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  1. Article ; Online: A Systematic Review and Revised Meta-analysis of the Effort-Reward Imbalance Model of Workplace Stress and Hypothalamic-Pituitary-Adrenal Axis Measures of Stress.

    Eddy, Pennie / Wertheim, Eleanor H / Hale, Matthew W / Wright, Bradley J

    Psychosomatic medicine

    2023  Volume 85, Issue 5, Page(s) 450–460

    Abstract: ... with increased HPA axis activity (r = 0.05, p = .02, k = 14, n = 2461). The cortisol waking concentrations (r = 0 ... considered collectively, OC was not associated with greater HPA axis activity (r = 0.01, p = .70, k = 10, n ... 1684), with only cortisol (pm) associated with OC (r = -0.24, p = .02, k = 2, n = 95).: Conclusions ...

    Abstract Objective: Despite considerable research in the past 20 years into associations between the effort-reward imbalance (ERI) model and various health outcomes, the mechanisms responsible for the association remain unclear. Our meta-analysis assessed the associations of ERI and overcommitment (OC) in the workplace with measures from the hypothalamic-pituitary-adrenal (HPA) axis.
    Methods: Electronic databases were searched with the phrase "effort * reward * imbalance," which yielded 319 studies leading to 56 full-text studies being screened. Thirty-two studies within 14 articles met the inclusion criteria and were meta-analyzed using mixed- and random-effects models.
    Results: Greater ERI was associated with increased HPA axis activity (r = 0.05, p = .02, k = 14, n = 2461). The cortisol waking concentrations (r = 0.11, p = .02, k = 6, n = 493) were the only subgroup associated with ERI. Meta-regression revealed that studies that contained more men had stronger ERI to HPA marker associations. When all HPA markers were considered collectively, OC was not associated with greater HPA axis activity (r = 0.01, p = .70, k = 10, n = 1684), with only cortisol (pm) associated with OC (r = -0.24, p = .02, k = 2, n = 95).
    Conclusions: ERI and OC were associated with HPA responsivity. Although the cortisol waking concentrations and not the CAR were associated with ERI, this may be due to heterogeneity in the experience of stress between studies. Future studies should consider the concurrent assessment of burnout to better assist the interpretation of ERI with HPA responsivity.
    MeSH term(s) Humans ; Male ; Hydrocortisone ; Hypothalamo-Hypophyseal System ; Occupational Stress ; Pituitary-Adrenal System ; Reward ; Stress, Psychological ; Surveys and Questionnaires ; Female
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Systematic Review ; Meta-Analysis ; Journal Article
    ZDB-ID 3469-1
    ISSN 1534-7796 ; 0033-3174
    ISSN (online) 1534-7796
    ISSN 0033-3174
    DOI 10.1097/PSY.0000000000001155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: High prevalence of occult hepatitis B among immigrant students in Canada: A case for universal immunization of young adults.

    Pennie, R A / Kang, C Y

    The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses

    2012  Volume 4, Issue 2, Page(s) 105–107

    Abstract: The prevalence and demographic characteristics of positive hepatitis B (HBV) serology were determined among post secondary health care students in Ottawa. Ontario. HBV seropositivity was defined as the presence of HBV surface antigen (HBsAg) or ... ...

    Abstract The prevalence and demographic characteristics of positive hepatitis B (HBV) serology were determined among post secondary health care students in Ottawa. Ontario. HBV seropositivity was defined as the presence of HBV surface antigen (HBsAg) or antibodies to HBV core or surface antigens by radioimmunoassay. HBsAg-positive students were advised to visit their family doctors; the health measures that resulted were observed. Among 600 students born in North America, the proportion of HBV seropositive and HBsAg-positive were 0.8 and 0.2%, respectively. Among the 63 students born outside Europe or North America. 22.2% were HBV seropositive (odds ratio 29.7. confidence interval 10.1 to 97.5) and 7.9% were HBsAg-positive (odds ratio 54.2, confidence interval 5.9 to 2568.3). Of the seven HBsAg-positive students, none had known their HBV status - five visited their doctors, two of whom sought and immunized susceptible household contacts. This survey supports the view that many sexually active young adults integrating into Canadian society from immigrant families are unknowingly HBsAg-positive, and when their HBV status is identified to them and their doctors, appropriate measures for the protection of close contacts are often overlooked. Physician education about the management of HBV carriers should be improved and consideration given to the universal HBV immunization of young adults.
    Language English
    Publishing date 2012-02-17
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1057056-1
    ISSN 1180-2332 ; 1712-9532
    ISSN 1180-2332 ; 1712-9532
    DOI 10.1155/1993/719693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diagnostic yield and concordance of image-guided biopsy in musculoskeletal lesions.

    Wong, Hayley / Tarr, Gregory P / Anand, Rahul / Atkinson, Nicola / Flint, Michael / Clarke, Andrew / Symmans, Pennie / Doyle, Anthony

    Skeletal radiology

    2023  Volume 53, Issue 1, Page(s) 75–84

    Abstract: Objective: Image-guided biopsy is well-established in the diagnosis of musculoskeletal lesions. While several studies have demonstrated a high diagnostic yield in image-guided biopsy, there are no current guidelines around procedural factors such as ... ...

    Abstract Objective: Image-guided biopsy is well-established in the diagnosis of musculoskeletal lesions. While several studies have demonstrated a high diagnostic yield in image-guided biopsy, there are no current guidelines around procedural factors such as number of cores. Furthermore, there have been mixed results regarding which lesions are more favourable to a diagnostic biopsy. We wanted to evaluate diagnostic yield and concordance for image-guided biopsies for musculoskeletal lesions. The null hypothesis was that there are no controllable factors that contribute to positive yield.
    Materials and methods: Retrospective review of consecutive patients who underwent image-guided biopsy at a large teaching hospital for musculoskeletal lesions discussed at the sarcoma multi-disciplinary meeting. The formal biopsy histology report was evaluated, and biopsies were considered diagnostic or non-diagnostic. In those that had subsequent surgery (by wide excision or open biopsy), final and initial histology was compared and biopsies were considered concordant or not. Overall diagnostic yield and concordance were calculated. Statistical analysis was performed with Stata 13.0 (StataCorp).
    Results: Over the 14-year period, 429 biopsies were included. Diagnostic yield was 85% and concordance was 100%. No cases of malignant lesions were initially called benign on biopsy. One biopsy had a complication (0.2%). Factors associated with higher diagnostic yield included soft tissue versus bone lesions, three or more cores and longer total specimen length. Factors that were not associated included core size, use of FNA cytology, gender, age, benign versus malignant, anatomic location and lesion appearance.
    Conclusion: The null hypothesis is rejected. The main predictor of diagnostic biopsy was total specimen length, independent of number of cores taken. Three or more cores and longer cores are optimal, though these factors are influenced by lesion biology and not always able to be controlled.
    MeSH term(s) Humans ; Image-Guided Biopsy ; Academic Medical Centers ; Bone Diseases ; Cartilage Diseases ; Sarcoma
    Language English
    Publishing date 2023-06-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-023-04363-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Identifying potential high-risk zones for land-derived plastic litter to marine megafauna and key habitats within the North Atlantic.

    Garrard, Samantha L / Clark, James R / Martin, Nicola / Nelms, Sarah E / Botterell, Zara L R / Cole, Matthew / Coppock, Rachel L / Galloway, Tamara S / Green, Dannielle S / Jones, Megan / Lindeque, Pennie K / Tillin, Heidi M / Beaumont, Nicola J

    The Science of the total environment

    2024  Volume 922, Page(s) 171282

    Abstract: The pervasive use of plastic in modern society has led to plastic litter becoming ubiquitous within the ocean. Land-based sources of plastic litter are thought to account for the majority of plastic pollution in the marine environment, with plastic bags, ...

    Abstract The pervasive use of plastic in modern society has led to plastic litter becoming ubiquitous within the ocean. Land-based sources of plastic litter are thought to account for the majority of plastic pollution in the marine environment, with plastic bags, bottles, wrappers, food containers and cutlery among the most common items found. In the marine environment, plastic is a transboundary pollutant, with the potential to cause damage far beyond the political borders from where it originated, making the management of this global pollutant particularly complex. In this study, the risks of land-derived plastic litter (LDPL) to major groups of marine megafauna - seabirds, cetaceans, pinnipeds, elasmobranchs, turtles, sirenians, tuna and billfish - and a selection of productive and biodiverse biogenic habitats - coral reefs, mangroves, seagrass, saltmarsh and kelp beds - were analysed using a Spatial Risk Assessment approach. The approach combines metrics for vulnerability (mechanism of harm for megafauna group or habitat), hazard (plastic abundance) and exposure (distribution of group or habitat). Several potential high-risk zones (HRZs) across the North Atlantic were highlighted, including the Azores, the UK, the French and US Atlantic coasts, and the US Gulf of Mexico. Whilst much of the modelled LDPL driving risk in the UK originated from domestic sources, in other HRZs, such as the Azores archipelago and the US Gulf of Mexico, plastic originated almost exclusively from external (non-domestic) sources. LDPL from Caribbean islands - some of the largest generators of marine plastic pollution in the dataset of river plastic emissions used in the study - was noted as a significant input to HRZs across both sides of the Atlantic. These findings highlight the potential of Spatial Risk Assessment analyses to determine the location of HRZs and understand where plastic debris monitoring and management should be prioritised, enabling more efficient deployment of interventions and mitigation measures.
    MeSH term(s) Environmental Monitoring ; Plastics ; Ecosystem ; Environmental Pollution ; Environmental Pollutants ; Waste Products/analysis
    Chemical Substances Plastics ; Environmental Pollutants ; Waste Products
    Language English
    Publishing date 2024-02-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Pneumococcal vaccine.

    Pennie, R A

    Canadian family physician Medecin de famille canadien

    1999  Volume 45, Page(s) 2271–2, 2275–7

    MeSH term(s) Aged ; Aged, 80 and over ; Canada ; Chronic Disease ; Family Practice ; Health Policy ; Humans ; Middle Aged ; Pneumonia, Pneumococcal/immunology ; Pneumonia, Pneumococcal/prevention & control ; Public Health ; Vaccination
    Language French
    Publishing date 1999-10
    Publishing country Canada
    Document type Comment ; Editorial
    ZDB-ID 603565-6
    ISSN 0008-350X
    ISSN 0008-350X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Prospective study of antibiotic prescribing for children.

    Pennie, R A

    Canadian family physician Medecin de famille canadien

    1998  Volume 44, Page(s) 1850–1856

    Abstract: Objectives: To observe the frequency with which children in outpatient primary care settings are prescribed antibiotics and to investigate why these antibiotics are prescribed. To compare the prescribing behaviour of family doctors, primary care ... ...

    Abstract Objectives: To observe the frequency with which children in outpatient primary care settings are prescribed antibiotics and to investigate why these antibiotics are prescribed. To compare the prescribing behaviour of family doctors, primary care pediatricians, and urgent care physicians and to determine where refinements in management are most needed to reduce the number of antibiotic prescriptions appropriately.
    Design: Prospective study using a data entry form with mostly closed-ended questions.
    Setting: Ten primary care offices in urban south-central and eastern Ontario: five family practices, three pediatric practices, and two urgent care centres (UCC).
    Participants: Every child younger than 16 years visiting these offices during a 3-week period in February and March 1997.
    Main outcome measures: Frequency, clinical indications, and nature of the antibiotics prescribed.
    Results: There were 4344 observed visits. Of 1706 antibiotic prescriptions, 1481 were for 10 days, and 1577 (92%) were for acute respiratory infections, 920 (53%) specifically for acute otitis media (AOM). Full courses of antibiotics were given immediately (i.e., without test results) to 321 (76%) of 425 children with pharyngitis. Antibiotics were prescribed for 145 (90%) of 163 children with bronchitis. Urgent care physicians were significantly more likely than pediatricians or family physicians to prescribe immediate antibiotics and to disregard guidelines when choosing antibiotics for uncomplicated AOM.
    Conclusions: Three diagnoses accounted for 82% of antibiotic prescriptions: AOM, pharyngitis, and bronchitis. Physicians should be more selective when deciding whether, and for how long, to prescribe antibiotics for those three common conditions. Substantial reductions in antibiotic use will require changes in how physicians manage suspected AOM, the most common indication for antibiotics.
    MeSH term(s) Acute Disease ; Adolescent ; Anti-Bacterial Agents/therapeutic use ; Child ; Child, Preschool ; Drug Prescriptions/statistics & numerical data ; Drug Utilization/statistics & numerical data ; Emergency Medicine/statistics & numerical data ; Family Practice/statistics & numerical data ; Guideline Adherence/statistics & numerical data ; Health Services Research ; Humans ; Infant ; Infant, Newborn ; Ontario ; Otitis Media/drug therapy ; Pediatrics/statistics & numerical data ; Practice Guidelines as Topic ; Practice Patterns, Physicians'/statistics & numerical data ; Prospective Studies ; Respiratory Tract Infections/drug therapy ; Surveys and Questionnaires
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 1998-09
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 603565-6
    ISSN 0008-350X
    ISSN 0008-350X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Mantoux tests. Performing, interpreting, and acting upon them.

    Pennie, R A

    Canadian family physician Medecin de famille canadien

    1995  Volume 41, Page(s) 1025–1029

    Abstract: Interpreting and acting upon results of the tuberculin skin test (Mantoux test) can be confusing because the test is inherently ambiguous and published recommendations for investigation and prevention of tuberculosis are complex. This article presents a ... ...

    Abstract Interpreting and acting upon results of the tuberculin skin test (Mantoux test) can be confusing because the test is inherently ambiguous and published recommendations for investigation and prevention of tuberculosis are complex. This article presents a step-by-step guide to enable family physicians to make effective use of the Mantoux test.
    MeSH term(s) Clinical Protocols ; Family Practice/methods ; Humans ; Isoniazid/therapeutic use ; Tuberculin Test/methods ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/drug therapy
    Chemical Substances Isoniazid (V83O1VOZ8L)
    Language English
    Publishing date 1995-06
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 603565-6
    ISSN 0008-350X
    ISSN 0008-350X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Trait Mindfulness Helps Explain the Relationships Between Job Stress, Physiological Reactivity, and Self-Perceived Health.

    Eddy, Pennie / Wertheim, Eleanor H / Hale, Matthew W / Wright, Bradley J

    Journal of occupational and environmental medicine

    2018  Volume 61, Issue 1, Page(s) e12–e18

    Abstract: ... stress as measured by the job-demands resources (JD-R) model, trait mindfulness, and indices ... of the physiological stress response.: Method: Dairy farmers (N = 79) completed job stress (using the JD-R model), trait mindfulness ...

    Abstract Objective: The aim of this study was to assess, for the first time, the associations among work stress as measured by the job-demands resources (JD-R) model, trait mindfulness, and indices of the physiological stress response.
    Method: Dairy farmers (N = 79) completed job stress (using the JD-R model), trait mindfulness, burnout, and self-reported health questionnaires and provided physiological indices of the stress response.
    Results: Our findings suggest that those reporting higher mindfulness have better physical and mental health, and that being more mindful may buffer the effects of a large cortisol awakening response on poor physical health.
    Conclusion: Although assessments of both psychological and physiological indicators of stress and ill-health will inform the underlying mechanisms of the associations between work stress and disease, assessing the role of trait mindfulness in this relationship may prove useful.
    MeSH term(s) Adult ; Aged ; Dairying ; Health Status ; Humans ; Male ; Mental Health ; Middle Aged ; Mindfulness/statistics & numerical data ; Occupational Stress/epidemiology ; Occupational Stress/physiopathology ; Occupational Stress/psychology ; Self-Assessment ; Surveys and Questionnaires
    Language English
    Publishing date 2018-11-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000001493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Associations between the effort-reward imbalance model of workplace stress and indices of cardiovascular health: A systematic review and meta-analysis.

    Eddy, Pennie / Wertheim, Eleanor H / Kingsley, Michael / Wright, Bradley J

    Neuroscience and biobehavioral reviews

    2017  Volume 83, Page(s) 252–266

    Abstract: ... criteria. Greater ERI was most associated with increased hypertension (r=0.26, p<0.001, N=1180), intima ... media thickness (r=0.23, p<.001, N=828) and fibrinogen (r=0.13, p=0.03, N=4315). Trait over-commitment ... was most associated with increased hypertension (r=0.24, p=0.02, N=899) and intima media thickness (r ...

    Abstract Work stress can increase the risk of cardiovascular disease by 50%, with increasing research focusing on the underlying mechanisms responsible for these associations. Our meta-analysis assessed the associations of the effort-reward imbalance (ERI) workplace stress model with indices of cardiovascular disease. The search term 'effort*reward*imbalance' produced 22 papers (129 associations, N=93,817) meeting inclusion criteria. Greater ERI was most associated with increased hypertension (r=0.26, p<0.001, N=1180), intima media thickness (r=0.23, p<.001, N=828) and fibrinogen (r=0.13, p=0.03, N=4315). Trait over-commitment was most associated with increased hypertension (r=0.24, p=0.02, N=899) and intima media thickness (r=0.19, p=0.02, N=828). Interventions aimed at reducing the impact of ERI and over-commitment on cardiovascular disease should consider concurrently assessing changes in physiological markers of cardiovascular disease.
    MeSH term(s) Blood Pressure/physiology ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Carotid Intima-Media Thickness/trends ; Fibrinogen/metabolism ; Heart Rate/physiology ; Humans ; Occupational Stress/complications ; Occupational Stress/epidemiology ; Occupational Stress/psychology ; Reward
    Chemical Substances Fibrinogen (9001-32-5)
    Language English
    Publishing date 2017-10-27
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2017.10.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Identifying critical features of type two diabetes prevention interventions

    Jillian C Ryan / Bonnie Wiggins / Sarah Edney / Grant D Brinkworth / Natalie D Luscombe-March / Kristin V Carson-Chahhoud / Pennie J Taylor / Annemien A Haveman-Nies / David N Cox

    PLoS ONE, Vol 16, Iss 8, p e

    A Delphi study with key stakeholders.

    2021  Volume 0255625

    Abstract: Aims This study aims to identify critically important features of digital type two diabetes mellitus (T2DM) prevention interventions. Methods A stakeholder mapping exercise was undertaken to identify key end-user and professional stakeholders, followed ... ...

    Abstract Aims This study aims to identify critically important features of digital type two diabetes mellitus (T2DM) prevention interventions. Methods A stakeholder mapping exercise was undertaken to identify key end-user and professional stakeholders, followed by a three-round Delphi procedure to generate and evaluate evidence statements related to the critical elements of digital T2DM prevention interventions in terms of product (intervention), price (funding models/financial cost), place (distribution/delivery channels), and promotion (target audiences). Results End-user (n = 38) and professional (n = 38) stakeholders including patients, dietitians, credentialed diabetes educators, nurses, medical doctors, research scientists, and exercise physiologists participated in the Delphi study. Fifty-two critical intervention characteristics were identified. Future interventions should address diet, physical activity, mental health (e.g. stress, diabetes-related distress), and functional health literacy, while advancing behaviour change support. Programs should be delivered digitally or used multiple delivery modes, target a range of population subgroups including children, and be based on collaborative efforts between national and local and government and non-government funded organisations. Conclusions Our findings highlight strong support for digital health to address T2DM in Australia and identify future directions for T2DM prevention interventions. The study also demonstrates the feasibility and value of stakeholder-led intervention development processes.
    Keywords Medicine ; R ; Science ; Q
    Subject code 360
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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