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Article ; Online: CXCR3-CXCL9: It's All in the Tumor.

Humblin, Etienne / Kamphorst, Alice O

2019 Volume 50, Issue 6, Page(s) 1347–1349

Abstract: In this issue of Immunity, Chow et al. (2019) show that the CXCR3-CXCL9 axis is required for reinvigoration of intratumoral ... ...

Abstract	In this issue of Immunity, Chow et al. (2019) show that the CXCR3-CXCL9 axis is required for reinvigoration of intratumoral CD8
MeSH term(s)	Chemokine CXCL10 ; Chemokine CXCL9 ; Dendritic Cells ; Humans ; Neoplasms ; Programmed Cell Death 1 Receptor ; Receptors, CXCR3 ; T-Lymphocytes
Chemical Substances	CXCL9 protein, human ; CXCR3 protein, human ; Chemokine CXCL10 ; Chemokine CXCL9 ; Programmed Cell Death 1 Receptor ; Receptors, CXCR3
Language	English
Publishing date	2019-07-24
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2019.05.013
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Zs.MG 69: Show issues

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Article ; Online: Universal recording of immune cell interactions in vivo.

Nakandakari-Higa, Sandra / Walker, Sarah / Canesso, Maria C C / van der Heide, Verena / Chudnovskiy, Aleksey / Kim, Dong-Yoon / Jacobsen, Johanne T / Parsa, Roham / Bilanovic, Jana / Parigi, S Martina / Fiedorczuk, Karol / Fuchs, Elaine / Bilate, Angelina M / Pasqual, Giulia / Mucida, Daniel / Kamphorst, Alice O / Pritykin, Yuri / Victora, Gabriel D

Nature

2024 Volume 627, Issue 8003, Page(s) 399–406

Abstract: Immune cells rely on transient physical interactions with other immune and non-immune populations to regulate their ... ...

Abstract	Immune cells rely on transient physical interactions with other immune and non-immune populations to regulate their function
MeSH term(s)	CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; Cell Communication/immunology ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Ligands ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/immunology ; T Follicular Helper Cells/cytology ; T Follicular Helper Cells/immunology ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; Germinal Center/cytology ; Single-Cell Gene Expression Analysis ; Epithelial Cells/cytology ; Epithelial Cells/immunology ; Intestinal Mucosa/cytology ; Intestinal Mucosa/immunology ; Lymphocytic choriomeningitis virus/immunology ; Lymphocytic Choriomeningitis/immunology ; Lymphocytic Choriomeningitis/virology ; Organ Specificity
Chemical Substances	Ligands
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07134-4
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

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Article ; Online: Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1

Humblin, Etienne / Korpas, Isabel / Lu, Jiahua / Filipescu, Dan / van der Heide, Verena / Goldstein, Simon / Vaidya, Abishek / Soares-Schanoski, Alessandra / Casati, Beatrice / Selvan, Myvizhi E / Gümüş, Zeynep H / Wieland, Andreas / Corrado, Mauro / Cohen-Gould, Leona / Bernstein, Emily / Homann, Dirk / Chipuk, Jerry / Kamphorst, Alice O

Science immunology

2023 Volume 8, Issue 86, Page(s) eadg0878

Abstract: During persistent antigen stimulation, such as in chronic infections and cancer, CD8 T cells differentiate into a hypofunctional programmed death protein 1-positive (PD- ... ...

Abstract	During persistent antigen stimulation, such as in chronic infections and cancer, CD8 T cells differentiate into a hypofunctional programmed death protein 1-positive (PD-1
MeSH term(s)	T Cell Transcription Factor 1/genetics ; CD28 Antigens ; Programmed Cell Death 1 Receptor ; CD8-Positive T-Lymphocytes ; Cell Differentiation ; Transcription Factors
Chemical Substances	T Cell Transcription Factor 1 ; CD28 Antigens ; Programmed Cell Death 1 Receptor ; Transcription Factors
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.adg0878
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Article ; Online: Characteristics and anatomic location of PD-1

Im, Se Jin / Obeng, Rebecca C / Nasti, Tahseen H / McManus, Daniel / Kamphorst, Alice O / Gunisetty, Sivaram / Prokhnevska, Nataliya / Carlisle, Jennifer W / Yu, Ke / Sica, Gabriel L / Cardozo, Lucas E / Gonçalves, André N A / Kissick, Haydn T / Nakaya, Helder I / Ramalingam, Suresh S / Ahmed, Rafi

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 41, Page(s) e2221985120

Abstract: CD8 T cells play an essential role in antitumor immunity and chronic viral infections. Recent findings have delineated the differentiation pathway of CD8 T cells in accordance with the progenitor-progeny relationship of ... ...

Abstract	CD8 T cells play an essential role in antitumor immunity and chronic viral infections. Recent findings have delineated the differentiation pathway of CD8 T cells in accordance with the progenitor-progeny relationship of TCF1
MeSH term(s)	Humans ; Animals ; Mice ; Lymphocytic Choriomeningitis ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/metabolism ; CD8-Positive T-Lymphocytes ; Lymphocytic choriomeningitis virus ; Persistent Infection ; Lung Neoplasms/metabolism ; Mice, Inbred C57BL
Chemical Substances	Programmed Cell Death 1 Receptor
Language	English
Publishing date	2023-10-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2221985120
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Article ; Online: MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping.

Filipescu, Dan / Carcamo, Saul / Agarwal, Aman / Tung, Navpreet / Humblin, Étienne / Goldberg, Matthew S / Vyas, Nikki S / Beaumont, Kristin G / Demircioglu, Deniz / Sridhar, Subhasree / Ghiraldini, Flavia G / Capparelli, Claudia / Aplin, Andrew E / Salmon, Hélène / Sebra, Robert / Kamphorst, Alice O / Merad, Miriam / Hasson, Dan / Bernstein, Emily

Nature cell biology

2023 Volume 25, Issue 9, Page(s) 1332–1345

Abstract: MacroH2A has established tumour suppressive functions in melanoma and other cancers, but an unappreciated role in the tumour microenvironment. Using an autochthonous, immunocompetent mouse model of melanoma, we demonstrate that mice devoid of macroH2A ... ...

Abstract	MacroH2A has established tumour suppressive functions in melanoma and other cancers, but an unappreciated role in the tumour microenvironment. Using an autochthonous, immunocompetent mouse model of melanoma, we demonstrate that mice devoid of macroH2A variants exhibit increased tumour burden compared with wild-type counterparts. MacroH2A-deficient tumours accumulate immunosuppressive monocytes and are depleted of functional cytotoxic T cells, characteristics consistent with a compromised anti-tumour response. Single cell and spatial transcriptomics identify increased dedifferentiation along the neural crest lineage of the tumour compartment and increased frequency and activation of cancer-associated fibroblasts following macroH2A loss. Mechanistically, macroH2A-deficient cancer-associated fibroblasts display increased myeloid chemoattractant activity as a consequence of hyperinducible expression of inflammatory genes, which is enforced by increased chromatin looping of their promoters to enhancers that gain H3K27ac. In summary, we reveal a tumour suppressive role for macroH2A variants through the regulation of chromatin architecture in the tumour stroma with potential implications for human melanoma.
MeSH term(s)	Animals ; Mice ; Cancer-Associated Fibroblasts ; Chromatin/genetics ; Gene Expression ; Histones/genetics ; Melanoma/genetics ; Tumor Microenvironment/genetics
Chemical Substances	Chromatin ; Histones
Language	English
Publishing date	2023-08-21
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1474722-4
ISSN	1476-4679 ; 1465-7392
ISSN (online)	1476-4679
ISSN	1465-7392
DOI	10.1038/s41556-023-01208-7
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Zs.A 5169: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 12: Show issues

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Article ; Online: Manipulating the PD-1 pathway to improve immunity.

Kamphorst, Alice O / Ahmed, Rafi

Current opinion in immunology

2013 Volume 25, Issue 3, Page(s) 381–388

Abstract: PD-1 is an inhibitory receptor induced in T cells by antigen stimulation and sustained PD-1 expression plays a key role in T cell dysfunction. Blocking PD-1 signaling rescues exhausted T cells and is an effective treatment for chronic infections and ... ...

Abstract	PD-1 is an inhibitory receptor induced in T cells by antigen stimulation and sustained PD-1 expression plays a key role in T cell dysfunction. Blocking PD-1 signaling rescues exhausted T cells and is an effective treatment for chronic infections and cancer. Nonetheless, combining PD-1 pathway blockade to therapeutic vaccination should further improve T cell rescue. PD-1 is induced shortly after T cell priming, but little is known about the role of PD-1 in the initiation of immune responses. In addition, the PD-1 pathway may also modulate humoral responses, since both B cells and Tfh cells express PD-1. Therefore, even though much progress has been achieved by manipulation of the PD-1 pathway to rescue exhausted T cells, this powerful immunotherapy could still be further exploited.
MeSH term(s)	Animals ; Gene Expression Regulation ; Humans ; Ligands ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/immunology ; Signal Transduction ; T-Lymphocytes/immunology ; Vaccination
Chemical Substances	Ligands ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2013-04-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2013.03.003
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Zs.A 2773: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 13: Show issues

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Article ; Online: CD4 T-cell immunotherapy for chronic viral infections and cancer.

Kamphorst, Alice O / Ahmed, Rafi

Immunotherapy

2013 Volume 5, Issue 9, Page(s) 975–987

Abstract: During chronic infections and cancer, T cells progressively lose function and become exhausted. However, effective T-cell responses are necessary to ultimately control viral infections and tumors. Hence, strategies that either restore endogenous immune ... ...

Abstract	During chronic infections and cancer, T cells progressively lose function and become exhausted. However, effective T-cell responses are necessary to ultimately control viral infections and tumors. Hence, strategies that either restore endogenous immune responses or provide functional T cells by adoptive immunotherapy need to be explored. CD8 T cells play a prominent role in viral infections, as well as cancer, but CD4 T cells are necessary to support CD8 T-cell function. In addition, CD4 T cells exert direct effector functions, induce optimal B-cell responses and orchestrate innate immunity. Therefore, we propose that adoptive transfer strategies should exploit CD4 T cells alone or in combination with CD8 T cells, for the treatment of chronic infections and cancer. Furthermore, since adoptively transferred cells are subject to exhaustion, combining adoptive transfer therapy with immunotherapies that inhibit T-cell exhaustion should maximize the longevity and success rate of responses.
MeSH term(s)	Adoptive Transfer/methods ; Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/transplantation ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/pathology ; Chronic Disease ; Humans ; Immunity, Innate ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Virus Diseases/immunology ; Virus Diseases/pathology ; Virus Diseases/therapy
Language	English
Publishing date	2013-09-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	1750-7448
ISSN (online)	1750-7448
DOI	10.2217/imt.13.91
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Article ; Online: Dendritic Cells in Tolerance and Immunity against Pathogens.

Boscardin, Silvia Beatriz / Rosa, Daniela Santoro / Kamphorst, Alice O / Trumpfheller, Christine

Journal of immunology research

2016 Volume 2016, Page(s) 6438036

MeSH term(s)	Animals ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/immunology ; Cardiovascular Diseases/pathology ; Dendritic Cells/immunology ; Dendritic Cells/pathology ; Humans ; Immune Tolerance ; Immunity ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/pathology ; Mice
Language	English
Publishing date	2016
Publishing country	Egypt
Document type	Editorial
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-8861
ISSN (online)	2314-7156
ISSN	2314-8861
DOI	10.1155/2016/6438036
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Article ; Online: Immune checkpoint inhibitors in advanced non-small cell lung cancer.

Assi, Hazem I / Kamphorst, Alice O / Moukalled, Nour M / Ramalingam, Suresh S

Cancer

2017 Volume 124, Issue 2, Page(s) 248–261

Abstract: The emergence of immune checkpoint inhibitors for the treatment of cancer has led to major changes to the therapeutic landscape of lung cancer. Improvements in overall survival relative to standard chemotherapy have been observed in the first-line and ... ...

Abstract	The emergence of immune checkpoint inhibitors for the treatment of cancer has led to major changes to the therapeutic landscape of lung cancer. Improvements in overall survival relative to standard chemotherapy have been observed in the first-line and second-line therapy settings for patients with advanced non-small cell lung cancer (NSCLC) who are treated with immune checkpoint inhibitors. Consequently, every patient with advanced-stage NSCLC is now a candidate for immune checkpoint inhibitor therapy. However, it is clear that the benefit from therapy is not universal, and identification of biomarkers to select therapy has assumed importance. In addition to programmed cell death receptor ligand 1 expression, both tissue-based and blood-based markers are under evaluation to select patients. In an era of increasing costs of care and potential for toxicities related to immune checkpoint inhibition, proper patient selection is critical to the optimal use of this new class of agents. In addition, development of novel combination approaches has also emerged as an important way to improve the efficacy of immune checkpoint inhibition. Studies in earlier stages of NSCLC are already underway with the hope of improving the cure rate. In this article, the authors review the current landscape of immune checkpoint inhibitors in the treatment of advanced NSCLC. Cancer 2018;124:248-61. © 2017 American Cancer Society.
MeSH term(s)	B7-H1 Antigen/antagonists & inhibitors ; Biomarkers ; CTLA-4 Antigen/antagonists & inhibitors ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Humans ; Immunotherapy ; Lung Neoplasms/drug therapy ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Salvage Therapy
Chemical Substances	B7-H1 Antigen ; Biomarkers ; CTLA-4 Antigen ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2017-12-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.31105
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Uh III Zs.146: Show issues

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Article: Manipulating the PD-1 pathway to improve immunity

Kamphorst, Alice O / Ahmed, Rafi

Current Opinion in Immunology. 2013 June, v. 25, no. 3

2013

Abstract	PD-1 is an inhibitory receptor induced in T cells by antigen stimulation and sustained PD-1 expression plays a key role in T cell dysfunction. Blocking PD-1 signaling rescues exhausted T cells and is an effective treatment for chronic infections and cancer. Nonetheless, combining PD-1 pathway blockade to therapeutic vaccination should further improve T cell rescue. PD-1 is induced shortly after T cell priming, but little is known about the role of PD-1 in the initiation of immune responses. In addition, the PD-1 pathway may also modulate humoral responses, since both B cells and Tfh cells express PD-1. Therefore, even though much progress has been achieved by manipulation of the PD-1 pathway to rescue exhausted T cells, this powerful immunotherapy could still be further exploited.
Keywords	T-lymphocytes ; antigens ; humoral immunity ; immune response ; vaccination
Language	English
Dates of publication	2013-06
Size	p. 381-388.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2013.03.003
Database	NAL-Catalogue (AGRICOLA)

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