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  1. Article ; Online: Managing the combined consequences of COVID-19 infection and lock-down policies on athletes

    Jean-Bernard Fabre / Laurent Grelot / William Vanbiervielt / Julien Mazerie / Raphael Manca / Vincent Martin

    BMJ Open Sport & Exercise Medicine, Vol 6, Iss

    narrative review and guidelines proposal for a safe return to sport

    2020  Volume 1

    Abstract: COVID-19 pandemic is a global health matter. The disease spread rapidly across the globe and brought the world of sports to an unprecedented stoppage. Usual symptoms of the disease are fever, cough, myalgia, fatigue, slight dyspnoea, sore throat and ... ...

    Abstract COVID-19 pandemic is a global health matter. The disease spread rapidly across the globe and brought the world of sports to an unprecedented stoppage. Usual symptoms of the disease are fever, cough, myalgia, fatigue, slight dyspnoea, sore throat and headache. In more severe cases, dyspnoea, hypoxaemia, respiratory failure, shock and multiorgan failure occur. This appears to be a self-limiting phenomenon related to individuals with coexisting medical conditions, such as hypertension, diabetes and cardiovascular disorders. Nevertheless, cases have been reported in professional soccer players in extremely good fitness condition, demonstrating that athletes are not spared by the disease. Despite COVID-19 clinical manifestations are mainly respiratory, major cardiac complications are being reported, leading to acute myocarditis. One difficulty is that symptoms of COVID-19 vary among individuals, with athletes being affected with no apparent sign of the disease. This could be a real danger for amateur or professional athletes when returning to their usual training and thus to play. Another threat is that the lock-down policies did not allow most athletes to follow their usual training routines. There is thus a need for a careful approach by the sports medicine community to ensure safety of all athletes before they return to sport. Here, we propose evaluation guidelines of fitness and health of athletes to (1) reduce any lethal risk of practice, especially myocarditis and sudden cardiac death; (2) evaluate the combined consequences of the disease and detraining on the physical abilities and biological profile of athletes; and (3) monitor postinfection fatigue symptoms.
    Keywords Medicine (General) ; R5-920
    Subject code 796
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Managing the combined consequences of COVID-19 infection and lock-down policies on athletes: narrative review and guidelines proposal for a safe return to sport.

    Fabre, Jean-Bernard / Grelot, Laurent / Vanbiervielt, William / Mazerie, Julien / Manca, Raphael / Martin, Vincent

    BMJ open sport & exercise medicine

    2020  Volume 6, Issue 1, Page(s) e000849

    Abstract: COVID-19 pandemic is a global health matter. The disease spread rapidly across the globe and brought the world of sports to an unprecedented stoppage. Usual symptoms of the disease are fever, cough, myalgia, fatigue, slight dyspnoea, sore throat and ... ...

    Abstract COVID-19 pandemic is a global health matter. The disease spread rapidly across the globe and brought the world of sports to an unprecedented stoppage. Usual symptoms of the disease are fever, cough, myalgia, fatigue, slight dyspnoea, sore throat and headache. In more severe cases, dyspnoea, hypoxaemia, respiratory failure, shock and multiorgan failure occur. This appears to be a self-limiting phenomenon related to individuals with coexisting medical conditions, such as hypertension, diabetes and cardiovascular disorders. Nevertheless, cases have been reported in professional soccer players in extremely good fitness condition, demonstrating that athletes are not spared by the disease. Despite COVID-19 clinical manifestations are mainly respiratory, major cardiac complications are being reported, leading to acute myocarditis. One difficulty is that symptoms of COVID-19 vary among individuals, with athletes being affected with no apparent sign of the disease. This could be a real danger for amateur or professional athletes when returning to their usual training and thus to play. Another threat is that the lock-down policies did not allow most athletes to follow their usual training routines. There is thus a need for a careful approach by the sports medicine community to ensure safety of all athletes before they return to sport. Here, we propose evaluation guidelines of fitness and health of athletes to (1) reduce any lethal risk of practice, especially myocarditis and sudden cardiac death; (2) evaluate the combined consequences of the disease and detraining on the physical abilities and biological profile of athletes; and (3) monitor postinfection fatigue symptoms.
    Keywords covid19
    Language English
    Publishing date 2020-10-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2817580-3
    ISSN 2055-7647
    ISSN 2055-7647
    DOI 10.1136/bmjsem-2020-000849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Does Matching Femoral Size and Shape Improve Bone Fit and Patient-reported Outcomes in TKA? A Matched Controlled Study.

    Bernard-de Villeneuve, Florent / Bizzozero, Paul / Fabre-Aubrespy, Maxime / Ollivier, Matthieu / Argenson, Jean-Noel

    Clinical orthopaedics and related research

    2023  Volume 481, Issue 6, Page(s) 1129–1139

    Abstract: Background: Some researchers have suggested that achieving good component coverage over the host bone during TKA (while avoiding implant overhang) may help achieve durable implant fixation and may be associated with better outcomes scores. However, the ... ...

    Abstract Background: Some researchers have suggested that achieving good component coverage over the host bone during TKA (while avoiding implant overhang) may help achieve durable implant fixation and may be associated with better outcomes scores. However, the evidence about this is limited and contradictory. Contemporary morphometric TKA includes a wide array of components with various shapes and sizes, based on large anatomic databases and specific software that simulates bone cuts. Morphometric tibial components have shown improved bone coverage and better clinical outcomes than standardized implants, but the role of morphometric femoral components in bone coverage has not been studied precisely.
    Questions/purposes: In a retrospective, controlled study that used patient matching, we asked: (1) Does the use of a contemporary morphometric component with more available sizes provide better femoral component fit and bone coverage than an earlier design with fewer sizes? (2) Are component fit and the presence of component overhang or underhang associated with different Knee Society Score (KSS) or Knee Injury and Osteoarthritis Outcome Score (KOOS) for Joint Replacement?
    Methods: From 2012 to 2013, we performed 403 TKAs according to the following criteria: TKA performed for primary tricompartmental arthritis of the knee; varus, valgus, and flexion deformity less than 15°; and age between 18 and 85 years on the day of surgery. Among these 403 TKAs, 237 were performed using a morphometric implant and 166 with the earlier nonmorphometric implant. At 2 years of follow-up, 3% of patients in the morphometric group and 5% in the nonmorphometric group were lost to follow-up. Based on age, BMI, gender, and preoperative KSS and KOOS, two groups of 30 patients were matched in a 1:1 ratio from this longitudinally maintained database. Clinical outcomes were measured preoperatively and at a minimum follow-up of 2 years in both groups, using the KSS and KOOS. We evaluated postoperative CT images for each patient to analyze femoral implant rotation, bone coverage, and overhang and underhang status.
    Results: The overhang status was similar between the two groups (23% had an overhang component in the morphometric knee group and 27% had an overhang component in the nonmorphometric knee group), and overhang was most frequently found in the lateral distal zone and medial anterior chamfer. Better cortical bone coverage was found in the morphometric knee group, with a thinner bone margin between the component edge and cortical border (morphometric group: 3 mm versus nonmorphometric knee group: 5 mm; p = 0.01). In general, there were few between-group differences in terms of patient-reported outcomes; of the seven metrics we analyzed, only the KSS favored the morphometric knee implant by a margin larger than the minimum clinically important difference (KSS mean difference: 21 points for the morphometric knee group; p < 0.05). Overhang of the femoral component of > 2 mm was associated with poorer KOOS, but not KSS, whereas a thinner bone margin had a beneficial impact on pain and global clinical scores (KOOS and KSS: p < 0.05).
    Conclusion: The use of a morphometric femoral component design showed slightly improved bone fit and pain score according to the KSS at midterm follow-up compared with earlier implants with fewer sizes. Overhang > 2 mm was associated with worse KOOS. The tendency toward better outcomes in morphometric implants warrants longer-term evaluation before any definite conclusions about the association between bone fit and clinical results can be drawn.Level of Evidence Level III, therapeutic study.
    MeSH term(s) Humans ; Infant, Newborn ; Infant ; Arthroplasty, Replacement, Knee/adverse effects ; Arthroplasty, Replacement, Knee/methods ; Retrospective Studies ; Knee Joint/diagnostic imaging ; Knee Joint/surgery ; Knee Prosthesis ; Patient Reported Outcome Measures ; Pain/complications ; Osteoarthritis, Knee/surgery
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1097/CORR.0000000000002530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Neuromelanin Locus Coeruleus MRI Contrast in Migraine With Aura.

    Gollion, Cédric / Arribarat, Germain / Ruidavets, Jean-Bernard / Fabre, Nelly / Barège, Michèle / Bonneville, Fabrice / Larrue, Vincent / Peran, Patrice

    Headache

    2020  Volume 60, Issue 4, Page(s) 752–760

    Abstract: Introduction: The locus coeruleus (LC) is one of the brainstem nuclei that may be activated during migraine attack. As LC contains neuromelanin, a by-product of norepinephrine synthesis, it can be delineated in vivo using neuromelanin sensitive magnetic ...

    Abstract Introduction: The locus coeruleus (LC) is one of the brainstem nuclei that may be activated during migraine attack. As LC contains neuromelanin, a by-product of norepinephrine synthesis, it can be delineated in vivo using neuromelanin sensitive magnetic resonance imaging (MRI). The neuromelanin content in LC has been suggested to reflect previous LC activation. We investigated LC MRI contrast in patients with migraine with aura (MWA) and its correlation with migraine features.
    Methods: This matched cohort study compared 23 MWA patients aged 30-55 and without comorbidity, to 23 sex- and age-matched healthy controls. The study was conducted in a University Hospital. LC contrast was measured with T1 neuromelanin-sensitive-weighted 3T MRI. Voxels were manually selected by 2 independent researchers and comparison was made twice using intersection and union of the voxels selected by the 2 observers.
    Results: No difference was found in neuromelanin LC contrast between MWA patients and controls with both the INTER method (0.224 ± 0.042 vs 0.228 ± 0.048; difference: 0.0001 (95%CI: -0.032 to 0.026), P = .799) and UNION method (0.218 ± 0.043 vs 0.222 ± 0.047; difference: -0.0012 (95%CI: -0.031 to 0.026), P = .775). Global LC volume was also similar between the 2 groups with INTER method (15.087 ± 3.965 vs 13.739 ± 3.583; difference: 2 (95%CI: -1 to 4), P = .233) and UNION method (17.522 ± 4.440 vs 16.087 ± 4.274; difference: 1 (95%CI: -2 to 4), P = .270). Moreover, no correlations were found between neuromelanin LC contrast and migraine features (duration of migraine and frequency of attacks).
    Conclusion: These negative findings do not support the use of neuromelanin LC contrast as a biomarker of MA.
    Language English
    Publishing date 2020-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410130-3
    ISSN 1526-4610 ; 0017-8748
    ISSN (online) 1526-4610
    ISSN 0017-8748
    DOI 10.1111/head.13771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Managing the combined consequences of COVID-19 infection and lock-down policies on athletes

    FABRE, JEAN-BERNARD / Grelot, Laurent / Vanbiervielt, William / Mazerie, Julien / Manca, Raphael / Martin, Vincent

    BMJ Open Sport & Exercise Medicine ; https://hal.uca.fr/hal-02988742 ; BMJ Open Sport & Exercise Medicine, 2020, 6 (1), pp.e000849. ⟨10.1136/bmjsem-2020-000849⟩

    narrative review and guidelines proposal for a safe return to sport

    2020  

    Abstract: International ... ...

    Abstract International audience
    Keywords [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ; covid19
    Language English
    Publishing date 2020-10-17
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Managing the combined consequences of COVID-19 infection and lock-down policies on athletes

    FABRE, JEAN-BERNARD / Grelot, Laurent / Vanbiervielt, William / Mazerie, Julien / Manca, Raphael / Martin, Vincent

    BMJ Open Sport & Exercise Medicine ; https://hal.uca.fr/hal-02988742 ; BMJ Open Sport & Exercise Medicine, 2020, 6 (1), pp.e000849. ⟨10.1136/bmjsem-2020-000849⟩

    narrative review and guidelines proposal for a safe return to sport

    2020  

    Abstract: International ... ...

    Abstract International audience
    Keywords [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ; covid19
    Language English
    Publishing date 2020-10-17
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Managing the combined consequences of COVID-19 infection and lock-down policies on athletes

    FABRE, JEAN-BERNARD / Grelot, Laurent / Vanbiervielt, William / Mazerie, Julien / Manca, Raphael / Martin, Vincent

    BMJ Open Sport & Exercise Medicine ; https://hal.uca.fr/hal-02988742 ; BMJ Open Sport & Exercise Medicine, 2020, 6 (1), pp.e000849. ⟨10.1136/bmjsem-2020-000849⟩

    narrative review and guidelines proposal for a safe return to sport

    2020  

    Abstract: International ... ...

    Abstract International audience
    Keywords [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ; covid19
    Language English
    Publishing date 2020-10-17
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Managing the combined consequences of COVID-19 infection and lock-down policies on athletes

    FABRE, JEAN-BERNARD / Grelot, Laurent / Vanbiervielt, William / Mazerie, Julien / Manca, Raphael / Martin, Vincent

    BMJ Open Sport & Exercise Medicine ; https://hal.uca.fr/hal-02988742 ; BMJ Open Sport & Exercise Medicine, 2020, 6 (1), pp.e000849. ⟨10.1136/bmjsem-2020-000849⟩

    narrative review and guidelines proposal for a safe return to sport

    2020  

    Abstract: International ... ...

    Abstract International audience
    Keywords [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ; covid19
    Language English
    Publishing date 2020-10-17
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Managing the combined consequences of COVID-19 infection and lock-down policies on athletes

    FABRE, JEAN-BERNARD / Grelot, Laurent / Vanbiervielt, William / Mazerie, Julien / Manca, Raphael / Martin, Vincent

    BMJ Open Sport & Exercise Medicine ; https://hal.uca.fr/hal-02988742 ; BMJ Open Sport & Exercise Medicine, 2020, 6 (1), pp.e000849. ⟨10.1136/bmjsem-2020-000849⟩

    narrative review and guidelines proposal for a safe return to sport

    2020  

    Abstract: International ... ...

    Abstract International audience
    Keywords [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ; covid19
    Language English
    Publishing date 2020-10-17
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice.

    Le Moal, Emmeran / Liu, Yuguo / Collerette-Tremblay, Jasmin / Dumontier, Simon / Fabre, Paul / Molina, Thomas / Dort, Junio / Orfi, Zakaria / Denault, Nicolas / Boutin, Joël / Michaud, Joris / Giguère, Hugo / Desroches, Alexandre / Trân, Kien / Ellezam, Benjamin / Vézina, François / Bedard, Sonia / Raynaud, Catherine / Balg, Frederic /
    Sarret, Philippe / Boudreault, Pierre-Luc / Scott, Michelle S / Denault, Jean-Bernard / Marsault, Eric / Feige, Jerome N / Auger-Messier, Mannix / Dumont, Nicolas A / Bentzinger, C Florian

    Science translational medicine

    2024  Volume 16, Issue 739, Page(s) eabn8529

    Abstract: Impaired skeletal muscle stem cell (MuSC) function has long been suspected to contribute to the pathogenesis of muscular dystrophy (MD). Here, we showed that defects in the endothelial cell (EC) compartment of the vascular stem cell niche in mouse models ...

    Abstract Impaired skeletal muscle stem cell (MuSC) function has long been suspected to contribute to the pathogenesis of muscular dystrophy (MD). Here, we showed that defects in the endothelial cell (EC) compartment of the vascular stem cell niche in mouse models of Duchenne MD, laminin α2-related MD, and collagen VI-related myopathy were associated with inefficient mobilization of MuSCs after tissue damage. Using chemoinformatic analysis, we identified the 13-amino acid form of the peptide hormone apelin (AP-13) as a candidate for systemic stimulation of skeletal muscle ECs. Systemic administration of AP-13 using osmotic pumps generated a pro-proliferative EC-rich niche that supported MuSC function through angiocrine factors and markedly improved tissue regeneration and muscle strength in all three dystrophic mouse models. Moreover, EC-specific knockout of the apelin receptor led to regenerative defects that phenocopied key pathological features of MD, including vascular defects, fibrosis, muscle fiber necrosis, impaired MuSC function, and reduced force generation. Together, these studies provide in vivo proof of concept that enhancing endogenous skeletal muscle repair by targeting the vascular niche is a viable therapeutic avenue for MD and characterized AP-13 as a candidate for further study for the systemic treatment of MuSC dysfunction.
    MeSH term(s) Mice ; Animals ; Stem Cell Niche ; Apelin/metabolism ; Muscle, Skeletal/metabolism ; Muscular Dystrophy, Duchenne/metabolism ; Signal Transduction
    Chemical Substances Apelin
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.abn8529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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