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  1. Article ; Online: Response to Letter to the Editor from Speeckaert et al: "Vitamin D Deficiency Is Associated With Higher Hospitalisation Risk from COVID-19: A Retrospective Case-Control Study".

    Jude, Edward B

    The Journal of clinical endocrinology and metabolism

    2021  Volume 107, Issue 1, Page(s) e442

    MeSH term(s) COVID-19 ; Case-Control Studies ; Hospitalization ; Humans ; Retrospective Studies ; SARS-CoV-2 ; Vitamin D ; Vitamin D Deficiency/epidemiology
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-09-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgab607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: The Importance of PTH for Heart Failure. Comment on Thiele et al. The Role of Vitamin D

    Grant, William B / Jude, Edward B

    Journal of clinical medicine

    2022  Volume 11, Issue 20

    Abstract: The communication by Thiele et al. reported that there were no significant differences in serum 25-hydroxyvitamin D (25(OH)D) for the 22 of 118 acute heart failure (HF) patients, 71% with de novo HF and 29% with chronic HF, who died within 12 months ... ...

    Abstract The communication by Thiele et al. reported that there were no significant differences in serum 25-hydroxyvitamin D (25(OH)D) for the 22 of 118 acute heart failure (HF) patients, 71% with de novo HF and 29% with chronic HF, who died within 12 months after admission to the intermediate care unit of a maximum care hospital in Germany compared to those who survived [...].
    Language English
    Publishing date 2022-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11206038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Diabetes, COVID-19 and Mucormycosis: Unanswered Questions!

    Rastogi, Ashu / Jude, Edward B

    Indian journal of endocrinology and metabolism

    2021  Volume 25, Issue 3, Page(s) 191–192

    Language English
    Publishing date 2021-10-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 2600211-5
    ISSN 2230-9500 ; 2230-8210
    ISSN (online) 2230-9500
    ISSN 2230-8210
    DOI 10.4103/ijem.ijem_284_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Parathyroid carcinoma presenting as severe hypercalcaemia responding to steroids.

    Mathew, Susan Vincy / Ellis, Tracey / Jude, Edward B

    BMJ case reports

    2023  Volume 16, Issue 5

    Abstract: A man in his 50s was referred with profound, symptomatic hypercalcaemia. He was diagnosed with primary hyperparathyroidism, confirmed ... ...

    Abstract A man in his 50s was referred with profound, symptomatic hypercalcaemia. He was diagnosed with primary hyperparathyroidism, confirmed on
    MeSH term(s) Male ; Humans ; Parathyroid Neoplasms/complications ; Parathyroid Neoplasms/diagnosis ; Parathyroid Neoplasms/surgery ; Hypercalcemia/drug therapy ; Hypercalcemia/etiology ; Calcium ; Hyperparathyroidism, Primary/complications ; Hyperparathyroidism, Primary/diagnosis ; Hyperparathyroidism, Primary/surgery ; Pandemics ; COVID-19/complications ; Parathyroidectomy ; Steroids ; Parathyroid Hormone
    Chemical Substances Calcium (SY7Q814VUP) ; Steroids ; Parathyroid Hormone
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-252120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Euvolaemic hyponatraemia as a rare first presentation of chronic hypopituitarism.

    Coe, Calvin / Mathew, Susan Vincy / Jude, Edward B

    BMJ case reports

    2023  Volume 16, Issue 6

    Abstract: A man in his late 40s with no significant medical history presented with 2 weeks of lethargy, nausea and dizziness, alongside worsening headaches. Initial assessment revealed severe hyponatraemia and secondary hypothyroidism; urgent MRI pituitary was ... ...

    Abstract A man in his late 40s with no significant medical history presented with 2 weeks of lethargy, nausea and dizziness, alongside worsening headaches. Initial assessment revealed severe hyponatraemia and secondary hypothyroidism; urgent MRI pituitary was requested with a clinical suspicion of pituitary apoplexy. This demonstrated a likely cystic pituitary adenoma, with further testing revealing pituitary gland suppression, leading to a diagnosis of chronic secondary hypopituitarism. Initiating hormone replacement allowed substantial reported improvements in this patient's quality of life.A review of the patient's work-up revealed areas in which best practice was not followed. Cortisol measurements and paired urinary and serum osmolalities were initially not sent, nor results appropriately chased. A subsequent literature review identified that conformation with national and local guidelines on hyponatraemia management is poor. This patient's case, when combined with the literature review, provides evidence to support methods to increase educational awareness of an appropriate work-up of hyponatraemia among clinicians.
    MeSH term(s) Male ; Humans ; Hyponatremia/etiology ; Hyponatremia/complications ; Quality of Life ; Hypopituitarism/complications ; Hypopituitarism/diagnosis ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/diagnosis ; Pituitary Gland/diagnostic imaging
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-254469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Interplay between endocrinology, metabolism and COVID-19 infection.

    Mung, Sai Man / Jude, Edward B

    Clinical medicine (London, England)

    2021  Volume 21, Issue 5, Page(s) e499–e504

    Abstract: There are more than 170 million confirmed cases of COVID-19 worldwide, yet its effects on the endocrine system remain under-reported due to lack of awareness by the public, primary care givers and specialists. This is a narrative review using up-to-date ... ...

    Abstract There are more than 170 million confirmed cases of COVID-19 worldwide, yet its effects on the endocrine system remain under-reported due to lack of awareness by the public, primary care givers and specialists. This is a narrative review using up-to-date literature discussing the consequences that infection with SARS-CoV-2 can have on diabetes and the endocrine glands including the adrenals, thyroid and pituitary, as well as hyponatremia and hypogonadism. Endocrinologists, internists and primary care physicians need to be aware of the involvement of the endocrine organs when dealing with people recovering from COVID-19 and actively manage any complications to reduce mortality and improve the quality of life of those affected.
    MeSH term(s) COVID-19 ; Diabetes Mellitus ; Endocrinology ; Humans ; Quality of Life ; SARS-CoV-2
    Language English
    Publishing date 2021-09-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2021-0200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Hypoglycaemia following the 2-hour 75g OGTT in pregnancy - Investigating maternal and foetal outcomes.

    Blunt, Callum / Mathew, Susan / Mung, Sai Man / Krishnamurthy, Roopa / Jude, Edward B

    Diabetes & metabolic syndrome

    2024  Volume 18, Issue 3, Page(s) 102977

    Abstract: Aims: To investigate differences in maternal and foetal outcomes in pregnancy, where patients developed hypoglycaemia following the 2-hour 75g oral glucose tolerance test (OGTT).: Method: A retrospective cohort study of 200 pregnancies attending the ... ...

    Abstract Aims: To investigate differences in maternal and foetal outcomes in pregnancy, where patients developed hypoglycaemia following the 2-hour 75g oral glucose tolerance test (OGTT).
    Method: A retrospective cohort study of 200 pregnancies attending the Antenatal Clinic at Tameside General Hospital between 2018 and 2022. Outcomes were compared between 4 groups: normal OGTT [G1; (n = 39, 20%), diagnosis of gestational diabetes mellitus (GDM) based on OGTT [G2; BG ≥ 5.6 mmol/L or 2-h OGTT ≥7.8 (n = 41, 21%)], hypoglycaemia [G3; 2 h OGTT 3.0-3.9 mmol/L (n = 93, 47%)], or clinically significant hypoglycaemia [G4; 2 h OGTT <3.0 mmol/L (n = 27, 14%)]. Maternal BMI, foetal birth weight (FBW), neonatal complications, neo-natal intensive care unit (NICU) stay and conversion to GDM were assessed.
    Results: Maternal BMI was lower in G3 and G4 (27.3 kg/m
    Conclusion: Higher rates of NICU stay and foetal complications were seen in both hypoglycaemic groups. In patients with hypoglycaemia following OGTT there is evidence to support self-monitoring blood glucose as 28% were later diagnosed with GDM.
    Language English
    Publishing date 2024-03-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2024.102977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Inflammatory Arthritis Associated with COVID-19 Vaccination.

    Mung, Sai Man / Goh, Tee Lin / Hughes, Michael / Jude, Edward B

    Cureus

    2023  Volume 15, Issue 3, Page(s) e35951

    Abstract: COVID-19 vaccines have been shown to be highly efficacious in preventing symptomatic COVID-19 infections throughout the pandemic. There have been emerging cases of inflammatory arthritis occurring in close relation to COVID-19 vaccination. We illustrate ... ...

    Abstract COVID-19 vaccines have been shown to be highly efficacious in preventing symptomatic COVID-19 infections throughout the pandemic. There have been emerging cases of inflammatory arthritis occurring in close relation to COVID-19 vaccination. We illustrate a case of new-onset inflammatory arthritis 10 days after receiving their second Vaxzevria COVID-19 vaccine. The patient responded dramatically to prednisolone treatment but subsequently required hydroxychloroquine due to persistent inflammatory joint symptoms. Inflammatory arthritis is an increasingly recognized rare adverse effect of COVID-19 vaccination and clinicians should actively consider this in patients with new or flares of inflammatory joint disease.
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.35951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pedal acrometastasis secondary to urothelial carcinoma masquerading as Charcot arthropathy in a patient with diabetes.

    Coe, Calvin / Chirputkar, Kedar / Joseph, Leena / Jude, Edward B

    BMJ case reports

    2023  Volume 16, Issue 9

    Abstract: A woman in her 80s with known diabetes mellitus and bladder cancer presented to her general practitioner (GP) with pain and swelling in her left foot following trauma. Initial radiographs were reported as normal, prompting a diagnosis of a simple sprain ... ...

    Abstract A woman in her 80s with known diabetes mellitus and bladder cancer presented to her general practitioner (GP) with pain and swelling in her left foot following trauma. Initial radiographs were reported as normal, prompting a diagnosis of a simple sprain and conservative management. Three months later, the patient was referred to the orthopaedic team due to progressively increasing pain and swelling. Repeat X-rays revealed lytic lesions in both the talus and navicular bones; MRI confirmed the presence of a lytic and proliferative defect in the mid-foot, which was reported as acute Charcot arthropathy with superimposed infection. This was also considered the most likely diagnosis when imaging was reviewed in two separate multidisciplinary team) meetings. However, biopsy demonstrated that the cause of the presentation was in fact acrometastasis from urothelial carcinoma, an infrequently described entity.
    MeSH term(s) Female ; Humans ; Carcinoma, Transitional Cell/diagnosis ; Carcinoma, Transitional Cell/diagnostic imaging ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/diagnostic imaging ; Foot ; Arthropathy, Neurogenic/diagnostic imaging ; Arthropathy, Neurogenic/etiology ; Diabetes Mellitus ; Pain
    Language English
    Publishing date 2023-09-20
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-254468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A paradigm shift for cardiovascular outcome evaluation in diabetes: Major adverse cardiovascular events (MACE) to major adverse vascular events (MAVE).

    Rastogi, Ashu / Sudhayakumar, Anand / Schaper, Nicolaas C / Jude, Edward B

    Diabetes & metabolic syndrome

    2023  Volume 17, Issue 11, Page(s) 102875

    Abstract: Background and aims: Drugs for diabetes are required to demonstrate cardiovascular safety through CV outcome trials (CVOT). The pre-defined end-points for cardiovascular outcome studies may not be sufficient to capture all clinically relevant ... ...

    Abstract Background and aims: Drugs for diabetes are required to demonstrate cardiovascular safety through CV outcome trials (CVOT). The pre-defined end-points for cardiovascular outcome studies may not be sufficient to capture all clinically relevant atherosclerotic cardio vascular disease (ASCVD) events particularly peripheral arterial disease (PAD).
    Methods: We planned a scoping review and searched database to identify CVOT conducted in population with diabetes measuring lower limb events due to PAD as the primary outcome measure. We also searched CVOT for reported differential cardiovascular outcomes in population with PAD.
    Results: We identified that CV outcomes are measured as 3 point major adverse cardiovascular outcomes (3P-MACE) that includes nonfatal MI and nonfatal stroke or 4P-MACE that included additional unstable angina which is further expanded to 5P-MACE by the inclusion of hospitalization for heart failure (HHF). These CV end points are captured as surrogate for CV mortality based on the biological plausibility of relation between the surrogate and final outcome from pathophysiological studies. We found the prevalence of PAD is no lesser than other CV events in people with diabetes. Moreover, PAD contributes to the significant morbidity associated with diabetes as a surrogate for mortality. However, none of the CVOT with anti-diabetic drugs include PAD events as primary outcome measure despite the inclusion of 6-25 % participants with PAD in major CVOT. PAD outcomes are objectively measurable with tibial arterial waveforms and clinical end-point as lower extremity amputation. PAD outcomes do improve with treatment including intensive glycemic control and novel oral anticoagulants. We suggest the inclusion of PAD to MACE as a pre-specified outcome for a comprehensive capture of major adverse vascular event in future studies for people with diabetes.
    Conclusions: MACE should be expanded to include PAD event as major adverse vascular event in cardiovascular outcome studies since PAD is clinically relevant and objectively measurable in diabetes.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/therapeutic use ; Risk Factors ; Atherosclerosis/drug therapy ; Peripheral Arterial Disease/complications ; Peripheral Arterial Disease/epidemiology ; Outcome Assessment, Health Care ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/chemically induced
    Chemical Substances Hypoglycemic Agents
    Language English
    Publishing date 2023-10-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2023.102875
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