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  1. Article: Editorial: Women in neurodegeneration.

    Saha, Sukanya / Cvetanovic, Marija

    Frontiers in neuroscience

    2024  Volume 18, Page(s) 1388520

    Language English
    Publishing date 2024-03-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2024.1388520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Global excellence in inflammation pharmacology.

    Saha, Sukanya / Ghosh, Shatadal

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1307503

    Language English
    Publishing date 2023-10-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1307503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction: Mangiferin ameliorates collateral neuropathy in

    Saha, Sukanya / Mahalanobish, Sushweta / Dutta, Sayanta / Sil, Parames C

    Food & function

    2024  Volume 15, Issue 3, Page(s) 1717–1719

    Abstract: Correction for 'Mangiferin ameliorates collateral neuropathy ... ...

    Abstract Correction for 'Mangiferin ameliorates collateral neuropathy in
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d4fo90005g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Potential of Epigallocatechin Gallate in Targeting Cancer Stem Cells: A Comprehensive Review.

    Chaudhuri, Rupa / Samanta, Anurima / Saha, Priyanka / Ghosh, Sukanya / Sinha, Dona

    Current medicinal chemistry

    2024  

    Abstract: The dreadful scenario of cancer prevails due to the presence of cancer stem cells (CSCs), which contribute to tumor growth, metastasis, invasion, resistance to chemo- and radiotherapy, and recurrence. CSCs are a small subpopulation of cells within the ... ...

    Abstract The dreadful scenario of cancer prevails due to the presence of cancer stem cells (CSCs), which contribute to tumor growth, metastasis, invasion, resistance to chemo- and radiotherapy, and recurrence. CSCs are a small subpopulation of cells within the tumor that are characterized by self-renewal capability and have the potential to manifest heterogeneous lineages of cancer cells that constitute the tumor. The major bioactive green tea polyphenol (-)-epigallocatechin gallate (EGCG) has been fruitful in downgrading cancer stemness signaling and CSC biomarkers in cancer progression. EGCG has been evidenced to maneuver extrinsic and intrinsic apoptotic pathways in order to decrease the viability of CSCs. Cancer stemness is intricately related to epithelial-mesenchymal transition (EMT), metastasis and therapy resistance, and EGCG has been evidenced to regress all these CSC-related effects. By inhibiting CSC characteristics EGCG has also been evidenced to sensitize the tumor cells to radiotherapy and chemotherapy. However, the use of EGCG in in vitro and in vivo cancer models raises concern about its bioavailability, stability and efficacy against spheroids raised from parental cells. Therefore, novel nano formulations of EGCG and adjuvant therapy of EGCG with other phytochemicals or drugs or small molecules may have a better prospect in targeting CSCs. However, extensive clinical research is still awaited to elucidate a full proof impact of EGCG in cancer therapy.
    Language English
    Publishing date 2024-01-17
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0109298673281666231227053726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Corrigendum on "Mangiferin alleviates arsenic induced oxidative lung injury via upregulation of the Nrf2-HO1 axis" [126 (2019) 41-55].

    Mahalanobish, Sushweta / Saha, Sukanya / Dutta, Sayanta / Sil, Parames C

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2023  Volume 182, Page(s) 114194

    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Published Erratum
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2023.114194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: "Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice" [Food Chem. Toxicol. 144 (2020) 111588/ doi: 10.1016/j.fct.2020.111588].

    Mahalanobish, Sushweta / Dutta, Sayanta / Saha, Sukanya / Sil, Parames C

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2023  Volume 184, Page(s) 114408

    Language English
    Publishing date 2023-12-25
    Publishing country England
    Document type Published Erratum
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2023.114408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Short Communication

    SUMEDHA SAHA / ARINDAM GHOSH / SUKANYA ACHARYYA / MALAY BHATTACHARYA

    Biodiversitas, Vol 23, Iss

    Metabolites of Albizia inhibit in vitro growth of phosphate solubilizing microbial consortia isolated from tea garden soil of Darjeeling hills, India

    2022  Volume 6

    Abstract: Abstract. Saha S, Ghosh A, Acharyya S, Bhattacharya M. 2022. Short Communication: Metabolites ...

    Abstract Abstract. Saha S, Ghosh A, Acharyya S, Bhattacharya M. 2022. Short Communication: Metabolites of Albizia inhibit in vitro growth of phosphate solubilizing microbial consortia isolated from tea garden soil of Darjeeling hills, India. Biodiversitas 23: 2865-2870. Phosphate solubilizing microorganisms (PSM) play a crucial role in maintaining the nutritional status and fertility of the soil. PSMs help in solubilizing the metallic phosphate salts of soil into available phosphate anions for easy uptake by plants. However, this beneficial group of microorganisms also face different challenges for survival from its immediate surroundings. This study was carried out to assess the effect of shade tree litters on the PSM consortia isolated from different tea garden soils of Darjeeling hills, since shade trees are an integral part of tea plantations. Albizia odoratissima, Albizia chinensis and Albizia procera, widely used in tea gardens as shade trees were selected. GC-MS analysis was carried out to detect the metabolites produced by the litters. Twenty-three compounds exhibiting antimicrobial activities were detected. Major peak was found in A. odoratissima, followed by A. chinensisand least in A. procera. Compounds like 1-heptanol, 2-propyl-, neophytadiene, phytol and squalene were common in all three extracts and are considered to provided antimicrobial activity to Albizia. A proportional relation has been observed between magnitude of inhibition zones and peak area percentage in Albizia spp. PSM isolates from shade tree gardens were observed to be more tolerant toward the leaf extracts.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MBI & UNS Solo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Short Communication: Metabolites of Albizia inhibit in vitro growth of phosphate solubilizing microbial consortia isolated from tea garden soil of Darjeeling hills, India

    SAHA, SUMEDHA / GHOSH, ARINDAM / ACHARYYA, SUKANYA / BHATTACHARYA, MALAY

    Biodiversitas. 2022 June, v. 23, no. 6

    2022  

    Abstract: Saha S, Ghosh A, Acharyya S, Bhattacharya M. 2022. Short Communication: Metabolites of Albizia ...

    Abstract Saha S, Ghosh A, Acharyya S, Bhattacharya M. 2022. Short Communication: Metabolites of Albizia inhibit in vitro growth of phosphate solubilizing microbial consortia isolated from tea garden soil of Darjeeling hills, India. Biodiversitas 23: 2865-2870. Phosphate solubilizing microorganisms (PSM) play a crucial role in maintaining the nutritional status and fertility of the soil. PSMs help in solubilizing the metallic phosphate salts of soil into available phosphate anions for easy uptake by plants. However, this beneficial group of microorganisms also face different challenges for survival from its immediate surroundings. This study was carried out to assess the effect of shade tree litters on the PSM consortia isolated from different tea garden soils of Darjeeling hills, since shade trees are an integral part of tea plantations. Albizia odoratissima, Albizia chinensis and Albizia procera, widely used in tea gardens as shade trees were selected. GC-MS analysis was carried out to detect the metabolites produced by the litters. Twenty-three compounds exhibiting antimicrobial activities were detected. Major peak was found in A. odoratissima, followed by A. chinensisand least in A. procera. Compounds like 1-heptanol, 2-propyl-, neophytadiene, phytol and squalene were common in all three extracts and are considered to provided antimicrobial activity to Albizia. A proportional relation has been observed between magnitude of inhibition zones and peak area percentage in Albizia spp. PSM isolates from shade tree gardens were observed to be more tolerant toward the leaf extracts.
    Keywords Albizia chinensis ; Albizia odoratissima ; Albizia procera ; antimicrobial properties ; gardens ; leaves ; metabolites ; nutritional status ; phosphates ; solubilization ; squalene ; tea ; India
    Language English
    Dates of publication 2022-06
    Publishing place MBI & UNS Solo
    Document type Article
    ZDB-ID 2660049-3
    ISSN 2085-4722
    ISSN 2085-4722
    DOI 10.13057/biodiv/d230612
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Characterization of a mercury tolerant strain of Staphylococcus arlettae from Darjeeling hills with an account of its antibiotic resistance pattern and metabolome.

    Acharyya, Sukanya / Saha, Sumedha / Majumder, Soumya / Bhattacharya, Malay

    Archives of microbiology

    2021  Volume 203, Issue 9, Page(s) 5745–5754

    Abstract: Mercury (Hg) is a ubiquitous heavy metal grouped with the top ten most toxic pollutants affecting both human and environmental health. Consequently, mercury contamination due to anthropogenic interference has become a rising global concern. The bacterial ...

    Abstract Mercury (Hg) is a ubiquitous heavy metal grouped with the top ten most toxic pollutants affecting both human and environmental health. Consequently, mercury contamination due to anthropogenic interference has become a rising global concern. The bacterial strain MTD10A was isolated from soil samples collected over the Darjeeling hills. Heavy metal tolerance study conducted exhibited considerable tolerance to mercury by this bacterial isolate at unprecedented concentrations of up to 0.1 mg/mL of HgCl
    MeSH term(s) Biodegradation, Environmental ; Drug Resistance, Microbial ; Humans ; Mercury ; Metabolome ; Metals, Heavy ; RNA, Ribosomal, 16S/genetics ; Soil Microbiology ; Soil Pollutants ; Staphylococcus
    Chemical Substances Metals, Heavy ; RNA, Ribosomal, 16S ; Soil Pollutants ; Mercury (FXS1BY2PGL)
    Language English
    Publishing date 2021-09-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124824-8
    ISSN 1432-072X ; 0302-8933
    ISSN (online) 1432-072X
    ISSN 0302-8933
    DOI 10.1007/s00203-021-02563-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Gene Alterations Induced by Glutamine (Q) Encoding CAG Repeats Associated with Neurodegeneration.

    Saha, Gundappa / Ghosh, Sukanya / Dubey, Vikash Kumar / Saudagar, Prakash

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2575, Page(s) 3–23

    Abstract: Several studies have been reported linking the role of polyglutamine (polyQ) disease-associated proteins with altered gene regulation induced by an unstable trinucleotide (CAG) repeat. Owing to their dynamic nature of expansion, these DNA repeats form ... ...

    Abstract Several studies have been reported linking the role of polyglutamine (polyQ) disease-associated proteins with altered gene regulation induced by an unstable trinucleotide (CAG) repeat. Owing to their dynamic nature of expansion, these DNA repeats form secondary structures interfering with the normal cellular mechanisms like replication and transcription and, thereby, have become the underlying cause of numerous neurodegenerative disorders involving mental retardation and/or muscular or neuronal degeneration. Despite the widespread expression of the disease-causing protein, specific subsets of neurons are susceptible to specific patterns of inheritance and clinical symptoms. Although this cell-type selectivity is still elusive and less understood, it has been found that aberrant transcriptional regulation is one of the primary causes of polyQ diseases where the functions of histone-modifying complexes are disrupted. Besides, epigenetic modifications play a critical role in the pathogenesis of these diseases. In this chapter, we will be delving into how these polyQ repeats induce the self-assembly and aggregation of altered carrier proteins based on gene alterations, causing neuronal toxicity and cellular deaths. Besides, genomic instability in CAG repeats due to altered chromatin-related enzymes will be highlighted, along with epigenetic changes present in many polyQ disorders. Understanding the underlying molecular mechanisms in the root cause of these disorders will culminate in identifying therapeutic approaches for the treatment of these neurodegenerative disorders.
    MeSH term(s) Humans ; Glutamine/genetics ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/therapy ; Protein Structure, Secondary ; Histones/genetics ; Epigenesis, Genetic ; Trinucleotide Repeat Expansion ; Trinucleotide Repeats
    Chemical Substances Glutamine (0RH81L854J) ; Histones
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2716-7_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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