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  1. Article ; Online: Improving Treatment Approaches for Rectal Cancer.

    Sanoff, Hanna K

    The New England journal of medicine

    2022  Volume 386, Issue 25, Page(s) 2425–2426

    MeSH term(s) DNA Mismatch Repair ; Humans ; Programmed Cell Death 1 Receptor ; Rectal Neoplasms/therapy ; Rectum
    Chemical Substances Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2022-06-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2204282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Social Determinants of Health and the Link to Colorectal Cancer Outcomes.

    Lorentsen, Michael K / Sanoff, Hanna K

    Current treatment options in oncology

    2024  Volume 25, Issue 4, Page(s) 453–464

    Abstract: OPINION  STATEMENT: Colorectal cancer (CRC) remains the second most deadly cancer in the United States, behind only lung cancer. Despite improvements in incidence due to screening and mortality in part due to better treatments, there are some groups that ...

    Abstract OPINION  STATEMENT: Colorectal cancer (CRC) remains the second most deadly cancer in the United States, behind only lung cancer. Despite improvements in incidence due to screening and mortality in part due to better treatments, there are some groups that have not seen these promising changes. American Indian/Alaska Native and non-Hispanic Black individuals, certain geographic regions, and lower socioeconomic groups have all been shown to have worse CRC outcomes. A significant body of evidence has linked these disparities in outcomes to social determinants of health (SDH). SDH are defined by the WHO as "the non-medical factors that influence health outcomes." These factors include but are not limited to income, education, social support, neighborhood of residence, and access to healthcare. Individuals who are negatively impacted by SDH have been shown to have a higher incidence of CRC. These individuals are also less likely to receive adequate CRC screening, are less likely to receive appropriate treatment, and have increased CRC mortality. Interventions that target different SDH domains have been shown to lead to increased rates of CRC screening and receipt of appropriate treatment while simultaneously improving CRC mortality. The aim of this review is to highlight the connection between SDH and CRC outcomes while also exploring interventions that target SDH and thereby improve CRC outcomes.
    MeSH term(s) Humans ; United States/epidemiology ; Social Determinants of Health ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/etiology ; Early Detection of Cancer ; Surveys and Questionnaires
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057351-0
    ISSN 1534-6277 ; 1527-2729
    ISSN (online) 1534-6277
    ISSN 1527-2729
    DOI 10.1007/s11864-024-01191-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5523: Show issues Location:
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  3. Article ; Online: Managing Grief, Loss, and Connection in Oncology-What COVID-19 Has Taken.

    Sanoff, Hanna K

    JAMA oncology

    2020  Volume 6, Issue 11, Page(s) 1700–1701

    MeSH term(s) Attitude of Health Personnel ; Attitude to Computers ; Attitude to Death ; COVID-19 ; Grief ; Health Knowledge, Attitudes, Practice ; Humans ; Medical Oncology ; Oncologists/psychology ; Physician-Patient Relations ; Telemedicine
    Keywords covid19
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2020.2839
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  4. Article ; Online: Best Evidence Supports Annual Surveillance for Resected Colorectal Cancer.

    Sanoff, Hanna K

    JAMA

    2018  Volume 319, Issue 20, Page(s) 2083–2085

    MeSH term(s) Colonic Neoplasms ; Colonoscopy ; Colorectal Neoplasms ; Humans ; Population Surveillance
    Language English
    Publishing date 2018-05-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2018.5817
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  6. Article ; Online: Managing Grief, Loss, and Connection in Oncology—What COVID-19 Has Taken

    Sanoff, Hanna K.

    JAMA Oncology ; ISSN 2374-2437

    2020  

    Keywords General Medicine ; covid19
    Language English
    Publisher American Medical Association (AMA)
    Publishing country us
    Document type Article ; Online
    DOI 10.1001/jamaoncol.2020.2839
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Changing the Course of Cancer Care With Greater Precision.

    Zafar, S Yousuf / Sanoff, Hanna K

    JAMA oncology

    2020  Volume 6, Issue 5, Page(s) 634–636

    MeSH term(s) Humans ; Neoplasms/therapy ; Precision Medicine/methods
    Language English
    Publishing date 2020-03-18
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2019.6843
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  8. Article ; Online: Targeting HER2 beyond progression in gastroesophageal cancer.

    Sanoff, Hanna K

    The Lancet. Oncology

    2017  Volume 18, Issue 5, Page(s) 562–564

    MeSH term(s) Humans ; Neoplasms ; Receptor, ErbB-2 ; Stomach Neoplasms ; Trastuzumab
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(17)30102-X
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    Zs.MO 460: Show issues

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  9. Article ; Online: Cancer of unknown primary.

    Lee, Michael S / Sanoff, Hanna K

    BMJ (Clinical research ed.)

    2020  Volume 371, Page(s) m4050

    Abstract: Cancers of unknown primary (CUPs) are histologically confirmed, metastatic malignancies with a primary tumor site that is unidentifiable on the basis of standard evaluation and imaging studies. CUP comprises 2-5% of all diagnosed cancers worldwide and is ...

    Abstract Cancers of unknown primary (CUPs) are histologically confirmed, metastatic malignancies with a primary tumor site that is unidentifiable on the basis of standard evaluation and imaging studies. CUP comprises 2-5% of all diagnosed cancers worldwide and is characterized by early and aggressive metastasis. Current standard evaluation of CUP requires histopathologic evaluation and identification of favorable risk subtypes that can be more definitively treated or have superior outcomes. Current standard treatment of the unfavorable risk subtype requires assessment of prognosis and consideration of empiric chemotherapy. The use of molecular tissue of origin tests to identify the likely primary tumor site has been extensively studied, and here we review the rationale and the evidence for and against the use of such tests in the assessment of CUPs. The expanding use of next generation sequencing in advanced cancers offers the potential to identify a subgroup of patients who have actionable genomic aberrations and may allow for further personalization of therapy.
    MeSH term(s) Anaplastic Lymphoma Kinase/genetics ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/metabolism ; Biopsy ; Circulating Tumor DNA/genetics ; Gene Expression Profiling ; Genes, erbB-1 ; Genes, erbB-2 ; High-Throughput Nucleotide Sequencing ; Humans ; Lymph Nodes/pathology ; Mammography ; Molecular Diagnostic Techniques ; Molecular Targeted Therapy ; Mutation ; Neoplasms, Unknown Primary/diagnosis ; Neoplasms, Unknown Primary/drug therapy ; Neoplasms, Unknown Primary/epidemiology ; Neoplasms, Unknown Primary/genetics ; Occult Blood ; Physical Examination ; Physical Functional Performance ; Positron Emission Tomography Computed Tomography ; Proto-Oncogene Proteins B-raf/genetics ; Real-Time Polymerase Chain Reaction ; Risk Assessment ; Tomography, X-Ray Computed
    Chemical Substances Antineoplastic Agents ; Biomarkers, Tumor ; Circulating Tumor DNA ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2020-12-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m4050
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    Ua VI Zs.10: Show issues Location:
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  10. Article ; Online: Identifying patient profiles of disparate care in resectable pancreas cancer using latent class analysis.

    Maduekwe, Ugwuji N / Stephenson, Briana J K / Yeh, Jen Jen / Troester, Melissa A / Sanoff, Hanna K

    Journal of surgical oncology

    2023  Volume 128, Issue 2, Page(s) 254–261

    Abstract: BACKGROUND AND OBJECTIVES: Disparities in pancreas cancer care are multifactorial, but factors are often examined in isolation. Research that integrates these factors in a single conceptual framework is lacking. We use latent class analysis (LCA) to ... ...

    Abstract BACKGROUND AND OBJECTIVES: Disparities in pancreas cancer care are multifactorial, but factors are often examined in isolation. Research that integrates these factors in a single conceptual framework is lacking. We use latent class analysis (LCA) to evaluate the association between intersectionality and patterns of care and survival in patients with resectable pancreas cancer.
    Methods: LCA was used to identify demographic profiles in resectable pancreas cancer (n = 140 344) diagnosed from 2004 to 2019 in the National Cancer Database (NCDB). LCA-derived patient profiles were used to identify differences in receipt of minimum expected treatment (definitive surgery), optimal treatment (definitive surgery and chemotherapy), time to treatment, and overall survival.
    Results: Minimum expected treatment (hazard ratio [HR] 0.69, 95% confidence interval [CI]: 0.65, 0.75) and optimal treatment (HR 0.58, 95% CI: 0.55, 0.62) were associated with improved overall survival. Seven latent classes were identified based on age, race/ethnicity, and socioeconomic status (SES) attributes (zip code-linked education and income, insurance, geography). Compared to the referent group (≥65 years + White + med/high SES), the ≥65 years + Black profile had the longest time-to-treatment (24 days vs. 28 days) and lowest odds of receiving minimum (odds ratio [OR] 0.67, 95% CI: 0.64, 0.71) or optimal treatment (OR 0.76, 95% CI: 0.72, 0.81). The Hispanic patient profile had the lowest median overall survival-55.3 months versus 67.5 months.
    Conclusions: Accounting for intersectionality in the NCDB resectable pancreatic cancer patient cohort identifies subgroups at higher risk for inequities in care. LCA demonstrates that older Black patients and Hispanic patients are at particular risk for being underserved and should be prioritiz for directed interventions.
    MeSH term(s) Humans ; Ethnicity ; Healthcare Disparities ; Latent Class Analysis ; Pancreatic Neoplasms/surgery ; Social Class ; Socioeconomic Factors ; White People ; Intersectional Framework ; Black or African American ; Hispanic or Latino ; Aged ; Age Factors ; Race Factors ; Pancreatic Neoplasms
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82063-5
    ISSN 1096-9098 ; 0022-4790
    ISSN (online) 1096-9098
    ISSN 0022-4790
    DOI 10.1002/jso.27275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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