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Article ; Online: Advances of 3D printing technologies in orthopaedic trauma and surgical training: a transformative approach.

Neijhoft, Jonas / IJpma, Frank Fa

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2024 Volume 50, Issue 1, Page(s) 1–2

MeSH term(s)	Humans ; Orthopedics ; Printing, Three-Dimensional ; Orthopedic Procedures
Language	English
Publishing date	2024-02-14
Publishing country	Germany
Document type	Editorial
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-024-02464-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1221: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: The Impact of Defect Size on Bone Healing in Critical-Size Bone Defects Investigated on a Rat Femur Defect Model Comparing Two Treatment Methods.

Kammerer, Andreas / Hartmann, Frederik Alexander / Nau, Christoph / Leiblein, Maximilian / Schaible, Alexander / Neijhoft, Jonas / Henrich, Dirk / Verboket, René / Janko, Maren

Bioengineering (Basel, Switzerland)

2024 Volume 11, Issue 3

Abstract: Critical-size bone defects up to 25 cm can be treated successfully using the induced membrane technique established by Masquelet. To shorten this procedure, human acellular dermis (HAD) has had success in replacing this membrane in rat models. The aim of ...

Abstract	Critical-size bone defects up to 25 cm can be treated successfully using the induced membrane technique established by Masquelet. To shorten this procedure, human acellular dermis (HAD) has had success in replacing this membrane in rat models. The aim of this study was to compare bone healing for smaller and larger defects using an induced membrane and HAD in a rat model. Using our established femoral defect model in rats, the animals were placed into four groups and defects of 5 mm or 10 mm size were set, either filling them with autologous spongiosa and surrounding the defect with HAD or waiting for the induced membrane to form around a cement spacer and filling this cavity in a second operation with a cancellous bone graft. Healing was assessed eight weeks after the operation using µ-CT, histological staining, and an assessment of the progress of bone formation using an established bone healing score. The α-smooth muscle actin used as a signal of blood vessel formation was stained and counted. The 5 mm defects showed significantly better bone union and a higher bone healing score than the 10 mm defects. HAD being used for the smaller defects resulted in a significantly higher bone healing score even than for the induced membrane and significantly higher blood vessel formation, corroborating the good results achieved by using HAD in previous studies. In comparison, same-sized groups showed significant differences in bone healing as well as blood vessel formation, suggesting that 5 mm defects are large enough to show different results in healing depending on treatment; therefore, 5 mm is a viable size for further studies on bone healing.
Language	English
Publishing date	2024-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2746191-9
ISSN	2306-5354
ISSN	2306-5354
DOI	10.3390/bioengineering11030287
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sterilization of PLA after Fused Filament Fabrication 3D Printing: Evaluation on Inherent Sterility and the Impossibility of Autoclavation.

Neijhoft, Jonas / Henrich, Dirk / Kammerer, Andreas / Janko, Maren / Frank, Johannes / Marzi, Ingo

Polymers

2023 Volume 15, Issue 2

Abstract: Three-dimensional printing, especially fused filament fabrication (FFF), offers great possibilities in (bio-)medical applications, but a major downside is the difficulty in sterilizing the produced parts. This study evaluates the questions of whether ... ...

Abstract	Three-dimensional printing, especially fused filament fabrication (FFF), offers great possibilities in (bio-)medical applications, but a major downside is the difficulty in sterilizing the produced parts. This study evaluates the questions of whether autoclaving is a possible solution for FFF-printed parts and if the printer itself could be seen as an inherent sterilization method. In a first step, an investigation was performed on the deformation of cylindrically shaped test parts after running them through the autoclaving process. Furthermore, the inherent sterility possibilities of the printing process itself were evaluated using culture medium sterility tests. It could be shown that, depending on the needed accuracy, parts down to a diameter of 5-10 mm can still be sterilized using autoclaving, while finer parts suffer from major deformations. For these, inherent sterilization of the printer itself is an option. During the printing process, over a certain contact time, heat at a higher level than that used in autoclaving is applied to the printed parts. The contact time, depending on the printing parameters, is calculated using the established formula. The results show that for stronger parts, autoclaving offers a cheap and good option for sterilization after FFF-printing. However, the inherent sterility possibilities of the printer itself can be considered, especially when printing with small layer heights for finer parts.
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15020369
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Visualization of complicated fractures by 3D-printed models for teaching and surgery: hands-on transitional fractures of the ankle.

Neijhoft, Jonas / Henrich, Dirk / Mörs, Katharina / Marzi, Ingo / Janko, Maren

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2022 Volume 48, Issue 5, Page(s) 3923–3931

Abstract: Aims: Understanding the orientation of fracture lines and mechanisms is the essential key to sufficient surgical therapy, but there is still a lack of visualization and teaching methods in traumatology and fracture theory. 3D-printed models offer easy ... ...

Abstract	Aims: Understanding the orientation of fracture lines and mechanisms is the essential key to sufficient surgical therapy, but there is still a lack of visualization and teaching methods in traumatology and fracture theory. 3D-printed models offer easy approach to those fractures. This paper explains the use of the teaching possibility with 3-dimensional models of transitional fractures of the ankle. Methods and results: For generating 3D printable models, already obtained CT data were used and segmented into its different tissues, especially parts concerning the fracture. After the segmentation process, the models were produced with FFF (fused filament fabrication) printing technology. The fracture models then were used for hands-on teaching courses in AO course (Arbeitsgemeinschaft für Osteosynthesefragen) of pediatric traumatology in 2020 in Frankfurt. In the course fracture anatomy with typical fracture lines, approaches, and screw placement could be shown, discussed and practiced. Conclusion: The study shows the use of 3D-printed teaching models and helps to understand complicated fractures, in this case, transitional fractures of the ankle. The teaching method can be adapted to numerous other use cases.
MeSH term(s)	Ankle ; Bone Screws ; Child ; Fractures, Bone/diagnostic imaging ; Fractures, Bone/surgery ; Humans ; Printing, Three-Dimensional ; Traumatology/education
Language	English
Publishing date	2022-02-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-022-01879-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1221: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Evaluation of a 3D-printed hands-on radius fracture model during teaching courses.

Neijhoft, Jonas / Sterz, Jasmina / Rüsseler, Miriam / Britz, Vanessa / Bepler, Lena / Freund, Verena / Horz, Christian / Henrich, Dirk / Marzi, Ingo / Janko, Maren

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2023 Volume 50, Issue 1, Page(s) 49–57

Abstract: Objective: This study aimed to evaluate the effectiveness of a 3D-printed hands-on radius fracture model for teaching courses. The model was designed to enhance understanding and knowledge of radius fractures among medical students during their clinical ...

Abstract	Objective: This study aimed to evaluate the effectiveness of a 3D-printed hands-on radius fracture model for teaching courses. The model was designed to enhance understanding and knowledge of radius fractures among medical students during their clinical training. Methods: The 3D models of radius fractures were generated using CT scans and computer-aided design software. The models were then 3D printed using Fused-Filament-Fabrication (FFF) technology. A total of 170 undergraduate medical students participated in the study and were divided into three groups. Each group was assigned one of three learning aids: conventional X-ray, CT data, or a 3D-printed model. After learning about the fractures, students completed a questionnaire to assess their understanding of fracture mechanisms, ability to assign fractures to the AO classification, knowledge of surgical procedures, and perception of the teaching method as well as the influence of such courses on their interest in the specialty of trauma surgery. Additionally, students were tested on their ability to allocate postoperative X-ray images to the correct preoperative image or model and to classify them to the AO classification. Results: The 3D models were well received by the students, who rated them as at least equal or better than traditional methods such as X-ray and CT scans. Students felt that the 3D models improved their understanding of fracture mechanisms and their ability to explain surgical procedures. The results of the allocation test showed that the combination of the 3D model and X-ray yielded the highest accuracy in classifying fractures according to the AO classification system, although the results were not statistically significant. Conclusion: The 3D-printed hands-on radius fracture model proved to be an effective teaching tool for enhancing students' understanding of fracture anatomy. The combination of 3D models with the traditional imaging methods improved students' ability to classify fractures and allocate postoperative images correctly.
MeSH term(s)	Humans ; Radius Fractures/diagnostic imaging ; Radius Fractures/surgery ; Software ; Tomography, X-Ray Computed/methods ; Hand Injuries ; Students, Medical ; Printing, Three-Dimensional
Language	English
Publishing date	2023-07-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-023-02327-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1221: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: 3D-Printed PLA-Bioglass Scaffolds with Controllable Calcium Release and MSC Adhesion for Bone Tissue Engineering.

Schätzlein, Eva / Kicker, Christoph / Söhling, Nicolas / Ritz, Ulrike / Neijhoft, Jonas / Henrich, Dirk / Frank, Johannes / Marzi, Ingo / Blaeser, Andreas

Polymers

2022 Volume 14, Issue 12

Abstract: Large bone defects are commonly treated by replacement with auto- and allografts, which have substantial drawbacks including limited supply, donor site morbidity, and possible tissue rejection. This study aimed to improve bone defect treatment using a ... ...

Abstract	Large bone defects are commonly treated by replacement with auto- and allografts, which have substantial drawbacks including limited supply, donor site morbidity, and possible tissue rejection. This study aimed to improve bone defect treatment using a custom-made filament for tissue engineering scaffolds. The filament consists of biodegradable polylactide acid (PLA) and a varying amount (up to 20%) of osteoconductive S53P4 bioglass. By employing an innovative, additive manufacturing technique, scaffolds with optimized physico-mechanical and biological properties were produced. The scaffolds feature adjustable macro- and microporosity (200-2000 µm) with adaptable mechanical properties (83-135 MPa). Additionally, controllable calcium release kinetics (0-0.25 nMol/µL after 24 h), tunable mesenchymal stem cell (MSC) adhesion potential (after 24 h by a factor of 14), and proliferation (after 168 h by a factor of 18) were attained. Microgrooves resulting from the 3D-printing process on the surface act as a nucleus for cell aggregation, thus being a potential cell niche for spheroid formation or possible cell guidance. The scaffold design with its adjustable biomechanics and the bioglass with its antimicrobial properties are of particular importance for the preclinical translation of the results. This study comprehensibly demonstrates the potential of a 3D-printed bioglass composite scaffold for the treatment of critical-sized bone defects.
Language	English
Publishing date	2022-06-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym14122389
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Conference proceedings: 3D-gedruckte, röhrenförmige poröse Scaffolds auf Polylaktat-Basis führen zu einer soliden Durchbauung segmentaler Femurdefekte in der Ratte

Neijhoft, Jonas / Kammerer, Andreas / Feriduni, Roxana / Schätzlein, Eva / Ritz, Ulrike / Söhling, Nicolas / Blaeser, Andreas / Frank, Johannes / Marzi, Ingo / Henrich, Dirk

2023 , Page(s) AB14–2191

Event/congress	Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2023); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2023
Keywords	Medizin, Gesundheit ; tissue engineering ; langstreckige Knochendefekte ; critical size defects ; Knochenersatzscaffolds ; 3D-Druck ; Bioglas ; fused-filament-fabrication ; Kompositfilamente
Publishing date	2023-10-23
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/23dkou019
Database	German Medical Science

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Article ; Online: Manufacturing and supply of face shields in hospital operation in case of unclear and confirmed COVID-19 infection status of patients.

Neijhoft, Jonas / Viertmann, Tobias / Meier, Simon / Söhling, Nicolas / Wicker, Sabine / Henrich, Dirk / Marzi, Ingo

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2020 Volume 46, Issue 4, Page(s) 743–745

MeSH term(s)	Asymptomatic Infections ; Betacoronavirus/isolation & purification ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Equipment Design ; Eye Protective Devices ; Germany ; Humans ; Infection Control/instrumentation ; Infection Control/methods ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Masks ; Pandemics/prevention & control ; Personal Protective Equipment ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-27
Publishing country	Germany
Document type	Letter
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-020-01392-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1221: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Book ; Online ; Thesis: Entwicklung und Realisierung neuer Designs zur Nutzung als Knochenersatzmaterial mittels Fused-Deposition-Modelling-3D-Druck

Neijhoft, Jonas [Verfasser] / Henrich, Dirk [Akademischer Betreuer] / Henrich, Dirk [Gutachter] / Sader, Robert Alexander [Gutachter]

2021

Author's details	Jonas Neijhoft ; Gutachter: Dirk Henrich, Robert Alexander Sader ; Betreuer: Dirk Henrich
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitätsbibliothek Johann Christian Senckenberg
Publishing place	Frankfurt am Main
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: 3D-Printed PLA-Bioglass Scaffolds with Controllable Calcium Release and MSC Adhesion for Bone Tissue Engineering

Eva Schätzlein / Christoph Kicker / Nicolas Söhling / Ulrike Ritz / Jonas Neijhoft / Dirk Henrich / Johannes Frank / Ingo Marzi / Andreas Blaeser

Polymers, Vol 14, Iss 2389, p

2022 Volume 2389

Abstract	Large bone defects are commonly treated by replacement with auto- and allografts, which have substantial drawbacks including limited supply, donor site morbidity, and possible tissue rejection. This study aimed to improve bone defect treatment using a custom-made filament for tissue engineering scaffolds. The filament consists of biodegradable polylactide acid (PLA) and a varying amount (up to 20%) of osteoconductive S53P4 bioglass. By employing an innovative, additive manufacturing technique, scaffolds with optimized physico-mechanical and biological properties were produced. The scaffolds feature adjustable macro- and microporosity (200–2000 µm) with adaptable mechanical properties (83–135 MPa). Additionally, controllable calcium release kinetics (0–0.25 nMol/µL after 24 h), tunable mesenchymal stem cell (MSC) adhesion potential (after 24 h by a factor of 14), and proliferation (after 168 h by a factor of 18) were attained. Microgrooves resulting from the 3D-printing process on the surface act as a nucleus for cell aggregation, thus being a potential cell niche for spheroid formation or possible cell guidance. The scaffold design with its adjustable biomechanics and the bioglass with its antimicrobial properties are of particular importance for the preclinical translation of the results. This study comprehensibly demonstrates the potential of a 3D-printed bioglass composite scaffold for the treatment of critical-sized bone defects.
Keywords	bone tissue engineering ; cell seeding ; biofabrication ; fused filament fabrication ; 3D printing ; bioactive glass ; Organic chemistry ; QD241-441
Subject code	571
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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