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  1. Book: Palliativmedizin

    Clemens, Katri Elina / Jaspers, Birgit / Husebø, Stein

    mit 41 Tabellen ; [Grundlagen und Praxis ; Schmerztherapie, Gesprächsführung, Ethik]

    2009  

    Author's details S. Husebø ... (Hrsg.). Mit Beitr. von K. E. Clemens ... Bearb. von B. Jaspers
    Keywords Palliative Care ; Palliativtherapie
    Subject Palliativbehandlung ; Palliative Therapie ; Palliative Behandlung
    Language German
    Size XXIII, 584 S. : Ill., graph. Darst.
    Edition 5., aktualisierte Aufl.
    Publisher Springer
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book
    HBZ-ID HT015990157
    ISBN 978-3-642-01548-9 ; 3-642-01548-4
    Database Catalogue ZB MED Medicine, Health

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  2. Book: Palliativmedizin

    Husebø, Stein / Klaschik, Eberhard / Clemens, Katri Elina

    [Grundlagen und Praxis ; Schmerztherapie, Gesprächsführung, Ethik] ; mit 43 Tabellen

    2006  

    Author's details S. Husebø ; E. Klaschik. Mit Beitr. von K. E. Clemens
    Keywords Palliative Care ; Palliativtherapie
    Subject Palliativbehandlung ; Palliative Therapie ; Palliative Behandlung
    Language German
    Size XXX, 559 S. : Ill., graph. Darst.
    Edition 4., aktualisierte Aufl.
    Publisher Springer
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book
    HBZ-ID HT014758531
    ISBN 978-3-540-29888-6 ; 3-540-29888-6 ; 978-3-540-29888-5
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Thesis: Das globale Wiederaufleben der Tuberkulose

    Clemens, Katri Elina

    Ursachenforschung und Bekämpfungsmöglichkeiten am Beispiel der Situation in Namibia

    2000  

    Author's details von Katri Elina Clemens
    Language German
    Size 102 Bl., Ill., graph. Darst., Kt.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 2000 (Nur beschränkt für den Austausch)
    HBZ-ID HT013310394
    Database Catalogue ZB MED Medicine, Health

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  4. Book: Palliativmedizin

    Husebø, Stein / Klaschik, Eberhard / Clemens, Katri Elina

    [Schmerztherapie, Gesprächsführung, Ethik ; mit vielen Beispielen aus der Praxis] ; mit 39 Tabellen

    2003  

    Author's details S. Husebø ; E. Klaschik. Mit Beitr. von K. E. Clemens
    Keywords Palliative Care ; Terminal Care ; Ethics, Medical ; Physician-Patient Relations ; Communication ; Palliativtherapie
    Subject Palliativbehandlung ; Palliative Therapie ; Palliative Behandlung
    Language German
    Size XXVIII, 545 S. : Ill., graph. Darst., Kt.
    Edition 3. Aufl.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT013754809
    ISBN 3-540-44095-X ; 978-3-540-44095-6
    Database Catalogue ZB MED Medicine, Health

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  5. Article: Opioide WHO-Stufe II oder Stufe III? : Serie Schmerztherapie, Folge 4.

    Clemens, Katri Elina

    MMW Fortschritte der Medizin

    2011  Volume 153, Issue 39, Page(s) 52–56

    Language German
    Publishing date 2011-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478211-x
    ISSN 1438-3276
    ISSN 1438-3276
    DOI 10.1007/BF03368823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The foundation of a medical faculty at the University of Namibia.

    Clemens, Katri Elina

    Journal of pain and symptom management

    2003  Volume 25, Issue 2, Page(s) 97–99

    MeSH term(s) Faculty, Medical ; Namibia ; Universities
    Language English
    Publishing date 2003-01-28
    Publishing country United States
    Document type Letter
    ZDB-ID 639142-4
    ISSN 0885-3924
    ISSN 0885-3924
    DOI 10.1016/s0885-3924(02)00634-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Quality of life and healthcare resource in patients receiving opioids for chronic pain: a review of the place of oxycodone/naloxone.

    Morlion, Bart / Clemens, Katri Elina / Dunlop, Will

    Clinical drug investigation

    2015  Volume 35, Issue 1, Page(s) 1–11

    Abstract: In patients managed with opioids for chronic pain, opioid-induced bowel dysfunction—specifically, opioid-induced constipation (OIC)—is a common side effect, which has a significant impact on quality of life (QoL). The most recent developments for ... ...

    Abstract In patients managed with opioids for chronic pain, opioid-induced bowel dysfunction—specifically, opioid-induced constipation (OIC)—is a common side effect, which has a significant impact on quality of life (QoL). The most recent developments for management of OIC are opioid antagonists, including naloxone, a competitive antagonist of peripheral opioid receptors that reverses opioid-induced peripheral gastrointestinal (GI) effects. A prolonged-release formulation of naloxone is available in combination with oxycodone (OXN PR). To review the specific role of OXN PR in the management of chronic pain and OIC and its impact on QoL and healthcare costs, a review of available relevant literature was conducted. Healthcare costs can be up to ten times higher for patients with GI events than for those without. Assessment of QoL in patients with OIC is essential, and multiple tools for its evaluation are available. The Bowel Function Index (BFI), a tool that was specifically developed and validated to measure bowel function in patients with OIC, can be an indication of QoL. In patients with moderate-to-severe chronic pain, randomized trials have demonstrated that OXN PR has equal analgesic efficacy and safety, but results in improved bowel function, compared with prolonged-release oxycodone (Oxy PR) alone. In conclusion, randomized studies using the BFI, as well as real-world clinical practice observations, have demonstrated improved QoL for patients taking OXN PR. This combination should allow more patients to benefit from the analgesic efficacy of opioid therapy and should minimize the side effects of constipation that correspond to improvements in QoL and healthcare offsets.
    MeSH term(s) Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/adverse effects ; Animals ; Chronic Pain/drug therapy ; Chronic Pain/psychology ; Constipation/chemically induced ; Constipation/prevention & control ; Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/adverse effects ; Drug Combinations ; Gastrointestinal Diseases/chemically induced ; Gastrointestinal Diseases/diagnosis ; Health Resources/trends ; Humans ; Naloxone/administration & dosage ; Naloxone/adverse effects ; Narcotic Antagonists/administration & dosage ; Narcotic Antagonists/adverse effects ; Oxycodone/administration & dosage ; Oxycodone/adverse effects ; Quality of Life ; Randomized Controlled Trials as Topic/methods
    Chemical Substances Analgesics, Opioid ; Delayed-Action Preparations ; Drug Combinations ; Narcotic Antagonists ; oxycodone naloxone combination ; Naloxone (36B82AMQ7N) ; Oxycodone (CD35PMG570)
    Language English
    Publishing date 2015-01
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1220136-4
    ISSN 1179-1918 ; 0114-2402 ; 1173-2563
    ISSN (online) 1179-1918
    ISSN 0114-2402 ; 1173-2563
    DOI 10.1007/s40261-014-0254-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Managing opioid-induced constipation in advanced illness

    Katri Elina Clemens / Eberhard Klaschik

    Therapeutics and Clinical Risk Management, Vol 2010, Iss default, Pp 77-

    focus on methylnaltrexone bromide

    2010  Volume 82

    Abstract: Katri Elina Clemens1,2, Eberhard Klaschik11Department of Science and Research, Centre ...

    Abstract Katri Elina Clemens1,2, Eberhard Klaschik11Department of Science and Research, Centre for Palliative Medicine, University of Bonn, Germany; 2Department of Palliative Medicine and Pain Therapy, Malteser Hospital Bonn/Rhein-Sieg, GermanyAbstract: Constipation is a common symptom in palliative care patients which can generate considerable suffering. There is uncertainty about the choice of treatment options from varying recommendations for management of constipation and a varying clinical practice in palliative care settings. The purpose of the review was to evaluate the current recommendations of therapy guidelines for the management of opioid-induced constipation in palliative care patients with a focus on methylnaltrexone bromide. Recent findings in the literature and related information on the opioid-induced gastrointestinal disorders in patients with advanced illness, as well as information on the opioid-antagonist methylnaltrexone, are discussed. Knowledge of the role of definitions, the causes of constipation and the pathophysiology of opioid-induced constipation must be given high priority in the treatment of patients receiving opioids. Diagnosis and therapy of constipation, therefore, should relate to findings in clinical investigation. Opioid-induced constipation and its adequate treatment is an important issue for patients with advanced illness and also poses therapeutic challenge for clinicians in daily routine. Methylnaltrexone bromide may represent an important therapeutic option for palliative care patients who are suffering from opioid-induced constipation with failure of conventional prophylactic oral laxative treatment.Keywords: opioid-induced constipation, palliative care, opioids, methylnaltrexone bromide
    Keywords Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2010-02-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Wie läßt sich Atemnot bei Tumorpatienten effizient lindern?

    Clemens, Katri Elina

    Forschung und Praxis

    2006  Volume 25, Issue 430, Page(s) 15

    Language German
    Document type Article
    ZDB-ID 20678-7
    ISSN 0935-2899
    Database Current Contents Medicine

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  10. Article ; Online: Managing opioid-induced constipation in advanced illness: focus on methylnaltrexone bromide.

    Clemens, Katri Elina / Klaschik, Eberhard

    Therapeutics and clinical risk management

    2010  Volume 6, Page(s) 77–82

    Abstract: Constipation is a common symptom in palliative care patients which can generate considerable suffering. There is uncertainty about the choice of treatment options from varying recommendations for management of constipation and a varying clinical practice ...

    Abstract Constipation is a common symptom in palliative care patients which can generate considerable suffering. There is uncertainty about the choice of treatment options from varying recommendations for management of constipation and a varying clinical practice in palliative care settings. The purpose of the review was to evaluate the current recommendations of therapy guidelines for the management of opioid-induced constipation in palliative care patients with a focus on methylnaltrexone bromide. Recent findings in the literature and related information on the opioid-induced gastrointestinal disorders in patients with advanced illness, as well as information on the opioid-antagonist methylnaltrexone, are discussed. Knowledge of the role of definitions, the causes of constipation and the pathophysiology of opioid-induced constipation must be given high priority in the treatment of patients receiving opioids. Diagnosis and therapy of constipation, therefore, should relate to findings in clinical investigation. Opioid-induced constipation and its adequate treatment is an important issue for patients with advanced illness and also poses therapeutic challenge for clinicians in daily routine. Methylnaltrexone bromide may represent an important therapeutic option for palliative care patients who are suffering from opioid-induced constipation with failure of conventional prophylactic oral laxative treatment.
    Language English
    Publishing date 2010-03-03
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2186560-7
    ISSN 1178-203X ; 1176-6336
    ISSN (online) 1178-203X
    ISSN 1176-6336
    DOI 10.2147/tcrm.s4301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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