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Article ; Online: Characterization of key odorants in Langyatai Baijiu with Jian flavour by sensory-directed analysis.

Du, Jingyi / Li, Yueming / Xu, Jianchun / Huang, Mingquan / Wang, Juan / Chao, Jinfu / Wu, Jihong / Sun, Huibin / Ding, Haimei / Ye, Hong

Food chemistry

2021 Volume 352, Page(s) 129363

Abstract: ... Baijiu with Jian flavour (LBJF) using sensory omics analysis (SOA). A total of 56 odorants were screened ... This study uncovers the characteristics of Jian flavour Baijiu (JFB) and provides a scientific basis ...

Abstract	A study was carried out to determine systematically the key aroma-active compounds of Langyatai Baijiu with Jian flavour (LBJF) using sensory omics analysis (SOA). A total of 56 odorants were screened out using gas chromatography-olfactometry-mass spectrometry (GC-O-MS)/Osme analysis. Among them, 15 aroma-active components were first identified. After quantitation, 30 odorants had odour activity values (OAVs) > 1.0 in LBJF. Recombinant and omission experiments proved that the esters, alcohols, acids, especially ethyl hexanoate, γ-nonalactone, and dimethyl trisulfide, were critical to the flavour of LBJF. The basic and commercial liquors had obvious differences in the skeleton compositions of esters and acids. This study uncovers the characteristics of Jian flavour Baijiu (JFB) and provides a scientific basis for the quality control of JFB, which is helpful for the development of Chinese Baijiu flavour styles.
MeSH term(s)	Alcoholic Beverages/analysis ; Food Analysis/methods ; Gas Chromatography-Mass Spectrometry ; Humans ; Odorants/analysis ; Olfactometry ; Taste ; Volatile Organic Compounds/analysis
Chemical Substances	Volatile Organic Compounds
Language	English
Publishing date	2021-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2021.129363
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Article: Network Pharmacology and Experimental Verification Strategies to Illustrate the Mechanism of Jian-Pi-Yi-Shen Formula in Suppressing Epithelial-Mesenchymal Transition.

Zhao, Yuan / Li, Xiangbin / Wang, Fochang / Huang, Shiying / Du, Hanqian / Li, Shunmin / Chen, Jianping

Frontiers in pharmacology

2022 Volume 13, Page(s) 873023

Abstract: Jian-Pi-Yi-Shen formula (JPYSF), a traditional Chinese medicine, has been recommended to treat ...

Abstract	Jian-Pi-Yi-Shen formula (JPYSF), a traditional Chinese medicine, has been recommended to treat renal fibrosis for decades. Previous studies had shown that JPYSF could inhibit epithelial-mesenchymal transition (EMT), an important regulatory role in renal fibrosis. However, the mechanism of JPYSF action is largely unknown. In this study, network pharmacology and experimental verification were combined to elucidate and identify the potential mechanism of JPYSF against renal fibrosis by suppressing EMT at molecular and pathway levels. Network pharmacology was first performed to explore the mechanism of JPYSF against renal fibrosis targeting EMT, and then a 5/6 nephrectomy (5/6 Nx)-induced rat model of renal fibrosis was selected to verify the predictive results by Masson's trichrome stains and western blot analysis. Two hundred and thirty-two compounds in JPYSF were selected for the network approach analysis, which identified 137 candidate targets of JPYSF and 4,796 known therapeutic targets of EMT. The results of the Gene Ontology (GO) function enrichment analysis included 2098, 88, and 133 GO terms for biological processes (BPs), molecular functions (MFs), and cell component entries, respectively. The top 10 enrichment items of BP annotations included a response to a steroid hormone, a metal ion, oxygen levels, and so on. Cellular composition (CC) is mainly enriched in membrane raft, membrane microdomain, membrane region, etc. The MF of JPYSF analysis on EMT was predominately involved in proximal promoter sequence-specific DNA binding, protein heterodimerization activity, RNA polymerase II proximal promoter sequence-specific DNA binding, and so on. The involvement signaling pathway of JPYSF in the treatment of renal fibrosis targeting EMT was associated with anti-fibrosis, anti-inflammation, podocyte protection, and metabolism regulation. Furthermore, the
Language	English
Publishing date	2022-05-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.873023
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Article: Effects of dietary γ‐aminobutyric acid levels on the growth, serum biochemical indexes, immune‐related signalling molecules of Jian carp

Chen, Xiumei / Gao, Chunshan / Du, Xiaoyan / Xu, He / Wang, Guiqin / Zhang, Dongming

Aquaculture research. 2021 Mar., v. 52, no. 3

2021

Abstract: ... biochemical indexes, immune‐related signalling molecules of Jian carp (Cyprinus carpio var. Jian), fish were ... pre‐supplementation improved the growth in Jian carp, which could be related to the activation ... as a novel feed additive to prevent stress. The recommendation dietary GABA level for Jian carp, estimated ...

Abstract	In order to evaluate the protect effects of γ‐aminobutyric acid (GABA) on the growth, serum biochemical indexes, immune‐related signalling molecules of Jian carp (Cyprinus carpio var. Jian), fish were randomly divided into 6 groups, which fed six diets with different GABA levels (0, 30, 60, 90, 120 and 150 mg/kg) for 8 weeks, respectively. The results indicated the following: body weight gain, specific growth rate, feed intake, feed efficiency ratio and protein efficiency ratio were significantly improved by dietary GABA supplementation, the levels of total protein, albumin, glucose and the activity of superoxide dismutase in serum responded same trend; whereas, the activities of aspartate aminotransferase, alanine aminotransferase and malondialdehyde contents were opposite. Moreover, the activities of lysozyme and alkaline phosphatase and the content of nitric oxide in head kidney and spleen showed significantly increased under GABA pre‐supplementation. Furthermore, GABA pre‐supplementation had significantly higher expressions of interleukin‐2, interleukin 10, interferon γ and lower expressions of nuclear factor‐kappa B, interleukin‐1β, tumour necrosis factor α in head kidney and spleen when compared to the control group. These results indicated that GABA pre‐supplementation improved the growth in Jian carp, which could be related to the activation of serum biochemical indexes and immune‐related signalling molecules, showing the potential of GABA as a novel feed additive to prevent stress. The recommendation dietary GABA level for Jian carp, estimated by quadratic regression analysis based on BWG and FER, was 99.01 mg/kg and 96.75 mg/kg, respectively.
Keywords	Cyprinus carpio ; alanine transaminase ; albumins ; alkaline phosphatase ; aquaculture ; aspartate transaminase ; blood serum ; body weight changes ; carp ; feed additives ; feed conversion ; feed intake ; glucose ; interleukin-10 ; interleukin-2 ; kidneys ; lysozyme ; malondialdehyde ; nitric oxide ; protein content ; protein efficiency ratio ; regression analysis ; research ; specific growth rate ; spleen ; superoxide dismutase ; transcription factor NF-kappa B
Language	English
Dates of publication	2021-03
Size	p. 1096-1105.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-light ; JOURNAL ARTICLE
ZDB-ID	1227359-4
ISSN	1355-557X
ISSN	1355-557X
DOI	10.1111/are.14965
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of Rhizoma Alismatis extract on biochemical indices and adipose gene expression in oleic acid-induced hepatocyte injury in Jian carp (Cyprinus carpio var. Jian).

Du, Jinliang / Jia, Rui / Cao, Li-Ping / Ding, Weidong / Xu, Pao / Yin, Guojun

Fish physiology and biochemistry

2018 Volume 44, Issue 3, Page(s) 747–768

Abstract: ... extract (RAE) in Jian carp using this model. Primary hepatocytes from Jian carp were isolated and purified ...

Abstract	Fatty liver is an increasingly serious disease of fish in aquaculture. However, the mechanisms responsible for the occurrence of fatty liver remain unclear, and no effective methods for the prevention and treatment of this disease have yet been found. In the present study, we aimed to develop an in vitro model of hepatocyte injury using oleic acid as hepatotoxicant and evaluate the protective effects of Rhizoma Alismatis extract (RAE) in Jian carp using this model. Primary hepatocytes from Jian carp were isolated and purified and cultured in vitro. The result indicated that 0.4 mmol L
MeSH term(s)	Alisma ; Animals ; Carps/genetics ; Carps/metabolism ; Cell Survival/drug effects ; Cells, Cultured ; Cytochrome P-450 Enzyme System/metabolism ; Fatty Liver/metabolism ; Fatty Liver/veterinary ; Fish Diseases/metabolism ; Gene Expression/drug effects ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Hepatocytes/pathology ; L-Lactate Dehydrogenase/metabolism ; Lipid Metabolism/drug effects ; NF-kappa B/metabolism ; Oleic Acid ; Plant Extracts/pharmacology ; Rhizome ; Transaminases/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; gamma-Glutamyltransferase/metabolism
Chemical Substances	NF-kappa B ; Plant Extracts ; Tumor Necrosis Factor-alpha ; Oleic Acid (2UMI9U37CP) ; Cytochrome P-450 Enzyme System (9035-51-2) ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; gamma-Glutamyltransferase (EC 2.3.2.2) ; Transaminases (EC 2.6.1.-)
Language	English
Publishing date	2018-03-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	292907-7
ISSN	1573-5168 ; 0920-1742
ISSN (online)	1573-5168
ISSN	0920-1742
DOI	10.1007/s10695-017-0428-2
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Article: Hepatoprotective and antioxidant effects of dietary Glycyrrhiza polysaccharide against TCDD-induced hepatic injury and RT-PCR quantification of AHR2, ARNT2, CYP1A mRNA in Jian Carp (Cyprinus carpio var. Jian).

Du, Jinliang / Cao, Liping / Jia, Rui / Yin, Guojun

Journal of environmental sciences (China)

2017 Volume 51, Page(s) 181–190

Abstract: ... tetrachlorodibenzo-p-dioxin (TCDD)-induced hepatotoxicity in Jian carp, the fish were fed diets containing GPS ...

Abstract	To evaluate the protective effects of Glycyrrhiza polysaccharide (GPS) against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced hepatotoxicity in Jian carp, the fish were fed diets containing GPS at doses of 0.1, 0.5 and 1.0g/kg for 60days before an intraperitoneal injection of 0.6μg/kg TCDD at a volume of 0.05mL/10g body weight. At 72hr post-injection, blood and liver samples were taken for biochemical analysis and the fish liver samples were used for the preparation of pathological slices. The results showed that increases in alanine aminotransferase (GPT), aspartate aminotransferase (GOT), lactate dehydrogenase (LDH), and alkaline phosphatase (AKP) in serum induced by TCDD were significantly inhibited by pre-treatment with 1.0g/kg GPS. Following the 1.0g/kg GPS pre-treatment, total protein (TP), albumin (Alb), catalase (CAT), glutathione peroxidase (GPx), total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) activities in liver tissue increased significantly, malondialdehyde (MDA) formation (P<0.05 or P<0.01) was significantly inhibited, and the expression of cytochrome P4501A (CYP1A), aryl hydrocarbon receptor 2 (AHR2) and aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) mRNA (P<0.05) was significantly enhanced. Histological observations on fish liver were obtained by preparing paraffin tissue sections via HE staining, and the results showed that histological changes were obviously reduced by 0.5 and 1.0g/kg GPS. GPS significantly reduced liver tissue damage caused by TCDD. Overall, these results proved the hepatoprotective effect of GPS in protecting against fish liver injury induced by TCDD, and supported the use of GPS (1.0g/kg) as a hepatoprotective and antioxidant agent in fish.
MeSH term(s)	Animals ; Aryl Hydrocarbon Receptor Nuclear Translocator/genetics ; Aryl Hydrocarbon Receptor Nuclear Translocator/metabolism ; Carps ; Catalase/metabolism ; Cytochrome P-450 CYP1A1/genetics ; Cytochrome P-450 CYP1A1/metabolism ; Glutathione Peroxidase/metabolism ; Glycyrrhiza/chemistry ; Liver/metabolism ; Malondialdehyde/metabolism ; Oxidation-Reduction ; Polychlorinated Dibenzodioxins/toxicity ; Polysaccharides/pharmacology ; Protective Agents/pharmacology ; RNA, Messenger ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism ; Superoxide Dismutase/metabolism ; Water Pollutants, Chemical/toxicity
Chemical Substances	Polychlorinated Dibenzodioxins ; Polysaccharides ; Protective Agents ; RNA, Messenger ; Receptors, Aryl Hydrocarbon ; Water Pollutants, Chemical ; Aryl Hydrocarbon Receptor Nuclear Translocator (138391-32-9) ; Malondialdehyde (4Y8F71G49Q) ; Catalase (EC 1.11.1.6) ; Glutathione Peroxidase (EC 1.11.1.9) ; Cytochrome P-450 CYP1A1 (EC 1.14.14.1) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2017-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1092300-7
ISSN	1878-7320 ; 1001-0742
ISSN (online)	1878-7320
ISSN	1001-0742
DOI	10.1016/j.jes.2016.06.026
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Article ; Online: A multicenter, randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of Taoren Honghua Jian granule in patients with stable coronary artery disease.

Wang, Yiru / Zhang, Yiyi / Du, Yiyue / Yang, Ying / Wei, Jing / Zhang, Na / Mao, Meijiao / Du, Wenting / Liu, Ping

Medicine

2019 Volume 98, Issue 44, Page(s) e17753

Abstract: ... to treat stable angina pectoris as an alternative therapy. Taoren Honghua Jian granule (THJG) is ...

Abstract	Introduction: Stable coronary artery disease (SCAD) is a common clinical style in patients with coronary artery disease. Inflammation and immune injury in SCAD have been proven. Current interventions can relieve patients' symptoms, but none are stable to improve the immune damage significantly. Chinese herb is used to treat stable angina pectoris as an alternative therapy. Taoren Honghua Jian granule (THJG) is a classical formula from which patients can benefit, but lack convincing evidence. Therefore, we report a protocol of high-quality randomized controlled trial. Methods/design: We will conduct a randomized, double-blind, placebo-controlled clinical trial to assess the effect of THJG in relief of symptoms and blood immune indexes. A total of 80 patients with SCAD will be enrolled, and treated with THJG or placebo for 4 weeks. The primary outcome measurement is change of integral traditional Chinese medicine (TCM) syndrome score from baseline to 4 weeks' treatment. The 2nd outcome measurements include change of integral TCM syndrome scores from baseline to 2 weeks' treatment and another 4 weeks' follow-up, inflammation indexes at baseline and 4 weeks' treatment. It also includes Seattle Angina Questionnaire, major adverse cardiovascular events, Athens Insomnia scale, and 36-item short form health survey score from baseline to 2 weeks' and 4 weeks' treatment, and another 4 weeks' follow-up. Adverse events will be evaluated throughout the trial. Discussion: The results of this trial will prove whether THJG could alleviate symptoms, control inflammation, and improve quality of life in patients with SCAD. Trial registration: ChiCTR1900021772, registered 8 March, 2019.
MeSH term(s)	Adolescent ; Adult ; Aged ; Coronary Artery Disease/drug therapy ; Double-Blind Method ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Male ; Medicine, Chinese Traditional/methods ; Middle Aged ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Young Adult
Chemical Substances	Drugs, Chinese Herbal ; taoren-honghua
Language	English
Publishing date	2019-11-18
Publishing country	United States
Document type	Clinical Trial Protocol ; Journal Article ; Multicenter Study
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000017753
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Article: Effects of Angelica sinensis extracts on lipid oxidation in fish feeds and growth performance of juvenile Jian carp (Cyprinus carpio var. Jian)

Li, Huatao / Yang, Dandan / Li, Zhihao / He, Mingquan / Li, Fengyi / Jiang, Jun / Tang, Siyi / Peng, Peiyuan / Du, Wenhao / Ma, Yuting / Liu, Ying

Chinese Association of Animal Science and Veterinary Medicine Animal nutrition. 2018 June 12,

2018

Abstract: ... Cyprinus carpio var. Jian). Firstly, fish feeds were respectively added with EQ, and ethyl ether extract ... as a natural antioxidant in feeds for Jian carp. ...

Abstract	The study was to explore the effect of the extracts of Angelica sinensis (EAs) on lipid oxidation in fish feeds compared with ethoxyquin (EQ) and the effect of dietary EAs on growth performance of carp (Cyprinus carpio var. Jian). Firstly, fish feeds were respectively added with EQ, and ethyl ether extract, ethyl acetate extract (EAE), acetone extract, ethanol extract (EE) and aqueous extract (AQE) of Angelica sinensis, except for the control. The results showed that EAs and EQ inhibited lipid oxidation in fish feeds (P < 0.05). Of all of the examined EAs, EAE showed the strongest protective effects against lipid oxidation (P < 0.05). Moreover, EAE at high concentrations showed a stronger effect on lipid oxidation compared with EQ (P < 0.05). Then, 7 experimental diets respectively supplemented with 0.0, 1.0, 2.0, 3.0, 4.0, 5.0 and 6.0 g/kg of EAE were fed to the respective treatment groups for 30 d. Four replicates were performed for each treatment group; 20 carp (mean weight: 12.10 ± 0.13 g) were in each replicate. The results indicated that dietary EAE improved the growth performance in carp (P < 0.05). The appropriate concentration of EAE for carp growth was estimated to be 3.643 g/kg diet. Thus, EAE could be used as a natural antioxidant in feeds for Jian carp.
Keywords	Angelica sinensis ; Cyprinus carpio ; acetone ; animal nutrition ; antioxidants ; carp ; ethanol ; ethoxyquin ; ethyl acetate ; ethyl ether ; experimental diets ; fish feeds ; growth performance ; juveniles ; lipid peroxidation ; protective effect
Language	English
Dates of publication	2018-0612
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	2834745-6
ISSN	2405-6545
ISSN	2405-6545
DOI	10.1016/j.aninu.2018.06.004
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Article ; Online: Effects of curcumin on antioxidative activities and cytokine production in Jian carp (Cyprinus carpio var. Jian) with CCl4-induced liver damage.

Cao, Liping / Ding, Weidong / Du, Jingliang / Jia, Rui / Liu, Yingjuan / Zhao, Caiyuan / Shen, Yujin / Yin, Guojun

Fish & shellfish immunology

2015 Volume 43, Issue 1, Page(s) 150–157

Abstract: We investigated the protective effects of curcumin on liver-damaged Cyprinus carpio var. Jian (Jian ... that curcumin reduces CCl(4)-induced liver damage in Jian carp by upregulating antioxidative activities and ...

Abstract	We investigated the protective effects of curcumin on liver-damaged Cyprinus carpio var. Jian (Jian carp). The carp were fed 0.1%, 0.5%, or 1.0% curcumin for 60 days, then injected intraperitoneally with 30% carbon tetrachloride solution. Liver and blood samples were collected to measure the liver index, serum- and liver-associated enzymes, liver histology, nuclear factor-κB (NF-κB)/c-Rel, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and IL-12 mRNA expression, and the level of NF-κB/c-Rel protein in the liver, and for a comet assay. We found that 0.5% and 1.0% curcumin significantly reduced the CCl(4)-induced increase in the liver index. The comet assay showed that the tail moment, olive tail moment, tail length, and tail DNA% improved in fish pretreated with 0.5 or 1.0% curcumin. CCl(4)-induced histological changes, including extensive hepatocyte degeneration, indistinct cell borders, nuclear condensation, and karyolysis were clearly reduced after treatment with 0.5% and 1.0% curcumin. Moreover, 0.5% and 1.0% curcumin significantly inhibited the CCl(4)-induced increase in serum glutamic oxaloacetic transaminase and promoted the restoration of superoxide dismutase in the liver; 1.0% curcumin significantly reduced serum glutamic pyruvic transaminase and lactate dehydrogenase and hepatic malondialdehyde, but significantly increased the total antioxidant capacity and glutathione levels in the liver. The CCl(4)-induced upregulation of NF-κB/c-Rel, IL-1β, and TNF-α mRNAs and NF-κB/c-Rel protein levels was inhibited by 0.5% and 1.0% curcumin, and IL-12 mRNA was reduced by all three doses of curcumin. The effects of curcumin on the liver index, enzymes, histological changes, and cytokines were dose-dependent. Our results indicate that curcumin reduces CCl(4)-induced liver damage in Jian carp by upregulating antioxidative activities and inhibiting NF-κB, IL-1β, TNF-α, and IL-12 expression.
MeSH term(s)	Animals ; Carbon Tetrachloride/toxicity ; Carps/genetics ; Carps/metabolism ; Curcumin/pharmacology ; Cytokines/genetics ; Cytokines/metabolism ; Fish Proteins/genetics ; Fish Proteins/metabolism ; Gene Expression Regulation/drug effects ; Liver/drug effects ; Liver/enzymology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Cytokines ; Fish Proteins ; RNA, Messenger ; Tumor Necrosis Factor-alpha ; Carbon Tetrachloride (CL2T97X0V0) ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2015-03
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2014.12.025
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Article ; Online: A Study of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induced Liver Injury in Jian Carp (Cyprinus carpio var. Jian) Using Precision-Cut Liver Slices.

Du, Jin-Liang / Cao, Li-Ping / Liu, Ying-Juan / Jia, Rui / Yin, Guo-Jun

Bulletin of environmental contamination and toxicology

2016 Volume 96, Issue 1, Page(s) 55–61

Abstract: ... tetrachlorodibenzo-p-dioxin (TCDD) in Jian carp using precision-cut liver slices (PCLS). PCLS were treated with TCDD ... and oxidative stress in Jian carp. These results also support the use of PCLS as an in vitro model ... for the evaluation of hepatotoxicity in Jian carp. ...

Abstract	The aim of this study was to establish a model for the study of liver injury induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Jian carp using precision-cut liver slices (PCLS). PCLS were treated with TCDD at concentrations of 0, 0.05, 0.1, 0.3, and 0.6 μg/L for 6 h, followed by collection of the culture supernatant and PCLS for analysis. Several biochemical indices were analyzed, including glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT), lactate dehydrogenase (LDH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA). Expression of mRNA was also estimated for cytochrome P4501A (CYP1A), aryl hydrocarbon receptor2 (AhR2), and aryl hydrocarbon receptor nuclear translocator2 (ARNT2). Results showed that some significant effects (p < 0.05) in MDA, GSH-Px and PCLS viability were observed at a TCDD concentration as low as 0.05 µg/L, and the observed effects increased with exposure concentration. Following exposure to TCDD for 6 h at a concentration of 0.3 μg/L, significant increases (p < 0.01) in the content of GPT, GOT, MDA, and LDH were observed, while SOD activity, GSH-Px activity, and PCLS viability were decreased (p < 0.01 or p < 0.05). Exposure to 0.3 μg/L TCDD also resulted in increased expression of mRNA for CYP1A, AhR2, and ARNT2. Overall, these results provide evidence of TCDD-induced liver injury and oxidative stress in Jian carp. These results also support the use of PCLS as an in vitro model for the evaluation of hepatotoxicity in Jian carp.
MeSH term(s)	Animals ; Carps/metabolism ; Glutathione Peroxidase/metabolism ; In Vitro Techniques/methods ; Liver/drug effects ; Liver/metabolism ; Malondialdehyde/metabolism ; Oxidation-Reduction ; Oxidative Stress/drug effects ; Polychlorinated Dibenzodioxins/toxicity ; RNA, Messenger/metabolism ; Receptors, Aryl Hydrocarbon/metabolism ; Superoxide Dismutase/metabolism
Chemical Substances	Polychlorinated Dibenzodioxins ; RNA, Messenger ; Receptors, Aryl Hydrocarbon ; Malondialdehyde (4Y8F71G49Q) ; Glutathione Peroxidase (EC 1.11.1.9) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	6895-0
ISSN	1432-0800 ; 0007-4861
ISSN (online)	1432-0800
ISSN	0007-4861
DOI	10.1007/s00128-015-1683-5
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Book ; Audio / Video: Da shi jian

Du, Qifeng

Breaking news

2004

Author's details	[Regie: Du Qifeng]
Language	Chinese
Size	1 DVD (Region 1-8), 89 Min
Publishing place	Hongkong
Document type	Book ; Audio / Video
Note	Audiosprachen: Chinesisch, Kantonesisch ; Untertitel: Chinesisch (Lang- und Kurzzeichen), Englisch
Database	Former special subject collection: coastal and deep sea fishing

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