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Article ; Online: SPINAL EPIDURAL HAEMATOMA WITHOUT SIGNIFICANT TRAUMA IN A CHILD

Urška Vračko / Jani Breznik / Matevž Benedičič / Barbara Faganel Kotnik

Slovenska pediatrija, Vol 28, Iss 2, Pp 98-

2021 Volume 102

Abstract: Spinal epidural haematoma without signiﬁcant precedent trauma is an emergency medical condition, which is rarely encountered in paediatrics. The diagnosis is made by clinical examination and imaging. Treatment is generally surgical. In this paper, we ... ...

Abstract	Spinal epidural haematoma without signiﬁcant precedent trauma is an emergency medical condition, which is rarely encountered in paediatrics. The diagnosis is made by clinical examination and imaging. Treatment is generally surgical. In this paper, we present the clinical picture and treatment of spinal epidural haematoma in an eleven-year-old previously healthy boy, who complained of sudden pain in the right shoulder blade area. Clinically, we suspected spinal pathology, which was eventually proven by magnetic resonance imaging. After surgical evacuation of the haematoma, the boy made a complete recovery.
Keywords	spinal epidural haematoma ; child ; pain ; neurological signs ; laminectomy ; Medicine ; R ; Pediatrics ; RJ1-570
Language	Slovenian
Publishing date	2021-06-01T00:00:00Z
Publisher	The Society for Children with Metabolic Disorders
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SPINALNI EPIDURALNI HEMATOM BREZ POMEMBNE POŠKODBE PRI OTROKU

Urška Vračko / Jani Breznik / Matevž Benedičič / Barbara Faganel Kotnik

Slovenska pediatrija, Vol 28, Iss 2, Pp 98-

2021 Volume 102

Abstract: Spinalni epiduralni hematom brez pomembne predhodne poškodbe je nujno stanje, s katerim se v pediatriji srečamo zelo redko. Diagnozo postavimo s kliničnim pregledom in slikovno preiskavo. Zdravljenje je večinoma kirurško. V prispevku predstavljamo ... ...

Abstract	Spinalni epiduralni hematom brez pomembne predhodne poškodbe je nujno stanje, s katerim se v pediatriji srečamo zelo redko. Diagnozo postavimo s kliničnim pregledom in slikovno preiskavo. Zdravljenje je večinoma kirurško. V prispevku predstavljamo spinalni epiduralni hematom pri enajstletnem, do tedaj zdravem dečku, ki je nenadoma začutil bolečino v predelu desne lopatice. Po kliničnem pregledu smo sum na patološko dogajanje v predelu hrbtenice potrdili z magnetnoresonančnim slikanjem. Po kirurški evakuaciji hematoma je deček popolnoma okreval.
Keywords	spinalni epiduralni hematom ; otrok ; bolečina ; nevrološki znaki ; laminektomija ; Medicine ; R ; Pediatrics ; RJ1-570
Language	Slovenian
Publishing date	2021-06-01T00:00:00Z
Publisher	The Society for Children with Metabolic Disorders
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The evolution of community-based primary health care, Slovenia.

Johansen, Anne S / Vracko, Pia / West, Robert

Bulletin of the World Health Organization

2020 Volume 98, Issue 5, Page(s) 353–359

Abstract: Problem: Slovenia's model of primary health care relied on reactive, episodic care and was ill-equipped to address the country's burden of disease dominated by noncommunicable diseases.: Approach: The government has developed a multidisciplinary, ... ...

Abstract	Problem: Slovenia's model of primary health care relied on reactive, episodic care and was ill-equipped to address the country's burden of disease dominated by noncommunicable diseases. Approach: The government has developed a multidisciplinary, community-based, prevention-oriented service delivery model for primary health care. A compulsory family medicine residency programme was introduced in 2000, and from 2004 screening and control of chronic diseases were established in family medicine practices. Health promotion centres were established, providing group interventions to support healthy lifestyles. After 2011, registered nurses were introduced to conduct screening for chronic diseases, provide counselling and manage patients with stable noncommunicable diseases. Local setting: In 1992, the government transformed Slovenia's health financing scheme to a social insurance system based on mandatory payroll taxes. The system enabled private provision of health services, although primary care was mostly provided by publicly funded community health centres. A strong gatekeeping role was introduced. Relevant changes: Despite spending less on health than the European Union (EU) average, by 2013 Slovenia's life expectancy was higher than the average for EU countries. The increase was due in part to rapidly declining infant and under-five mortality and a faster decline in premature mortality due to chronic diseases. Lessons learnt: Slovenia's approach was enabled by strong public health and governance structures, along with accountability mechanisms that monitored outcomes and took corrective action when necessary. New programmes were piloted, creating a strong evidence base that facilitated obtaining sustainable financing, while national roll-out was supported by regional branches of the National Institute of Public Health.
MeSH term(s)	Community Health Services ; Delivery of Health Care/methods ; Health Care Reform ; Health Promotion/methods ; Humans ; Life Expectancy ; Primary Health Care ; Quality of Health Care ; Slovenia
Language	English
Publishing date	2020-03-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	80213-x
ISSN	1564-0604 ; 0042-9686 ; 0366-4996 ; 0510-8659
ISSN (online)	1564-0604
ISSN	0042-9686 ; 0366-4996 ; 0510-8659
DOI	10.2471/BLT.19.239616
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Article ; Online: Slovenia: Health System Review.

Albreht, Tit / Polin, Katherine / Pribaković Brinovec, Radivoje / Kuhar, Marjeta / Poldrugovac, Mircha / Ogrin Rehberger, Petra / Prevolnik Rupel, Valentina / Vracko, Pia

Health systems in transition

2022 Volume 23, Issue 1, Page(s) 1–183

Abstract: This analysis of the Slovene health system reviews recent developments in organization and governance, health financing, health care provision, health reforms and health system performance. Slovenia has a statutory health insurance system with a single ... ...

Abstract	This analysis of the Slovene health system reviews recent developments in organization and governance, health financing, health care provision, health reforms and health system performance. Slovenia has a statutory health insurance system with a single public insurer, providing almost universal coverage for a broad benefits package, though some services require relatively high levels of co-insurance (called co-payments in Slovenia). To cover these costs, about 95% of the population liable for cost-sharing purchases complementary, voluntary health insurance. Health expenditure per capita and as a share of GDP has increased slightly, but still trails behind the EU average. Among statutory health insurance countries, Slovenia is rather unique in that it relies almost exclusively on payroll contributions to fund its system, making health sector revenues vulnerable to economic and labour market fluctuations, and population ageing. Important organizational changes are underway or have been implemented, especially in prevention, primary, emergency and long-term care. Access to services is generally good, given wide coverage of statutory health insurance. Further, Slovenia has some of the lowest rates of out-of-pocket and catastrophic spending in the EU, due to extensive uptake of complementary voluntary health insurance. Yet long waiting times for some services are a persistent issue. Though population health has improved in the last decades, health inequalities due to gender, social and economic determinants and geography remain an important challenge. There is variation in health care performance indicators, but Slovenia performs comparatively well for its level of health spending overall. As such, there is clear scope to improve health and efficiency, including balancing population needs when planning health service volumes. Recently, the Slovene health care system was overwhelmed by the demand for COVID-19-related care. The pandemicâs longer-term effects are still unknown, but it has significantly impacted on life expectancy in the short-term and resulted in delayed or forgone consultations and treatments for other health issues, and longer waiting times. Additional challenges, which are necessary to address to ensure long-term sustainability, strengthen resiliency and improve the capacity for service delivery and quality of care of the health system include: 1) health workforce planning; 2) outdated facilities; 3) health system performance assessment; and 4) implementation of current LTC reform.
MeSH term(s)	COVID-19 ; Health Care Reform ; Health Expenditures ; Healthcare Financing ; Humans ; Insurance, Health ; Quality of Health Care ; SARS-CoV-2 ; Slovenia
Language	English
Publishing date	2022-01-07
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	2182429-0
ISSN	1817-6127 ; 1020-9085 ; 1020-9077 ; 1817-6119
ISSN (online)	1817-6127 ; 1020-9085
ISSN	1020-9077 ; 1817-6119
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Journal ; Article ; Online: The evolution of community-based primary health care, Slovenia

Johansen, Anne S / Vracko, Pia / West, Robert

2020

Abstract: ... 353 ... ...

Abstract	353 359
Keywords	Lessons from the Field
Language	English
Publisher	World Health Organization
Document type	Journal ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quantitative structure-activity relationship study of antitubercular fluoroquinolones.

Minovski, Nikola / Vračko, Marjan / Solmajer, Tom

Molecular diversity

2011 Volume 15, Issue 2, Page(s) 417–426

Abstract: ... models: Assay1, R = 0.8108; Assay2, R = 0.8454, and Assay3, R = 0.9212) obtained on external, previously ...

Abstract	Quantitative structure-activity relationship study on three diverse sets of structurally similar fluoroquinolones was performed using a comprehensive set of molecular descriptors. Multiple linear regression technique was applied as a preprocessing tool to find the set of relevant descriptors (10) which are subsequently used in the artificial neural networks approach (non-linear procedure). The biological activity in the series (minimal inhibitory concentration (μg/mL) was treated as negative decade logarithm, pMIC). Using the non-linear technique counter propagation artificial neural networks, we obtained good predictive models. All models were validated using cross validation leave-one-out procedure. The results (the best models: Assay1, R = 0.8108; Assay2, R = 0.8454, and Assay3, R = 0.9212) obtained on external, previously excluded test datasets show the ability of these models in providing structure-activity relationship of fluoroquinolones. Thus, we demonstrated the advantage of non-linear approach in prediction of biological activity in these series. Furthermore, these validated models could be proficiently used for the design of novel structurally similar fluoroquinolone analogues with potentially higher activity.
MeSH term(s)	Algorithms ; Antitubercular Agents/chemistry ; Antitubercular Agents/metabolism ; Drug Design ; Fluoroquinolones/chemistry ; Fluoroquinolones/metabolism ; Humans ; Models, Statistical ; Quantitative Structure-Activity Relationship
Chemical Substances	Antitubercular Agents ; Fluoroquinolones
Language	English
Publishing date	2011-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1376507-3
ISSN	1573-501X ; 1381-1991
ISSN (online)	1573-501X
ISSN	1381-1991
DOI	10.1007/s11030-010-9238-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: QSTR modelling of the acute toxicity of pharmaceuticals to fish.

Tugcu, G / Saçan, M Türker / Vračko, M / Novič, M / Minovski, N

SAR and QSAR in environmental research

2012 Volume 23, Issue 3-4, Page(s) 297–310

Abstract: ... for the training set are R(2 )= 0.664, F = 13.588, and R(cv)(2) (LOO) = 0.542 while it achieves R(2 )= 0.605 ... obtained from several databases. The R(pred)(2) is 0.777, reflecting a relatively good predictive power ...

Abstract	Extensive use of pharmaceuticals as human and veterinary medication raises concerns for their adverse effects on non-target organisms. The purpose of this study was to employ multiple linear regression (MLR) to predict the toxicities of a diverse set of pharmaceuticals to fish. The descriptor pool consisted of about 1500 descriptors calculated using Dragon 5.4, Spartan 06 and Codessa 2.2 software. Descriptor selection was made by the heuristic method available in Codessa 2.2. The data set was divided into training and test sets using Kohonen networks. The training set contained approximately 65% of the compounds of the full data set (99 compounds). The training set model contained eight descriptors from all dimensions, all of which were obtained from Dragon 5.4. The statistical parameters of the model for the training set are R(2 )= 0.664, F = 13.588, and R(cv)(2) (LOO) = 0.542 while it achieves R(2 )= 0.605 for the test set. The training, test and external sets have no response outliers considering the standardized residual greater than three. The external validation of the model was made with a set of pharmaceuticals obtained from several databases. The R(pred)(2) is 0.777, reflecting a relatively good predictive power for the external set.
MeSH term(s)	Animals ; Drug-Related Side Effects and Adverse Reactions ; Fishes ; Linear Models ; Models, Molecular ; Quantitative Structure-Activity Relationship
Language	English
Publishing date	2012
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2023559-8
ISSN	1029-046X ; 1062-936X
ISSN (online)	1029-046X
ISSN	1062-936X
DOI	10.1080/1062936X.2012.657678
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Article ; Online: Quantitative and qualitative models for carcinogenicity prediction for non-congeneric chemicals using CP ANN method for regulatory uses.

Fjodorova, Natalja / Vračko, Marjan / Tušar, Marjan / Jezierska, Aneta / Novič, Marjana / Kühne, Ralph / Schüürmann, Gerrit

Molecular diversity

2009 Volume 14, Issue 3, Page(s) 581–594

Abstract: The new European chemicals regulation Registration, Evaluation, Authorization and Restriction of Chemicals entered into force in June 2007 and accelerated the development of quantitative structure-activity relationship (QSAR) models for a variety of ... ...

Abstract	The new European chemicals regulation Registration, Evaluation, Authorization and Restriction of Chemicals entered into force in June 2007 and accelerated the development of quantitative structure-activity relationship (QSAR) models for a variety of endpoints, including carcinogenicity. Here, we would like to present quantitative (continuous) and qualitative (categorical) models for non-congeneric chemicals for prediction of carcinogenic potency. A dataset of 805 substances was obtained after a preliminary screening of findings of rodent carcinogenicity for 1,481 chemicals accessible via Distributed Structure-Searchable Toxicity (DSSTox) Public Database Network originated from the Lois Gold Carcinogenic Potency Database (CPDB). Twenty seven two-dimensional MDL descriptors were selected using Kohonen mapping and principal component analysis. The counter propagation artificial neural network (CP ANN) technique was applied. Quantitative models were developed exploring the relationship between the experimental and predicted carcinogenic potency expressed as a tumorgenic dose TD(50) for rats. The obtained models showed low prediction power with correlation coefficient less than 0.5 for the test set. In the next step, qualitative models were developed. We found that the qualitative models exhibit good accuracy for the training set (92%). The model demonstrated good predicted performance for the test set. It was obtained accuracy (68%), sensitivity (73%), and specificity (63%). We believe that CP ANN method is a good in silico approach for modeling and predicting rodent carcinogenicity for non-congeneric chemicals and may find application for other toxicological endpoints.
MeSH term(s)	Animals ; Carcinogenicity Tests ; Carcinogens/toxicity ; Databases, Factual ; Drug and Narcotic Control/methods ; Humans ; Neural Networks, Computer ; Principal Component Analysis ; Quantitative Structure-Activity Relationship ; ROC Curve ; Rats
Chemical Substances	Carcinogens
Language	English
Publishing date	2009-08-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1376507-3
ISSN	1573-501X ; 1381-1991
ISSN (online)	1573-501X
ISSN	1381-1991
DOI	10.1007/s11030-009-9190-4
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Article: Indole-spot test in bacteriology.

VRACKO, R / SHERRIS, J C

Technical bulletin of the Registry of Medical Technologists. American Society of Clinical Pathologists. Registry of Medical Technologists

2003 Volume 33, Page(s) 47–50

MeSH term(s)	Bacteriological Techniques ; Bacteriology ; Enterobacteriaceae ; Indoles ; Proteus
Chemical Substances	Indoles ; indole (8724FJW4M5)
Language	English
Publishing date	2003-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	391754-x
ISSN	0097-0654
ISSN	0097-0654
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Article ; Online: Computer-Assisted and Data Driven Approaches for Surveillance, Drug Discovery, and Vaccine Design for the Zika Virus

Subhash C. Basak / Subhabrata Majumdar / Ashesh Nandy / Proyasha Roy / Tathagata Dutta / Marjan Vracko / Apurba K. Bhattacharjee

Pharmaceuticals, Vol 12, Iss 4, p

2019 Volume 157

Abstract: Human life has been at the edge of catastrophe for millennia due diseases which emerge and reemerge at random. The recent outbreak of the Zika virus (ZIKV) is one such menace that shook the global public health community abruptly. Modern technologies, ... ...

Abstract	Human life has been at the edge of catastrophe for millennia due diseases which emerge and reemerge at random. The recent outbreak of the Zika virus (ZIKV) is one such menace that shook the global public health community abruptly. Modern technologies, including computational tools as well as experimental approaches, need to be harnessed fast and effectively in a coordinated manner in order to properly address such challenges. In this paper, based on our earlier research, we have proposed a four-pronged approach to tackle the emerging pathogens like ZIKV: (a) Epidemiological modelling of spread mechanisms of ZIKV; (b) assessment of the public health risk of newly emerging strains of the pathogens by comparing them with existing strains/pathogens using fast computational sequence comparison methods; (c) implementation of vaccine design methods in order to produce a set of probable peptide vaccine candidates for quick synthesis/production and testing in the laboratory; and (d) designing of novel therapeutic molecules and their laboratory testing as well as validation of new drugs or repurposing of drugs for use against ZIKV. For each of these stages, we provide an extensive review of the technical challenges and current state-of-the-art. Further, we outline the future areas of research and discuss how they can work together to proactively combat ZIKV or future emerging pathogens.
Keywords	viral epidemics ; zika virus (zikv) ; sir models ; 2d graphical method ; peptide vaccine design ; mahalanobis distance ; principal component analysis (pca) ; neighborhood matrix ; computer-assisted anti-zika drug discovery ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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