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  1. Article: Hyper-CVAD-based regimens in adult patients with acute lymphoblastic leukemia.

    Jabbour, Elias J

    Clinical advances in hematology & oncology : H&O

    2022  Volume 20, Issue 9, Page(s) 547–549

    MeSH term(s) Adult ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Vincristine
    Chemical Substances Vincristine (5J49Q6B70F)
    Language English
    Publishing date 2022-04-04
    Publishing country United States
    Document type Interview
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6505: Show issues Location:
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  2. Article ; Online: Inotuzumab in Older Patients with Newly Diagnosed Acute Lymphoblastic Leukemia-A Podcast.

    Jabbour, Elias J / Stelljes, Matthias

    Targeted oncology

    2024  Volume 19, Issue 2, Page(s) 135–141

    Abstract: Older patients with acute lymphoblastic leukemia (ALL) have historically had poor outcomes (5-year survival rate, 20%) with standard intensive and dose-adjusted chemotherapy regimens, due to a high incidence of adverse biologic features including high- ... ...

    Abstract Older patients with acute lymphoblastic leukemia (ALL) have historically had poor outcomes (5-year survival rate, 20%) with standard intensive and dose-adjusted chemotherapy regimens, due to a high incidence of adverse biologic features including high-risk cytogenetics, presence of TP53 mutations, and poor tolerance to intensive therapy. Thus, there is an unmet medical need in this patient population. Inotuzumab ozogamicin is a humanized antibody-drug conjugate that targets CD22-positive leukemic blasts. It is approved for the treatment of relapsed or refractory ALL and has been shown to be effective and tolerable in older patients. Several ongoing trials in older patients with newly diagnosed ALL have yielded encouraging data with inotuzumab ozogamicin in induction alone and in combination with low-intensity chemotherapy. In this podcast, the authors summarize and highlight some of the recent findings on the use of inotuzumab ozogamicin as induction therapy for older adults with newly diagnosed ALL.
    MeSH term(s) Humans ; Aged ; Inotuzumab Ozogamicin/pharmacology ; Inotuzumab Ozogamicin/therapeutic use ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Antibodies, Monoclonal, Humanized/adverse effects
    Chemical Substances Inotuzumab Ozogamicin (P93RUU11P7) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-03-08
    Publishing country France
    Document type Letter
    ZDB-ID 2222136-0
    ISSN 1776-260X ; 1776-2596
    ISSN (online) 1776-260X
    ISSN 1776-2596
    DOI 10.1007/s11523-023-01023-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Optimizing tyrosine kinase inhibitor therapy in chronic myeloid leukemia

    Jabbour, Elias / Talpaz, Moshe

    a new era

    (Clinical lymphoma & myeloma ; 8, Suppl. 3)

    2008  

    Author's details suppl. ed.: Moshe Talpaz. Contributors Elias Jabbour
    Series title Clinical lymphoma & myeloma ; 8, Suppl. 3
    Collection
    Language English
    Size S. S69 - S117 : Ill., graph. Darst.
    Publisher CIG Media Group
    Publishing place Dallas, Tex
    Publishing country United States
    Document type Book
    HBZ-ID HT015540549
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 5903 -8,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  4. Book: Unmet needs in the management of chronic myelogenous leukemia

    Jabbour, Elias / Bixby, Dale / Akard, Luke P.

    (Clinical advances in hematology & oncology ; 10,12, Suppl. 22)

    2012  

    Author's details discussants Elias J. Jabbour ; Dale Bixby ; Luke P. Akard
    Series title Clinical advances in hematology & oncology ; 10,12, Suppl. 22
    Collection
    Language English
    Size 15 S. : Ill., graph. Darst.
    Publisher Millennium Med. Publ
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT017526668
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 6505 -10,Suppl.22- verfügbar in Königswinter Königswinter

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  5. Article ; Online: SOHO State of the Art Updates and Next Questions, Measurable Residual Disease in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.

    Short, Nicholas J / Jabbour, Elias / Kantarjian, Hagop

    Clinical lymphoma, myeloma & leukemia

    2024  

    Abstract: Assessment of measurable residual disease (MRD) provides important prognostic information and can inform decision-making about appropriate consolidative therapy in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). ... ...

    Abstract Assessment of measurable residual disease (MRD) provides important prognostic information and can inform decision-making about appropriate consolidative therapy in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Many contemporary treatment protocols for Ph+ ALL achieve high rates of MRD negativity, and several analyses suggest that allogeneic hematopoietic stem cell transplant in first remission can be safely deferred in most patients who achieve MRD negativity by PCR for BCR::ABL1 within 3 months. Given the close association between achievement of MRD negativity and favorable long-term outcomes in Ph+ ALL, MRD response rates may aid in the evaluation of novel regimens, particularly in the absence of randomized data or robust survival data. While most studies in Ph+ ALL have used PCR for BCR::ABL1 to measure MRD and correlate with outcomes, this assay has several limitations. PCR or next-generation sequencing-based assays for immunoglobin or T-cell receptor (IG/TR) gene rearrangements may provide a more accurate assessment of clinically significant MRD in Ph+ ALL, particularly in patients with multilineage involvement of BCR::ABL1. Herein, we discuss the prognostic and therapeutic role of MRD in Ph+ ALL. We review the available methods of MRD assessment in Ph+ ALL and discuss the advantages of MRD assays that track IG/TR rearrangements rather than BCR::ABL1.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2024.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5903: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Therapy Options in Treating Acute Lymphoblastic Leukemia in Adults.

    Jabbour, Elias

    Oncology (Williston Park, N.Y.)

    2019  Volume 33, Issue 7

    MeSH term(s) Adult ; Antigens, CD19/immunology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; Immunoconjugates/immunology ; Immunotherapy, Adoptive/methods ; Molecular Targeted Therapy/methods ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Protein Kinase Inhibitors/therapeutic use ; Sialic Acid Binding Ig-like Lectin 2/antagonists & inhibitors ; Treatment Outcome
    Chemical Substances Antigens, CD19 ; CD19 molecule, human ; CD22 protein, human ; Immunoconjugates ; Protein Kinase Inhibitors ; Sialic Acid Binding Ig-like Lectin 2
    Language English
    Publishing date 2019-07-16
    Publishing country United States
    Document type Interview
    ZDB-ID 1067950-9
    ISSN 0890-9091
    ISSN 0890-9091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3168: Show issues Location:
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    Zs.MO 372: Show issues

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  7. Article ; Online: SOHO State of the Art Updates and Next Questions | Novel Agents and the Diminishing Role of Allogeneic Stem Cell Transplant in B-Acute Lymphoblastic Leukemia.

    Jen, Wei-Ying / Jabbour, Elias / Kantarjian, Hagop M / Short, Nicholas J

    Clinical lymphoma, myeloma & leukemia

    2024  

    Abstract: Outcomes of patients with B-acute lymphoblastic leukemia (B-ALL) have improved remarkably in the past decade. This has largely been due to the development and introduction of novel immunotherapies such as blinatumomab, inotuzumab ozogamicin, chimeric ... ...

    Abstract Outcomes of patients with B-acute lymphoblastic leukemia (B-ALL) have improved remarkably in the past decade. This has largely been due to the development and introduction of novel immunotherapies such as blinatumomab, inotuzumab ozogamicin, chimeric antigen receptor T (CAR-T) cells, highly potent tyrosine kinase inhibitors, and improved risk stratification, including better understanding of high risk genomic subgroups and better methods of measurable residual disease (MRD) detection. Historically, allogeneic stem cell transplant (allo-SCT) has been the consolidative treatment of choice in first complete remission for fit adults with B-ALL. However, allo-SCT is associated with significant treatment-related mortality and morbidity. Current research is directed at the incorporation of novel immunotherapies into frontline regimens to improve depth and durability of responses and ultimately increase cure rates. In this review, we will discuss the emerging role of novel immune-based treated strategies in both the frontline and relapsed/refractory settings. We present our approach to newly diagnosed patients with B-ALL and illustrate how the incorporation of novel agents and use of high-sensitivity MRD assays can abrogate the need for allo-SCT in most patients with B-ALL.
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2024.02.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5903: Show issues Location:
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  8. Article ; Online: Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring.

    Jabbour, Elias / Kantarjian, Hagop

    American journal of hematology

    2022  Volume 97, Issue 9, Page(s) 1236–1256

    Abstract: Disease overview: Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm with an incidence of 1-2 cases per 100 000 adults. It accounts for approximately 15% of newly diagnosed cases of leukemia in adults.: Diagnosis: CML is characterized by ...

    Abstract Disease overview: Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm with an incidence of 1-2 cases per 100 000 adults. It accounts for approximately 15% of newly diagnosed cases of leukemia in adults.
    Diagnosis: CML is characterized by a balanced genetic translocation, t (9;22) (q34;q11.2), involving a fusion of the Abelson gene (ABL1) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome 22q11.2. This rearrangement is known as the Philadelphia chromosome. The molecular consequence of this translocation is the generation of a BCR::ABL1 fusion oncogene, which in turn translates into a BCR::ABL1 oncoprotein.
    Frontline therapy: Four tyrosine kinase inhibitors (TKIs), imatinib, dasatinib, bosutinib, and nilotinib are approved by the United States Food and Drug Administration for first-line treatment of newly diagnosed CML in chronic phase (CML-CP). Clinical trials with second generation TKIs reported significantly deeper and faster responses but had no impact on survival prolongation, likely because of the availability of effective TKIs salvage therapies for patients who have a cytogenetic relapse with frontline TKI therapy.
    Salvage therapy: For CML post failure on frontline therapy, second-line options include second and third generation TKIs. Although potent and selective, these TKIs exhibit unique pharmacological profiles and response patterns relative to different patient and disease characteristics, such as patients' comorbidities, disease stage, and BCR::ABL1 mutational status. Patients who develop the T315I "gatekeeper" mutation display resistance to all currently available TKIs except ponatinib, asciminib, and olverembatinib. Allogeneic stem cell transplantation remains an important therapeutic option for patients with CML-CP and failure (due to resistance) of at least two TKIs, and for all patients in advanced phase disease. Older patients who have a cytogenetic relapse post failure on all TKIs can maintain long-term survival if they continue a daily most effective/least toxic TKI, with or without the addition of non-TKI anti-CML agents (hydroxyurea, omacetaxine, azacitidine, decitabine, cytarabine, busulfan and others).
    MeSH term(s) Adult ; Antineoplastic Agents/adverse effects ; Dasatinib/therapeutic use ; Drug Resistance, Neoplasm/genetics ; Fusion Proteins, bcr-abl/genetics ; Humans ; Imatinib Mesylate/therapeutic use ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/diagnosis ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myeloid, Chronic-Phase/drug therapy ; Protein Kinase Inhibitors/adverse effects ; Recurrence
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors ; Imatinib Mesylate (8A1O1M485B) ; Fusion Proteins, bcr-abl (EC 2.7.10.2) ; Dasatinib (RBZ1571X5H)
    Language English
    Publishing date 2022-07-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1251: Show issues Location:
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  9. Article ; Online: The presence of additional cytogenetic abnormalities (ACAs) or Philadelphia chromosome variants do not adversely affect the achievement of treatment-free remission in chronic myeloid leukemia.

    Haddad, Fadi G / Sasaki, Koji / Issa, Ghayas C / Jabbour, Elias / Kantarjian, Hagop

    American journal of hematology

    2024  

    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Letter
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: SOHO State of the Art Updates and Next Questions | Hyper-CVAD in 2022: Lessons Learned and New Approaches.

    Rausch, Caitlin R / Kantarjian, Hagop M / Jabbour, Elias J

    Clinical lymphoma, myeloma & leukemia

    2023  Volume 23, Issue 4, Page(s) 238–243

    Abstract: Combination chemotherapy is the mainstay of treatment for acute lymphoblastic leukemia (ALL). The Hyper-CVAD regimen was developed in 1992 at MD Anderson Cancer Center and has since become a standard of care option for adult patients with ALL. Since its ... ...

    Abstract Combination chemotherapy is the mainstay of treatment for acute lymphoblastic leukemia (ALL). The Hyper-CVAD regimen was developed in 1992 at MD Anderson Cancer Center and has since become a standard of care option for adult patients with ALL. Since its conception, a number of modifications have been implemented to customize the regimen for different patient populations and safely incorporate novel therapies without compromising tolerability. We aim to review the evolution of the Hyper-CVAD regimen over the past 3 decades, focusing on clinical pearls, as well as future directions.
    MeSH term(s) Adult ; Humans ; Doxorubicin/therapeutic use ; Cyclophosphamide/therapeutic use ; Retrospective Studies ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Dexamethasone/therapeutic use ; Vincristine/therapeutic use
    Chemical Substances Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Dexamethasone (7S5I7G3JQL) ; Vincristine (5J49Q6B70F)
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2023.01.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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