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  1. Article ; Online: Editorial: Prevention of viral diseases by gene targeting.

    Luo, Fan / Wang, Qiankun / Chen, Shuliang

    Frontiers in genome editing

    2024  Volume 6, Page(s) 1395468

    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Editorial
    ISSN 2673-3439
    ISSN (online) 2673-3439
    DOI 10.3389/fgeed.2024.1395468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The role of the hepatic autonomic nervous system.

    Luo, Qiankun / Liu, Pan / Dong, Yifei / Qin, Tao

    Clinical and molecular hepatology

    2023  Volume 29, Issue 4, Page(s) 1052–1055

    MeSH term(s) Humans ; Autonomic Nervous System/physiology ; Liver
    Language English
    Publishing date 2023-07-25
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2672560-5
    ISSN 2287-285X ; 2287-2728
    ISSN (online) 2287-285X
    ISSN 2287-2728
    DOI 10.3350/cmh.2023.0244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6769: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Managing clinical trials for covid-19: the importance of ethics committees.

    Luo, Qiankun / Qin, Tao

    BMJ (Clinical research ed.)

    2020  Volume 369, Page(s) m1369

    Keywords covid19
    Language English
    Publishing date 2020-04-03
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m1369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.10: Show issues Location:
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  4. Article ; Online: Cancer Stem Cells are Actually Stem Cells with Disordered Differentiation: the Monophyletic Origin of Cancer.

    Luo, Qiankun / Liu, Pan / Yu, Pengfei / Qin, Tao

    Stem cell reviews and reports

    2023  Volume 19, Issue 4, Page(s) 827–838

    Abstract: Cancer stem cells (CSCs) play an important role in cancer development. Based on advancements in CSC research, we propose a monophyletic model of cancer. This model is based on the idea that CSCs are stem cells with disordered differentiation whose ... ...

    Abstract Cancer stem cells (CSCs) play an important role in cancer development. Based on advancements in CSC research, we propose a monophyletic model of cancer. This model is based on the idea that CSCs are stem cells with disordered differentiation whose original purpose was to repair damaged tissues. Inflammatory responses and damage repair signals are crucial for the creation and maintenance of CSCs. Normal quiescent stem cells are activated by environmental stimulation, such as an inflammatory response, and undergo cell division and differentiation. In the initial stage of cancer development, stem cell differentiation leads to heteromorphism due to the accumulation of gene mutations, resulting in the development of metaplasia or precancerosis. In the second stage, accumulated mutations induce poor differentiation and lead to cancer development. The monophyletic model illustrates the evolution, biological behavior, and hallmarks of CSCs, proposes a concise understanding of the origin of cancer, and may encourage a novel therapeutic approach.
    MeSH term(s) Humans ; Neoplasms/genetics ; Neoplasms/therapy ; Neoplastic Stem Cells ; Cell Differentiation/genetics ; Cell Division
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2495577-2
    ISSN 2629-3277 ; 1558-6804 ; 1550-8943
    ISSN (online) 2629-3277 ; 1558-6804
    ISSN 1550-8943
    DOI 10.1007/s12015-023-10508-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6198: Show issues Location:
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  5. Article ; Online: Self-management in patients with adult spinal deformity: a best practice implementation project.

    Zhang, Zhao / Liu, Huaxi / Shi, Yiqin / Yang, Qiankun / Zheng, Tingting / Luo, Fei / Liu, Lei

    JBI evidence implementation

    2024  

    Abstract: Introduction: The prevalence of adult spinal deformity (ASD) has increased in recent years. Patients often have to live for a prolonged period from the onset of the condition, up until the need for surgical treatment. Self-management plays a crucial ... ...

    Abstract Introduction: The prevalence of adult spinal deformity (ASD) has increased in recent years. Patients often have to live for a prolonged period from the onset of the condition, up until the need for surgical treatment. Self-management plays a crucial role in disease progression and prognosis.
    Objectives: This project aimed to promote evidence-based practices for the self-management of patients with ASD.
    Methods: This project was guided by the JBI Evidence Implementation Framework project and was conducted in the orthopedic department of a tertiary care hospital in China. A baseline audit was conducted to evaluate current practice against best practice recommendations. Barriers were identified and, after the implementation of improvement strategies, a follow-up audit was conducted to assess project effectiveness.
    Results: A comparison between the baseline and follow-up audits revealed a significant increase in nurses' compliance with best practices (rising from 0%-64% to 97.7%-100%) in the following areas: improved health promotion behaviors by nurses in self-management of ASD patients; acquisition and application of communication skills with patients; increased availability of educational materials in the ward; and establishment of conservative treatment follow-up instructions for patients. For patients, the Visual Analog Scale of pain decreased from (2.72 ± 1.67) to (1.90 ± 1.14), the Oswestry Disability Index decreased from (49.96 ± 16.49) to (39.83 ± 18.97), self-management behaviors improved from (10.84 ± 4.31) to (19.52 ± 6.31), and maximum isometric muscle strength in the standing position increased from (179.48 ± 91.18)N to (250.03 ± 91.50)N, all with statistically significant improvements (p <0.05). For nurses, the knowledge questionnaire score improved from (34.83 ± 24.16) to (82.00 ± 11.11) (p <0.05).
    Conclusions: This project helped ASD patients improve self-management, alleviated their clinical symptoms, and improved nurses' knowledge of best practices. Future audits will be conducted to review long-term project outcomes.
    Spanish abstract: http://links.lww.com/IJEBH/A193.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ISSN 2691-3321
    ISSN (online) 2691-3321
    DOI 10.1097/XEB.0000000000000421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Managing clinical trials for covid-19

    Luo, Qiankun / Qin, Tao

    the importance of ethics committees

    2020  

    Keywords LETTERS ; covid19
    Language English
    Publishing date 2020-04-03 04:41:05.0
    Publisher BMJ Publishing Group Ltd
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Managing clinical trials for covid-19

    Luo, Qiankun / Qin, Tao

    BMJ

    the importance of ethics committees

    2020  , Page(s) m1369

    Keywords covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m1369
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
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  9. Article: Inhibition Effect of Pancreatic Exocrine Insufficiency on Immune Checkpoint Inhibitor Treatment in Pancreatic Cancer: A Retrospective Study.

    Luo, Qiankun / Dong, Yifei / Liu, Pan / He, Chao / Chen, Lei / Zhang, Kailun / Pan, Changjie / Gao, Yahui / Qin, Tao

    ImmunoTargets and therapy

    2024  Volume 13, Page(s) 45–54

    Abstract: Introduction: Chemotherapy combined with immune checkpoint inhibitors (ChIM) is used to treat advanced pancreatic ductal adenocarcinoma (PDAC). However, the efficacy of ChIM is similar to that of chemotherapy alone.: Methods: To assess potential ... ...

    Abstract Introduction: Chemotherapy combined with immune checkpoint inhibitors (ChIM) is used to treat advanced pancreatic ductal adenocarcinoma (PDAC). However, the efficacy of ChIM is similar to that of chemotherapy alone.
    Methods: To assess potential factors affecting the effectiveness of ChIM, we analyzed the clinical data of 359 patients with PDAC who visited the hospital during June 2017 to December 2022.
    Results: Surgical resection, diabetes, and ChIM were risk factors for pancreatic exocrine insufficiency (PEI). The adjusted odds ratio of ChIM was 2.63 (95% confidence interval (CI) 1.492-4.626) (
    Conclusion: Immune checkpoint inhibitors (ICIs) increased the incidence of PEI in patients with PDAC. The OS was not different between patients receiving chemotherapy and ChIM due to irregular PERT treatment. The finding show that pancreatic enzyme replacement therapy may improve the response rate of patients with PDAC to ICIs.
    Language English
    Publishing date 2024-02-01
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2706272-7
    ISSN 2253-1556
    ISSN 2253-1556
    DOI 10.2147/ITT.S442247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Ambient Degradation Anisotropy and Mechanism of van der Waals Ferroelectric NbOI

    Yan, Qingyu / Weng, Yuyan / Wang, Shun / Zhou, Zhou / Hu, Yiqi / Li, Qiankun / Xue, Jinshuo / Feng, Zhijian / Luo, Zhongshen / Feng, Runcang / You, Lu / Fang, Liang

    ACS applied materials & interfaces

    2024  Volume 16, Issue 7, Page(s) 9051–9059

    Abstract: The spontaneous centrosymmetry-breaking and robust room-temperature ferroelectricity in niobium oxide dihalides spurs a flurry of explorations into its promising second-order nonlinear optical properties, and promises potential applications in ... ...

    Abstract The spontaneous centrosymmetry-breaking and robust room-temperature ferroelectricity in niobium oxide dihalides spurs a flurry of explorations into its promising second-order nonlinear optical properties, and promises potential applications in nonvolatile electro-optical and optoelectronic devices. However, the ambient stability of the niobium oxide dihalides remains questionable, which overshadows their future development. In this work, the chemical degradation of NbOI
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c18018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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