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Article ; Online: Corrigendum to "A survey of critical care nurses' practices and perceptions surrounding early intravenous antibiotic initiation during septic shock" [Intensive Crit. Care Nurs. 41 (2017) 90-97].

Roberts, Russel J / Alhammad, Abdullah M / Crossley, Lindsay / Anketell, Eric / Wood, LeeAnn / Schumaker, Greg / Garpestad, Erik / Devlin, John W

Intensive & critical care nursing

2020 Volume 63, Page(s) 102997

Language	English
Publishing date	2020-12-18
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	1105892-4
ISSN	1532-4036 ; 0964-3397
ISSN (online)	1532-4036
ISSN	0964-3397
DOI	10.1016/j.iccn.2020.102997
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Article ; Online: Severe Thrombocytopenia in Adults with Severe Acute Respiratory Distress Syndrome: Impact of Extracorporeal Membrane Oxygenation Use.

Dzierba, Amy L / Roberts, Russel / Muir, Justin / Alhammad, Abdullah / Schumaker, Greg / Clark, Jacqueline / Ruthazer, Robin / Devlin, John W

ASAIO journal (American Society for Artificial Internal Organs : 1992)

2016 Volume 62, Issue 6, Page(s) 710–714

Abstract: Extracorporeal membrane oxygenation (ECMO) use is perceived to cause thrombocytopenia (T), but the role of non-ECMO factors in the development of T remains unclear. We sought to evaluate the incidence and factors associated with severe T (platelet count ≤ ...

Abstract	Extracorporeal membrane oxygenation (ECMO) use is perceived to cause thrombocytopenia (T), but the role of non-ECMO factors in the development of T remains unclear. We sought to evaluate the incidence and factors associated with severe T (platelet count ≤ 50,000/μl) in adults with severe acute respiratory distress syndrome (ARDS) managed with or without ECMO. The ECMO (n = 32) versus the non-ECMO (n = 53) groups had a similar baseline platelet count (214,000 vs. 179,000/μl), Acute Physiology and Chronic Health Evaluation (APACHE) II score (p = 0.13), unfractionated heparin (UFH) exposure (p = 0.62), and severe T incidence (25 vs. 19%, p = 0.5). Although the APACHE II score (p = 0.01), presence of liver failure (p = 0.08), and platelet transfusion (p = 0.0009) were different between the severe T (18/85 [21%]) and non-severe T groups (67/85 [79%]), the incidence of septic shock (p = 0.64), heparin infusion use (p = 0.41), exposure to non-heparin T-causing medications (p = 0.77) and ECMO use (p = 0.5) were not. An adjusted multivariate linear regression model revealed that only the APACHE II score was independently associated with the development of severe T (p = 0.01) but use of ECMO was not (p = 0.32) ECMO use may not affect the incidence of severe T among adults with severe ARDS. Larger studies that are prospective in nature are required to confirm this finding.
MeSH term(s)	Adult ; Aged ; Extracorporeal Membrane Oxygenation/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Respiratory Distress Syndrome, Adult/complications ; Thrombocytopenia/etiology
Language	English
Publishing date	2016-07-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	759982-1
ISSN	1538-943X ; 0162-1432 ; 1058-2916
ISSN (online)	1538-943X
ISSN	0162-1432 ; 1058-2916
DOI	10.1097/MAT.0000000000000415
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Article: Managing acute respiratory failure during exacerbation of chronic obstructive pulmonary disease.

Schumaker, Greg L / Epstein, Scott K

Respiratory care

2004 Volume 49, Issue 7, Page(s) 766–782

Abstract: Exacerbations of chronic obstructive pulmonary disease (COPD) are a major health problem, causing more than half a million hospital admissions per year in the United States. Although overall mortality is low, it is substantially higher with severe ... ...

Abstract	Exacerbations of chronic obstructive pulmonary disease (COPD) are a major health problem, causing more than half a million hospital admissions per year in the United States. Although overall mortality is low, it is substantially higher with severe exacerbations that require intensive care and mechanical ventilation. The majority of COPD exacerbations result from infection, with typical bacterial organisms most commonly identified. Numerous randomized controlled trials and meta-analyses have documented the benefits of antibiotics, low-flow oxygen, and systemic corticosteroids, and the therapeutic equivalency of the major classes of bronchodilators (short-acting beta-agonist and anticholinergics). Randomized controlled trials also demonstrate that noninvasive ventilation can decrease the incidence of intubation, shorten stay, reduce infectious complications, and improve survival. Although patients who require intubation have the worst prognosis, the vast majority of them can be successfully liberated from mechanical ventilation. For invasively ventilated patients the clinical emphasis should be on improving patient-ventilator interaction and avoiding dynamic hyperinflation (intrinsic positive end-expiratory pressure).
MeSH term(s)	Acute Disease ; Adrenal Cortex Hormones/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Bronchodilator Agents/therapeutic use ; Disease Management ; Evidence-Based Medicine ; Humans ; Oxygen Inhalation Therapy ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Respiration, Artificial/methods ; Respiratory Insufficiency/drug therapy ; Respiratory Insufficiency/therapy ; United States ; Ventilator Weaning
Chemical Substances	Adrenal Cortex Hormones ; Anti-Bacterial Agents ; Bronchodilator Agents
Language	English
Publishing date	2004-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603252-7
ISSN	0020-1324 ; 0098-9142
ISSN	0020-1324 ; 0098-9142
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Article: Identifying factors that could account for differences in duration of mechanical ventilation between intermittent lorazepam- and propofol-treated patients.

Devlin, John W / Fong, Jeffrey J / Schumaker, Greg L

Critical care medicine

2006 Volume 34, Issue 12, Page(s) 3063–4; author reply 3064

MeSH term(s)	Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/adverse effects ; Analgesics, Opioid/therapeutic use ; Humans ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/therapeutic use ; Lorazepam/administration & dosage ; Lorazepam/therapeutic use ; Propofol/administration & dosage ; Propofol/therapeutic use ; Respiration, Artificial
Chemical Substances	Analgesics, Opioid ; Hypnotics and Sedatives ; Lorazepam (O26FZP769L) ; Propofol (YI7VU623SF)
Language	English
Publishing date	2006-12
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/01.CCM.0000248911.24389.14
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Article: A looming crisis in demand for intensive care unit resources?

Schumaker, Greg L / Hill, Nicholas S / Garpestad, Erik / Teres, Daniel

Critical care medicine

2005 Volume 33, Issue 3, Page(s) 683–684

MeSH term(s)	Aged ; Forecasting ; Hospital Planning ; Humans ; Intensive Care Units/statistics & numerical data ; Needs Assessment ; Ontario ; Population Dynamics ; Respiration, Artificial/statistics & numerical data
Language	English
Publishing date	2005-03
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/01.ccm.0000156443.96959.f4
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Article ; Online: Effect of Extracorporeal Membrane Oxygenation Use on Sedative Requirements in Patients with Severe Acute Respiratory Distress Syndrome.

Nigoghossian, Caroline Der / Dzierba, Amy L / Etheridge, Joshua / Roberts, Russel / Muir, Justin / Brodie, Daniel / Schumaker, Greg / Bacchetta, Matthew / Ruthazer, Robin / Devlin, John W

Pharmacotherapy

2016 Volume 36, Issue 6, Page(s) 607–616

Abstract: Study objectives: To compare sedative dose requirements during the 6-hour period when they are greatest in patients with severe acute respiratory distress syndrome (ARDS), as well as the time from severe ARDS onset to reach this maximum sedation ... ...

Abstract	Study objectives: To compare sedative dose requirements during the 6-hour period when they are greatest in patients with severe acute respiratory distress syndrome (ARDS), as well as the time from severe ARDS onset to reach this maximum sedation exposure, between patients with severe ARDS who were managed either with or without extracorporeal membrane oxygenation (ECMO). Also, to explore factors other than ECMO use that may influence sedation requirements during this period of maximum sedation. Design: Retrospective comparative cohort analysis. Data sources: Two academic centers, one with an adult ECMO program and one without. Patients: Consecutive adults with severe ARDS who were receiving continuous-infusion sedative therapy for at least 48 hours from the time of severe ARDS diagnosis and who were managed with ECMO (34 patients) or without ECMO (60 patients) between 2009 and 2013. Measurements and main results: Among patients managed with ECMO, the maximum median (interquartile range [IQR]) 6-hr sedative exposure (in midazolam equivalents) was nearly twice as high (118 [IQR 48-225] mg vs 60 [37-99] mg, p=0.004) and was reached, on average, 3 days later (4 [IQR 1-8] vs 1 [IQR 0.5-6] days, p=0.003) than patients not managed with ECMO. Patients managed with ECMO were younger, had a higher Sequential Organ Failure Assessment score, and, in the 24 hours prior to the period of maximum sedative exposure, had a higher ratio of partial pressure of oxygen in arterial blood to fraction of inspired oxygen and were more likely to receive renal replacement and high-dose fentanyl (2000 μg or more/24 hrs) therapy. An adjusted multivariable linear regression model using the natural logarithmic value of the maximum sedative exposure in a 6-hour period revealed that patient age (p=0.04) and administration of high-dose fentanyl in the 24 hours prior to the 6-hour period of maximum sedative use (p<0.0001) were each independently associated with the maximum 6-hour sedative requirement reached, but the use of ECMO was not (p=0.52). Conclusion: Although the application of ECMO during severe ARDS resulted in a period of maximum sedation exposure that was both greater and took longer to reach, factors other than ECMO, particularly high-dose opioid administration, appeared more likely to account for this maximum sedation use. Further research surrounding sedative requirements, clearance, and patient response during ECMO is required.
MeSH term(s)	Adult ; Dose-Response Relationship, Drug ; Extracorporeal Membrane Oxygenation/adverse effects ; Female ; Humans ; Hypnotics and Sedatives/therapeutic use ; Linear Models ; Male ; Middle Aged ; Respiratory Distress Syndrome, Adult/drug therapy ; Retrospective Studies ; Time Factors
Chemical Substances	Hypnotics and Sedatives
Language	English
Publishing date	2016
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	603158-4
ISSN	1875-9114 ; 0277-0008
ISSN (online)	1875-9114
ISSN	0277-0008
DOI	10.1002/phar.1760
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Article ; Online: A survey of critical care nurses' practices and perceptions surrounding early intravenous antibiotic initiation during septic shock.

Roberts, Russel J / Alhammad, Abdullah M / Crossley, Lindsay / Anketell, Eric / Wood, LeeAnn / Schumaker, Greg / Garpestad, Erik / Devlin, John W

Intensive & critical care nursing

2017 Volume 41, Page(s) 90–97

Abstract: Background: Delays in antibiotic administration after severe sepsis recognition increases mortality. While physician and pharmacy-related barriers to early antibiotic initiation have been well evaluated, those factors that affect the speed by which ... ...

Abstract	Background: Delays in antibiotic administration after severe sepsis recognition increases mortality. While physician and pharmacy-related barriers to early antibiotic initiation have been well evaluated, those factors that affect the speed by which critical care nurses working in either the emergency department or the intensive care unit setting initiate antibiotic therapy remains poorly characterized. Aim: To evaluate the knowledge, practices and perceptions of critical care nurses regarding antibiotic initiation in patients with newly recognised septic shock. Methods: A validated survey was distributed to 122 critical care nurses at one 320-bed academic institution with a sepsis protocol advocating intravenous(IV) antibiotic initiation within 1hour of shock recognition. Results: Among 100 (82%) critical care nurses responding, nearly all (98%) knew of the existence of the sepsis protocol. However, many critical care nurses stated they would optimise blood pressure [with either fluid (38%) or both fluid and a vasopressor (23%)] before antibiotic initiation. Communicated barriers to rapid antibiotic initiation included: excessive patient workload (74%), lack of awareness IV antibiotic(s) ordered (57%) or delivered (69%), need for administration of multiple non-antibiotic IV medications (54%) and no IV access (51%). Conclusions: Multiple nurse-related factors influence IV antibiotic(s) initiation speed and should be incorporated into sepsis quality improvement efforts.
MeSH term(s)	Administration, Intravenous ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Clinical Competence/standards ; Clinical Competence/statistics & numerical data ; Critical Care Nursing/methods ; Critical Care Nursing/statistics & numerical data ; Humans ; Intensive Care Units/organization & administration ; Intensive Care Units/standards ; Intensive Care Units/statistics & numerical data ; Nurses/psychology ; Nurses/statistics & numerical data ; Perception ; Shock, Septic/drug therapy ; Shock, Septic/mortality ; Shock, Septic/nursing ; Surveys and Questionnaires ; Time Factors ; Workforce
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2017-03-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1105892-4
ISSN	1532-4036 ; 0964-3397
ISSN (online)	1532-4036
ISSN	0964-3397
DOI	10.1016/j.iccn.2017.02.002
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Article ; Online: Predictors of mortality in patients with suspected propofol infusion syndrome.

Fong, Jeffrey J / Sylvia, Lynne / Ruthazer, Robin / Schumaker, Greg / Kcomt, Marisol / Devlin, John W

Critical care medicine

2008 Volume 36, Issue 8, Page(s) 2281–2287

Abstract: Objectives: To identify predictors of mortality in patients with suspected propofol infusion syndrome and to develop a simple scoring system to identify patients with suspected propofol infusion syndrome who are most at risk of death.: Design: ... ...

Abstract	Objectives: To identify predictors of mortality in patients with suspected propofol infusion syndrome and to develop a simple scoring system to identify patients with suspected propofol infusion syndrome who are most at risk of death. Design: Retrospective, database analysis. Setting: MEDWATCH system. Participants: Reports (1989-2005) where propofol was associated with > or = 1 of 24 published propofol infusion syndrome clinical manifestations. Interventions: None. Measurements and main results: After comparison of demographic and clinical manifestations between survivors and nonsurvivors, a multivariate logistic regression model was built through a stepwise selection process and then used to develop a simplified mortality scoring system. Of 1139 patients with suspected propofol infusion syndrome, 342 (30%) were fatal. Death was more likely if patients were < or = 18 yrs (odds ratio [95% confidence interval], 2.3 [1.7-3.2]), male (1.3 [1.1-1.7]), received a vasopressor (1.8 [1.3-2.5)]), or had the following clinical manifestations: cardiac (3.8 [2.88-4.91]), metabolic acidosis (3.7 [2.7-5.0]), renal failure (1.9 [1.4-2.6]), hypotension (1.8 [1.3-2.3]), rhabdomyolysis (1.8 [1.3-2.3]), or dyslipidemia (2.0 [1.2-3.4]). The multivariable modeling process found that cardiac symptoms, rhabdomyolosis, hypotension, metabolic acidosis, renal failure, and age each affected survival, although significant interactions existed between some of these factors. Based on the combination of the presence or absence of the six factors in the multivariate model, a propofol infusion syndrome mortality risk score of 0 to 4 resulted in a predicted %/observed % mortality for each score of 0 (10%/10%), 1 (24%/24%), 2 (47%/44%), 3 (72%/81%), and 4 (89%/83%). Conclusions: A number of characteristics are independently associated with higher mortality in patients with suspected propofol infusion syndrome, only some of which are currently reflected in the package insert. Further research should focus on prospectively evaluating the mortality scoring system in patients with suspected propofol infusion syndrome.
MeSH term(s)	Adolescent ; Anesthetics, Intravenous/administration & dosage ; Anesthetics, Intravenous/adverse effects ; Child ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Mortality ; Predictive Value of Tests ; Propofol/administration & dosage ; Propofol/adverse effects ; Retrospective Studies ; Risk Factors ; Syndrome
Chemical Substances	Anesthetics, Intravenous ; Propofol (YI7VU623SF)
Language	English
Publishing date	2008-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0b013e318180c1eb
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Article ; Online: Nanosecond formation of diamond and lonsdaleite by shock compression of graphite.

Kraus, D / Ravasio, A / Gauthier, M / Gericke, D O / Vorberger, J / Frydrych, S / Helfrich, J / Fletcher, L B / Schaumann, G / Nagler, B / Barbrel, B / Bachmann, B / Gamboa, E J / Göde, S / Granados, E / Gregori, G / Lee, H J / Neumayer, P / Schumaker, W /

Döppner, T / Falcone, R W / Glenzer, S H / Roth, M

Nature communications

2016 Volume 7, Page(s) 10970

Abstract: The shock-induced transition from graphite to diamond has been of great scientific and technological interest since the discovery of microscopic diamonds in remnants of explosively driven graphite. Furthermore, shock synthesis of diamond and lonsdaleite, ...

Abstract	The shock-induced transition from graphite to diamond has been of great scientific and technological interest since the discovery of microscopic diamonds in remnants of explosively driven graphite. Furthermore, shock synthesis of diamond and lonsdaleite, a speculative hexagonal carbon polymorph with unique hardness, is expected to happen during violent meteor impacts. Here, we show unprecedented in situ X-ray diffraction measurements of diamond formation on nanosecond timescales by shock compression of pyrolytic as well as polycrystalline graphite to pressures from 19 GPa up to 228 GPa. While we observe the transition to diamond starting at 50 GPa for both pyrolytic and polycrystalline graphite, we also record the direct formation of lonsdaleite above 170 GPa for pyrolytic samples only. Our experiment provides new insights into the processes of the shock-induced transition from graphite to diamond and uniquely resolves the dynamics that explain the main natural occurrence of the lonsdaleite crystal structure being close to meteor impact sites.
MeSH term(s)	Crystallization ; Diamond/chemistry ; Earth (Planet) ; Graphite/chemistry ; Hardness ; Meteoroids ; Meteorological Concepts ; Phase Transition ; Pressure ; X-Ray Diffraction
Chemical Substances	Diamond (7782-40-3) ; Graphite (7782-42-5)
Language	English
Publishing date	2016-03-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/ncomms10970
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Article ; Online: Nanosecond formation of diamond and lonsdaleite by shock compression of graphite

D. Kraus / A. Ravasio / M. Gauthier / D. O. Gericke / J. Vorberger / S. Frydrych / J. Helfrich / L. B. Fletcher / G. Schaumann / B. Nagler / B. Barbrel / B. Bachmann / E. J. Gamboa / S. Göde / E. Granados / G. Gregori / H. J. Lee / P. Neumayer / W. Schumaker /

T. Döppner / R. W. Falcone / S. H. Glenzer / M. Roth

Nature Communications, Vol 7, Iss 1, Pp 1-

2016 Volume 6

Abstract: Shock synthesis of diamond and even harder carbon polymorphs from graphite is of great interest for science and technology. Here, the authors present unprecedented in situmeasurements of the structural changes, showing ultrafast formation of diamond and, ...

Abstract	Shock synthesis of diamond and even harder carbon polymorphs from graphite is of great interest for science and technology. Here, the authors present unprecedented in situmeasurements of the structural changes, showing ultrafast formation of diamond and, at higher pressures, evidence for a pure lonsdaleite structure.
Keywords	Science ; Q
Language	English
Publishing date	2016-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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