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  1. Article ; Online: Editorial: Oral mucosal immunity: homeostasis and inflammation.

    Zhang, Dunfang / Xu, Junji / Wang, Zhi / Nakatsukasa, Hiroko

    Frontiers in immunology

    2023  Volume 14, Page(s) 1214926

    MeSH term(s) Humans ; Immunity, Mucosal ; Inflammation ; Mouth Mucosa ; Homeostasis
    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1214926
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: High sucralose intake suppresses autoimmunity and promotes tumor growth by limiting T cell‐mediated immune responses

    Yubin Lin / Qipeng Zhan / Dunfang Zhang

    MedComm – Future Medicine, Vol 2, Iss 4, Pp n/a-n/a (2023)

    2023  

    Keywords Medical technology ; R855-855.5 ; Computer applications to medicine. Medical informatics ; R858-859.7
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Editorial: Hexose Uptake and Metabolism in Immune Homeostasis and Inflammation.

    Zhang, Dunfang / Liu, Chaohong / Nakatsukasa, Hiroko / Chen, WanJun

    Frontiers in immunology

    2022  Volume 12, Page(s) 832293

    MeSH term(s) Animals ; Biomarkers ; Carbohydrate Metabolism ; Disease Susceptibility ; Hexoses/metabolism ; Homeostasis/immunology ; Humans ; Immune System ; Inflammation/etiology ; Inflammation/metabolism
    Chemical Substances Biomarkers ; Hexoses
    Language English
    Publishing date 2022-01-10
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.832293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reactive oxygen species formation and its effect on CD4

    Shu, Panyin / Liang, Hantian / Zhang, Jianan / Lin, Yubin / Chen, Wenjing / Zhang, Dunfang

    Frontiers in immunology

    2023  Volume 14, Page(s) 1199233

    Abstract: Reactive oxygen species (ROS) are produced both enzymatically and non- ... ...

    Abstract Reactive oxygen species (ROS) are produced both enzymatically and non-enzymatically
    MeSH term(s) Humans ; Reactive Oxygen Species ; T-Lymphocytes ; Autoimmune Diseases ; Inflammation ; CD4-Positive T-Lymphocytes
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2023-05-25
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1199233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: TSG-6 Inhibits the NF-κB Signaling Pathway and Promotes the Odontogenic Differentiation of Dental Pulp Stem Cells via CD44 in an Inflammatory Environment.

    Wang, Ying / Xie, Yulang / Xue, Ningning / Xu, Hao / Zhang, Dunfang / Ji, Ning / Chen, Qianming

    Biomolecules

    2024  Volume 14, Issue 3

    Abstract: In pulpitis, dentinal restorative processes are considerably associated with undifferentiated mesenchymal cells in the pulp. This study aimed to investigate strategies to improve the odonto/osteogenic differentiation of dental pulp stem cells (DPSCs) in ... ...

    Abstract In pulpitis, dentinal restorative processes are considerably associated with undifferentiated mesenchymal cells in the pulp. This study aimed to investigate strategies to improve the odonto/osteogenic differentiation of dental pulp stem cells (DPSCs) in an inflammatory environment. After pretreatment of DPSCs with 20 ng/mL tumor necrosis factor-induced protein-6 (TSG-6), DPSCs were cultured in an inflammation-inducing solution. Real-time polymerase chain reaction and Western blotting were performed to measure the expression levels of nuclear factor kappa B (NF-κB) and odonto/osteogenic differentiation markers, respectively. Cell Counting Kit-8 and 5-ethynyl-2'-deoxyuridine assays were used to assess cell proliferation and activity. Subcutaneous ectopic osteogenesis and mandibular bone cultures were performed to assess the effects of TSG-6 in vivo. The expression levels of odonto/osteogenic markers were higher in TSG-6-pre-treated DPSCs than nontreated DPSCs, whereas NF-κB-related proteins were lower after the induction of inflammation. An anti-CD44 antibody counteracted the rescue effect of TSG-6 on DPSC activity and mineralization in an inflammatory environment. Exogenous administration of TSG-6 enhanced the anti-inflammatory properties of DPSCs and partially restored their mineralization function by inhibiting NF-κB signaling. The mechanism of action of TSG-6 was attributed to its interaction with CD44. These findings reveal novel mechanisms by which DPSCs counter inflammation and provide a basis for the treatment of pulpitis.
    MeSH term(s) Humans ; NF-kappa B/metabolism ; Osteogenesis ; Pulpitis/metabolism ; Dental Pulp/metabolism ; Signal Transduction ; Cell Differentiation ; Inflammation/metabolism ; Stem Cells ; Cells, Cultured ; Cell Proliferation ; Hyaluronan Receptors/metabolism
    Chemical Substances NF-kappa B ; CD44 protein, human ; Hyaluronan Receptors
    Language English
    Publishing date 2024-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14030368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Interactions between neutrophils and T-helper 17 cells.

    Fan, Xinzou / Shu, Panyin / Wang, Ying / Ji, Ning / Zhang, Dunfang

    Frontiers in immunology

    2023  Volume 14, Page(s) 1279837

    Abstract: Neutrophils comprise the majority of immune cells in human peripheral circulation, have potent antimicrobial activities, and are clinically significant in their abundance, heterogeneity, and subcellular localization. In the past few years, the role of ... ...

    Abstract Neutrophils comprise the majority of immune cells in human peripheral circulation, have potent antimicrobial activities, and are clinically significant in their abundance, heterogeneity, and subcellular localization. In the past few years, the role of neutrophils as components of the innate immune response has been studied in numerous ways, and these cells are crucial in fighting infections, autoimmune diseases, and cancer. T-helper 17 (Th17) cells that produce interleukin 17 (IL-17) are critical in fighting infections and maintaining mucosal immune homeostasis, whereas they mediate several autoimmune diseases. Neutrophils affect adaptive immune responses by interacting with adaptive immune cells. In this review, we describe the physiological roles of both Th17 cells and neutrophils and their interactions and briefly describe the pathological processes in which these two cell types participate. We provide a summary of relevant drugs targeting IL-17A and their clinical trials. Here, we highlight the interactions between Th17 cells and neutrophils in diverse pathophysiological situations.
    MeSH term(s) Humans ; Neutrophils ; Th17 Cells ; Immunity, Innate ; Autoimmune Diseases
    Language English
    Publishing date 2023-10-18
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1279837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: TGF-β controls development of TCRγδ

    Han, Jiajia / Liu, Na / Jin, Wenwen / Zanvit, Peter / Zhang, Dunfang / Xu, Junji / Bynum, Andrew / Kazmi, Rida / Zhang, Jianmin / He, Wei / Chen, WanJun

    Cell discovery

    2023  Volume 9, Issue 1, Page(s) 52

    Abstract: γδ intestinal intraepithelial lymphocytes (IELs) constitute the majority of IELs with unique ... ...

    Abstract γδ intestinal intraepithelial lymphocytes (IELs) constitute the majority of IELs with unique CD8αα
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article
    ISSN 2056-5968
    ISSN 2056-5968
    DOI 10.1038/s41421-023-00542-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Role of Cytokines in Thymic Regulatory T Cell Generation: Overview and Updates.

    Tang, Mei / Jia, Fuya / Nan, Fang / Zuo, Fengqiong / Yuan, Zhu / Zhang, Dunfang

    Frontiers in immunology

    2022  Volume 13, Page(s) 883560

    Abstract: ... ...

    Abstract CD4
    MeSH term(s) Cytokines/metabolism ; Forkhead Transcription Factors/metabolism ; Signal Transduction ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta/metabolism
    Chemical Substances Cytokines ; Forkhead Transcription Factors ; Transforming Growth Factor beta
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.883560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Signaling pathways involved in the biological functions of dendritic cells and their implications for disease treatment.

    Cheng, Hao / Chen, Wenjing / Lin, Yubin / Zhang, Jianan / Song, Xiaoshuang / Zhang, Dunfang

    Molecular biomedicine

    2023  Volume 4, Issue 1, Page(s) 15

    Abstract: The ability of dendritic cells (DCs) to initiate and regulate adaptive immune responses is fundamental for maintaining immune homeostasis upon exposure to self or foreign antigens. The immune regulatory function of DCs is strictly controlled by their ... ...

    Abstract The ability of dendritic cells (DCs) to initiate and regulate adaptive immune responses is fundamental for maintaining immune homeostasis upon exposure to self or foreign antigens. The immune regulatory function of DCs is strictly controlled by their distribution as well as by cytokines, chemokines, and transcriptional programming. These factors work in conjunction to determine whether DCs exert an immunosuppressive or immune-activating function. Therefore, understanding the molecular signals involved in DC-dependent immunoregulation is crucial in providing insight into the generation of organismal immunity and revealing potential clinical applications of DCs. Considering the many breakthroughs in DC research in recent years, in this review we focused on three basic lines of research directly related to the biological functions of DCs and summarized new immunotherapeutic strategies involving DCs. First, we reviewed recent findings on DC subsets and identified lineage-restricted transcription factors that guide the development of different DC subsets. Second, we discussed the recognition and processing of antigens by DCs through pattern recognition receptors, endogenous/exogenous pathways, and the presentation of antigens through peptide/major histocompatibility complexes. Third, we reviewed how interactions between DCs and T cells coordinate immune homeostasis in vivo via multiple pathways. Finally, we summarized the application of DC-based immunotherapy for autoimmune diseases and tumors and highlighted potential research prospects for immunotherapy that targets DCs. This review provides a useful resource to better understand the immunomodulatory signals involved in different subsets of DCs and the manipulation of these immune signals can facilitate DC-based immunotherapy.
    Language English
    Publishing date 2023-05-15
    Publishing country Singapore
    Document type Journal Article ; Review
    ISSN 2662-8651
    ISSN (online) 2662-8651
    DOI 10.1186/s43556-023-00125-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pathogenesis and treatment of Sjogren's syndrome: Review and update.

    Zhan, Qipeng / Zhang, Jianan / Lin, Yubin / Chen, Wenjing / Fan, Xinzou / Zhang, Dunfang

    Frontiers in immunology

    2023  Volume 14, Page(s) 1127417

    Abstract: Sjogren's syndrome (SS) is a chronic autoimmune disease accompanied by multiple lesions. The main manifestations include dryness of the mouth and eyes, along with systemic complications (e.g., pulmonary disease, kidney injury, and lymphoma). In this ... ...

    Abstract Sjogren's syndrome (SS) is a chronic autoimmune disease accompanied by multiple lesions. The main manifestations include dryness of the mouth and eyes, along with systemic complications (e.g., pulmonary disease, kidney injury, and lymphoma). In this review, we highlight that IFNs, Th17 cell-related cytokines (IL-17 and IL-23), and B cell-related cytokines (TNF and BAFF) are crucial for the pathogenesis of SS. We also summarize the advances in experimental treatment strategies, including targeting Treg/Th17, mesenchymal stem cell treatment, targeting BAFF, inhibiting JAK pathway, et al. Similar to that of SLE, RA, and MS, biotherapeutic strategies of SS consist of neutralizing antibodies and inflammation-related receptor blockers targeting proinflammatory signaling pathways. However, clinical research on SS therapy is comparatively rare. Moreover, the differences in the curative effects of immunotherapies among SS and other autoimmune diseases are not fully understood. We emphasize that targeted drugs, low-side-effect drugs, and combination therapies should be the focus of future research.
    MeSH term(s) Humans ; Sjogren's Syndrome ; Autoimmune Diseases/complications ; Cytokines/metabolism ; Signal Transduction ; B-Lymphocytes/metabolism
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1127417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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