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Article: Case report: A frameshift mutation in CLCN2-related leukoencephalopathy and retinopathy.

Cheng, Yizhe / Liu, Xinyu / Sun, Limei / Ding, Xiaoyan

2023 Volume 14, Page(s) 1278961

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-11-09
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1278961
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Article ; Online: Tough polyvinyl alcohol-gelatin biological macromolecules ionic hydrogel temperature, humidity, stress and strain, sensors.

Sun, Shuang / Xu, Yizhe / Maimaitiyiming, Xieraili

International journal of biological macromolecules

2023 Volume 249, Page(s) 125978

Abstract: High strength, high toughness and high sensitivity were some of the most popular characteristics of flexible sensors. However, the mechanical properties and reproducibility of current single biomacromolecule gelatin hydrogel sensors are lower, and few ... ...

Abstract	High strength, high toughness and high sensitivity were some of the most popular characteristics of flexible sensors. However, the mechanical properties and reproducibility of current single biomacromolecule gelatin hydrogel sensors are lower, and few hydrogel sensors have been able to provide excellent mechanical properties and flexibility at the same time so far. To address this challenge, a simple method to prepare tough polyvinyl alcohol (PVA) and gelatin hydrogel was proposed in this study. The PVA-gelatin-Fe
MeSH term(s)	Humans ; Humidity ; Gelatin ; Polyvinyl Alcohol ; Reproducibility of Results ; Temperature ; Hydrogels ; Ions ; Electric Conductivity
Chemical Substances	Gelatin (9000-70-8) ; polyvinyl alcohol hydrogel ; Polyvinyl Alcohol (9002-89-5) ; Hydrogels ; Ions
Language	English
Publishing date	2023-07-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.125978
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Article ; Online: Tough polyvinyl alcohol-gelatin biological macromolecules ionic hydrogel temperature, humidity, stress and strain, sensors

Sun, Shuang / Xu, Yizhe / Maimaitiyiming, Xieraili

International Journal of Biological Macromolecules. 2023 Sept., v. 249 p.125978-

2023

Abstract	High strength, high toughness and high sensitivity were some of the most popular characteristics of flexible sensors. However, the mechanical properties and reproducibility of current single biomacromolecule gelatin hydrogel sensors are lower, and few hydrogel sensors have been able to provide excellent mechanical properties and flexibility at the same time so far. To address this challenge, a simple method to prepare tough polyvinyl alcohol (PVA) and gelatin hydrogel was proposed in this study. The PVA-gelatin-Fe³⁺ biological macromolecules hydrogel was prepared by a freeze-casting-assisted solution substitution method, which exhibited high strength (2.5 MPa), toughness (7.22 MJ m⁻³), and excellent temperature, humidity, stress, strain, and human motion sensing properties. This combination of mechanical properties and flexibility makes PVA-gelatin biological macromolecules hydrogel a promising material for flexible sensing. In addition, an ionic immersion strategy could also impart multiple functions to the hydrogel and be applied to various hydrogel sensor materials. Thus, this work provided an all-around solution for the preparation of advanced and robust sensors with good application prospects.
Keywords	gelatin ; humans ; humidity ; hydrogels ; polyvinyl alcohol ; temperature ; Hydrogel ; Flexible hydrogel
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.125978
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Article ; Online: Application of artificial intelligence in (waste)water disinfection: Emphasizing the regulation of disinfection by-products formation and residues prediction.

Ding, Yizhe / Sun, Qiya / Lin, Yuqian / Ping, Qian / Peng, Nuo / Wang, Lin / Li, Yongmei

Water research

2024 Volume 253, Page(s) 121267

Abstract: Water/wastewater ((waste)water) disinfection, as a critical process during drinking water or wastewater treatment, can simultaneously inactivate pathogens and remove emerging organic contaminants. Due to fluctuations of (waste)water quantity and quality ... ...

Abstract	Water/wastewater ((waste)water) disinfection, as a critical process during drinking water or wastewater treatment, can simultaneously inactivate pathogens and remove emerging organic contaminants. Due to fluctuations of (waste)water quantity and quality during the disinfection process, conventional disinfection models cannot handle intricate nonlinear situations and provide immediate responses. Artificial intelligence (AI) techniques, which can capture complex variations and accurately predict/adjust outputs on time, exhibit excellent performance for (waste)water disinfection. In this review, AI application data within the disinfection domain were searched and analyzed using CiteSpace. Then, the application of AI in the (waste)water disinfection process was comprehensively reviewed, and in addition to conventional disinfection processes, novel disinfection processes were also examined. Then, the application of AI in disinfection by-products (DBPs) formation control and disinfection residues prediction was discussed, and unregulated DBPs were also examined. Current studies have suggested that among AI techniques, fuzzy logic-based neuro systems exhibit superior control performance in (waste)water disinfection, while single AI technology is insufficient to support their applications in full-scale (waste)water treatment plants. Thus, attention should be paid to the development of hybrid AI technologies, which can give full play to the characteristics of different AI technologies and achieve a more refined effectiveness. This review provides comprehensive information for an in-depth understanding of AI application in (waste)water disinfection and reducing undesirable risks caused by disinfection processes.
MeSH term(s)	Disinfection/methods ; Wastewater ; Artificial Intelligence ; Water Pollutants, Chemical/analysis ; Water Purification/methods ; Disinfectants/analysis ; Drinking Water ; Halogenation
Chemical Substances	Wastewater ; Water Pollutants, Chemical ; Disinfectants ; Drinking Water
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2024.121267
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Article ; Online: Research progress on occupational hazards of cosmic radiation for aircrew

Yizhe SUN / Yongbin LUO / Na TU

环境与职业医学, Vol 39, Iss 3, Pp 337-

2022 Volume 342

Abstract: According to the data released by the Civil Aviation Administration of China in 2020, there are more than 60000 pilots and more than 100000 flight attendants in China working with certificates in various airlines. The health of these aircrew is the basis ...

Abstract	According to the data released by the Civil Aviation Administration of China in 2020, there are more than 60000 pilots and more than 100000 flight attendants in China working with certificates in various airlines. The health of these aircrew is the basis for maintaining and continuing the smooth development of civil aviation. Aircrew are exposed to cosmic radiation at high altitudes. However, because the types of cosmic radiation are complex, changeable, and difficult to measure accurately, there is no definite conclusion as to whether it has any effect on the health of aircrew. This paper introduced the impacts of cosmic radiation on aircrew, reviewed the estimation of cosmic radiation dose at home and abroad, and summarized the cosmic radiation dose measurement methods and their limitations. It also pointed out the shortcomings of existing occupational health management of aircrew and put forward new suggestions on strengthening the health management of radiation hazards for aircrew.
Keywords	aircrew ; cosmic radiation ; radiation hazard ; cosmic radiation dose ; method of dose estimation ; Medicine (General) ; R5-920 ; Toxicology. Poisons ; RA1190-1270
Subject code	535
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Editorial Committee of Journal of Environmental and Occupational Medicine
Document type	Article ; Online
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Article ; Online: Anti-inflammatory effect of chlorogenic acid in Klebsiella pneumoniae-induced pneumonia by inactivating the p38MAPK pathway

Yizhe Zhang / Chaoyin Zhu / Hongjun Zhao / Zhanyang Sun / Xiaodi Wang

International Journal of Medical Microbiology, Vol 313, Iss 2, Pp 151576- (2023)

2023

Abstract: Introduction: Pneumonia is an inflammation-related respiratory infection and chlorogenic acid (CGA) possesses a wide variety of bioactive properties, such as anti-inflammation and anti-bacteria. Aim: This study explored the anti-inflammatory mechanism of ...

Abstract	Introduction: Pneumonia is an inflammation-related respiratory infection and chlorogenic acid (CGA) possesses a wide variety of bioactive properties, such as anti-inflammation and anti-bacteria. Aim: This study explored the anti-inflammatory mechanism of CGA in Klebsiella pneumoniae (Kp)-induced rats with severe pneumonia. Methods: The pneumonia rat models were established by infection with Kp and treated with CGA. Survival rates, bacterial load, lung water content, and cell numbers in the bronchoalveolar lavage fluid were recorded, lung pathological changes were scored, and levels of inflammatory cytokines were determined by enzyme-linked immunosorbent assay. RLE6TN cells were infected with Kp and treated with CGA. The expression levels of microRNA (miR)-124–3p, p38, and mitogen-activated protein kinase (MAPK)-activated protein kinase 2 (MK2) in lung tissues and RLE6TN cells were quantified by real-time quantitative polymerase chain reaction or Western blotting. The binding of miR-124–3p to p38 was validated by the dual-luciferase and RNA pull-down assays. In vitro, the functional rescue experiments were performed using miR-124–3p inhibitor or p38 agonist. Results: Kp-induced pneumonia rats presented high mortality, increased lung inflammatory infiltration and the release of inflammatory cytokines, and enhanced bacterial load, while CGA treatment improved rat survival rates and the above situations. CGA increased miR-124–3p expression, and miR-124–3p inhibited p38 expression and inactivated the p38MAPK pathway. Inhibition of miR-124–3p or activation of the p38MAPK pathway reversed the alleviative effect of CGA on pneumonia in vitro. Conclusion: CGA upregulated miR-124–3p expression and inactivated the p38MAPK pathway to downregulate inflammatory levels, facilitating the recovery of Kp-induced pneumonia rats.
Keywords	Chlorogenic acid ; Klebsiella pneumoniae ; Pneumonia ; MiR-124–3p ; P38 ; Anti-inflammation ; Microbiology ; QR1-502 ; Other systems of medicine ; RZ201-999
Subject code	500
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Construction of an Angular Tricyclic Benzofuran Skeleton Using the C-H Activation Strategy.

Sun, Qianqian / Guo, Feixiang / Liu, Yi / Zhang, Yizhe / Zhang, Kunyi / Wang, Yakun / Gao, Qinghe / Lim, Vuanghao / Duan, Yingchao / Fang, Lizhen

The Journal of organic chemistry

2024 Volume 89, Issue 5, Page(s) 3304–3308

Abstract: A protocol for the construction of an angular tricyclic benzofuran skeleton based on the C-H activation strategy has been established. Different phthalide lactones on this skeleton can be easily assembled with various side chains by using C-H activation ... ...

Abstract	A protocol for the construction of an angular tricyclic benzofuran skeleton based on the C-H activation strategy has been established. Different phthalide lactones on this skeleton can be easily assembled with various side chains by using C-H activation with aldehydes and subsequent reduction. This skeleton provides a versatile and crucial motif for the total synthesis of naturally occurring angular tricyclic benzofurans and their derivatives. Based on this protocol, the improved total syntheses of daldinin A and annullatin D were achieved in yields of 17.3 and 7.6%, respectively.
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.3c02754
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Article ; Online: Manipulating Pt-skin of porous network Pt-Cu alloy nanospheres toward efficient oxygen reduction.

Chen, Yizhe / Zhao, Xiao / Yan, Huangli / Sun, Liangyu / Chen, Shengli / Zhang, Shiming / Zhang, Jiujun

Journal of colloid and interface science

2023 Volume 652, Issue Pt A, Page(s) 1006–1015

Abstract: Designing Pt-skin on the catalyst surface is critical to developing efficient and stable electrocatalysts toward oxygen reduction reaction (ORR) in proton exchange membrane fuel cells. In this paper, an acidic reductant is proposed to synchronously ... ...

Abstract	Designing Pt-skin on the catalyst surface is critical to developing efficient and stable electrocatalysts toward oxygen reduction reaction (ORR) in proton exchange membrane fuel cells. In this paper, an acidic reductant is proposed to synchronously manipulate in-situ growth of Pt-skin on the surface of alloyed Pt-Cu nanospheres (PtCu
Language	English
Publishing date	2023-08-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.08.134
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Article ; Online: Anti-inflammatory effect of chlorogenic acid in Klebsiella pneumoniae-induced pneumonia by inactivating the p38MAPK pathway.

Zhang, Yizhe / Zhu, Chaoyin / Zhao, Hongjun / Sun, Zhanyang / Wang, Xiaodi

International journal of medical microbiology : IJMM

2023 Volume 313, Issue 2, Page(s) 151576

Abstract: Introduction: Pneumonia is an inflammation-related respiratory infection and chlorogenic acid (CGA) possesses a wide variety of bioactive properties, such as anti-inflammation and anti-bacteria.: Aim: This study explored the anti-inflammatory ... ...

Abstract	Introduction: Pneumonia is an inflammation-related respiratory infection and chlorogenic acid (CGA) possesses a wide variety of bioactive properties, such as anti-inflammation and anti-bacteria. Aim: This study explored the anti-inflammatory mechanism of CGA in Klebsiella pneumoniae (Kp)-induced rats with severe pneumonia. Methods: The pneumonia rat models were established by infection with Kp and treated with CGA. Survival rates, bacterial load, lung water content, and cell numbers in the bronchoalveolar lavage fluid were recorded, lung pathological changes were scored, and levels of inflammatory cytokines were determined by enzyme-linked immunosorbent assay. RLE6TN cells were infected with Kp and treated with CGA. The expression levels of microRNA (miR)-124-3p, p38, and mitogen-activated protein kinase (MAPK)-activated protein kinase 2 (MK2) in lung tissues and RLE6TN cells were quantified by real-time quantitative polymerase chain reaction or Western blotting. The binding of miR-124-3p to p38 was validated by the dual-luciferase and RNA pull-down assays. In vitro, the functional rescue experiments were performed using miR-124-3p inhibitor or p38 agonist. Results: Kp-induced pneumonia rats presented high mortality, increased lung inflammatory infiltration and the release of inflammatory cytokines, and enhanced bacterial load, while CGA treatment improved rat survival rates and the above situations. CGA increased miR-124-3p expression, and miR-124-3p inhibited p38 expression and inactivated the p38MAPK pathway. Inhibition of miR-124-3p or activation of the p38MAPK pathway reversed the alleviative effect of CGA on pneumonia in vitro. Conclusion: CGA upregulated miR-124-3p expression and inactivated the p38MAPK pathway to downregulate inflammatory levels, facilitating the recovery of Kp-induced pneumonia rats.
MeSH term(s)	Rats ; Animals ; p38 Mitogen-Activated Protein Kinases/metabolism ; p38 Mitogen-Activated Protein Kinases/therapeutic use ; Klebsiella pneumoniae/genetics ; Chlorogenic Acid/pharmacology ; Chlorogenic Acid/therapeutic use ; Klebsiella/genetics ; Klebsiella/metabolism ; MicroRNAs/genetics ; Pneumonia/drug therapy ; Pneumonia/microbiology ; Cytokines/metabolism ; Anti-Inflammatory Agents/pharmacology
Chemical Substances	p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Chlorogenic Acid (318ADP12RI) ; MicroRNAs ; Cytokines ; Anti-Inflammatory Agents ; MIRN124 microRNA, rat
Language	English
Publishing date	2023-01-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2006518-8
ISSN	1618-0607 ; 1438-4221
ISSN (online)	1618-0607
ISSN	1438-4221
DOI	10.1016/j.ijmm.2023.151576
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Article ; Online: Current Status and Perspectives of Dual-Atom Catalysts Towards Sustainable Energy Utilization.

Li, Yizhe / Li, Yajie / Sun, Hao / Gao, Liyao / Jin, Xiangrong / Li, Yaping / Lv, Zhi / Xu, Lijun / Liu, Wen / Sun, Xiaoming

Nano-micro letters

2024 Volume 16, Issue 1, Page(s) 139

Abstract: The exploration of sustainable energy utilization requires the implementation of advanced electrochemical devices for efficient energy conversion and storage, which are enabled by the usage of cost-effective, high-performance electrocatalysts. Currently, ...

Abstract	The exploration of sustainable energy utilization requires the implementation of advanced electrochemical devices for efficient energy conversion and storage, which are enabled by the usage of cost-effective, high-performance electrocatalysts. Currently, heterogeneous atomically dispersed catalysts are considered as potential candidates for a wide range of applications. Compared to conventional catalysts, atomically dispersed metal atoms in carbon-based catalysts have more unsaturated coordination sites, quantum size effect, and strong metal-support interactions, resulting in exceptional catalytic activity. Of these, dual-atomic catalysts (DACs) have attracted extensive attention due to the additional synergistic effect between two adjacent metal atoms. DACs have the advantages of full active site exposure, high selectivity, theoretical 100% atom utilization, and the ability to break the scaling relationship of adsorption free energy on active sites. In this review, we summarize recent research advancement of DACs, which includes (1) the comprehensive understanding of the synergy between atomic pairs; (2) the synthesis of DACs; (3) characterization methods, especially aberration-corrected scanning transmission electron microscopy and synchrotron spectroscopy; and (4) electrochemical energy-related applications. The last part focuses on great potential for the electrochemical catalysis of energy-related small molecules, such as oxygen reduction reaction, CO
Language	English
Publishing date	2024-02-29
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2642093-4
ISSN	2150-5551 ; 2150-5551
ISSN (online)	2150-5551
ISSN	2150-5551
DOI	10.1007/s40820-024-01347-y
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