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Article ; Online: Applying the WHO INSPIRE Framework to Ending Violence Against Pregnant Women and Unborn Children: A Case Study in Vietnam.

Do, Huyen Phuc / Dunne, Michael P / Vo, Thang Van / Nguyen, Lan Hoang / Luong-Thanh, Bao-Yen / Valdebenito, Sara / Baker, Philip R A / Tran, Bach Xuan / Hoang, Tuyen Dinh / Eisner, Manuel

Violence against women

2024 , Page(s) 10778012241230324

Abstract: This article adapted the INSPIRE framework, developed by the World Health Organization to prevent violence against children, to the systematic analysis of city-level healthcare services for pregnant women who experienced intimate partner violence. A ... ...

Abstract	This article adapted the INSPIRE framework, developed by the World Health Organization to prevent violence against children, to the systematic analysis of city-level healthcare services for pregnant women who experienced intimate partner violence. A mixed-methods study conducted in-depth interviews with 22 health and social care professionals and 140 pregnant women in Vietnam. The women were more likely to report limited system-level support for partners regarding violence and mental health, while the professionals perceived more weaknesses in policies and management of services. Traditional values tend to isolate abused women from receiving social services. The INSPIRE framework is innovative and could be applied in other contexts.
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2031375-5
ISSN	1552-8448 ; 1077-8012
ISSN (online)	1552-8448
ISSN	1077-8012
DOI	10.1177/10778012241230324
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Article ; Online: Phylogenetic variation in heavy metal accumulation in angiosperms.

Broadley, Martin R / Willey, Neil J / Wilkins, Janine C / Baker, Alan J M / Mead, Andrew / White, Philip J

The New phytologist

2022 Volume 152, Issue 1, Page(s) 9–27

Abstract: The influence of phylogeny on shoot heavy metal content in plants was investigated and the hypothesis tested that traits impacting on the accumulation of cadmium, chromium, copper, nickel, lead and zinc in plant shoots are associated. • Data suitable ...

Abstract	• The influence of phylogeny on shoot heavy metal content in plants was investigated and the hypothesis tested that traits impacting on the accumulation of cadmium, chromium, copper, nickel, lead and zinc in plant shoots are associated. • Data suitable for comparative analyses were generated from a literature survey, using a residual maximum likelihood (REML) procedure. Both pair-wise regressions and principal components analyses (PCA) were performed on independent contrasts of shoot metal content. • Significant variation in shoot metal content occurred at the classification level of order and above, suggesting an ancient evolution of traits. Traits impacting on the accumulation of metals in plant shoots were associated. • This information can be used to improve predictions of soil-to-plant metal transfer, to formulate hypotheses on the origins of metal-accumulating phenotypes and to inform the exploitation of plant genetic resources for nutritional improvement and phytoremediation.
Language	English
Publishing date	2022-08-16
Publishing country	England
Document type	Journal Article
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1046/j.0028-646x.2001.00238.x
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Article ; Online: Technology in Public Health Higher Education.

Baker, Philip R A / Demant, Daniel / Cathcart, Abby

Asia-Pacific journal of public health

2018 Volume 30, Issue 7, Page(s) 655–665

Abstract: Streamed and recorded lectures as well as audience response technology are increasingly used in public health tertiary education, to train practitioners to address Asia-Pacific region's rapidly changing health needs. However, little is known about the ... ...

Abstract	Streamed and recorded lectures as well as audience response technology are increasingly used in public health tertiary education, to train practitioners to address Asia-Pacific region's rapidly changing health needs. However, little is known about the impact on student performance, satisfaction, and understanding. This study aimed to assess postgraduate students' perceptions and their use of technology in a large epidemiology subject at an Australian university in internal and external modes. The study used both routinely collected student data (n = 453) and survey data (n = 88). Results indicate that students accept and use technology-based learning tools, and perceive audience response technology as well as streamed and recorded lectures as useful for their learning (96.6%). Students have shown a preference to review recorded lectures rather than viewing streamed lectures. Analyses further suggest that the use of recorded and streamed lectures may be linked to better student performance for external students (passing, any use odds ratio = 3.32). However, these effects are not consistent across all student subgroups and externally enrolled students may profit more than those enrolled internally.
MeSH term(s)	Australia ; Education, Graduate ; Educational Technology/statistics & numerical data ; Epidemiology/education ; Humans ; Learning ; Public Health/education ; Students, Public Health/psychology ; Surveys and Questionnaires ; Universities
Language	English
Publishing date	2018-10-05
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1025444-4
ISSN	1941-2479 ; 1010-5395
ISSN (online)	1941-2479
ISSN	1010-5395
DOI	10.1177/1010539518800337
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Article ; Online: Future of Public Health Training: What Are the Challenges? What Might the Solutions Look Like?

Baker, Philip R A / Dingle, Kaeleen / Dunne, Michael P

Asia-Pacific journal of public health

2018 , Page(s) 1010539518810555

Abstract: The Asia-Pacific region has rapidly changing health needs. This reshaping of health priorities is directly affecting current and future public health education. This brief review focuses on foundational public health skills including epidemiology, ... ...

Abstract	The Asia-Pacific region has rapidly changing health needs. This reshaping of health priorities is directly affecting current and future public health education. This brief review focuses on foundational public health skills including epidemiology, biostatistics, and health informatics. Epidemiological skills, in particular, are essential for policymakers and practitioners to identify the emergence of problems and to inform priority setting of public health efforts. Training needs to move beyond didactic, passive learning methods in class settings to approaches that engage and challenge students and academics in active, flexible learning and realistic problem-solving. We provide an overview of future trends in public health training in the Asia-Pacific region and illustrate the diversity of online training resources globally that can enrich staff and student skills and complement our active, class-based teaching.
Language	English
Publishing date	2018-11-16
Publishing country	China
Document type	Journal Article
ZDB-ID	1025444-4
ISSN	1941-2479 ; 1010-5395
ISSN (online)	1941-2479
ISSN	1010-5395
DOI	10.1177/1010539518810555
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Article: Novel LIPA-Targeted Therapy for Treating Ovarian Cancer.

Cancers

2024 Volume 16, Issue 3

Abstract: Ovarian cancer (OCa) is the most lethal form of gynecologic cancer, and the tumor heterogeneities at the molecular, cellular, and tissue levels fuel tumor resistance to standard therapies and pose a substantial clinical challenge. Here, we tested the ... ...

Abstract	Ovarian cancer (OCa) is the most lethal form of gynecologic cancer, and the tumor heterogeneities at the molecular, cellular, and tissue levels fuel tumor resistance to standard therapies and pose a substantial clinical challenge. Here, we tested the hypothesis that the heightened basal endoplasmic reticulum stress (ERS) observed in OCa represents an exploitable vulnerability and may overcome tumor heterogeneity. Our recent studies identified LIPA as a novel target to induce ERS in cancer cells using the small molecule ERX-41. However, the role of LIPA and theutility of ERX-41 to treat OCa remain unknown. Expression analysis using the TNMplot web tool, TCGA data sets, and immunohistochemistry analysis using a tumor tissue array showed that LIPA is highly expressed in OCa tissues, compared to normal tissues. ERX-41 treatment significantly reduced the cell viability and colony formation ability and promoted the apoptosis of OCa cells. Mechanistic studies revealed a robust and consistent induction of ERS markers, including CHOP, elF2α, PERK, and ATF4, upon ERX-41 treatment. In xenograft and PDX studies, ERX-41 treatment resulted in a significant reduction in tumor growth. Collectively, our results suggest that ERX-41 is a novel therapeutic agent that targets the LIPA with a unique mechanism of ERS induction, which could be exploited to treat heterogeneity in OCa.
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16030500
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Article ; Online: Primary and Secondary Attack Rates by Vaccination Status after a SARS-CoV-2 B.1.617.2 (Delta) Variant Outbreak at a Youth Summer Camp-Texas, June 2021.

Baker, Julia M / Shah, Melisa M / O'Hegarty, Michelle / Pomeroy, Mary / Keiser, Philip / Ren, Ping / Weaver, Scott C / Maknojia, Sara / Machado, Rafael R G / Mitchell, Brooke M / McConnell, Allan / Tate, Jacqueline E / Kirking, Hannah L

Journal of the Pediatric Infectious Diseases Society

2023 Volume 11, Issue 12, Page(s) 550–556

Abstract: Children are capable of initiating COVID-19 transmission into households, but many questions remain about the impact of vaccination on transmission. Data from a COVID-19 Delta variant outbreak at an overnight camp in Texas during June 23-27, 2021, were ... ...

Abstract	Children are capable of initiating COVID-19 transmission into households, but many questions remain about the impact of vaccination on transmission. Data from a COVID-19 Delta variant outbreak at an overnight camp in Texas during June 23-27, 2021, were analyzed. The camp had 451 attendees, including 364 youths aged < 18 years and 87 adults. Detailed interviews were conducted with 92 (20.4%) of consenting attendees and 117 household members of interviewed attendees with COVID-19. Among 450 attendees with known case status, the attack rate was 41%, including 42% among youths; attack rates were lower among vaccinated (13%) than among unvaccinated youths (48%). The secondary attack rate was 51% among 115 household contacts of 55 interviewed index patients. Secondary infections occurred in 67% of unvaccinated household members and 33% of fully or partially vaccinated household members. Analyses suggested that household member vaccination and camp attendee masking at home protected against household transmission.
MeSH term(s)	Adult ; Child ; Humans ; Adolescent ; Aged ; Incidence ; SARS-CoV-2 ; Texas/epidemiology ; COVID-19/epidemiology ; COVID-19/prevention & control ; Disease Outbreaks ; Vaccination
Language	English
Publishing date	2023-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2668791-4
ISSN	2048-7207 ; 2048-7193
ISSN (online)	2048-7207
ISSN	2048-7193
DOI	10.1093/jpids/piac086
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Article ; Online: A Mock Randomized Controlled Trial With Audience Response Technology for Teaching and Learning Epidemiology.

Baker, Philip R A / Francis, Daniel P / Cathcart, Abby

Asia-Pacific journal of public health

2017 Volume 29, Issue 3, Page(s) 229–240

Abstract: The study's objective was to apply and assess an active learning approach to epidemiology and critical appraisal. Active learning comprised a mock, randomized controlled trial (RCT) conducted with learners in 3 countries. The mock trial consisted of ... ...

Abstract	The study's objective was to apply and assess an active learning approach to epidemiology and critical appraisal. Active learning comprised a mock, randomized controlled trial (RCT) conducted with learners in 3 countries. The mock trial consisted of blindly eating red Smarties candy (intervention) compared to yellow Smarties (control) to determine whether red Smarties increase happiness. Audience response devices were employed with the 3-fold purposes to produce outcome data for analysis of the effects of red Smarties, identify baseline and subsequent changes in participant's knowledge and confidence in understanding of RCTs, and assess the teaching approach. Of those attending, 82% (117 of 143 learners) participated in the trial component. Participating in the mock trial was a positive experience, and the use of the technology aided learning. The trial produced data that learners analyzed in "real time" during the class. The mock RCT is a fun and engaging approach to teaching RCTs and helping students to develop skills in critical appraisal.
MeSH term(s)	Educational Technology ; Epidemiology/education ; Feasibility Studies ; Female ; Humans ; Male ; Problem-Based Learning/methods ; Randomized Controlled Trials as Topic ; Teaching
Language	English
Publishing date	2017-04
Publishing country	China
Document type	Journal Article
ZDB-ID	1025444-4
ISSN	1941-2479 ; 1010-5395
ISSN (online)	1941-2479
ISSN	1010-5395
DOI	10.1177/1010539517700473
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Article ; Online: The Report of the 2022-2023 AACP Professional Affairs Standing Committee: Focused Integration of Community-Based Pharmacy Practice Within the AACP Transformation Center.

Mehta, Bella / Smith, Megan G / Bacci, Jennifer / Brooks, Amie / Dopp, Anna / Groves, Brigid / Hritcko, Philip / Kebodeaux, Clark / Law, Anandi V / Marciniak, Macary W / McGivney, Melissa A / Steinkopf, Miranda / Traylor, Carlie / Bradley-Baker, Lynette R

American journal of pharmaceutical education

2023 Volume 87, Issue 8, Page(s) 100561

Abstract: The 2022-2023 Professional Affairs Committee was charged to (1) Devise a framework and 3-year workplan for the Academia-Community Pharmacy Transformation Pharmacy Collaborative to be integrated within the American Association of Colleges of Pharmacy ( ... ...

Abstract	The 2022-2023 Professional Affairs Committee was charged to (1) Devise a framework and 3-year workplan for the Academia-Community Pharmacy Transformation Pharmacy Collaborative to be integrated within the American Association of Colleges of Pharmacy (AACP) Transformation Center. This plan should include the focus area(s) to be continued and developed by the Center, potential milestone dates or events, and necessary resources; and (2) Provide recommendations on focus areas and/or potential questions for the Pharmacy Workforce Center to consider for the 2024 National Pharmacist Workforce Study. This report provides the background and methodology utilized to develop the framework and 3-year workplan focused on (1) community-based pharmacy pipeline development for recruitment, programming, and retention, (2) programming and resources for community-based pharmacy practice, and (3) research areas for community-based pharmacy practice. The Committee offers suggested revisions for 5 current AACP policy statements, 7 recommendations pertaining to the first charge, and 9 recommendations pertaining to the second charge.
MeSH term(s)	Humans ; United States ; Pharmacies ; Education, Pharmacy ; Students, Pharmacy ; Pharmacy ; Pharmaceutical Services ; Schools, Pharmacy
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Practice Guideline
ZDB-ID	603807-4
ISSN	1553-6467 ; 0002-9459
ISSN (online)	1553-6467
ISSN	0002-9459
DOI	10.1016/j.ajpe.2023.100561
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Article ; Online: Incidence and relevance of clinically indeterminate nonregional lymph nodes in the treatment of oesophageal cancer.

Pucher, Philip H / White, Annabelle / Padfield, Olivia / Davies, Andrew R / Maisey, Nick / Qureshi, Asad / Subesinghe, Manil / Baker, Cara / Gossage, James A

Nuclear medicine communications

2021 Volume 42, Issue 11, Page(s) 1270–1276

Abstract: Objectives: Metastatic involvement of nonregional supraclavicular or superior mediastinal lymph nodes in distal oesophageal cancer is rare but has important implications for prognosis and management. The management of nonregional lymph nodes which ... ...

Abstract	Objectives: Metastatic involvement of nonregional supraclavicular or superior mediastinal lymph nodes in distal oesophageal cancer is rare but has important implications for prognosis and management. The management of nonregional lymph nodes which appear indeterminate on CT and FDG PET-CT (subcentimeter nodes or those with preserved normal morphology, but increased FDG avidity) can present a diagnostic dilemma. This study investigates the incidence, work-up and clinical significance of nonregional clinically indeterminate FDG avid lymph nodes. Methods: A single-centre retrospective review of all FDG PET-CT scans conducted over 5 years was conducted. Patients with mid- or distal oesophageal cancer with nonregional FDG avid nodes were identified. Subsequent work-up, management and outcomes were retrieved from electronic health records. Results: Reports for 1189 PET-CT scans were reviewed. A total of 79 patients met the inclusion criteria. Of these, 18 (23%) were deemed to have disease and performance status potentially amenable to radical surgery and underwent further assessment. The indeterminate lymph nodes were successfully sampled via endobronchial ultrasound (EBUS) or ultrasound-guided fine-needle aspiration (US-FNA) in 100% of cases. 15/18 (83.3%) of samples were benign and proceeded to surgery. Outcomes for patients who proceeded to surgery were similar to other cohorts. None had pathology suggesting false-negative lymph node sampling. Conclusions: EBUS and US-FNA are effective means of sampling clinically indeterminate nonregional lymph nodes, and can significantly impact prognosis, and management. Further investigations in this context are of value in this cohort and should be pursued. Nonregional clinically indeterminate lymph nodes represent a diagnostic dilemma in oesophageal cancer staging. Additional investigations in the form of endobronchial ultrasound are effective at providing additional staging information, and can substantially influence patient care.
MeSH term(s)	Positron Emission Tomography Computed Tomography
Language	English
Publishing date	2021-07-30
Publishing country	England
Document type	Journal Article
ZDB-ID	758141-5
ISSN	1473-5628 ; 0143-3636
ISSN (online)	1473-5628
ISSN	0143-3636
DOI	10.1097/MNM.0000000000001457
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Article ; Online: A low-cost, paper-based hybrid capture assay to detect high-risk HPV DNA for cervical cancer screening in low-resource settings.

Smith, Chelsey A / Chang, Megan M / Kundrod, Kathryn A / Novak, Emilie N / Parra, Sonia G / López, Leticia / Mavume, Celda / Lorenzoni, Cesaltina / Maza, Mauricio / Salcedo, Mila P / Carns, Jennifer L / Baker, Ellen / Montealegre, Jane / Scheurer, Michael / Castle, Philip E / Schmeler, Kathleen M / Richards-Kortum, Rebecca R

Lab on a chip

2023 Volume 23, Issue 3, Page(s) 451–465

Abstract: Cervical cancer is a leading cause of cancer death for women in low-resource settings. The World Health Organization recommends that cervical cancer screening programs incorporate HPV DNA testing, but available tests are expensive, require laboratory ... ...

Abstract	Cervical cancer is a leading cause of cancer death for women in low-resource settings. The World Health Organization recommends that cervical cancer screening programs incorporate HPV DNA testing, but available tests are expensive, require laboratory infrastructure, and cannot be performed at the point-of-care. We developed a two-dimensional paper network (2DPN), hybrid-capture, signal amplification assay and a point-of-care sample preparation protocol to detect high-risk HPV DNA from exfoliated cervical cells within an hour. The test does not require expensive equipment and has an estimated cost of <$3 per test without the need for batching. We evaluated performance of the paper HPV DNA assay with short synthetic and genomic HPV DNA targets, HPV positive and negative cellular samples, and two sets of clinical samples. The first set of clinical samples consisted of 16 biobanked, provider-collected cervical samples from a study in El Salvador previously tested with careHPV and subsequently tested in a controlled laboratory environment. The paper HPV DNA test correctly identified eight of eight HPV-negative clinical samples and seven of eight HPV-positive clinical samples. We then performed a field evaluation of the paper HPV DNA test in a hospital laboratory in Mozambique. Cellular controls generated expected results throughout field testing with fully lyophilized sample preparation and 2DPN reagents. When evaluated with 16 residual self-collected cervicovaginal samples previously tested by the GeneXpert HPV assay ("Xpert"), the accuracy of the HPV DNA paper test in the field was reduced compared to testing in the controlled laboratory environment, with positive results obtained for all eight HPV-positive samples as well as seven of eight HPV-negative samples. Further evaluation showed reduction in performance was likely due in part to increased concentration of exfoliated cells in the self-collected clinical samples from Mozambique compared with provider-collected samples from El Salvador. Finally, a formal usability assessment was conducted with users in El Salvador and Mozambique; the assay was rated as acceptable to perform after minimal training. With additional optimization for higher cell concentrations and inclusion of an internal cellular control, the paper HPV DNA assay offers promise as a low-cost, point-of-care cervical cancer screening test in low-resource settings.
MeSH term(s)	Female ; Humans ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/prevention & control ; Papillomavirus Infections/diagnosis ; Early Detection of Cancer/methods ; User-Computer Interface ; Papillomaviridae/genetics ; DNA
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-01-31
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2056646-3
ISSN	1473-0189 ; 1473-0197
ISSN (online)	1473-0189
ISSN	1473-0197
DOI	10.1039/d2lc00885h
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