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  1. Article ; Online: Commentary on Long-term clinical outcome after epineural coaptation of digital nerves. R. M. Fakin, M. Calcagni, H. J. Klein and P. Giovanoli. J Hand Surg. 2016, 41: 148-154.

    Clarke, A M

    The Journal of hand surgery, European volume

    2016  Volume 41, Issue 2, Page(s) 155–156

    MeSH term(s) Hand ; Humans ; Peripheral Nerves
    Language English
    Publishing date 2016-02
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2272801-6
    ISSN 2043-6289 ; 1753-1934
    ISSN (online) 2043-6289
    ISSN 1753-1934
    DOI 10.1177/1753193415622729
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    Zs.A 1940: Show issues Location:
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  2. Article: Retraction concerning the E2 protein of human papillovirus type 16: overexpression and purification of an active transcriptional regulator [Lees, M.E., Dreissen, H.P.C., Crawford, L.V. & Clarke, A.R. (1990) Eur. J. Biochem. 190, 85-92.] Expression of the human papillovirus type 16 E2 protein in Escherichia coli.

    Lees, E M / Dreissen, H P / Crawford, L V / Clarke, A R

    European journal of biochemistry

    1993  Volume 212, Issue 1, Page(s) 271

    Language English
    Publishing date 1993-02-15
    Publishing country England
    Document type Retraction of Publication
    ZDB-ID 3032-6
    ISSN 1432-1033 ; 0014-2956
    ISSN (online) 1432-1033
    ISSN 0014-2956
    DOI 10.1111/j.1432-1033.1993.tb17659.x
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  3. Article ; Online: Association of antibiotic test doses with reduced likelihood of severe antibiotic anaphylaxis: a re-analysis of data from the 6th National Audit Project (NAP6).

    Sadleir, Paul H M / Clarke, Russell C / Platt, Peter R

    British journal of anaesthesia

    2024  Volume 132, Issue 3, Page(s) 621–624

    MeSH term(s) Humans ; Anaphylaxis/chemically induced ; Anaphylaxis/drug therapy ; Anti-Bacterial Agents/adverse effects ; Drug Hypersensitivity ; Anesthesia
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2023.12.007
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  4. Article ; Online: Impact of economic growth on physical activity and sedentary behaviors: a Systematic Review.

    Yang, H / An, R / Clarke, C V / Shen, J

    Public health

    2023  Volume 215, Page(s) 17–26

    Abstract: Objectives: This study systematically reviewed scientific evidence regarding the impact of economic growth on physical activity (PA) and sedentary behaviors.: Methods: A keyword and reference search was conducted in PubMed, Web of Science, Cochrane ... ...

    Abstract Objectives: This study systematically reviewed scientific evidence regarding the impact of economic growth on physical activity (PA) and sedentary behaviors.
    Methods: A keyword and reference search was conducted in PubMed, Web of Science, Cochrane Library, Scopus, and EBSCO from the inception of an electronic bibliographic database to November 2021. Studies that met all of the following criteria were included in the review: (1) study designs: observational studies; (2) study subjects: people of all ages; (3) exposure: macroeconomic growth; (4) outcomes: PA or sedentary behaviors/sitting time.
    Results: 15 studies were identified. Eight among 12 studies found economic growth positively associated with at least one domain/measure of PA, whereas the remaining four found an inverse relationship. One of two studies examined the association of economic growth and physical inactivity found a positive relationship, while another found no significant relationship. Four studies examined the associations between economic growth and sedentary behaviors, and the results were inconclusive. The impact of economic growth on PA is through three main pathways-(a) building and maintaining parks and green spaces, (b) adoption of the modern workplace and high technology, and (c) motorized transportation.
    Conclusion: Building and maintaining parks and green spaces can effectively promote leisure time physical activity and active commute in developed countries, whereas promoting workplace and transportation-related PA could be prioritized in developing nations. Future research calls for longitudinal study design and further exploration of macro-environmental factors. Policymakers and stakeholders should be informed about the potential PA reduction resulting from economic growth and develop preventive strategies to alleviate the problem.
    MeSH term(s) Humans ; Sedentary Behavior ; Longitudinal Studies ; Economic Development ; Exercise ; Motor Activity
    Language English
    Publishing date 2023-01-04
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 427333-3
    ISSN 1476-5616 ; 0033-3506
    ISSN (online) 1476-5616
    ISSN 0033-3506
    DOI 10.1016/j.puhe.2022.11.020
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  5. Article ; Online: Mediating Effects of Technology-Based Therapy on the Relationship Between Socioeconomic Status and Glycemic Management in Pediatric Type 1 Diabetes.

    Stanley, Joshua R / Clarke, Antoine B M / Shulman, Rayzel / Mahmud, Farid H

    Diabetes technology & therapeutics

    2022  Volume 25, Issue 3, Page(s) 186–193

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Child ; Diabetes Mellitus, Type 1/drug therapy ; Hypoglycemic Agents/therapeutic use ; Blood Glucose Self-Monitoring ; Retrospective Studies ; Cross-Sectional Studies ; Glycated Hemoglobin ; Blood Glucose ; Insulin Infusion Systems ; Insulin/therapeutic use ; Social Class
    Chemical Substances Hypoglycemic Agents ; Glycated Hemoglobin ; Blood Glucose ; Insulin
    Language English
    Publishing date 2022-12-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1452816-2
    ISSN 1557-8593 ; 1520-9156
    ISSN (online) 1557-8593
    ISSN 1520-9156
    DOI 10.1089/dia.2022.0388
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  6. Article ; Online: Correction: Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.

    Daly, C S / Shaw, P / Ordonez, L D / Williams, G T / Quist, J / Grigoriadis, A / Van Es, J H / Clevers, H / Clarke, A R / Reed, K R

    Oncogene

    2024  Volume 43, Issue 12, Page(s) 918

    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Published Erratum
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-024-02941-5
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    Zs.A 2218: Show issues Location:
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  7. Article ; Online: Evaluation of the Amblyopia tracker app.

    O'Connor, Anna R / Warburton, Ashli / Farrelly-Waters, Martha / England, Laura / Clarke, Rachel / Kay, Hazel

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2024  

    Abstract: ... tested within 48 h of their appointment where the measurement was repeated by an orthoptist.: Results ...

    Abstract Purpose: The Amblyopia tracker app has been developed to be a tool for parents to monitor changes in vision at home during amblyopia treatment. The aims of this study were to evaluate the feasibility and repeatability of parents testing their children at home and to compare home test results to an assessment in clinic by an orthoptist.
    Methods: Children (age < 18 years) with amblyopia (interocular acuity difference of ≥ 0.2logMAR) were recruited. Parents were asked to test their child with the app three times during a two week period followed by an online questionnaire about the usability. Participants also tested within 48 h of their appointment where the measurement was repeated by an orthoptist.
    Results: Out of 277 potential participants contacted, 37 completed three home measurements, mean age 6.8 years (SD 2.94). Home tests comparisons were made between test two and three to ensure familiarity with the process. Paired t-tests showed no statistically significant difference for either eye or the interocular acuity difference (IAD). However, 29% had a difference in IAD of more than 0.1logMAR on repeated testing, with a maximum of 0.4logMAR difference in the IAD. Questionnaire responses from the parents who participated were predominantly positive with 97% of respondents saying they would use it if were available. Comparison of home and clinical measurements (n = 23, mean age 6.72 SD 2.60) showed no statistically significant differences for either eye or interocular acuity difference (paired t-test, p > 0.3 in all cases).
    Conclusion: Results show no statistically significant differences for the Amblyopia tracker app when used by parents at home on repeated testing, or between the home test by a parent and the test by a clinician. However, variability in the results does indicate that further improvements are required to ensure the results can be used as a reliable clinical tool.
    Language English
    Publishing date 2024-02-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-024-06413-0
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  8. Article ; Online: A conceptual framework for cautious escalation of anticancer treatment: How to optimize overall benefit and obviate the need for de-escalation trials.

    Pourmir, I / Van Halteren, H K / Elaidi, R / Trapani, D / Strasser, F / Vreugdenhil, G / Clarke, M

    Cancer treatment reviews

    2024  Volume 124, Page(s) 102693

    Abstract: Background: The developmental workflow of the currently performed phase 1, 2 and 3 cancer trial stages lacks essential information required for the determination of the optimal efficacy threshold of new anticancer regimens. Due to this there is a ... ...

    Abstract Background: The developmental workflow of the currently performed phase 1, 2 and 3 cancer trial stages lacks essential information required for the determination of the optimal efficacy threshold of new anticancer regimens. Due to this there is a serious risk of overdosing and/or treating for an unnecessary long time, leading to excess toxicity and a higher financial burden for society. But often post-approval de-escalation trials for dose-optimization and treatment de-intensification are not performed due to failing resources and time. Therefore, the developmental workflow needs to be restructured toward cautious systemic cancer treatment escalation, in order to guarantee optimal efficacy and sustainability.
    Methods: In this manuscript we discuss opportunities to produce the information needed for cautious escalation, based on models of cancer growth and cancer kill kinetics as well as exploratory biomarkers, for the purpose of designing the optimal phase 3 superiority trial. Subsequently, we compare the sample size needed for a phase 3 superiority trial, followed by a necessary de-escalation trial with the sample size needed for a multi-arm phase 3 trial with intervention arms of differing intensity. All essential items are structured within a Framework for Cautious Escalation (FCE). The discussion uses illustrations from the breast cancer setting, but aims to be applicable for all cancers.
    Results: The FCE is a promising model of clinical development in oncology to prevent overtreatment and associated issues, especially with regard to the number of repetitive treatment cycles. It will hopefully increase the relevance and success rate of clinical trials, to deliver improved patient-centric outcomes.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Biomarkers ; Medical Oncology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-01-30
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2024.102693
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  9. Article ; Online: Diverse mobile genetic elements shaped the evolution of

    Weisberg, Alexandra J / Pearce, Emma / Kramer, Charles G / Chang, Jeff H / Clarke, Christopher R

    Microbial genomics

    2023  Volume 9, Issue 11

    Abstract: Mobile genetic elements can innovate bacteria with new traits. In plant ... ...

    Abstract Mobile genetic elements can innovate bacteria with new traits. In plant pathogenic
    MeSH term(s) Virulence/genetics ; Crops, Agricultural ; Phenotype ; Streptomyces/genetics ; Interspersed Repetitive Sequences
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.001127
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  10. Article ; Online: Streptomyces caniscabiei

    Nguyen, Hien P / Weisberg, Alexandra J / Chang, Jeff H / Clarke, Christopher R

    International journal of systematic and evolutionary microbiology

    2022  Volume 72, Issue 1

    Abstract: Fourteen strains ... ...

    Abstract Fourteen strains of
    MeSH term(s) Bacterial Typing Techniques ; Base Composition ; DNA, Bacterial/genetics ; Fatty Acids/chemistry ; Phylogeny ; Plant Diseases/microbiology ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Solanum tuberosum/microbiology ; Streptomyces/classification ; Streptomyces/isolation & purification
    Chemical Substances DNA, Bacterial ; Fatty Acids ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2022-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2002336-4
    ISSN 1466-5034 ; 1466-5026
    ISSN (online) 1466-5034
    ISSN 1466-5026
    DOI 10.1099/ijsem.0.005225
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