE) of

    Nguyen, Brian T / Chapman, Nora M / Johnson, Niklas / Stessman, Holly A F / Tracy, Steven / Drescher, Kristen M

    Microbiology resource announcements

    2023  Volume 12, Issue 10, Page(s) e0032123

    Abstract: Ribosomal RNA is not encoded in chromosomal DNA in amoebae of the Naegleria genus but the rRNA genes are located on closed circular extrachromosomal ribosomal DNA (rDNA)-containing elements (CERE). In this report, we describe the sequence of the CERE ... ...

    Abstract Ribosomal RNA is not encoded in chromosomal DNA in amoebae of the Naegleria genus but the rRNA genes are located on closed circular extrachromosomal ribosomal DNA (rDNA)-containing elements (CERE). In this report, we describe the sequence of the CERE of
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00321-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity.

    Bucher, Meghan L / Dunn, Amy R / Bradner, Joshua M / Egerton, Kristen Stout / Burkett, James P / Johnson, Michelle A / Miller, Gary W

    The European journal of neuroscience

    2024  

    Abstract: Dopaminergic neurons of the substantia nigra exist in a persistent state of vulnerability resulting from high baseline oxidative stress, high-energy demand, and broad unmyelinated axonal arborisations. Impairments in the storage of dopamine compound this ...

    Abstract Dopaminergic neurons of the substantia nigra exist in a persistent state of vulnerability resulting from high baseline oxidative stress, high-energy demand, and broad unmyelinated axonal arborisations. Impairments in the storage of dopamine compound this stress because of cytosolic reactions that transform the vital neurotransmitter into an endogenous neurotoxicant, and this toxicity is thought to contribute to the dopamine neuron degeneration that occurs Parkinson's disease. We have previously identified synaptic vesicle glycoprotein 2C (SV2C) as a modifier of vesicular dopamine function, demonstrating that genetic ablation of SV2C in mice results in decreased dopamine content and evoked dopamine release in the striatum. Here, we adapted a previously published in vitro assay utilising false fluorescent neurotransmitter 206 (FFN206) to visualise how SV2C regulates vesicular dopamine dynamics and determined that SV2C promotes the uptake and retention of FFN206 within vesicles. In addition, we present data indicating that SV2C enhances the retention of dopamine in the vesicular compartment with radiolabelled dopamine in vesicles isolated from immortalised cells and from mouse brain. Further, we demonstrate that SV2C enhances the ability of vesicles to store the neurotoxicant 1-methyl-4-phenylpyridinium (MPP
    Language English
    Publishing date 2024-03-26
    Publishing country France
    Document type Journal Article
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.16311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2548: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Balance Confidence and Balance Performance, But Not Fall History Are Associated With Quality of Life in Community-Dwelling Older Adults: A Cross Sectional Study.

    Roberts, Holly J / Johnson, Kristen M / Sullivan, Jane E / Hoppes, Carrie W

    Journal of geriatric physical therapy (2001)

    2022  Volume 46, Issue 1, Page(s) 82–89

    Abstract: ... Mobility Scale (CB&M). Correlation and multiple regression analyses were calculated to determine ... and CB&M (ρ= 0.524, -0.509, 0.348, and r = 0.423, respectively), the WHOQOL-BREF psychological domain ... such as the CB&M and FGA, and patient-reported outcome measures for balance confidence and FoF avoidance behavior ...

    Abstract Background and purpose: Fear of falling (FoF) is highly prevalent in community-dwelling older adults and is associated with low health-related quality of life (QoL). Low QoL is associated with increased health care utilization and is a predictor of future falls, but few studies have examined the relationship between high-level balance and dynamic gait performance and QoL in community-dwelling older adults. The purpose of this cross-sectional study was to determine whether there is a relationship between FoF avoidance behaviors, balance confidence, performance on measures of high-level mobility, and QoL in community-dwelling older adults. The secondary purpose was to determine whether older adults who fall have a different QoL than older adults who have not fallen in the past year.
    Methods: Eighty-nine community-dwelling older adults (76.33 ± 6.84 years, 54 female, 34 fallers) completed the World Health Organization Quality of Life-BREF (WHOQOL-BREF), Activities-specific Balance Confidence Scale (ABC), Fear of Falling Avoidance Behavior Questionnaire (FFABQ), Functional Gait Assessment (FGA), and Community Balance and Mobility Scale (CB&M). Correlation and multiple regression analyses were calculated to determine the relationship between the outcome measures and domains on the WHOQOL-BREF.
    Results and discussion: Significant correlations were observed between the WHOQOL-BREF physical health domain and the ABC, FFABQ, FGA, and CB&M (ρ= 0.524, -0.509, 0.348, and r = 0.423, respectively), the WHOQOL-BREF psychological domain and the ABC (ρ= 0.284) and FFABQ (ρ=-0.384), and the WHOQOL-BREF environment domain and the ABC (ρ= 0.343) and FFABQ (ρ=-0.406). No correlations were found between WHOQOL-BREF domain scores and a history of falls.
    Conclusions: Performance-based outcome measures that measure high-level mobility such as the CB&M and FGA, and patient-reported outcome measures for balance confidence and FoF avoidance behavior such as the ABC and FFABQ, are correlated with the physical health QoL domain on the WHOQOL-BREF. The ABC and FFABQ are correlated with psychological and environment QoL. Fall history was not correlated with QoL. Interventions to decrease FoF or improve high-level mobility may improve QoL in community-dwelling older adults.
    MeSH term(s) Female ; Humans ; Aged ; Independent Living ; Quality of Life/psychology ; Cross-Sectional Studies ; Geriatric Assessment/methods ; Fear/psychology ; Surveys and Questionnaires
    Language English
    Publishing date 2022-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2250801-6
    ISSN 2152-0895 ; 1539-8412
    ISSN (online) 2152-0895
    ISSN 1539-8412
    DOI 10.1519/JPT.0000000000000349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The Congenital Syphilis Prevention Cascade: Reimagining a Missed Prevention Opportunities Framework for Effective Intervention.

    O'Callaghan, Kevin P / Johnson Jones, Michelle L / McDonald, Robert / Jackson, David A / Grey, Jeremy A / Kreisel, Kristen M / Torrone, Elizabeth

    Sexually transmitted diseases

    2023  Volume 51, Issue 1, Page(s) 8–10

    Abstract: Abstract: Congenital syphilis (CS) rates have risen in the United States since 2013. Prevention of CS requires testing and treatment of pregnant and pregnancy-capable persons at high risk for syphilis. We developed a CS Prevention Cascade to assess how ... ...

    Abstract Abstract: Congenital syphilis (CS) rates have risen in the United States since 2013. Prevention of CS requires testing and treatment of pregnant and pregnancy-capable persons at high risk for syphilis. We developed a CS Prevention Cascade to assess how effectively testing and treatment interventions reached pregnant persons with a CS outcome.
    MeSH term(s) Pregnancy ; Female ; Humans ; United States/epidemiology ; Syphilis, Congenital/epidemiology ; Syphilis, Congenital/prevention & control ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/prevention & control ; Infectious Disease Transmission, Vertical/prevention & control ; Syphilis/diagnosis ; Syphilis/epidemiology ; Syphilis/prevention & control
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 435191-5
    ISSN 1537-4521 ; 0148-5717
    ISSN (online) 1537-4521
    ISSN 0148-5717
    DOI 10.1097/OLQ.0000000000001892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1217: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity.

    Bucher, Meghan L / Dunn, Amy R / Bradner, Joshua M / Egerton, Kristen Stout / Burkett, James P / Johnson, Michelle A / Miller, Gary W

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Dopaminergic neurons of the substantia nigra exist in a persistent state of vulnerability resulting from high baseline oxidative stress, high energy demand, and broad unmyelinated axonal arborizations. Impairments in the storage of dopamine compound this ...

    Abstract Dopaminergic neurons of the substantia nigra exist in a persistent state of vulnerability resulting from high baseline oxidative stress, high energy demand, and broad unmyelinated axonal arborizations. Impairments in the storage of dopamine compound this stress due to cytosolic reactions that transform the vital neurotransmitter into an endogenous neurotoxicant, and this toxicity is thought to contribute to the dopamine neuron degeneration that occurs Parkinson's disease. We have previously identified synaptic vesicle glycoprotein 2C (SV2C) as a modifier of vesicular dopamine function, demonstrating that genetic ablation of SV2C in mice results in decreased dopamine content and evoked dopamine release in the striatum. Here, we adapted a previously published
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.26.546143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2.

    Bulos, Maya L / Grzelak, Edyta M / Li-Ma, Chloris / Chen, Emily / Hull, Mitchell / Johnson, Kristen A / Bollong, Michael J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Yes-associated protein (YAP), the downstream effector of the evolutionarily conserved Hippo pathway, promotes cellular proliferation and coordinates certain regenerative responses in mammals. Small molecule activators of YAP may therefore display ... ...

    Abstract Yes-associated protein (YAP), the downstream effector of the evolutionarily conserved Hippo pathway, promotes cellular proliferation and coordinates certain regenerative responses in mammals. Small molecule activators of YAP may therefore display therapeutic utility in treating disease states involving insufficient proliferative repair. From a high-throughput chemical screen of the comprehensive drug repurposing library ReFRAME, here we report the identification of SM04690, a clinical stage inhibitor of CLK2, as a potent activator of YAP driven transcriptional activity in cells. CLK2 inhibition promotes alternative splicing of the Hippo pathway protein AMOTL2, producing an exon-skipped gene product that can no longer associate with membrane-bound proteins, resulting in decreased phosphorylation and membrane localization of YAP. This study reveals a novel mechanism by which pharmacological perturbation of alternative splicing inactivates the Hippo pathway and promotes YAP dependent cellular growth.
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.19.537449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Accessible cholesterol is localized in bacterial plasma membrane protrusions.

    Abrams, Michael E / Johnson, Kristen A / Radhakrishnan, Arun / Alto, Neal M

    Journal of lipid research

    2020  Volume 61, Issue 12, Page(s) 1538

    MeSH term(s) Bacteria/cytology ; Cell Membrane/metabolism ; Cholesterol/metabolism
    Chemical Substances Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2020-07-13
    Publishing country United States
    Document type Editorial
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1194/jlr.ILR120000891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: The organizational role of ovarian hormones during puberty on risk for binge-like eating in rats.

    Hildebrandt, Britny A / Lee, Jenna R / Culbert, Kristen M / Sisk, Cheryl L / Johnson, Alexander W / Klump, Kelly L

    Physiology & behavior

    2023  Volume 265, Page(s) 114177

    Abstract: Puberty is a high-risk period for the development of dysregulated eating, including binge eating. While risk for binge eating in animals and humans increases in both males and females during puberty, the increased prevalence is significantly greater in ... ...

    Abstract Puberty is a high-risk period for the development of dysregulated eating, including binge eating. While risk for binge eating in animals and humans increases in both males and females during puberty, the increased prevalence is significantly greater in females. Emerging data suggest that the organizational effects of gonadal hormones may contribute to the female preponderance of binge eating. In this narrative review, we discuss studies conducted in animals that have examined these organizational effects as well as the neural systems that may serve as intermediary mechanisms. Relatively few studies have been conducted, but data thus far suggest that pubertal estrogens may organize risk for binge eating, potentially by altering key circuits in brain reward pathways. These promising results highlight the need for future studies to directly test organizational effects of pubertal hormones using hormone replacement techniques and circuit-level manipulations that can identify pathways contributing to binge eating across development.
    MeSH term(s) Humans ; Male ; Rats ; Female ; Animals ; Sexual Maturation ; Binge-Eating Disorder ; Bulimia ; Estrogens/metabolism ; Gonadal Hormones ; Puberty
    Chemical Substances Estrogens ; Gonadal Hormones
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3907-x
    ISSN 1873-507X ; 0031-9384
    ISSN (online) 1873-507X
    ISSN 0031-9384
    DOI 10.1016/j.physbeh.2023.114177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 747: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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