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Article ; Online: On "Recommendations for Hospital-Based Physical Therapists Managing Patients with COVID-19." Felten-Barentsz K, Van Oorsouw R, Klooster E, et al. Phys Ther. 2020;100:1444-1457. https://doi.org/10.1093/ptj/pzaa114.

Felten-Barentsz, Karin M / Sommers, Juultje / van Oorsouw, Roel / Klooster, Emily / Koenders, Niek / van Heusden-Scholtalbers, Linda / Ormel, Harm L / Werkman, Maarten S / Hulzebos, Erik H J / van der Wees, Philip J / van der Schaaf, Marike / Hoogeboom, Thomas J

Physical therapy

2023 Volume 103, Issue 6

MeSH term(s)	Humans ; Physical Therapists ; COVID-19 ; Patients
Language	English
Publishing date	2023-06-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	415886-6
ISSN	1538-6724 ; 0031-9023
ISSN (online)	1538-6724
ISSN	0031-9023
DOI	10.1093/ptj/pzad037
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Environmental pathways affecting gene expression (E.PAGE) as an R package to predict gene-environment associations.

Muralidharan, Sachin / Ali, Sarah / Yang, Lilin / Badshah, Joshua / Zahir, Syeda Farah / Ali, Rubbiya A / Chandra, Janin / Frazer, Ian H / Thomas, Ranjeny / Mehdi, Ahmed M

Scientific reports

2022 Volume 12, Issue 1, Page(s) 18710

Abstract: The purpose of this study is to manually and semi-automatically curate a database and develop an R ... the genes. The curated database and enrichment tool are available as R packages at https://github.com ... AhmedMehdiLab/E.PATH and https://github.com/AhmedMehdiLab/E.PAGE respectively. ...

Abstract	The purpose of this study is to manually and semi-automatically curate a database and develop an R package that will act as a comprehensive resource to understand how biological processes are dysregulated due to interactions with environmental factors. The initial database search run on the Gene Expression Omnibus and the Molecular Signature Database retrieved a total of 90,018 articles. After title and abstract screening against pre-set criteria, a total of 237 datasets were selected and 522 gene modules were manually annotated. We then curated a database containing four environmental factors, cigarette smoking, diet, infections and toxic chemicals, along with a total of 25,789 genes that had an association with one or more of gene modules. The database and statistical analysis package was then tested with the differentially expressed genes obtained from the published literature related to type 1 diabetes, rheumatoid arthritis, small cell lung cancer, COVID-19, cobalt exposure and smoking. On testing, we uncovered statistically enriched biological processes, which revealed pathways associated with environmental factors and the genes. The curated database and enrichment tool are available as R packages at https://github.com/AhmedMehdiLab/E.PATH and https://github.com/AhmedMehdiLab/E.PAGE respectively.
MeSH term(s)	Humans ; Gene Expression Profiling ; COVID-19 ; Gene Regulatory Networks ; Databases, Factual ; Gene Expression
Language	English
Publishing date	2022-11-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-21988-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Increased use of cross-sectional imaging for follow-up does not improve post-recurrence survival of surgically treated initially localized R.C.C.: results from a European multicenter database (R.E.C.U.R.).

Dabestani, Saeed / Beisland, Christian / Stewart, Grant D / Bensalah, Karim / Gudmundsson, Eirikur / Lam, Thomas B / Gietzmann, William / Zakikhani, Paimaun / Marconi, Lorenzo / Fernandéz-Pello, Sergio / Monagas, Serenella / Williams, Samuel P / Powles, Thomas / Van Werkhoven, Erik / Meijer, Richard / Volpe, Alessandro / Staehler, Michael / Ljungberg, Börje / Bex, Axel

Scandinavian journal of urology

2019 Volume 53, Issue 1, Page(s) 14–20

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Aged ; Carcinoma, Renal Cell/diagnostic imaging ; Carcinoma, Renal Cell/mortality ; Carcinoma, Renal Cell/surgery ; Databases, Factual ; Diagnostic Imaging/methods ; Europe ; Female ; Follow-Up Studies ; Humans ; Kidney Neoplasms/diagnostic imaging ; Kidney Neoplasms/mortality ; Kidney Neoplasms/surgery ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/mortality ; Prognosis ; Retrospective Studies ; Risk Factors ; Survival Rate
Language	English
Publishing date	2019-03-25
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2701936-6
ISSN	2168-1813 ; 2168-1805
ISSN (online)	2168-1813
ISSN	2168-1805
DOI	10.1080/21681805.2019.1588919
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Article ; Online: Environmental pathways affecting gene expression (E.PAGE) as an R package to predict gene–environment associations

Sachin Muralidharan / Sarah Ali / Lilin Yang / Joshua Badshah / Syeda Farah Zahir / Rubbiya A. Ali / Janin Chandra / Ian H. Frazer / Ranjeny Thomas / Ahmed M. Mehdi

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 19

Abstract: ... develop an R package that will act as a comprehensive resource to understand how biological processes are ... the genes. The curated database and enrichment tool are available as R packages at https://github.com ... AhmedMehdiLab/E.PATH and https://github.com/AhmedMehdiLab/E.PAGE respectively. ...

Abstract	Abstract The purpose of this study is to manually and semi-automatically curate a database and develop an R package that will act as a comprehensive resource to understand how biological processes are dysregulated due to interactions with environmental factors. The initial database search run on the Gene Expression Omnibus and the Molecular Signature Database retrieved a total of 90,018 articles. After title and abstract screening against pre-set criteria, a total of 237 datasets were selected and 522 gene modules were manually annotated. We then curated a database containing four environmental factors, cigarette smoking, diet, infections and toxic chemicals, along with a total of 25,789 genes that had an association with one or more of gene modules. The database and statistical analysis package was then tested with the differentially expressed genes obtained from the published literature related to type 1 diabetes, rheumatoid arthritis, small cell lung cancer, COVID-19, cobalt exposure and smoking. On testing, we uncovered statistically enriched biological processes, which revealed pathways associated with environmental factors and the genes. The curated database and enrichment tool are available as R packages at https://github.com/AhmedMehdiLab/E.PATH and https://github.com/AhmedMehdiLab/E.PAGE respectively.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Schlüssellochrettung aus dem PKW (S.IE.G.E.R-Konzept) – Schritt für Schritt

Tiesmeier, Jens / Südmersen, Rolf / Bachmann-Mennenga, Bernd / Jakob, Thomas

retten!

2019 Volume 8, Issue 02, Page(s) 140–145

Language	German
Publishing date	2019-04-01
Publisher	© Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	2193-2395 ; 2193-2387
ISSN (online)	2193-2395
ISSN	2193-2387
DOI	10.1055/a-0631-4084
Database	Thieme publisher's database

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Article ; Online: Erratum: Polarization of active Janus particles [Phys. Rev. E 89, 050303(R) (2014)].

Bickel, Thomas / Zecua, Guillermo / Würger, Alois

Physical review. E

2018 Volume 97, Issue 4-2, Page(s) 49901

Abstract: This corrects the article DOI: 10.1103/PhysRevE.89.050303. ...

Abstract	This corrects the article DOI: 10.1103/PhysRevE.89.050303.
Language	English
Publishing date	2018-05-14
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.97.049901
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Usefulness of R.E.N.A.L. nephrometry scoring system for predicting outcomes and complications of percutaneous ablation of 751 renal tumors.

Schmit, Grant D / Thompson, R Houston / Kurup, Anil N / Weisbrod, Adam J / Boorjian, Stephen A / Carter, Rickey E / Geske, Jennifer R / Callstrom, Matthew R / Atwell, Thomas D

The Journal of urology

2013 Volume 189, Issue 1, Page(s) 30–35

Abstract: Purpose: We applied the R.E.N.A.L. (radius, exophytic/endophytic, nearness to collecting system or ... ablation. R.E.N.A.L. tumor scores were analyzed to determine the association of the score with ablation ... treatment outcomes and complications according to Clavien criteria.: Results: The mean ± SD R.E.N.A.L. nephrometry ...

Abstract	Purpose: We applied the R.E.N.A.L. (radius, exophytic/endophytic, nearness to collecting system or sinus, anterior/posterior and location relative to polar lines) nephrometry scoring system to renal tumors treated with percutaneous ablation to determine whether this score is associated with oncological outcomes and complications. Materials and methods: A total of 751 renal tumors were treated at 679 percutaneous ablation sessions in 627 patients at our institution between 2000 and 2012. Of these renal masses 430 (57%) were treated with cryoablation and the remaining 321 were treated with radio frequency ablation. R.E.N.A.L. tumor scores were analyzed to determine the association of the score with ablation treatment outcomes and complications according to Clavien criteria. Results: The mean ± SD R.E.N.A.L. nephrometry score of all ablated tumors was 6.7 ± 1.9. Those treated with cryoablation had higher scores than those treated with radio frequency ablation (mean 7.2 ± 1.9 vs 6.1 ± 1.8, p <0.001). We identified a total of 28 local treatment failures (3.7%) in the 751 tumors during a mean computerized tomography/magnetic resonance imaging followup of 27.9 ± 27.8 months. There was a significant association between R.E.N.A.L. nephrometry score and local treatment failure. Mean nephrometry score was 7.6 ± 2.2 vs 6.7 ± 1.9 for tumors with vs without local treatment failure (p <0.001). Of the 679 ablation treatments 38 (5.6%) major (grade 3 or greater) patient complications occurred. There was a significant association between R.E.N.A.L. nephrometry score and major complications. Patients with vs without a major complication had a mean nephrometry score of 8.1 ± 2.0 vs 6.8 ± 1.9 (p <0.001). Conclusions: The R.E.N.A.L. nephrometry scoring system predicts treatment efficacy and complications following percutaneous renal ablation.
MeSH term(s)	Aged ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/surgery ; Catheter Ablation/adverse effects ; Female ; Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Male ; Nephrectomy/adverse effects ; Nephrectomy/methods ; Prognosis ; Retrospective Studies
Language	English
Publishing date	2013-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2012.08.180
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Article ; Online: Reply to Mekary, R.A.; Ding, E.L. Isotemporal Substitution as the Gold Standard Model for Physical Activity Epidemiology

Gregory J. H. Biddle / Charlotte L. Edwardson / Joseph Henson / Alex V. Rowlands / Thomas Yates

International Journal of Environmental Research and Public Health, Vol 16, Iss 16, p

Why It Is the Most Appropriate for Activity Time Research. Int. J. Environ. Res. Public Health 2019, 16 , 797

2019 Volume 2885

Abstract: Firstly, we would like to thank the authors for taking the time to review and comment on our paper [.] ...

Abstract	Firstly, we would like to thank the authors for taking the time to review and comment on our paper [.]
Keywords	n/a ; Medicine ; R
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development and blind clinical validation of a microRNA based predictor of response to treatment with R-CHO(E)P in DLBCL.

Knudsen, Steen / Hother, Christoffer / Grønbæk, Kirsten / Jensen, Thomas / Hansen, Anker / Mazin, Wiktor / Dahlgaard, Jesper / Møller, Michael Boe / Ralfkiær, Elizabeth / Brown, Peter de Nully

PloS one

2015 Volume 10, Issue 2, Page(s) e0115538

Abstract: ... with diffuse large B-cell lymphoma (DLBCL) treated with the drug combination R-CHOP. Based on the measured ... validated in a cohort of 116 de novo DLBCL patients treated with R-CHOP or R-CHOEP as first line treatment ...

Abstract	MicroRNAs (miRNA) are a group of short noncoding RNAs that regulate gene expression at the posttranscriptional level. It has been shown that microRNAs are independent predictors of outcome in patients with diffuse large B-cell lymphoma (DLBCL) treated with the drug combination R-CHOP. Based on the measured growth inhibition of 60 human cancer cell lines (NCI60) in the presence of doxorubicine, cyclophosphamide, vincristine and etoposide as well as the baseline microRNA expression of the 60 cell lines, a microRNA based response predictor to CHOP was developed. The response predictor consisting of 20 microRNAs was blindly validated in a cohort of 116 de novo DLBCL patients treated with R-CHOP or R-CHOEP as first line treatment. The predicted sensitivity based on diagnostic FFPE samples matched the clinical response, with decreasing sensitivity in poor responders (P = 0.03). When the International Prognostic Index (IPI) was included in the prediction analysis, the separation between responders and non-responders improved (P = 0.001). Thirteen patients developed relapse, and five patients predicted sensitive to their second and third line treatment survived a median 1194 days, while eight patients predicted not sensitive to their second and third line treatment survived a median 187 days (90% CI: 485 days versus 227 days). Among the latter group it was predicted that four would have been sensitive to another second line treatment than the one they received. The predictions were almost the same when diagnostic biopsies were used as when relapse biopsies were used. These preliminary findings warrant testing in a larger cohort of relapse patients to confirm whether the miRNA based predictor can select the optimal second line treatment and increase survival.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Murine-Derived ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biopsy ; Cyclophosphamide ; Doxorubicin ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/mortality ; Lymphoma, Large B-Cell, Diffuse/pathology ; Male ; MicroRNAs/genetics ; Middle Aged ; Prednisone ; Prognosis ; ROC Curve ; Recurrence ; Reproducibility of Results ; Treatment Outcome ; Vincristine ; Young Adult
Chemical Substances	Antibodies, Monoclonal, Murine-Derived ; MicroRNAs ; R-CHOP protocol ; Vincristine (5J49Q6B70F) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0115538
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Supersilyltrielane R nEHal3-n (E = Triel, R = SitBu3): Synthesen, Charakterisierung, Reaktionen, Strukturen [1] / Supersilyltrielanes R nEHal3-n (E = Triel, R = SitBu3): Syntheses, Characterization, Reactions, Structures [1]

Wiberg, Nils / Kerstin Amelunxen / Thomas Blank / Hans-Wolfram Lerner / Kurt Polborn / Heinrich Nöth / Ralf Littger / Manfred Rackl / Martin Schmidt-Amelunxen / Holger Schwenk-Kircher / Markus Warchold

Zeitschrift für Naturforschung. 2014 June 2, v. 56, no. 7

2014

Abstract: Water- and oxygen-sensitive compounds R*EHal₂•D, R*EHal₂ and R*₂EHal (R* = SitBu₃; E = B, Al, Ga ... by reaction of R*₂E-ER*₂ (E = Al, In) with I₂, H₂, AgF₂ or HBr. Thermal decomposition of the compounds ... ₄E₂ (E = AI, In, Tl), R*₃E₂• (E = AI, Ga), R*₄E₃• (E = Al, Ga), R*₄E₄ (E = AI, Ga), R*₆Ga₈, R*₈In₁₂ ...

Abstract	Water- and oxygen-sensitive compounds REHal₂•D, REHal₂ and R₂EHal (R = SitBu₃; E = B, Al, Ga, In, TI; Hal = F, Cl, Br, I; D = OR₂, NR₃) have been synthesized by reaction of EHal₃ with NaR* in the absence or presence of donors as well as by substitution of D, Hal or R* by other substituents, or by reaction of R₂E-ER₂ (E = Al, In) with I₂, H₂, AgF₂ or HBr. Thermal decomposition of the compounds in solution or in the gas phase leads to elimination of D from REHal₂•D, or of RHal from REHal₂ and R₂EHal, respectively. The dihalides REHal₂ act as Lewis acids with respect to donors OR₂ or NR₃ (formation of adducts REHal₂•D), the monohalides R₂EHal as Lewis bases with respect to acceptors EHal₃ (formation of R₂E⁺ EHal₄⁻). Dehalogenations of R₂EHal and REHal₂ with alkali metals or NaR* leads to compounds R₄E₂ (E = AI, In, Tl), R₃E₂• (E = AI, Ga), R₄E₃• (E = Al, Ga), R₄E₄ (E = AI, Ga), R₆Ga₈, R₈In₁₂, (R₂B⁻), R₂A⁻ , R₃Ga₂⁻, R₄Ga₃⁻, R₄Ga₄²⁻, R₄Tl₃Cl, or R₆Tl₆Cl₂. The structures of RBBr₂•Py, RAlBr₂•NEtMe₂, (RAlClOBu)₂, R₂BF as well as R₂ECl (E = B, Al, Ga, Tl) have been determined by X-ray structure analyses.
Keywords	Lewis acids ; Lewis bases ; X-radiation ; alkali metals ; aluminum ; boron ; bromine ; fluorine ; gases ; hydrobromic acid ; hydrogen ; iodine ; thermal degradation
Language	English
Dates of publication	2014-0602
Size	p. 634-651.
Publishing place	Verlag der Zeitschrift für Naturforschung
Document type	Article
ZDB-ID	124635-5
ISSN	0340-5087 ; 0044-3174 ; 0932-0776 ; 0341-0447 ; 0341-0420
ISSN	0340-5087 ; 0044-3174 ; 0932-0776 ; 0341-0447 ; 0341-0420
DOI	10.1515/znb-2001-0712
Database	NAL-Catalogue (AGRICOLA)

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